公开(公告)号：WO2008105698A1

公开(公告)日：2008-09-04

申请号：PCT/SE2007/000855

申请日：2007-09-27

Applicant: ST. JUDE MEDICAL AB ,  BJÖRLING, Anders ,  ÖHLANDER, Malin ,  ERIKSSON, Tom ,  ECKERDAL, Johan ,  LÖNN, Urban ,  NILSSON, Kenth ,  TUVSTEDT, Cecilia ,  SVAHN, Johan ,  JOHANSSON, Anna-Karin ,  NOREN, Kjell ,  BROOME, Michael

Inventor： BJÖRLING, Anders ,  ÖHLANDER, Malin ,  ERIKSSON, Tom ,  ECKERDAL, Johan ,  LÖNN, Urban ,  NILSSON, Kenth ,  TUVSTEDT, Cecilia ,  SVAHN, Johan ,  JOHANSSON, Anna-Karin ,  NOREN, Kjell ,  BROOME, Michael

IPC: A61N1/372 ,  A61B5/0205 ,  A61B5/145

CPC classification number: A61B5/14542 ,  A61B5/0031 ,  A61B5/076 ,  A61B5/1459 ,  A61B2562/0219 ,  A61N1/3627 ,  A61N1/36542 ,  A61N1/36557 ,  A61N1/36585

Abstract: A device and method of a medical implant for monitoring progression of heart failure in a human heart. An activity sensor provides information related to the activity level of a patient and an oxygen sensor provides information related to the level of oxygen content in venous blood. A determined level of venous oxygen content at a determined activity level is obtained, and that level of venous oxygen content is compared to stored values at a corresponding activity level. The result of the comparison is used as a basis for determining a degree of heart failure.

Abstract translation: 用于监测人类心脏心脏衰竭进展的医用植入物的装置和方法。 活动传感器提供与患者的活动水平相关的信息，氧传感器提供与静脉血中氧含量水平相关的信息。 在确定的活性水平获得确定水平的静脉氧含量，并将静脉氧含量的水平与在相应活动水平的储存值进行比较。 将比较结果用作确定心力衰竭程度的基础。

公开(公告)号：WO2006130056A1

公开(公告)日：2006-12-07

申请号：PCT/SE2005/000829

申请日：2005-05-31

Applicant: ST. JUDE MEDICAL AB ,  NILSSON, Kenth ,  JOHANSSON, Anna-Karin ,  ERIKSSON, Tom

Inventor： NILSSON, Kenth ,  JOHANSSON, Anna-Karin ,  ERIKSSON, Tom

IPC: A61N1/05

CPC classification number: A61N1/056 ,  A61N1/36564

Abstract: Implantable lead for sensing mechanical activity of a human heart. The lead comprises an insulating polymeric tube extending from a proximal end to a distal end of the lead, an electric conductor provided in the lumen of the polymeric tube, and a sensor connected to the conductor at a distal end thereof. The polymeric tube is provided with a conductive surface layer along the interface between the polymeric tube and the electric conductor. Thereby, accumulation of electrical charges between the electric conductor and the polymeric tube is prevented.

Abstract translation: 用于感测人体心脏的机械活动的植入性铅。 引线包括从引线的近端延伸到远端的绝缘聚合物管，设置在聚合物管的内腔中的电导体，以及在其远端连接到导体的传感器。 聚合物管沿着聚合物管和电导体之间的界面设置有导电表面层。 由此，能够防止电导体与聚合物管之间的电荷积聚。

公开(公告)号：WO2006130055A1

公开(公告)日：2006-12-07

申请号：PCT/SE2005/000823

申请日：2005-05-31

Applicant: ST. JUDE MEDICAL AB ,  ERIKSSON, Tom ,  NILSSON, Kenth ,  JOHANSSON, Anna-Karin ,  LJUNGSTRÖM, Karin ,  LASHGARI, Koroush ,  POHL, Annika ,  WESTIN, Gunnar

Inventor： ERIKSSON, Tom ,  NILSSON, Kenth ,  JOHANSSON, Anna-Karin ,  LJUNGSTRÖM, Karin ,  LASHGARI, Koroush ,  POHL, Annika ,  WESTIN, Gunnar

IPC: H01L41/187 ,  C04B35/495

CPC classification number: C04B35/495 ,  A61N1/056 ,  A61N1/0565 ,  A61N1/36542 ,  A61N1/36564 ,  C01G33/00 ,  C01G33/006 ,  C01P2002/72 ,  C01P2002/77 ,  C01P2002/82 ,  C01P2002/88 ,  C01P2004/03 ,  C04B35/624 ,  C04B35/62645 ,  C04B35/62675 ,  C04B2235/3201 ,  C04B2235/3251 ,  C04B2235/3255 ,  C04B2235/441 ,  C04B2235/6562 ,  C04B2235/768 ,  C04B2235/80 ,  C23C18/1216 ,  C23C18/1225 ,  C23C18/1254 ,  C23C18/1283 ,  H01L41/1873 ,  H01L41/318

Abstract: The invention refers to a method for producing a biocompatible material of the formula Na x K y NbO 3 , 0≤x≤0.8, 0.2≤y≤1, x+y=1, comprising the steps of: (i) providing a Na-precursor and a K-precursor for Na x K y NbO 3 ; (ii) mixing the precursors in solution, whereby they first react to form a sol and thereafter a gel; and heat treating the gel to obtain an oxide of the material Na x K y NbO 3 , 0≤x≤0.8, 0.2≤y≤1, x+y=1. Hereby, a biocompatible material having several advantages, such as a highly controlled composition, is produced. Further, the invention refers to a method for producing a film comprising the material, as well as a material and a film produced by the method of the invention. Moreover, the invention refers to an implant comprising the biocompatible film of the invention.

Abstract translation: 本发明涉及一种制备式Na生物相容性材料的方法，其中0 = x = 0.8,0.2 = y = 1，x + y = 1，包括以下步骤：（i）提供Na +前体和K-前体，用于Na + > 3 ; （ii）将前体在溶液中混合，由此它们首先反应形成溶胶，然后凝胶; 并且对所述凝胶进行热处理以获得所述材料的氧化物，所述氧化物为Na 2 O 3，NbO 3，0 = x = 0.8,0.2 = y = 1，x + y = 1。 因此，生产具有几个优点的生物相容性材料，例如高度控制的组合物。 此外，本发明涉及一种制造包含该材料的膜的方法，以及通过本发明的方法制备的材料和膜。 此外，本发明涉及包含本发明的生物相容性膜的植入物。

公开(公告)号：WO2007089175A1

公开(公告)日：2007-08-09

申请号：PCT/SE2006/000142

申请日：2006-01-31

Applicant: ST. JUDE MEDICAL AB ,  LAGERCRANTZ, Per ,  JOHANSSON, Anna-Karin ,  JÄRVERUD, Karin

Inventor： LAGERCRANTZ, Per ,  JOHANSSON, Anna-Karin ,  JÄRVERUD, Karin

IPC: A61N1/37 ,  G01K7/00 ,  A61N1/362 ,  A61N1/39

CPC classification number: G01K13/002 ,  A61B2562/245 ,  A61N1/3706 ,  A61N2001/083 ,  G01K7/32

Abstract: Device in a cardiac stimulator for monitoring the status of a cardiac lead implanted in a human heart. A temperature sensitive element is arranged in an implantable lead and is sensitive to the temperature of blood and the like in contact with the surface of the temperature sensitive element. The cardiac stimulator receives a temperature signal indicative of the temperatures to which the element is subjected. A status signal is provided which is indicative of the status of the implantable lead on the basis of the determined temperature signals .

Abstract translation: 心脏刺激器中的装置，用于监测植入人心脏的心脏线的状态。 温度敏感元件布置在可植入引线中并且对与温度敏感元件的表面接触的血液等的温度敏感。 心脏刺激器接收指示元件经受的温度的温度信号。 提供了基于所确定的温度信号来指示可植入引线的状态的状态信号。