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    COMPOUNDS CONTAINING THIOSULFATE MOIETIES
    2.
    发明申请
    COMPOUNDS CONTAINING THIOSULFATE MOIETIES 审中-公开

    公开(公告)号：WO2005047242A3

    公开(公告)日：2005-05-26

    申请号：PCT/US2004/036846

    申请日：2004-11-05

    申请人： MOLECULAR PROBES, INC. ,  HAUGLAND, Richard ,  KANG, Hee, Chol

    发明人： HAUGLAND, Richard ,  KANG, Hee, Chol

    IPC分类号： C07C381/02

    摘要： The present invention provides thiosulphate compounds having the formulae R-S-SO 3 ¯, R-S-SO 3 H, R-L-S-SO 3 , R-L-S-SO 3 H, X-L-S-SO 3 ¯and X-L-S-SO 3 H, where R is a reporter group, a carrier molecule or a solid support, L is a linker and X is a reactive group suitable for a crosslinking agent, and methods for their preparation and use. The thiosulphate group reacts with thiol group to form a disulphide bond, making the compound suitable for the labelling and immobilization of target analytes.

    FLUORESCENT PHOSPHOLIPASE A2 INDICATORS
    7.
    发明申请
    FLUORESCENT PHOSPHOLIPASE A2 INDICATORS 审中-公开

    公开(公告)号：WO2008151089A3

    公开(公告)日：2008-12-11

    申请号：PCT/US2008/065432

    申请日：2008-05-30

    申请人： INVITROGEN CORPORATION ,  KANG, Hee Chol

    发明人： KANG, Hee Chol

    IPC分类号： C12Q1/34 ,  G01N33/573

    摘要： Compositions, methods of synthesis and applications of phospholipase A 2 (PLA 2 ) specific enzyme substrates which exhibit fluorescence resonance energy transfer (FRET) are described. The compounds generally have the structure: (I) wherein, the variables are described throughout the application. These novel compounds provide a sensitive method to monitor real time PLA 2 specific enzyme activities in various cells, tissues and small organisms with fluorescence-ratiometric analysis.

    MODIFIED HYDROCYANINE DYES FOR THE DETECTION OF REACTIVE OXYGEN SPECIES
    9.
    发明申请
    MODIFIED HYDROCYANINE DYES FOR THE DETECTION OF REACTIVE OXYGEN SPECIES 审中-公开
    用于检测反应性氧化物种的改性的氢氯仿染料

    公开(公告)号：WO2012061403A1

    公开(公告)日：2012-05-10

    申请号：PCT/US2011/058806

    申请日：2011-11-01

    申请人： LIFE TECHNOLOGIES CORPORATION ,  KANG, Hee Chol ,  GEE, Kyle ,  MANDAVILLI, Bhaskar ,  YING, Lai-Qiang ,  BRANCHAUD, Bruce

    发明人： KANG, Hee Chol ,  GEE, Kyle ,  MANDAVILLI, Bhaskar ,  YING, Lai-Qiang ,  BRANCHAUD, Bruce

    IPC分类号： A61Q5/10 ,  A61K8/41

    CPC分类号： G01N21/6486 ,  C09B23/06 ,  C09B23/08 ,  C09B23/083 ,  C09B57/00

    摘要： ABSTRACT Described herein are compounds, compositions, methods, and kits for detecting reactive oxygen species (ROS) by conventional fluorescence microscopy, fluorescence spectroscopy, flow cytometry, and/or high content imaging. The compounds disclosed herein are novel reduced dyes, including Cy-based hydrocyanine dyes and Cy-based deuterocyanine dyes, which dyes are probes for detecting ROS and measuring oxidative stress in cells either in vitro and/or in vivo. Also described herein are processes for preparing novel reduced dyes, i.e., ROS probes, for use in the disclosed compositions, methods and kits.

    摘要翻译： 摘要本文描述了通过常规荧光显微镜，荧光光谱，流式细胞术和/或高含量成像检测活性氧（ROS）的化合物，组合物，方法和试剂盒。 本文公开的化合物是新的还原染料，包括基于Cy的氢化花青染料和Cy-基氘异氰染料，其染料是用于检测ROS的探针和测量体外和/或体内细胞中的氧化应激。 本文还描述了用于制备用于所公开的组合物，方法和试剂盒的新型还原染料即ROS探针的方法。