公开(公告)号：WO2013011444A1

公开(公告)日：2013-01-24

申请号：PCT/IB2012/053621

申请日：2012-07-16

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH ,  WIRTZ, Daniel ,  LEUSSLER, Christoph ,  KRUEGER, Sascha

Inventor： WIRTZ, Daniel ,  LEUSSLER, Christoph ,  KRUEGER, Sascha

IPC: G01R33/28

CPC classification number: G01R33/28 ,  G01R33/287 ,  G01R33/58

Abstract: A fiducial position marker (1) for use in a magnetic resonance (MR) imaging apparatus is disclosed for exciting and/or receiving MR signals in/from a local volume which at least substantially surrounds or adjoins the position marker, in order to determine and/or image from these MR signals the position of the position marker in an MR image of an examination object. Such a position marker (1) is especially used for determining and/or imaging a position of an interventional or non-interventional instrument to which the position marker may be attached, like a catheter, a surgical device, a biopsy needle, a pointer, a stent or another invasive or any non-invasive device in an MR image of an examination object. Further, a position marker system comprising such a position marker (1) and a circuit arrangement (5, 6, 6a, 8) for driving the position marker (1) for exciting MR signals and/or for processing MR signals received by the position marker is disclosed.

Abstract translation: 公开了一种用于在磁共振（MR）成像设备中使用的基准位置标记（1），用于激励和/或接收来自本地体积的MR信号，所述本地体积至少基本上围绕或邻接位置标记，以便确定和 /或来自这些MR的图像信号将检查对象的MR图像中的位置标记的位置。 这样的位置标记（1）特别用于确定和/或成像位置标记可以附着的介入或非介入性仪器的位置，如导管，手术装置，活检针，指针， 检查对象的MR图像中的支架或另一侵入性或任何非侵入性装置。 此外，包括这样的位置标记（1）和用于驱动用于激励MR信号的位置标记（1）和/或用于处理由位置接收的MR信号的电路装置（5,6,6a，8）的位置标记系统 标记被公开。

公开(公告)号：WO2010082150A1

公开(公告)日：2010-07-22

申请号：PCT/IB2010/050082

申请日：2010-01-11

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH ,  WEISS, Steffen ,  LIPS, Oliver ,  KRUEGER, Sascha ,  DAVID, Bernd

Inventor： WEISS, Steffen ,  LIPS, Oliver ,  KRUEGER, Sascha ,  DAVID, Bernd

IPC: A61M25/00 ,  G01R33/28

CPC classification number: A61M25/0021 ,  A61B18/1492 ,  A61B2018/00023 ,  A61B2018/00029 ,  A61B2018/00744 ,  A61B2034/2051 ,  A61B2090/374 ,  A61B2090/3954 ,  A61M25/0082 ,  A61M25/10 ,  A61M2025/0166 ,  G01R33/287

Abstract: The present invention relates toa catheter (2) for applying energy to an object (6) and a magnetic resonance imaging system (1) for localizing the catheter (2). The catheter (2) comprises an energyapplication element for applying energy to the object (6), and a cavity for providing a magnetic resonance fluid from which magnetic resonance signals generated by the magnetic resonance imaging system (1) arereceivable, wherein the cavity is adapted for providing a cooling fluid as the magnetic resonance fluidfor cooling the energy application element. The catheter (2) comprises further a tracking coil (15) for tracking the catheter (2), wherein the trackingcoil (15) is adapted to receive the magnetic resonance signals from the magnetic resonance fluid. Thus, the magnetic resonance fluid fulfils at least twofunctions, providing magnetic resonance signals for tracking the catheter (2) and cooling the energy application element.

Abstract translation: 本发明涉及用于对物体（6）施加能量的导管（2）和用于定位导管（2）的磁共振成像系统（1）。 导管（2）包括用于向物体（6）施加能量的能量施加元件，以及用于提供磁共振流体的空腔，由磁共振成像系统（1）产生的磁共振信号可从该磁共振流体中获得，其中腔适配 用于提供作为用于冷却能量施加元件的磁共振流体的冷却流体。 导管（2）还包括用于跟踪导管（2）的跟踪线圈（15），其中跟踪线圈（15）适于从磁共振流体接收磁共振信号。 因此，磁共振流体实现至少两个功能，提供用于跟踪导管（2）并且冷却能量施加元件的磁共振信号。

公开(公告)号：WO2009004548A3

公开(公告)日：2009-01-08

申请号：PCT/IB2008/052589

申请日：2008-06-27

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH ,  KRUEGER, Sascha ,  DAVID, Bernd ,  LIPS, Oliver ,  WEISS, Steffen ,  WIRTZ, Daniel

Inventor： KRUEGER, Sascha ,  DAVID, Bernd ,  LIPS, Oliver ,  WEISS, Steffen ,  WIRTZ, Daniel

IPC: G01R33/28

Abstract: A transmission cable for use in an elongate medical device (420) such as a catheter, guide wire, etc., wherein the transmission cable is capable of being switched to an MR-safe mode only when necessary, while retaining its optimal electrical transmission properties otherwise, is disclosed herein. The transmission cable comprises a transmission line including at least two electrically conductive line segments (104a, 104b) separated by a non-conductive gap (106a), a bridging unit comprising at least one electrically conductive bridge segment (108a) capable of bridging the non-conductive gap, and a switching unit (112) arranged to move the bridging unit and/or the transmission line to electrically connect the two line segments by closing the non-conductive gap using the bridge segment or to electrically disconnect the two line segments by opening the non-conductive gap.

公开(公告)号：WO2006131859A3

公开(公告)日：2007-04-26

申请号：PCT/IB2006051759

申请日：2006-06-01

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  KRUEGER SASCHA ,  NIELSEN TIM

Inventor： KRUEGER SASCHA ,  NIELSEN TIM

IPC: A61B5/026

CPC classification number: A61B5/0261

Abstract: The invention relates to a modified Laser Optical Feedback Tomography sensor (10) which comprises an evaluator (16) for the determination of an object velocity (vz) relative to the sensor (10). The primary optical frequency (f o ) of light emitted by a laser (11) is shifted by a first frequency shift F in a frequency shifter (13) and focused into an investigation region (3). A moving object (2) in said region produces an additional Doppler frequency shift ?F in the light sent back from the investigation region (3) which is re-injected into the laser (11). Resulting intensity oscillations of the laser (11), which critically depend on the shifted frequency of the re-injected light, are detected by a detector (15). Finally, the evaluator (16) coupled to the detector (15) determines from the observed oscillations the Doppler frequency shift ?F and therefrom the moving velocity (V z ) of the object (2).

Abstract translation: 本发明涉及一种修改的激光光学反馈层析成像传感器（10），其包括用于确定相对于传感器（10）的物体速度（vz）的评估器（16）。 由激光器（11）发射的光的初级光学频率（频率）在频移器（13）中偏移第一频移F并被聚焦到调查区域（3）中。 所述区域中的运动物体（2）在从再次注入激光器（11）的调查区域（3）返回的光中产生附加的多普勒频移ΔF。 检测器（15）检测激光器（11）的强烈的振动，其主要取决于重新注入的光的偏移频率。 最后，耦合到检测器（15）的评估器（16）根据观察到的振荡来确定多普勒频移ΔF，从而确定对象（2）的移动速度（V SUB）。

公开(公告)号：WO2007015180A1

公开(公告)日：2007-02-08

申请号：PCT/IB2006/052373

申请日：2006-07-12

Applicant: KONINKLIJKE PHILIPS ELECTRONICS, N.V. ,  U.S. PHILIPS CORPORATION ,  KRUEGER, Sascha ,  GLEICH, Bernhard

Inventor： KRUEGER, Sascha ,  GLEICH, Bernhard

IPC: G01D5/20

CPC classification number: G01D5/208 ,  G01D5/2073

Abstract: A system and method for determining the location of a remote object, using a magnetic tracking sensor. The system and method include locating a magnetic core (132) asymmetrically disposed within an induction coil (130) and operably connecting a single DC electrical circuit (136) to ends defining the induction coil (130). The DC electrical circuit (136) provides a DC current to the induction coil (130) while the induction coil (130) is disposed in an external AC magnetic field (108) . The DC current adjusts the level of saturation of the magnetic core (132), and hence varies a response signal of the induction coil (130) disposed in the external AC magnetic field (108) to provide magnetic tracking of the induction coil (130) in 6 degrees of freedom.

Abstract translation: 一种用于使用磁跟踪传感器确定远程物体的位置的系统和方法。 该系统和方法包括将不对称地设置在感应线圈（130）内的磁芯（132）定位并且将单个DC电路（136）可操作地连接到限定感应线圈（130）的端部。 直流电路（136）在感应线圈（130）设置在外部交流磁场（108）中时，向感应线圈（130）提供直流电流。 直流电流调节磁芯（132）的饱和度，因此改变设置在外部交流磁场（108）中的感应线圈（130）的响应信号，以提供感应线圈（130）的磁跟踪， 在6度自由度。

公开(公告)号：WO2004079444A3

公开(公告)日：2004-11-11

申请号：PCT/IB2004000555

申请日：2004-03-03

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  NIELSEN TIM ,  KRUEGER SASCHA

Inventor： NIELSEN TIM ,  KRUEGER SASCHA

IPC: A61B5/00 ,  G01N21/47 ,  G02F1/35 ,  G02F1/39 ,  H01S3/00 ,  H01S3/102

CPC classification number: H01S3/1022 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0086 ,  A61B5/7285 ,  A61B6/541 ,  G01N21/4795 ,  G02F1/39 ,  G02F2203/26

Abstract: The invention relates to a method for the selective amplification of signal photons of a signal pulse (4) in a desired time window. For this purpose, the signal photons (4) are passed through an activated amplification medium (1), where amplification takes place by induced emissions. The amplification is terminated at a desired point in time by the irradiation of a quench pulse (7). Optionally, the start of amplification can be determined by an irradiated pump pulse (8). Emissions that are not correlated with the signal pulse (4) can be suppressed by means of a spectral filter (2). Furthermore, an intensity filter such as a saturable absorber (3) can suppress unamplified fractions of the emission (5) leaving the amplification medium (1). Applications of the method include medical optical imaging and tomography by transillumination with time-gated detection of ballistic photons.

Abstract translation: 本发明涉及一种在期望的时间窗口中选择性地放大信号脉冲（4）的信号光子的方法。 为此，信号光子（4）通过激活的放大介质（1），其中通过诱导的发射进行放大。 通过骤冷脉冲（7）的照射，在期望的时间点终止放大。 可选地，放大开始可以通过照射的泵浦脉冲（8）来确定。 可以通过光谱滤波器（2）来抑制与信号脉冲（4）不相关的发射。 此外，诸如可饱和吸收体（3）的强度滤波器可以抑制离开放大介质（1）的发射（5）的未扩增分数。 该方法的应用包括医学光学成像和断层扫描，通过时间门控检测弹道光子。

公开(公告)号：WO2012137148A1

公开(公告)日：2012-10-11

申请号：PCT/IB2012/051661

申请日：2012-04-04

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH ,  WEISS, Steffen ,  HOLTHUIZEN, Ronaldus, Frederik, Johannes ,  KRUEGER, Sascha ,  KOKEN, Peter ,  WIRTZ, Daniel ,  AMTHOR, Thomas, Erik ,  UHLEMANN, Falk

Inventor： WEISS, Steffen ,  HOLTHUIZEN, Ronaldus, Frederik, Johannes ,  KRUEGER, Sascha ,  KOKEN, Peter ,  WIRTZ, Daniel ,  AMTHOR, Thomas, Erik ,  UHLEMANN, Falk

IPC: G01R33/28 ,  A61B5/055

CPC classification number: A61B5/055 ,  A61B5/064 ,  A61B5/6832 ,  A61B5/72 ,  G01R33/287 ,  G01R33/34084

Abstract: A medical apparatus (1100) comprising a magnetic resonance imaging system and an interventional device (300) comprising a shaft (302, 1014, 1120). The medical apparatus further comprises a toroidal magnetic resonance fiducial marker (306, 600, 800, 900, 1000, 1122) attached to the shaft. The shaft passes through a center point (610, 810, 908, 1006) of the fiducial marker. The medical apparatus further comprises machine executable instructions (1150, 1152, 1154, 1156, 1158) for execution by a processor. The instructions cause the processor to acquire (100, 200) magnetic resonance data, to reconstruct (102, 202) a magnetic resonance image (1142), and to receive (104, 204) the selection of a target volume (1118, 1144, 1168). The instructions further cause the processor to repeatedly: acquire (106, 206) magnetic resonance location data (1146) from the fiducial marker and render (108, 212) a view (1148, 1162) indicating the position of the shaft relative to the target zone..

Abstract translation: 一种包括磁共振成像系统和包括轴（302,1014,1120）的介入装置（300）的医疗装置（1100）。 医疗装置还包括连接到轴的环形磁共振基准标记（306,600,800,900,1000,1122）。 轴通过基准标记的中心点（610,810,908,1006）。 医疗设备还包括用于由处理器执行的机器可执行指令（1150,1152,1154,1156,1158）。 所述指令使得所述处理器获取（100,200）磁共振数据，以重建（102,202）磁共振图像（1142），并且接收（104,204）所述目标体积（1118,1144， 1168）。 所述指令还使所述处理器重复地：从所述基准标记获取（106,206）磁共振位置数据（1146），并且渲染（108,212）指示所述轴相对于所述目标的位置的视图（1148,1162） 区..

公开(公告)号：WO2012059845A1

公开(公告)日：2012-05-10

申请号：PCT/IB2011/054771

申请日：2011-10-26

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH ,  VAN DEN BRINK, Johan Samuel ,  GRAESSLIN, Ingmar ,  KRUEGER, Sascha ,  WEISS, Steffen ,  VERNICKEL, Peter

Inventor： VAN DEN BRINK, Johan Samuel ,  GRAESSLIN, Ingmar ,  KRUEGER, Sascha ,  WEISS, Steffen ,  VERNICKEL, Peter

IPC: G01R33/44

CPC classification number: G01R33/36 ,  G01R33/246 ,  G01R33/44 ,  G01R33/5612 ,  G01R33/583

Abstract: The invention relates to a method of characterizing the RF transmit chain of a magnetic resonance imaging scanner (1) using -a local transmit/receive coil system (204; 210), comprising a first local NMR probe and a first local magnetic resonance coil, the first NMR probe being spatially located in immediate neighborhood to the first coil, -a local receive coil system (206; 208), comprising a second local NMR probe and a second local magnetic resonance coil, the second NMR probe being spatially located in immediate neighborhood to the second coil, wherein the transmit chain comprises an external MR coil (9; 11; 12; 13), the method comprising: -determining with the first magnetic resonance coil, a first MR signal phase evolution of the local RF transmit field generated by MR excitation of the first probe using the first magnetic resonance coil by measuring the RF response of the first probe upon said excitation, -determining with the second magnetic resonance coil a second MR signal phase evolution of the local RF transmit field generated by MR excitation of the second probe using the external MR coil (9; 11; 12; 13) by measuring the RF response of the second probe upon said excitation, - calculating a phase offset between the first and second MR signal phase evolution.

Abstract translation: 本发明涉及一种使用本地发射/接收线圈系统（204; 210）来表征磁共振成像扫描仪（1）的RF发射链的方法，该系统包括第一局部NMR探针和第一局部磁共振线圈， 空间上位于第一线圈附近的第一NMR探针 - 局部接收线圈系统（206; 208），包括第二局部NMR探针和第二局部磁共振线圈，所述第二NMR探针在空间上位于立即 邻近于所述第二线圈，其中所述发射链包括外部MR线圈（9; 11; 12; 13），所述方法包括： - 利用所述第一磁共振线圈确定所述本地RF发射场的第一MR信号相位演变 通过在所述激发时测量第一探针的RF响应，使用第一磁共振线圈通过MR激发而产生的第一探针， - 用第二磁共振线圈确定第二MR信号phas 使用外部MR线圈（9; 9）的第二探针的MR激发产生的局部RF发射场的演变。 11; 12; 13）通过在所述激励时测量第二探针的RF响应， - 计算第一和第二MR信号相位演化之间的相位偏移。

公开(公告)号：WO2010113121A1

公开(公告)日：2010-10-07

申请号：PCT/IB2010/051398

申请日：2010-03-31

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH ,  GRAESSLIN, Ingmar ,  KRUEGER, Sascha

Inventor： GRAESSLIN, Ingmar ,  KRUEGER, Sascha

IPC: G01R33/28

CPC classification number: G01R33/285 ,  G01R33/288

Abstract: A magnetic resonance method comprises: performing (C1) a magnetic resonance procedure on a calibration subject including an implant device; detecting (C2) a pick-up coil (PUC) signal at least during a radio frequency transmit phase of operation (C1); performing (C3) three dimensional temperature mapping of the calibration subject using a magnetic resonance sequence configured to detect any temperature change induced in any part of the implant device by operation (C1); generating (C4) an unsafe condition criterion (30) for the detected PUC signal based on correlating a PUC signal characteristic detected by operation (C2) with a temperature change detected by operation (C3); performing (M5) the magnetic resonance procedure on a subject containing an implant device; detecting (M6) a PUC signal at least during a radio frequency transmit phase of operation (M5); and monitoring (M7) for an unsafe condition indicated by the PUC signal detected in operation (M6) satisfying the unsafe condition criterion (30).

Abstract translation: 磁共振方法包括：在包括植入装置的校准对象上执行（C1）磁共振程序; 至少在射频发射阶段（C1）期间检测（C2）拾波线圈（PUC）信号; 使用构造成通过操作（C1）检测在植入装置的任何部分中诱导的任何温度变化的磁共振序列来执行（C3）校准对象的三维温度映射; 基于通过操作（C2）检测到的PUC信号特性与由操作（C3）检测到的温度变化相关联，生成（C4）用于检测到的PUC信号的不安全条件标准（30）。 对包含植入装置的受试者执行（M5）磁共振程序; 至少在射频发射阶段（M5）期间检测（M6）PUC信号; 以及对满足不安全条件标准（30）的在操作中检测到​​的PUC信号（M6）指示的不安全状态进行监视（M7）。

公开(公告)号：WO2010076685A1

公开(公告)日：2010-07-08

申请号：PCT/IB2009/055301

申请日：2009-11-23

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH ,  KRUEGER, Sascha ,  EHNHOLM, Gosta, Jakob

Inventor： KRUEGER, Sascha ,  EHNHOLM, Gosta, Jakob

IPC: A61B18/14 ,  A61B19/00 ,  G01R33/28

CPC classification number: A61B18/1492 ,  A61B90/06 ,  A61B90/36 ,  A61B2017/00084 ,  A61B2017/00243 ,  A61B2017/22067 ,  A61B2090/374 ,  A61B2090/3954 ,  A61N7/022

Abstract: An interventional instrument (24) for use in performing an interventional procedure includes: a balloon (30) disposed proximate to a tip of the interventional instrument that inflates and anchors in a lumen of a fluid conduit during the interventional procedure; and one or more susceptibility markers (34) disposed proximate to the tip of the interventional instrument. A magnetic resonance scanner (10) is configured to image at least the tip of the interventional instrument during the interventional procedure using a magnetic resonance imaging sequence in which fluid flow (40) through the fluid conduit past the inflated balloon produces an extended magnetic resonance image artifact (42).

Abstract translation: 用于执行介入手术的介入器械（24）包括：靠近介入器械的尖端布置的球囊（30），其在介入手术过程中使流体导管的内腔膨胀并锚固; 以及设置在介入器械的尖端附近的一个或多个敏感性标记（34）。 磁共振扫描器（10）被配置为使用磁共振成像序列在介入手术过程中至少对介入器械的尖端进行成像，其中通过流体导管的经过充气气囊的流体流（40）产生延伸的磁共振图像 神器（42）。