公开(公告)号：WO2009069833A1

公开(公告)日：2009-06-04

申请号：PCT/JP2008/072113

申请日：2008-11-28

Applicant: KYOTO UNIVERSITY ,  CANON KABUSHIKI KAISHA ,  KONDO, Teruyuki ,  TSUJITA, Hiroshi ,  SIDDIQUE, Zainul, Abedin ,  MATSUKI, Shingo ,  MIURA, Hiroki ,  TOCHIO, Hidehito ,  MATSUDA, Tetsuya ,  NARAZAKI, Michiko ,  TSUZUKI, Hidetoshi ,  KUGE, Katsuaki ,  TOMIDA, Yoshinori ,  YOSHIMURA, Kimihiro ,  YANO, Tetsuya

Inventor： KONDO, Teruyuki ,  TSUJITA, Hiroshi ,  SIDDIQUE, Zainul, Abedin ,  MATSUKI, Shingo ,  MIURA, Hiroki ,  TOCHIO, Hidehito ,  MATSUDA, Tetsuya ,  NARAZAKI, Michiko ,  TSUZUKI, Hidetoshi ,  KUGE, Katsuaki ,  TOMIDA, Yoshinori ,  YOSHIMURA, Kimihiro ,  YANO, Tetsuya

IPC: C07D255/02 ,  C07D257/02 ,  C07D259/00 ,  C07D405/14 ,  A61K49/06 ,  A61K49/10

CPC classification number: C07F5/003 ,  A61K49/106 ,  C07D255/02 ,  C07D257/02 ,  C07D259/00 ,  C07D405/14

Abstract: A core of a cyclic structure represented by (-N-(CH 2 )n-) k is bonded to a dendrimer-type side chain with a specific branched structure at all nitrogen atoms in the core to produce a compound with a specific structure for producing a metal complex that exhibits a T1-reducing effect, and the resulting compound is coordinated to a metal ion that has a T1-reducing effect to obtain a metal complex that exhibits an excellent T1-reducing effect which is useful as an effective component of an MRI contrast agent and an MRI contrast agent using the same.

Abstract translation: 由（-N-（CH 2）n - ）k表示的环状结构的核心与核心中所有氮原子上具有特定支化结构的树枝状大分子侧链结合，生成具有特定结构的化合物， 具有T1还原效果的金属络合物，所得化合物与具有T1还原效果的金属离子配位，得到显示出优异的T1还原效果的金属络合物，其可用作有机组分 MRI造影剂和使用其的MRI造影剂。

公开(公告)号：WO2009031712A1

公开(公告)日：2009-03-12

申请号：PCT/JP2008/066495

申请日：2008-09-08

Applicant: KYOTO UNIVERSITY ,  CANON KABUSHIKI KAISHA ,  YOSHIMURA, Kimihiro ,  YAMAUCHI, Fumio ,  KUGE, Katsuaki ,  YANO, Tetsuya ,  SHIRAKAWA, Masahiro ,  AOYAMA, Yasuhiro

Inventor： YOSHIMURA, Kimihiro ,  YAMAUCHI, Fumio ,  KUGE, Katsuaki ,  YANO, Tetsuya ,  SHIRAKAWA, Masahiro ,  AOYAMA, Yasuhiro

IPC: C07C215/40 ,  A61K49/06 ,  A61K51/04

CPC classification number: C07C215/40 ,  A61K49/10 ,  C07B2200/05 ,  C07C219/06 ,  C07F9/091 ,  C07F9/106 ,  G01N24/08 ,  G01R33/4608 ,  G01R33/5601 ,  G01R33/5605

Abstract: To produce a labeled compound for a selected biological substance not using a radioisotope atom which has a risk of exposure to radioactivity and limitation on handling time but using a stable isotope atom; and that the labeled compound can be measured with good sensitivity separably from naturally occurring compounds of the selected biological substance which are substituted with the stable isotope atom. Choline as a biological substance is labeled by substituting the nitrogen atom of the quaternary ammonium group and all the carbon atoms of the methyl group attached to the nitrogen atom with respective isotopes 15 N and 13 C and used as a diagnostic agent.

Abstract translation: 为了生产不使用具有暴露于放射性和限制处理时间但使用稳定同位素原子的放射性同位素原子的选定生物物质的标记化合物; 并且可以以与稳定同位素原子取代的所选择的生物物质的天然存在的化合物分离地具有良好的灵敏度来测量标记的化合物。 胆碱作为生物物质通过用相同的同位素15N和13C代替季铵基团的氮原子和与氮原子连接的甲基的全部碳原子进行标记，并用作诊断剂。

公开(公告)号：WO2005003715A3

公开(公告)日：2005-05-26

申请号：PCT/JP2004009788

申请日：2004-07-02

Applicant: CANON KK ,  HASHIMOTO HIROYUKI ,  KUGE KATSUAKI ,  KOMATSU MANABU ,  NAKAMURA KUMI ,  BAN KAZUHIRO ,  IMAMURA TAKESHI ,  KOBAYASHI SHIN

Inventor： HASHIMOTO HIROYUKI ,  KUGE KATSUAKI ,  KOMATSU MANABU ,  NAKAMURA KUMI ,  BAN KAZUHIRO ,  IMAMURA TAKESHI ,  KOBAYASHI SHIN

IPC: G01N33/68 ,  H01J49/04 ,  H01J49/40

CPC classification number: G01N33/6848 ,  H01J49/04 ,  H01J49/40

Abstract: An information acquisition method for acquiring information on a target object, that includes a step of promoting ionization of the target object using a substance for promoting ionization of the target object to cause the target object to emit, and a step of acquiring information on the mass of the flew target object using time-of-flight secondary ion mass spectrometry.

Abstract translation: 一种用于获取关于目标对象的信息的信息获取方法，其包括使用促进所述目标对象的电离的物质促进所述目标对象的电离以使所述目标对象发射的步骤以及获取所述质量信息的步骤 的飞行目标物体使用飞行时间二次离子质谱法。

公开(公告)号：WO2005003715A2

公开(公告)日：2005-01-13

申请号：PCT/JP2004/009788

申请日：2004-07-02

Applicant: CANON KABUSHIKI KAISHA ,  HASHIMOTO, Hiroyuki ,  KUGE, Katsuaki ,  KOMATSU, Manabu ,  NAKAMURA, Kumi ,  BAN, Kazuhiro ,  IMAMURA, Takeshi ,  KOBAYASHI, Shin

Inventor： HASHIMOTO, Hiroyuki ,  KUGE, Katsuaki ,  KOMATSU, Manabu ,  NAKAMURA, Kumi ,  BAN, Kazuhiro ,  IMAMURA, Takeshi ,  KOBAYASHI, Shin

IPC: G01N

CPC classification number: G01N33/6848 ,  H01J49/04 ,  H01J49/40

Abstract: An information acquisition method for acquiring information on a target object, that includes a step of promoting ionization of the target object using a substance for promoting ionization of the target object to cause the target object to emit, and a step of acquiring information on the mass of the flew target object using time-of-flight secondary ion mass spectrometry.

Abstract translation: 一种用于获取关于目标对象的信息的信息获取方法，包括使用促进目标对象的电离的物质促进目标物体的离子化以使目标对象发射的步骤，以及获取关于物体的信息的步骤的步骤 的飞行目标物体使用飞行时间二次离子质谱法。

公开(公告)号：WO2004010144A1

公开(公告)日：2004-01-29

申请号：PCT/JP2003/009161

申请日：2003-07-18

Applicant: CANON KABUSHIKI KAISHA ,  ISHIBASHI, Toru ,  OKADA, Yoshikatsu ,  KUGE, Katsuaki

Inventor： ISHIBASHI, Toru ,  OKADA, Yoshikatsu ,  KUGE, Katsuaki

IPC: G01N33/547

CPC classification number: G01N33/54353

Abstract: A method of producing a probe carrier in which a probe is immobilized to a substrate is disclosed, which comprises providing the substrate and contacting a basic group introduced to the substrate with the probe having an acidic group to thereby immobilize the probe to the substrate. This method enables production of a probe carrier that can reduce the number of steps performed for immobilizing the probe to the substrate and easily immobilize the probe.

Abstract translation: 公开了一种生产探针载体的方法，其中将探针固定在基底上，其包括提供基底并使引入基底的碱性基团与具有酸性基团的探针接触，从而将探针固定在基底上。 该方法能够生产探针载体，其可以减少将探针固定到基底上并且容易地固定探针的步骤数。

公开(公告)号：WO2009031717A1

公开(公告)日：2009-03-12

申请号：PCT/JP2008/066510

申请日：2008-09-08

Applicant: KYOTO UNIVERSITY ,  CANON KABUSHIKI KAISHA ,  YAMAUCHI, Fumio ,  YOSHIMURA, Kimihiro ,  KUGE, Katsuaki ,  YANO, Tetsuya ,  SHIRAKAWA, Masahiro ,  AOYAMA, Yasuhiro ,  SANDO, Shinsuke

Inventor： YAMAUCHI, Fumio ,  YOSHIMURA, Kimihiro ,  KUGE, Katsuaki ,  YANO, Tetsuya ,  SHIRAKAWA, Masahiro ,  AOYAMA, Yasuhiro ,  SANDO, Shinsuke

IPC: G01R33/28 ,  G01R33/465 ,  G01R33/483 ,  A61B5/055

CPC classification number: C12Q1/54 ,  C12Q1/32 ,  C12Q1/34 ,  G01N24/088 ,  G01R33/281 ,  G01R33/4633 ,  G01R33/465 ,  G01R33/483 ,  G01R33/5601 ,  Y02P20/582

Abstract: Substrate probe capable of detecting enzyme activity with high accuracy and a method for detecting the enzyme activity by a multi nuclear magnetic resonance method using the substrate probe. Multi-dimensional nuclear magnetic resonance is performed by using a substrate probe, which is used for measuring enzyme activity by a multi-dimensional nuclear magnetic resonance method and characterized by containing a enzyme recognition site that is selectively recognized by an active-state enzyme, as at least one constitutional unit, and a group to which at least three nuclear magnetic resonance active nuclei each having a nuclear spin and a different resonance frequency are connected, being present specifically to the enzyme recognition, thereby detecting presence of the substrate probe and the enzyme activity.

Abstract translation: 能够高精度地检测酶活性的底物探针和使用底物探针的多核磁共振法检测酶活性的方法。 通过使用用于通过多维核磁共振法测定酶活性的底物探针进行多维核磁共振，其特征在于含有被活性酶选择性识别的酶识别位点作为 至少一个结构单元和至少三个具有核自旋和不同共振频率的核磁共振活性核连接的基团，其特异性地存在于酶识别中，从而检测底物探针和酶的存在 活动。

公开(公告)号：WO2009031716A1

公开(公告)日：2009-03-12

申请号：PCT/JP2008/066509

申请日：2008-09-08

Applicant: KYOTO UNIVERSITY ,  CANON KABUSHIKI KAISHA ,  KUGE, Katsuaki ,  YOSHIMURA, Kimihiro ,  YAMAUCHI, Fumio ,  YANO, Tetsuya ,  SHIRAKAWA, Masahiro ,  AOYAMA, Yasuhiro

Inventor： KUGE, Katsuaki ,  YOSHIMURA, Kimihiro ,  YAMAUCHI, Fumio ,  YANO, Tetsuya ,  SHIRAKAWA, Masahiro ,  AOYAMA, Yasuhiro

IPC: G01R33/46 ,  G01R33/485 ,  G01R33/483

CPC classification number: G01R33/485 ,  G01R33/4608 ,  G01R33/4633 ,  G01R33/4833 ,  G01R33/5605 ,  G01R33/5607

Abstract: The present invention provides a multi-dimensional method for measuring nuclear magnetic resonance that employs a compound in which a plurality of nuclei is labeled with isotopes as a probe agent, highly selectively and highly sensitively obtains a nuclear magnetic resonance signal of the above described probe agent, and can attach a spatial positional information to the above described nuclear magnetic resonance signal, and an apparatus therefore.

Abstract translation: 本发明提供一种用于测量核磁共振的多维方法，其采用其中多个核被同位素标记作为探针剂的化合物，高选择性和高度灵敏地获得上述探针剂的核磁共振信号 ，并且可以将空间位置信息附加到上述核磁共振信号，以及一种装置。