公开(公告)号：WO2010116961A1

公开(公告)日：2010-10-14

申请号：PCT/JP2010/056120

申请日：2010-03-30

Applicant: CANON KABUSHIKI KAISHA ,  KOMATSU, Manabu ,  HASHIMOTO, Hiroyuki

Inventor： KOMATSU, Manabu ,  HASHIMOTO, Hiroyuki

IPC: G01N27/62 ,  G01N33/483 ,  G01N33/68

CPC classification number: G06F19/26 ,  G01N33/6848 ,  H01J49/0004 ,  Y10T436/24

Abstract: An object of the present invention is to provide a method of comprehensively visualizing a constituent in tumor tissue or the like at a cellular level. The present invention provides a method of forming a two-dimensional distribution image of a target constituent based on information on the mass of constituents of the tissue section wherein, as the internal standard material, any one of actin, tubulin and GAPDH is used in the intracellular region, one of histone and nucleic acid is used in the nuclear region, and one of albumin and cytokine is used in the extracellular region.

Abstract translation: 本发明的目的是提供一种在细胞水平上全面显示肿瘤组织等中的成分的方法。 本发明提供一种基于组织部位成分质量的信息形成目标成分的二维分布图像的方法，其中作为内标物质，使用肌动蛋白，微管蛋白和GAPDH中的任一种 细胞内区域，组蛋白和核酸之一用于核区域，白蛋白和细胞因子之一用于细胞外区域。

公开(公告)号：WO2005061112A1

公开(公告)日：2005-07-07

申请号：PCT/JP2004/019716

申请日：2004-12-22

Applicant: CANON KABUSHIKI KAISHA ,  KOMATSU, Manabu ,  HASHIMOTO, Hiroyuki

Inventor： KOMATSU, Manabu ,  HASHIMOTO, Hiroyuki

IPC: B01L3/02

CPC classification number: H01J49/10 ,  B01L3/5085 ,  H01J49/40 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A test specimen is provided which has one or more chemical substances fixed to prescribed plural independent positions on a substrate, and the quantities of the chemical substances fixed at the respective prescribed positions are the total of integer multiples of existence quantity units defined for the respective chemical substances in the range from 1 amol to 1 nmol (excluding the case in which the total quantity is zero).

Abstract translation: 提供了一种试样，其具有在基板上固定为规定的多个独立位置的一种或多种化学物质，并且在各规定位置固定的化学物质的量为为各化学物质定义的存在量单位的整数倍的总和 物质在1〜1nmol范围内（不包括总量为零的情况）。

公开(公告)号：WO2005003715A2

公开(公告)日：2005-01-13

申请号：PCT/JP2004/009788

申请日：2004-07-02

Applicant: CANON KABUSHIKI KAISHA ,  HASHIMOTO, Hiroyuki ,  KUGE, Katsuaki ,  KOMATSU, Manabu ,  NAKAMURA, Kumi ,  BAN, Kazuhiro ,  IMAMURA, Takeshi ,  KOBAYASHI, Shin

Inventor： HASHIMOTO, Hiroyuki ,  KUGE, Katsuaki ,  KOMATSU, Manabu ,  NAKAMURA, Kumi ,  BAN, Kazuhiro ,  IMAMURA, Takeshi ,  KOBAYASHI, Shin

IPC: G01N

CPC classification number: G01N33/6848 ,  H01J49/04 ,  H01J49/40

Abstract: An information acquisition method for acquiring information on a target object, that includes a step of promoting ionization of the target object using a substance for promoting ionization of the target object to cause the target object to emit, and a step of acquiring information on the mass of the flew target object using time-of-flight secondary ion mass spectrometry.

Abstract translation: 一种用于获取关于目标对象的信息的信息获取方法，包括使用促进目标对象的电离的物质促进目标物体的离子化以使目标对象发射的步骤，以及获取关于物体的信息的步骤的步骤 的飞行目标物体使用飞行时间二次离子质谱法。

公开(公告)号：WO2004003552A1

公开(公告)日：2004-01-08

申请号：PCT/JP2003/008198

申请日：2003-06-27

Applicant: CANON KABUSHIKI KAISHA ,  HASHIMOTO, Hiroyuki ,  OKAMOTO, Tadashi ,  ISHII, Mie

Inventor： HASHIMOTO, Hiroyuki ,  OKAMOTO, Tadashi ,  ISHII, Mie

IPC: G01N33/53

CPC classification number: B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00387 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00693 ,  B01J2219/00707 ,  B01J2219/00722 ,  C40B40/06 ,  C40B60/14

Abstract: ABSTRACT To provide a technology for obtaining a probe carrier which is quality assured by an effective inspection program and an effective producing steps. Quality of a produced probe carrier is ensured by expanding test items in the processes from synthesis and purification of the probe to fixation thereof to a carrier.

Abstract translation: 摘要提供一种获得探针载体的技术，通过有效的检测程序和有效的生产步骤，质量得到保证。 通过在从探针的合成和纯化到固定到载体的过程中扩大测试项目来确保产生的探针载体的质量。

公开(公告)号：WO1993001411A1

公开(公告)日：1993-01-21

申请号：PCT/JP1992000881

申请日：1992-07-09

Applicant: CHEN, Chongyuan ,  HASHIMOTO, Hiroyuki ,  CHEN, Yian ,  CHIEN, Rungcheng

Inventor： CHEN, Chongyuan

IPC: F04B25/00

CPC classification number: F04B25/02

Abstract: By employing a sleeve piston construction, it is possible for a piston-type air pump (a compressor or a vacuum pump) to have a number of compression stages in one cylinder and for a piston-type fluid pump to continuously pump out fluid by means of a single small piston during reciprocating motion, unlike a case where differential and double-acting constructions are employed. Moreover, by using a driving system of electromagnetic and rotator-piston types, it is possible to attain a small-volume, large-compression-ratio (in the case of a compressor and a vacuum pump) and leakage-free piston pump.

Abstract translation: 通过使用套筒活塞结构，活塞式空气泵（压缩机或真空泵）可以在一个气缸中具有多个压缩级，并且对于活塞式流体泵可以通过装置连续泵出流体 在使用差动和双作用结构的情况下，在往复运动期间单个小活塞。 此外，通过使用电磁式和旋转活塞式的驱动系统，可以获得小体积，大的压缩比（在压缩机和真空泵的情况下）和无泄漏的活塞泵。

公开(公告)号：WO2009014154A1

公开(公告)日：2009-01-29

申请号：PCT/JP2008/063221

申请日：2008-07-16

Applicant: THE COCA-COLA COMPAGNY ,  SANYO ELECTRIC CO., LTD. ,  TACHIBANA, Yoshihisa ,  NISHIYAMA, Takashi ,  SAITO, Kazuhide ,  MIZUKAMI, Kazuaki ,  HASHIMOTO, Hiroyuki ,  ISHII, Takeshi ,  YAMAMOTO, Hiroshi

Inventor： TACHIBANA, Yoshihisa ,  NISHIYAMA, Takashi ,  SAITO, Kazuhide ,  MIZUKAMI, Kazuaki ,  HASHIMOTO, Hiroyuki ,  ISHII, Takeshi ,  YAMAMOTO, Hiroshi

IPC: F25D11/00 ,  B67D1/08

CPC classification number: B67D1/0884 ,  B01D61/025 ,  B67D1/0004 ,  B67D1/0015 ,  B67D1/0016 ,  B67D1/0021 ,  B67D1/04 ,  B67D1/0406 ,  B67D1/0864 ,  B67D1/0888 ,  B67D2210/00049 ,  F25B25/005 ,  F25B2400/06 ,  F25C1/00 ,  F25D31/002

Abstract: To provide a beverage dispenser capable of appropriately and smoothly supplying a supercooled beverage. [Solving Means] The present invention provides a beverage dispenser 1 which supplies a beverage brought into a supercooled state at a solidifying point or less and which releases the supercooled state in the outside, and the beverage dispenser includes a primary cooling device 13 which cools the beverage to an ice point or so, a beverage supply circuit 7 which supplies the beverage cooled by the primary cooling device 13 to the outside, a brine circuit 31 through which an antifreezing liquid cooled to the solidifying point or less of the beverage is circulated, and a heat exchanger 16 for supercooling the beverage, which performs heat exchange between the beverage flowing through the beverage supply circuit 7 and the antifreezing liquid flowing through the brine circuit 31.

Abstract translation: 提供能够适当且平稳地供应过冷饮料的饮料分配器。 本发明提供了一种饮料分配器1，其将凝固点或更低固化点处于过冷状态的饮料供给并且在外部释放过冷状态，并且饮料分配器包括主冷却装置13，冷却装置 将饮料供给到冰点的饮料供给回路7，将由一次冷却装置13冷却的饮料供给到外部，将冷却至饮料的凝固点以下的防冻液循环通过的盐水回路31， 以及用于过冷却饮料的热交换器16，其在流过饮料供应回路7的饮料和流过盐水回路31的防冻液之间进行热交换。

公开(公告)号：WO2009014152A1

公开(公告)日：2009-01-29

申请号：PCT/JP2008063216

申请日：2008-07-14

Applicant: COCA COLA COMPAGNY ,  SANYO ELECTRIC CO ,  TACHIBANA YOSHIHISA ,  NISHIYAMA TAKASHI ,  SAITO KAZUHIDE ,  MIZUKAMI KAZUAKI ,  HASHIMOTO HIROYUKI ,  ISHII TADESHI ,  YAMAMOTO HIROSHI

Inventor： TACHIBANA YOSHIHISA ,  NISHIYAMA TAKASHI ,  SAITO KAZUHIDE ,  MIZUKAMI KAZUAKI ,  HASHIMOTO HIROYUKI ,  ISHII TADESHI ,  YAMAMOTO HIROSHI

IPC: B67D1/04 ,  F25D11/00

CPC classification number: B67D1/0016 ,  B01D61/025 ,  B67D1/0004 ,  B67D1/0021 ,  B67D1/04 ,  B67D1/0406 ,  B67D1/0864 ,  B67D1/0884 ,  B67D1/0888 ,  B67D2210/0001 ,  F25B25/005 ,  F25B47/025 ,  F25B2400/06 ,  F25D31/003

Abstract: There is disclosed a beverage dispenser capable of appropriately and smoothly supplying a supercooled beverage without being influenced by a type of raw water. The present invention is a beverage dispenser 1 comprising: a raw water treatment device 63 which deaerates raw water and/or filters the raw water through a reverse osmosis film; a primary cooling device 13 which cools said raw water to an ice point or so; a raw water supply circuit 59 which supplies the raw water cooled by the primary cooling device 13 to the outside; a secondary cooling device 30 which cools the raw water flowing through the raw water supply circuit 59 into the supercooled state at the solidifying point or less; and a syrup circuit 53 which supplies a syrup to the raw water supplied to the outside through a heat exchanger 61 for supercooling the raw water of the secondary cooling device 30.

Abstract translation: 公开了一种饮料分配器，其能够适当且平稳地供应过冷饮料而不受一种原水的影响。 本发明是一种饮料分配器1，包括：原水处理装置63，其通过反渗透膜使原水脱水和/或对原水进行过滤; 将所述原水冷却至冰点的主冷却装置13; 原水供给回路59，其将由一次冷却装置13冷却的原水供给到外部; 二次冷却装置30，其将在原水供给回路59中流动的原水冷却至凝固点以下的过冷状态; 以及糖浆回路53，其通过用于过冷二次冷却装置30的原水的热交换器61向供给到外部的原水供给糖浆。

公开(公告)号：WO1986000481A1

公开(公告)日：1986-01-16

申请号：PCT/JP1985000356

申请日：1985-06-24

Applicant: TRIO KABUSHIKI KAISHA ,  HASHIMOTO, Hiroyuki ,  Iizuka, Nobuo ,  SUZUKI, Akira

Inventor： TRIO KABUSHIKI KAISHA

IPC: H04B07/26

CPC classification number: H04W36/06 ,  H04W4/10 ,  H04W76/45

Abstract: A radio communications system which makes communications on a vacant channel selected from a plurality of frequency channels, and wherein a calling station sends a station discrimination code to specify a remote station together with vacant channel data that enables communication, and the remote station specified by the station discrimination code is shifted to the specified vacant channel thereby to make communication between the two stations. When the channel on which the two stations are communicating is busy, and when it is desired to use another channel, one station sends the date for another channel on the channel on which the communications are made, and the other station receives the data and continues the communications on the other channel.

Abstract translation: 一种无线电通信系统，其在从多个频道中选择的空闲信道上进行通信，并且其中呼叫站发送站识别码以指定远程站点，以及能够进行通信的空闲信道数据，以及由 站识别码被转移到指定的空闲信道，从而在两个站之间进行通信。 当两个站正在通信的信道正忙时，当需要使用另一个信道时，一个站在通信进行的信道上发送另一个信道的日期，另一个站接收数据并继续 在另一个频道上的通信。

公开(公告)号：WO2012086391A1

公开(公告)日：2012-06-28

申请号：PCT/JP2011/078001

申请日：2011-11-28

Applicant: CANON KABUSHIKI KAISHA ,  MURAYAMA, Yohei ,  HASHIMOTO, Hiroyuki ,  KOMATSU, Manabu

Inventor： MURAYAMA, Yohei ,  HASHIMOTO, Hiroyuki ,  KOMATSU, Manabu

IPC: C07K14/475 ,  G01N33/574 ,  G01N33/68

CPC classification number: G01N33/57415 ,  C07K14/4756 ,  G01N33/6848 ,  G01N2333/4756

Abstract: The present invention relates to an information acquisition method of acquiring information of distribution of a protein or peptide in a sample based on mass information obtained by mass spectrometry of the protein or peptide. The method includes mass spectrometry of a definite region of the sample after limited proteolysis of the protein or peptide and acquisition of information relating to distribution using an ion peak that has a two-dimensional intensity distribution having a Pearson product-moment correlation coefficient of 0.5 to more and 1.0 or less in the definite region against the two-dimensional intensity distribution of the parent ion of the protein or the peptide subjected to the limited proteolysis and has a peak intensity ratio of larger than 1.0 against the peak intensity of the integrated spectrum of the parent ion in the definite region, wherein the m/z of the ion peak is greater than 500.

Abstract translation: 本发明涉及基于通过蛋白质或肽的质谱法获得的质量信息获取样品中蛋白质或肽的分布信息的信息获取方法。 该方法包括在蛋白质或肽的有限蛋白水解之后样品的确定区域的质谱，并且使用具有Pearson积矩相关系数为0.5的二维强度分布的离子峰获取与分布有关的信息 相对于蛋白质或经受有限蛋白水解的肽的母离子的二维强度分布，确定区域中的1.0和更小，并且具有大于1.0的峰强度比与峰积分的峰强度比 该定子区域中的母离子，其中离子峰的m / z大于500。

公开(公告)号：WO2011122692A1

公开(公告)日：2011-10-06

申请号：PCT/JP2011/058474

申请日：2011-03-28

Applicant: CANON KABUSHIKI KAISHA ,  NAITO, Jumpei ,  SATOH, Shuya ,  KOMATSU, Manabu ,  HASHIMOTO, Hiroyuki

Inventor： NAITO, Jumpei ,  SATOH, Shuya ,  KOMATSU, Manabu ,  HASHIMOTO, Hiroyuki

IPC: G01N27/62 ,  G01N27/64

CPC classification number: G01N33/6851 ,  H01J49/00 ,  Y10T436/182

Abstract: The problem to be solved by the present invention is to provide a method for treating a polypeptide including a cysteine residue for enhancing the sensitivity of detection thereof in mass spectrometry using charged particles. A mass spectrometry method for a polypeptide including a cysteine residue is provided which includes treating the polypeptide including a cysteine residue with a cyanation agent, treating the cyanated polypeptide with a base, and then desorption ionizing the base-treated polypeptides using charged particles for mass spectrometry.

Abstract translation: 本发明要解决的问题是提供一种用于在使用带电粒子的质谱法中治疗包含半胱氨酸残基的多肽以提高其检测灵敏度的方法。 提供了包含半胱氨酸残基的多肽的质谱法，其包括用氰化剂处理包含半胱氨酸残基的多肽，用碱处理氰化多肽，然后用带电粒子对碱处理的多肽进行解吸，用于质谱法 。