公开(公告)号：WO2006009890A2

公开(公告)日：2006-01-26

申请号：PCT/US2005021560

申请日：2005-06-17

Applicant: UNIV CALIFORNIA ,  OLEFSKY JERROLD M ,  USIU ISAO ,  IMAMURA TAKESHI

Inventor： OLEFSKY JERROLD M ,  USIU ISAO ,  IMAMURA TAKESHI

IPC: A61K38/22 ,  A61K31/426 ,  A61K31/4439

CPC classification number: C12Q1/485 ,  G01N2333/726 ,  G01N2500/02 ,  G01N2800/042 ,  Y10T436/143333

Abstract: The invention herein provides a mode of treating metabolic syndrome, which includes Type 2 diabetes mellitus and insulin resistance in human and other subjects by identifying and administering an insulin sensitizing compound which modulates GRK2 function in the insulin signaling pathway. The invention also provides polynucleotides, polypeptides, vectors, cells, tissues and organisms useful in the identification and treatment of metabolic syndrome. A number of desirable insulin sensitizing aspects are achieved by various embodiments of the present invention.

Abstract translation: 本发明提供了通过鉴定和施用调节胰岛素信号通路中的GRK2功能的胰岛素敏化化合物来治疗代谢综合征的方式，其包括人和其他受试者中的2型糖尿病和胰岛素抵抗。 本发明还提供可用于鉴定和治疗代谢综合征的多核苷酸，多肽，载体，细胞，组织和生物。 许多理想的胰岛素敏化方面通过本发明的各种实施方案实现。

公开(公告)号：WO2005016971A1

公开(公告)日：2005-02-24

申请号：PCT/JP2004/012153

申请日：2004-08-18

Applicant: CANON KABUSHIKI KAISHA ,  SHIOTSUKA, Hidenori ,  IMAMURA, Takeshi ,  NOMOTO, Tsuyoshi ,  OGAWA, Miki

Inventor： SHIOTSUKA, Hidenori ,  IMAMURA, Takeshi ,  NOMOTO, Tsuyoshi ,  OGAWA, Miki

IPC: C07K17/14

CPC classification number: C07K17/14 ,  C07K7/08 ,  C07K17/08 ,  C12N11/14 ,  G01N33/54353 ,  G01N33/552

Abstract: The invention provides an organic material-immobilizing structure employing new immobilization means, characterized in that at least a part of the surface of the substrate is comprised of one or more members containing silicon oxide, the organic material is bound to the surface of the substrate through a binding domain bound to the organic material and containing an amino acid sequence capable of binding to silicon oxide, selected from the group consisting of amino acid sequences of SEQ ID NOS: 1 and 2: Val-Ser-Pro-Met-Arg-Ser-Ala-Thr-Thr-His-Thr-Val; and Ile-Pro-Met-His-Val-His-His-Lys-His-Pro-His-Val, and derivatives thereof.

Abstract translation: 本发明提供一种使用新的固定装置的有机材料固定结构，其特征在于，基底表面的至少一部分由含有氧化硅的一个或多个构件组成，有机材料通过 与有机材料结合并含有能够结合氧化硅的氨基酸序列的结合结构域，其选自SEQ ID NO：1和2的氨基酸序列：Val-Ser-Pro-Met-Arg-Ser -Ala-THR-THR-的His-THR-缬氨酸; 和Ile-Pro-Met-His-Val-His-His-Lys-His-Pro-His-Val及其衍生物。

公开(公告)号：WO2004097417A1

公开(公告)日：2004-11-11

申请号：PCT/JP2004/006420

申请日：2004-05-06

Applicant: CANON KABUSHIKI KAISHA ,  IMAMURA, Takeshi ,  YANO, Tetsuya ,  HONMA, Tsutomu ,  KOZAKI, Shinya ,  NOMOTO, Tsuyoshi ,  TSUCHITANI, Akiko

Inventor： IMAMURA, Takeshi ,  YANO, Tetsuya ,  HONMA, Tsutomu ,  KOZAKI, Shinya ,  NOMOTO, Tsuyoshi ,  TSUCHITANI, Akiko

IPC: G01N33/543

CPC classification number: C12N9/93 ,  C07K2319/23 ,  C09D167/04 ,  C12N11/08 ,  C12P7/625 ,  G01N33/54326 ,  G01N33/54393 ,  G01N2333/21 ,  G01N2333/245

Abstract: There is provided a construct in which at least a part of the magnetic material is coated with polyhydroxyalkanoate (PHA), and a method for producing a construct by immobilizing a PHA synthesizing enzyme on the surface of the magnetic material thereby biosynthesizing a PHAand coatingsuch PHA on the material.

Abstract translation: 提供了其中至少一部分磁性材料涂覆有聚羟基链烷酸酯（PHA）的构造，以及通过将PHA合成酶固定在磁性材料的表面上从而生物合成PHA并将其涂覆在PHA上的方法 材料。

公开(公告)号：WO2004096188A1

公开(公告)日：2004-11-11

申请号：PCT/JP2004/006296

申请日：2004-04-30

Applicant: CANON KABUSHIKI KAISHA ,  YANO, Tetsuya ,  NOMOTO, Tsuyoshi ,  KOZAKI, Shinya ,  IMAMURA, Takeshi ,  HONMA, Tsutomu

Inventor： YANO, Tetsuya ,  NOMOTO, Tsuyoshi ,  KOZAKI, Shinya ,  IMAMURA, Takeshi ,  HONMA, Tsutomu

IPC: A61K9/50

CPC classification number: A61K9/5094 ,  A61K49/226 ,  Y10T428/12014

Abstract: A structure containing polyhydroxyalkanoate and a magnetic substance includes an external phase part containing polyhydroxyalkanoate and an internal phase part contained in the external phase part, at least one of the external phase part and the internal phase part containing a magnetic substance. Accordingly, provided is a microcapsule, which can be suitably used for formation of an active ingredient of a sustained release pharmaceutical preparation or an ultrasonic contrast agent.

Abstract translation: 包含聚羟基链烷酸酯和磁性物质的结构包括含有聚羟基链烷酸酯的外部部分和包含在外部相部分中的内相部分，外部相部分和内部相中的至少一个含有磁性物质。 因此，提供了可适用于形成持续释放药物制剂或超声造影剂的活性成分的微胶囊。

公开(公告)号：WO2004044213A1

公开(公告)日：2004-05-27

申请号：PCT/JP2003/013531

申请日：2003-10-23

Applicant: CANON KABUSHIKI KAISHA ,  SUGAWA, Etsuko ,  KENMOKU, Takashi ,  YANO, Tetsuya ,  MIHARA, Chieko ,  KOZAKI, Shinya ,  HONMA, Tsutomu ,  FUKUI, Tatsuki ,  IMAMURA, Takeshi

Inventor： KENMOKU, Takashi ,  YANO, Tetsuya ,  MIHARA, Chieko ,  KOZAKI, Shinya ,  HONMA, Tsutomu ,  FUKUI, Tatsuki ,  IMAMURA, Takeshi

IPC: C12P7/62

CPC classification number: C08G63/06 ,  C08G63/6882 ,  C12P7/625

Abstract: The invention provides a PHA copolymer including at least a 3-hydroxy-ω-carboxyalkanoic acid represented by a formula (19) or (32) and simultaneously at least a unit represented by a formula (2) or a formula (3) in a molecule, a precursor PHA copolymer having a corresponding vinyl group or a corresponding alkoxycarbonyl group, a biosynthesis method thereof by microorganisms, and a method of producing a desired PHA copolymer from the precursor PHA copolymer: (wherein k, m, n are integers; R 18 represents H, Na, K, R¿27? represents (A); R 1 represents a substituent on a cyclohexyl group and represents H, CN, NO 2 , a halogen atom, CH 3 , C 2 H 5 , C 3 H 7 , CF 3 , C 2 F 5 , or C 3 F 7 ; R includes a residue including a phenyl structure or a thienyl structure; these being independent for each unit).

Abstract translation: 本发明提供一种PHA共聚物，其包含至少一种由式（19）或（32）表示的3-羟基-ω-羧基烷酸，同时至少由式（2）或式（3）表示的单元在 分子，具有相应的乙烯基或相应的烷氧基羰基的前体PHA共聚物，微生物的生物合成方法以及由前体PHA共聚物制备所需PHA共聚物的方法（其中k，m，n为整数; R18 代表H，Na，K，R表示（A）; R1表示环己基上的取代基，代表H，CN，NO2，卤素原子，CH3，C2H5，C3H7，CF3，C2F5或C3F7; R 包括残基，包括苯基结构或噻吩基结构;它们对于每个单元是独立的）。

公开(公告)号：WO2004012864A1

公开(公告)日：2004-02-12

申请号：PCT/JP2003/009923

申请日：2003-08-05

Applicant: CANON KABUSHIKI KAISHA ,  IMAMURA, Takeshi ,  YAMAZAKI, Takeo

Inventor： IMAMURA, Takeshi ,  YAMAZAKI, Takeo

IPC: B01L3/00

CPC classification number: B01F13/0079 ,  B01F13/1013 ,  B01F13/1016 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00804 ,  B01J2219/00819 ,  B01J2219/00867 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01L3/5027 ,  B01L2200/027 ,  B01L2300/0861 ,  B01L2400/0439 ,  B01L2400/0442 ,  B01L2400/0605 ,  Y10T436/2575

Abstract: A liquid transfer apparatus comprises a liquid containing section for containing liquid, a liquid introducing section for introducing liquid into the liquid containing section and a liquid leading out section for leading out the liquid introduced into the liquid containing section. When a number of such liquid transfer apparatuses are connected together, the liquid introducing section and the liquid leading out section of such liquid transfer apparatus are arranged such that the liquid leading out section of a liquid transfer apparatus communicates with the liquid introducing section of another liquid transfer apparatus.

Abstract translation: 液体传送装置包括用于容纳液体的液体容纳部分，用于将液体引入液体容纳部分的液体引入部分和用于引出引入液体容纳部分的液体的液体引出部分。 当多个这样的液体传送装置连接在一起时，液体传送装置的液体导入部分和液体导出部分被布置成使得液体传送装置的液体引出部分与另一种液体的液体导入部分连通 传送装置。

公开(公告)号：WO2004012863A1

公开(公告)日：2004-02-12

申请号：PCT/JP2003/009909

申请日：2003-08-05

Applicant: CANON KABUSHIKI KAISHA ,  YAMAZAKI, Takeo ,  IMAMURA, Takeshi

Inventor： YAMAZAKI, Takeo ,  IMAMURA, Takeshi

IPC: B01L3/00

CPC classification number: B01F15/0255 ,  B01F13/0059 ,  B01F15/0203 ,  B01L3/0241 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2400/0439 ,  B01L2400/0442 ,  Y10T436/2575

Abstract: A liquid transport device capable of introducing and transporting a liquid and preventing a backward flow of the liquid in a small-sized analysis system is provided. The liquid transport device has a substrate 201, a ejection orifice 205 which is formed integrally with the substrate 201 and through which a liquid is ejected, a space portion 210 which is formed so as to communicate with the ejection orifice 205 and through which the liquid ejected from the ejection orifice flies, and a flow channel 204 which communicates with the space portion 210 and which is positioned within such a distance range that the flying liquid can reach the flow channel.

Abstract translation: 提供一种能够引入和输送液体并防止液体在小型分析系统中反向流动的液体输送装置。 液体输送装置具有基板201，与基板201一体形成并喷射有液体的喷射孔205，形成为与喷射孔205连通的空间部210，液体 从喷射口喷射的飞行物，以及与空间部分210连通并且位于飞行液体可以到达流动通道的距离范围内的流动通道204。

公开(公告)号：WO2005071414A3

公开(公告)日：2006-03-02

申请号：PCT/JP2005001316

申请日：2005-01-25

Applicant: CANON KK ,  BAN KAZUHIRO ,  SHIOTSUKA HIDENORI ,  IMAMURA TAKESHI

Inventor： BAN KAZUHIRO ,  SHIOTSUKA HIDENORI ,  IMAMURA TAKESHI

IPC: C12N11/14 ,  G01N33/543 ,  C07K7/06 ,  C07K7/08 ,  C12N15/09 ,  G01N33/551

CPC classification number: G01N33/54353 ,  G01N33/551

Abstract: To provide an organic substance-immobilized structure employing a novel immobilizing technique and a manufacturing method thereof using the novel immobilizing technique, where, when an organic substance, particularly a biological substance is immobilized on the surface of a substrate, the organic substance, particularly the biological substance can be stably immobilized on the surface of the substrate through orientation of the organic substance, particularly the biological substance suitable for exerting physiological functions thereof. At least part of the substrate's surface is constructed of one or more substrates containing aluminum oxide. The immobilization of the organic substance to the surface of the substrate is carried out by binding at least part of the binding domain to the surface of the substrate through a binding domain containing a peptide having an affinity to aluminum oxide and composed of at least one or more amino acids, which is coupled with the organic substance.

Abstract translation: 为了提供采用新型固定化技术的有机物质固定化结构及其制造方法，其中，当将有机物质，特别是生物物质固定在基材表面上时，有机物质，特别是 生物物质可以通过有机物质，特别是适于发挥其生理功能的生物物质的取向，稳定地固定在基材的表面上。 衬底表面的至少一部分由含有氧化铝的一个或多个衬底构成。 有机物质固定到底物的表面是通过结合结构域与底物的表面结合而进行的，所述结合结构域含有与氧化铝具有亲和性的肽，并且由至少一个或多个 更多的氨基酸，其与有机物质偶联。

公开(公告)号：WO2005003715A3

公开(公告)日：2005-05-26

申请号：PCT/JP2004009788

申请日：2004-07-02

Applicant: CANON KK ,  HASHIMOTO HIROYUKI ,  KUGE KATSUAKI ,  KOMATSU MANABU ,  NAKAMURA KUMI ,  BAN KAZUHIRO ,  IMAMURA TAKESHI ,  KOBAYASHI SHIN

Inventor： HASHIMOTO HIROYUKI ,  KUGE KATSUAKI ,  KOMATSU MANABU ,  NAKAMURA KUMI ,  BAN KAZUHIRO ,  IMAMURA TAKESHI ,  KOBAYASHI SHIN

IPC: G01N33/68 ,  H01J49/04 ,  H01J49/40

CPC classification number: G01N33/6848 ,  H01J49/04 ,  H01J49/40

Abstract: An information acquisition method for acquiring information on a target object, that includes a step of promoting ionization of the target object using a substance for promoting ionization of the target object to cause the target object to emit, and a step of acquiring information on the mass of the flew target object using time-of-flight secondary ion mass spectrometry.

Abstract translation: 一种用于获取关于目标对象的信息的信息获取方法，其包括使用促进所述目标对象的电离的物质促进所述目标对象的电离以使所述目标对象发射的步骤以及获取所述质量信息的步骤 的飞行目标物体使用飞行时间二次离子质谱法。

公开(公告)号：WO2004079241A1

公开(公告)日：2004-09-16

申请号：PCT/JP2004/002499

申请日：2004-03-01

Applicant: CANON KABUSHIKI KAISHA ,  YAMAZAKI, Takeo ,  TERASAKI, Atsunori ,  IMAMURA, Takeshi ,  EZAKI, Takahiro ,  YASUDA, Susumu ,  NAKAKUBO, Toru

Inventor： YAMAZAKI, Takeo ,  TERASAKI, Atsunori ,  IMAMURA, Takeshi ,  EZAKI, Takahiro ,  YASUDA, Susumu ,  NAKAKUBO, Toru

IPC: F16K17/30

CPC classification number: H01M8/04089 ,  B01L3/502738 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2400/0418 ,  B01L2400/0487 ,  B01L2400/0638 ,  F16K99/0001 ,  F16K99/0009 ,  F16K99/0028 ,  F16K99/0057 ,  F16K2099/0074 ,  F16K2099/008 ,  F16K2099/0084 ,  G01N30/20 ,  G01N2030/205 ,  G01N2035/00247 ,  H01M8/04201 ,  H01M8/04216 ,  H01M8/065 ,  H01M2008/1095 ,  Y10T137/2191 ,  Y10T137/7869 ,  Y10T137/7895 ,  G01N30/10

Abstract: A fluid delivery device is provided which comprises a microchannel device for cutting out a certain amount of a sample from a micorochannel by controlling a valve opening. The fluid delivery device has a valve (301) for controlling a flow of a fluid, comprising a flow channel (304) for the fluid, and a valve (301) in the flow channel, wherein the valve operates in accordance with a pressure difference between the upstream side (304) and downstream side (303) of the valve caused by the flow of the fluid through the flow channel, allowing the fluid to flow when the pressure difference is lower than a prescribed value P0, and intercepting the fluid not to flow when the pressure difference is P0 or more.

Abstract translation: 提供了一种流体输送装置，其包括用于通过控制阀开口从微通道切出一定量的样品的微通道装置。 流体输送装置具有用于控制流体流动的阀（301），其包括用于流体的流动通道（304）和流动通道中的阀（301），其中阀根据压差 在通过流路的流体流动引起的阀的上游侧（304）和下游侧（303）之间，允许流体在压力差低于规定值P0时流动，并且使流体不截止流体 当压力差为P0以上时流动。