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公开(公告)号：WO2007044084A3
公开(公告)日：2009-04-16
申请号：PCT/US2006019108
申请日：2006-05-17
申请人： ARRAY BIOPHARMA INC , ASTRAZENECA AB , MARLOW ALLISON L , WALLACE ELI , SEO JEONGBEOB , LYSSIKATOS JOSEPH P , YANG HONG WOON , BLAKE JIM , STOREY RICHARD ANTHONY , BOOTH REBECCA JANE , PITTAM JOHN DAVID , LEONARD JOHN , FIELDING MARK RICHARD
发明人： MARLOW ALLISON L , WALLACE ELI , SEO JEONGBEOB , LYSSIKATOS JOSEPH P , YANG HONG WOON , BLAKE JIM , STOREY RICHARD ANTHONY , BOOTH REBECCA JANE , PITTAM JOHN DAVID , LEONARD JOHN , FIELDING MARK RICHARD
IPC分类号： A61K31/50 , A61K31/4412 , C07D211/74 , C07D211/86 , C07D213/63 , C07D213/70 , C07D237/12 , C07D237/14
CPC分类号： C07D237/24 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85
摘要： Disclosed are MEK inhibitors useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
摘要翻译： 公开了可用于治疗哺乳动物和炎性病症中过度增殖性疾病如癌症和炎症的MEK抑制剂。 还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法和含有这些化合物的药物组合物。
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公开(公告)号：WO2005051906A3
公开(公告)日：2005-06-09
申请号：PCT/US2004/039053
申请日：2004-11-18
申请人： ARRAY BIOPHARMA INC. , WALLACE, Eli , SEO, Jeongbeob , LYSSIKATOS, Joseph, P. , YANG, Hong, Woon , HURLEY, T., Brian , BLAKE, Jim , MARLOW, Allison, L.
发明人： WALLACE, Eli , SEO, Jeongbeob , LYSSIKATOS, Joseph, P. , YANG, Hong, Woon , HURLEY, T., Brian , BLAKE, Jim , MARLOW, Allison, L.
IPC分类号： A61K31/50
摘要： Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R 1 , R 2 , R 7 , R 8 and R 9 , W, X, Y and Z are as defined in the specification. Such compounds are MEK inhibitors and are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
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公开(公告)号：WO2005023251A1
公开(公告)日：2005-03-17
申请号：PCT/US2004/027199
申请日：2004-08-20
申请人： ARRAY BIOPHARMA INC. , WALLACE, Eli, M. , LYSSIKATOS, Joseph, P. , MARLOW, Allison, L. , HURLEY, Brian, T. , KOCH, Kevin
发明人： WALLACE, Eli, M. , LYSSIKATOS, Joseph, P. , MARLOW, Allison, L. , HURLEY, Brian, T. , KOCH, Kevin
IPC分类号： A61K31/4184
CPC分类号： C07D235/06 , C04B35/632 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12 , C07F9/65068 , C07F9/65586
摘要： Disclosed are compounds of the formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R 1 , R 2 , R 7 , R 8 , R 9 , and R 10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.
摘要翻译： 公开了式I化合物及其药学上可接受的盐和前药，其中W，R 1，R 2，R 7，R 8，R 9和R 10分别为 在规范中定义。 这些化合物是MEK抑制剂，可用于治疗哺乳动物中的过度增殖性疾病，如癌症和炎症。 还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法，以及含有这些化合物的药物组合物。
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公开(公告)号：WO2003077914A1
公开(公告)日：2003-09-25
申请号：PCT/US2003/007864
申请日：2003-03-13
申请人： ARRAY BIOPHARMA, INC , WALLACE, Eli, M. , LYSSIKATOS, Joseph, P. , HURLEY, Brian, T. , MARLOW, Allison, L.
IPC分类号： A61K31/4184
CPC分类号： C07D235/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12
摘要： Disclosed are compounds of the formula I, and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R 1 , R 2 , R 7 , R 8 , R 9 and R 10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.
摘要翻译： 公开了式I化合物及其药学上可接受的盐和前药，其中W，R 1，R 2，R 7，R 8，R 9和R 10分别为 在规范中定义。 这些化合物是MEK抑制剂，可用于治疗哺乳动物中的过度增殖性疾病，如癌症和炎症。 还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法，以及含有这些化合物的药物组合物。
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公开(公告)号：WO2003077855A3
公开(公告)日：2003-09-25
申请号：PCT/US2003/007565
申请日：2003-03-13
申请人： ARRAY BIOPHARMA, INC , WALLACE, Eli, M. , LYSSIKATOS, Joseph, P. , HURLEY, Brian, T. , MARLOW, Allison, L.
IPC分类号： A61K31/5377
摘要： Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts and prodrugs thereof, wherein W, t, R 1 , R 2 , R 7 , R 9 , R 10 , R 11 and R 12 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.
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公开(公告)号：WO2008063202A2
公开(公告)日：2008-05-29
申请号：PCT/US2007002352
申请日：2007-01-30
申请人： ARRAY BIOPHARMA INC , BLAKE JAMES F , BOYD STEVEN , DE MEESE JASON , GAUDINO JOHN J , MARLOW ALLISON L , SEO JEONGBEOB , THOMAS ALLEN A , TIAN HONGQI
发明人： BLAKE JAMES F , BOYD STEVEN , DE MEESE JASON , GAUDINO JOHN J , MARLOW ALLISON L , SEO JEONGBEOB , THOMAS ALLEN A , TIAN HONGQI
CPC分类号： C07D495/04 , C07D519/00
摘要： Compounds of Formula I and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula I and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译： 式I化合物及其药学上可接受的盐可用于抑制受体酪氨酸激酶和用于治疗由此介导的病症。 公开了使用式I化合物及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：WO2007146824A3
公开(公告)日：2008-04-10
申请号：PCT/US2007070787
申请日：2007-06-08
申请人： ARRAY BIOPHARMA INC , GENENTECH INC , GAUDINO JOHN , BOYD STEVEN ARMEN , MARLOW ALLISON L , KAPLAN TOMAS , FONG KIN CHIU , SEO JEONGBEOB , TIAN HONGQI , BLAKE JAMES , KOCH KEVIN
发明人： GAUDINO JOHN , BOYD STEVEN ARMEN , MARLOW ALLISON L , KAPLAN TOMAS , FONG KIN CHIU , SEO JEONGBEOB , TIAN HONGQI , BLAKE JAMES , KOCH KEVIN
IPC分类号： C07D215/22
CPC分类号： C07D401/14 , C07D215/22 , C07D401/12
摘要： Compounds of Formula (I), and stereoisomers, geometric isomers, tautomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof, are useful for inhibiting receptor tyrosine kinases and for treating hyperproliferative disorders mediated thereby. Methods of using compounds of Formula (I), and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译： 式（I）化合物和立体异构体，几何异构体，互变异构体，溶剂合物，代谢物，盐和药学上可接受的前药可用于抑制受体酪氨酸激酶和治疗由此介导的过度增殖性疾病。 使用式（I）化合物及其立体异构体，几何异构体，互变异构体，溶剂化物及其药学上可接受的盐在哺乳动物细胞体外，原位和体内诊断，预防或治疗这些病症或相关病理学 条件被披露。
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公开(公告)号：WO2007103308A3
公开(公告)日：2007-09-13
申请号：PCT/US2007/005583
申请日：2007-03-06
申请人： ARRAY BIOPHARMA INC. , GENENTECH, INC. , BLAKE, James F. , BOYD, Steven Armen , COHEN, Frederick , DE MEESE, Jason , FONG, Kin Chiu , GAUDINO, John J. , KAPLAN, Tomas , MARLOW, Allison L. , SEO, Jeongbeob , THOMAS, Allen A. , TIAN, Hongqi , YOUNG, Wendy B.
发明人： BLAKE, James F. , BOYD, Steven Armen , COHEN, Frederick , DE MEESE, Jason , FONG, Kin Chiu , GAUDINO, John J. , KAPLAN, Tomas , MARLOW, Allison L. , SEO, Jeongbeob , THOMAS, Allen A. , TIAN, Hongqi , YOUNG, Wendy B.
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： Compounds of Formulas (Ia) and (Ib), and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：WO2007044084A2
公开(公告)日：2007-04-19
申请号：PCT/US2006/019108
申请日：2006-05-17
申请人： ARRAY BIOPHARMA INC. , ASTRAZENECA AB , MARLOW, Allison, L. , WALLACE, Eli , SEO, Jeongbeob , LYSSIKATOS, Joseph, P. , YANG, Hong, Woon , BLAKE, Jim , STOREY, Richard, Anthony , BOOTH, Rebecca, Jane , PITTAM, John, David , LEONARD, John , FIELDING, Mark, Richard
发明人： MARLOW, Allison, L. , WALLACE, Eli , SEO, Jeongbeob , LYSSIKATOS, Joseph, P. , YANG, Hong, Woon , BLAKE, Jim , STOREY, Richard, Anthony , BOOTH, Rebecca, Jane , PITTAM, John, David , LEONARD, John , FIELDING, Mark, Richard
IPC分类号： C07D213/84 , C07D213/63 , A61K31/44
CPC分类号： C07D237/24 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85
摘要： Disclosed are MEK inhibitors useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
摘要翻译： 公开了可用于治疗哺乳动物和炎性病症中过度增殖性疾病如癌症和炎症的MEK抑制剂。 还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法和含有这些化合物的药物组合物。
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公开(公告)号：WO2005023759A3
公开(公告)日：2005-09-22
申请号：PCT/US2004028649
申请日：2004-09-01
申请人： ARRAY BIOPHARMA INC , WALLACE ELI , HURLEY BRIAN , YANG HOON WOON , LYSSIKATOS JOSEPH , MARLOW ALLISON L , BLAKE JIM
发明人： WALLACE ELI , HURLEY BRIAN , YANG HOON WOON , LYSSIKATOS JOSEPH , MARLOW ALLISON L , BLAKE JIM
IPC分类号： A61K31/42 , C07D20060101 , C07D261/20 , C07D471/04
CPC分类号： C07D471/04 , C07D261/20
摘要： Disclosed are compounds of the Formula (I) and pharmaceutically acceptable salts and prodrugs thereof, wherein R , R , R , R , R and R , W and Y are defined in the specification. Such compounds are MEK inhibitors and useful in the treament of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative disease in mammals and pharmaceutical compositons conataining such compounds.
摘要翻译： 公开了式（I）化合物及其药学上可接受的盐和前药，其中R 1，R 2，R 7，R 8，R 9和R 10，W和 Y在说明书中定义。 这些化合物是MEK抑制剂，可用于哺乳动物中过度增殖疾病如癌症和炎症。 还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法和与此类化合物相关的药物组合物。
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