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公开(公告)号：WO2011123674A1
公开(公告)日：2011-10-06
申请号：PCT/US2011/030769
申请日：2011-03-31
Applicant: ARRAY BIOPHARMA INC. , GENENTECH, INC. , CLARK, Christopher, T. , COOK, Adam , GUNAWARDANA, Indrani, W. , HUNT, Kevin W. , KALLAN, Nicholas, C. , SIU, Michael , THOMAS, Allen, A. , VOLGRAF, Matthew
Inventor： CLARK, Christopher, T. , COOK, Adam , GUNAWARDANA, Indrani, W. , HUNT, Kevin W. , KALLAN, Nicholas, C. , SIU, Michael , THOMAS, Allen, A. , VOLGRAF, Matthew
IPC: C07D401/10 , C07D401/14 , C07D403/10 , C07D413/10 , C07D417/10 , C07D263/64 , A61K31/41 , A61P25/28
CPC classification number: C07D401/14 , C07D263/64 , C07D401/10 , C07D403/10 , C07D413/10 , C07D417/10
Abstract: The invention provides novel spirotetrahydronaphthalene compounds of Formula α that inhibit β-secretase cleavage of APP and are useful as therapeutic agents for treating neurodegenerative diseases.
Abstract translation: 本发明提供新颖的抑制APP分泌酶切割的式（a）的四氢四氢化合物，可用作治疗神经变性疾病的治疗剂。
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公开(公告)号：WO2008063202A3
公开(公告)日：2008-05-29
申请号：PCT/US2007/002352
申请日：2007-01-30
Applicant: ARRAY BIOPHARMA INC. , BLAKE, James, F. , BOYD, Steven , DE MEESE, Jason , GAUDINO, John, J. , MARLOW, Allison, L. , SEO, Jeongbeob , THOMAS, Allen, A. , TIAN, Hongqi
Inventor： BLAKE, James, F. , BOYD, Steven , DE MEESE, Jason , GAUDINO, John, J. , MARLOW, Allison, L. , SEO, Jeongbeob , THOMAS, Allen, A. , TIAN, Hongqi
IPC: C07D495/04 , C07D519/00 , A61K31/4353 , A61P35/00
Abstract: Compounds of Formula I and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula I and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：WO2007103308A2
公开(公告)日：2007-09-13
申请号：PCT/US2007005583
申请日：2007-03-06
Applicant: ARRAY BIOPHARMA INC , GENENTECH INC , BLAKE JAMES F , BOYD STEVEN ARMEN , COHEN FREDERICK , DE MEESE JASON , FONG KIN CHIU , GAUDINO JOHN J , KAPLAN TOMAS , MARLOW ALLISON L , SEO JEONGBEOB , THOMAS ALLEN A , TIAN HONGQI , YOUNG WENDY B
Inventor： BLAKE JAMES F , BOYD STEVEN ARMEN , COHEN FREDERICK , DE MEESE JASON , FONG KIN CHIU , GAUDINO JOHN J , KAPLAN TOMAS , MARLOW ALLISON L , SEO JEONGBEOB , THOMAS ALLEN A , TIAN HONGQI , YOUNG WENDY B
CPC classification number: C07D471/04
Abstract: Compounds of Formulas (Ia) and (Ib), and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Abstract translation: 式（Ia）和（Ib）的化合物及其立体异构体，几何异构体，互变异构体，溶剂合物，代谢物和药学上可接受的盐可用于抑制受体酪氨酸激酶和用于治疗由此介导的病症。 使用式Ia和Ib化合物及其立体异构体，几何异构体，互变异构体，溶剂化物及其药学上可接受的盐的方法用于体外，原位和体内诊断，预防或治疗哺乳动物细胞中的这种病症或相关病理学 条件被公开。
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4.发明申请BICYCLIC UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN 审中-公开双酚尿素，硫脲，胍和氰尿嘧啶化合物可用于治疗疼痛
公开(公告)号：WO2014078454A1
公开(公告)日：2014-05-22
申请号：PCT/US2013/069951
申请日：2013-11-13
Applicant: ARRAY BIOPHARMA INC. , ALLEN, Shelley , ANDREWS, Steven, Wade , BLAKE, James, F. , BRANDHUBER, Barbara, J. , HAAS, Julia , JIANG, Yutong , KERCHER, Timothy , KOLAKOWSKI, Gabrielle, R. , THOMAS, Allen, A. , WINSKI, Shannon, L.
Inventor： ALLEN, Shelley , ANDREWS, Steven, Wade , BLAKE, James, F. , BRANDHUBER, Barbara, J. , HAAS, Julia , JIANG, Yutong , KERCHER, Timothy , KOLAKOWSKI, Gabrielle, R. , THOMAS, Allen, A. , WINSKI, Shannon, L.
IPC: C07D401/14 , C07D405/14 , C07D231/40 , C07D231/54 , C07D401/12 , C07D403/02 , C07D403/04 , C07D403/14 , C07D405/12 , C07D413/12 , C07D453/02 , A61K31/4155 , A61K31/416 , A61K31/4162 , A61P25/00
CPC classification number: C07D491/048 , C07D231/40 , C07D231/52 , C07D231/54 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/02 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D453/02 , C07D471/08
Abstract: Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
Abstract translation: 式I化合物或其立体异构体，互变异构体或其药学上可接受的盐，溶剂合物或前药，其中环A，环C和X如本文所定义，是TrkA激酶的抑制剂，并且可用于治疗可治疗的疾病 具有TrkA激酶抑制剂如疼痛，癌症，炎症/炎性疾病，神经变性疾病，某些感染性疾病，干燥综合征，子宫内膜异位症，糖尿病性周围神经病变，前列腺炎和骨盆疼痛综合征。
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5.发明申请N-(ARYLALKYL)-N'-PYRAZOLYL-UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS 审中-公开作为TRKA激酶抑制剂的N-（ARYLALKYL）-N'-吡唑并 - 尿素，硫脲，胍和氰基胍化合物
公开(公告)号：WO2014078331A1
公开(公告)日：2014-05-22
申请号：PCT/US2013/069750
申请日：2013-11-12
Applicant: ARRAY BIOPHARMA INC. , BLAKE, James F. , BRANDHUBER, Barbara J. , HAAS, Julia , NEWHOUSE, Brad , THOMAS, Allen A. , WINSKI, Shannon L.
Inventor： BLAKE, James F. , BRANDHUBER, Barbara J. , HAAS, Julia , NEWHOUSE, Brad , THOMAS, Allen A. , WINSKI, Shannon L.
IPC: C07D403/12 , C07D401/14 , C07D231/40 , C07D231/52 , C07D231/54 , C07D401/04 , C07D401/12 , C07D403/04 , C07D413/12 , C07D495/04 , A61K31/4155 , A61P35/00 , A61P29/00
CPC classification number: C07D231/52 , C07D231/38 , C07D231/40 , C07D231/54 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D453/02 , C07D495/04
Abstract: Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C, X, Ra, Rb, Rc, Rd and n are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.
Abstract translation: 式I或其立体异构体，互变异构体或其药学上可接受的盐，溶剂合物或前药的化合物，其中环A，环C，X，R a，R b，R c，R d和n如本文所定义，是TrkA激酶的抑制剂，并且是有用的 治疗可用TrkA激酶抑制剂如疼痛，癌症，炎症/炎性疾病，神经变性疾病，某些感染性疾病，干燥综合征，子宫内膜异位症，糖尿病性周围神经病变，前列腺炎或骨盆疼痛综合征治疗的疾病。
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Patent Agency Ranking6.发明申请HETEROCYCLIC INHIBITORS OF BETA - SECRETASE FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES 审中-公开用于治疗神经损伤性疾病的β-分泌酶的杂环抑制剂
公开(公告)号：WO2012071458A1
公开(公告)日：2012-05-31
申请号：PCT/US2011/061930
申请日：2011-11-22
Applicant: ARRAY BIOPHARMA INC. , GENENTECH, INC. , COOK, Adam , GUNAWARDANA, Indrani, W. , HUESTIS, Malcolm , HUNT, Kevin, W. , KALLAN, Nicholas, C. , METCALF, Andrew, T. , NEWHOUSE, Brad , SIU, Michael , TANG, Tony, P. , THOMAS, Allen, A. , VOLGRAF, Matthew
Inventor： COOK, Adam , GUNAWARDANA, Indrani, W. , HUESTIS, Malcolm , HUNT, Kevin, W. , KALLAN, Nicholas, C. , METCALF, Andrew, T. , NEWHOUSE, Brad , SIU, Michael , TANG, Tony, P. , THOMAS, Allen, A. , VOLGRAF, Matthew
IPC: C07D491/20 , C07D498/20 , C07D491/107 , C07D498/10 , C07D513/10 , C07D513/20 , A61K31/4439 , A61K31/527 , A61K31/444 , A61K31/506 , A61K31/424 , A61K31/429 , A61K31/437 , A61P25/28
CPC classification number: C07D498/20 , C07D491/107 , C07D491/20 , C07D498/10 , C07D513/10 , C07D513/20
Abstract: The invention provides novel tricyclic compounds of Formula I' that inhibit β-secretase cleavage of APP and are useful as therapeutic agents for treating neurodegenerative diseases.
Abstract translation: 本发明提供抑制APP的β-分泌酶切割的新颖的式I'三环化合物，并且可用作治疗神经变性疾病的治疗剂。
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公开(公告)号：WO2012040641A2
公开(公告)日：2012-03-29
申请号：PCT/US2011/053118
申请日：2011-09-23
Applicant: ARRAY BIOPHARMA INC. , HUNT, Kevin W. , TANG, Tony P. , THOMAS, Allen A.
Inventor： HUNT, Kevin W. , TANG, Tony P. , THOMAS, Allen A.
IPC: C07D491/107 , C07D491/20 , A61K31/4188 , A61P25/28
CPC classification number: A61K31/4188 , C07D491/107 , C07D491/20
Abstract: The invention provides novel tricyclic compounds of Formula I' that inhibit β-secretase cleavage of APP and are useful as therapeutic agents for treating neurodegenerative diseases.
Abstract translation: 本发明提供抑制APP的β-分泌酶切割的新颖的式I'三环化合物，并且可用作治疗神经变性疾病的治疗剂。
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公开(公告)号：WO2012040641A3
公开(公告)日：2012-06-07
申请号：PCT/US2011053118
申请日：2011-09-23
Applicant: ARRAY BIOPHARMA INC , HUNT KEVIN W , TANG TONY P , THOMAS ALLEN A
Inventor： HUNT KEVIN W , TANG TONY P , THOMAS ALLEN A
IPC: C07D491/107 , A61K31/4188 , A61P25/28 , C07D491/20
CPC classification number: A61K31/4188 , C07D491/107 , C07D491/20
Abstract: The invention provides novel tricyclic compounds of Formula I' that inhibit ß-secretase cleavage of APP and are useful as therapeutic agents for treating neurodegenerative diseases.
Abstract translation: 本发明提供了抑制APP的β-分泌酶裂解并且可用作治疗神经退行性疾病的治疗剂的式I'的新三环化合物。
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公开(公告)号：WO2012118850A1
公开(公告)日：2012-09-07
申请号：PCT/US2012/027009
申请日：2012-02-28
Applicant: ARRAY BIOPHARMA INC. , GENENTECH, INC. , BLAKE, James F. , CHEN, Huifen , CHICARELLI, Mark Joseph , DEMEESE, Jason , GARREY, Rustam , GAUDINO, John J. , KAUS, Robert J. , KOLAKOWSKI, Gabrielle R. , MARLOW, Allison L. , MOHR, Peter J. , REN, Li , SCHWARZ, Jacob , SIEDEM, Christopher S. , THOMAS, Allen A. , WALLACE, Eli , WENGLOWSKY, Steven Mark
Inventor： BLAKE, James F. , CHEN, Huifen , CHICARELLI, Mark Joseph , DEMEESE, Jason , GARREY, Rustam , GAUDINO, John J. , KAUS, Robert J. , KOLAKOWSKI, Gabrielle R. , MARLOW, Allison L. , MOHR, Peter J. , REN, Li , SCHWARZ, Jacob , SIEDEM, Christopher S. , THOMAS, Allen A. , WALLACE, Eli , WENGLOWSKY, Steven Mark
IPC: C07D471/04 , A61K31/519 , A61P35/00
CPC classification number: C07D471/04 , A61K31/519 , A61K45/06 , C07D491/052
Abstract: Compounds having the formula I wherein Z, Z 1 Z 2 Z 3 , R 3a , R 3b and R b and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
Abstract translation: 具有式I的化合物，其中Z，Z 1 Z 2 Z 3，R 3a，R 3b和R b如本文所定义是ERK激酶的抑制剂。 还公开了用于治疗过度增殖性疾病的组合物和方法。
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公开(公告)号：WO2008063202A2
公开(公告)日：2008-05-29
申请号：PCT/US2007002352
申请日：2007-01-30
Applicant: ARRAY BIOPHARMA INC , BLAKE JAMES F , BOYD STEVEN , DE MEESE JASON , GAUDINO JOHN J , MARLOW ALLISON L , SEO JEONGBEOB , THOMAS ALLEN A , TIAN HONGQI
Inventor： BLAKE JAMES F , BOYD STEVEN , DE MEESE JASON , GAUDINO JOHN J , MARLOW ALLISON L , SEO JEONGBEOB , THOMAS ALLEN A , TIAN HONGQI
CPC classification number: C07D495/04 , C07D519/00
Abstract: Compounds of Formula I and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula I and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Abstract translation: 式I化合物及其药学上可接受的盐可用于抑制受体酪氨酸激酶和用于治疗由此介导的病症。 公开了使用式I化合物及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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