SYSTEM AND METHOD FOR DECOMPENSATION DETECTION AND TREATMENT BASED ON PATIENT HEMODYNAMICS
    1.
    发明申请
    SYSTEM AND METHOD FOR DECOMPENSATION DETECTION AND TREATMENT BASED ON PATIENT HEMODYNAMICS 审中-公开
    基于患者血液动力学的去除检测和治疗的系统和方法

    公开(公告)号:WO2010141280A1

    公开(公告)日:2010-12-09

    申请号:PCT/US2010/036137

    申请日:2010-05-26

    CPC classification number: A61N1/36564

    Abstract: A system and method for detecting and treating symptoms of early decompensation utilizing a cardiac rhythm management. The system applies an electrical stimulus to the patient's heart at a first set of pacing parameters including a lower rate limit (LRL) setting, and acquires a coronary venous pressure (CVP) signal from a pressure sensor implanted in a coronary vein of the patient. An average coronary venous end diastolic pressure (CV-EDP) value is calculated from the CVP signal. The system monitors the average CV-EDP value over a predetermined interval, and dynamically adjusts the LRL setting responsive to the detection of a first or a second predetermined event based on the average CV-EDP value.

    Abstract translation: 一种利用心律管理检测和治疗早期失代偿症状的系统和方法。 该系统以包括较低速率限制(LRL)设置在内的第一组起搏参数对患者的心脏施加电刺激,并从植入患者冠状静脉的压力传感器获取冠状静脉压(CVP)信号。 根据CVP信号计算平均冠状静脉舒张末期压(CV-EDP)值。 该系统在预定间隔内监视平均CV-EDP值,并且响应于基于平均CV-EDP值的第一或第二预定事件的检测动态地调整LRL设置。

    NEUROSTIMULATION SYSTEMS FOR CARDIAC CONDITIONS
    2.
    发明申请
    NEUROSTIMULATION SYSTEMS FOR CARDIAC CONDITIONS 审中-公开
    心脏病条件的神经系统

    公开(公告)号:WO2009042030A2

    公开(公告)日:2009-04-02

    申请号:PCT/US2008/010515

    申请日:2008-09-09

    Abstract: Various embodiments provide an implantable medical device comprising a detector, a neural stimulator, and a controller. The detector is configured to detect a pathological condition indicated for an acute neural stimulation therapy. The neural stimulator is capable of delivering a chronic neural stimulation therapy and the acute neural stimulation therapy. The controller is configured to control the neural stimulator to provide the chronic neural stimulation therapy, receive an indicator from the detector that the pathological condition is detected, and control the neural stimulator to integrate the acute neural stimulation therapy with the chronic neural stimulation therapy in response to the indicator.

    Abstract translation: 各种实施例提供了包括检测器,神经刺激器和控制器的可植入医疗装置。 检测器被配置为检测针对急性神经刺激治疗指示的病理状况。 神经刺激器能够递送慢性神经刺激治疗和急性神经刺激治疗。 控制器被配置为控制神经刺激器以提供慢性神经刺激治疗,从检测器接收到检测到病理状况的指示器,并且控制神经刺激器将急性神经刺激治疗与慢性神经刺激治疗结合起来 到指标。

    VALVELESS PULSED DETONATION COMBUSTOR
    3.
    发明申请

    公开(公告)号:WO2007112442A3

    公开(公告)日:2007-10-04

    申请号:PCT/US2007/065378

    申请日:2007-03-28

    Abstract: Pulse detonation combustors of valveless construction. One valveless pulse detonation combustor, having a tube with a closed end and an open end, is constructed with a flame accelerator within the tube, adjacent the open end. A valveless, apertured flow restrictor is positioned between the flame accelerator and the closed end of the tube. A sparking device is positioned within the tube, between the flow restrictor and the flame accelerator. Valveless fuel and air ports are positioned between the flow restrictor and the closed end of the tube. Substantially right-angle manifold passageways are in communication with each of the ports.

    PATTERNED SPINNING DISK BASED OPTICAL PHASE SHIFTER FOR SPECTRAL DOMAIN OPTICAL
    4.
    发明申请
    PATTERNED SPINNING DISK BASED OPTICAL PHASE SHIFTER FOR SPECTRAL DOMAIN OPTICAL 审中-公开
    用于光谱域光学的基于旋转盘的光学相位变换器

    公开(公告)号:WO2006028926A1

    公开(公告)日:2006-03-16

    申请号:PCT/US2005/031204

    申请日:2005-08-30

    Abstract: A low cost patterned spinning disk is disclosed for achieving relatively rapid discrete optical phase shifts for an optical beam. The invention is particularly useful in a 5 spectral domain optical coherence tomography system. The disk contains stepped patterns of different heights and/or refractive index distribution such that as it spins, an optical beam passing through or being reflected by the disk will experience different discrete optical phase delays. The disk can be operated as a phase shifter or it can be operated in synchronization with an intensity modulating chopper disk or a direct 10 intensity modulation of the light source. The disk can also contain intensity modulating patterns such that both phase shifting and intensity modulation can be achieved at the same time. Various possible methods are also disclosed for the fabrication of the disk.

    Abstract translation: 公开了一种低成本图案旋转盘,用于实现光束的相对快速的离散光学相移。 本发明在5光谱域光学相干断层摄影系统中特别有用。 盘包含不同高度和/或折射率分布的阶梯图案,使得当其旋转时,通过或被盘反射的光束将经历不同的离散光学相位延迟。 磁盘可以作为移相器来操作,或者可以与强度调制斩波盘同步操作,也可以直接对光源进行10次强度调制。 磁盘还可以包含强度调制模式,使得可以同时实现相移和强度调制。 还公开了用于制造盘的各种可能的方法。

    SYSTEMS AND METHODS FOR ENHANCING CARDIAC SIGNAL FEATURES USED IN MORPHOLOGY DISCRIMINATION
    9.
    发明申请
    SYSTEMS AND METHODS FOR ENHANCING CARDIAC SIGNAL FEATURES USED IN MORPHOLOGY DISCRIMINATION 审中-公开
    用于增强在形态学辨证中使用的心脏信号特征的系统和方法

    公开(公告)号:WO2008112060A1

    公开(公告)日:2008-09-18

    申请号:PCT/US2008/001986

    申请日:2008-02-14

    Abstract: Methods and devices used to classify cardiac events based on morphological analysis of sensed signals are described. A signal comprising a cardiac signal component and a noise signal component is sensed. The sensed signal is processed to preferentially alter morphology of the cardiac signal component. The altered morphology of the cardiac signal component enhances detection of one or more features of the cardiac signal component. The features of the cardiac signal component are detected and the cardiac event is classified using the detected features. Processing the sensed signal may involve the use of adaptable signal processing parameters. For example, the signal processing parameters may be selected to accentuate one or more desirable features of the cardiac signal component or to mitigate one or more undesirable features of the cardiac signal component.

    Abstract translation: 描述了基于感测信号的形态学分析来分类心脏事件的方法和装置。 检测包括心脏信号分量和噪声信号分量的信号。 处理感测到的信号以优先改变心脏信号分量的形态。 心脏信号分量改变的形态增强了对心脏信号分量的一个或多个特征的检测。 检测心脏信号分量的特征,并使用检测到的特征对心脏事件进行分类。 处理感测信号可能涉及使用适应性信号处理参数。 例如,可以选择信号处理参数以强调心脏信号分量的一个或多个期望特征或减轻心脏信号分量的一个或多个不期望的特征。

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