公开(公告)号：WO2016054483A1

公开(公告)日：2016-04-07

申请号：PCT/US2015/053677

申请日：2015-10-02

Applicant: NOVARTIS AG ,  FAIRHURST, Robin, Alec ,  FURET, Pascal ,  KNÖPFEL, Thomas ,  LEBLANC, Catherine ,  LIAO, Lv ,  MAH, Robert ,  NIMSGERN, Pierre ,  RIPOCHE, Sebastien ,  XIONG, Jing ,  ZHAO, Xianglin ,  HAN, Bo ,  WANG, Can ,  PORTER, Dale ,  BUSCHMANN, Nicole ,  GRAUS PORTA, Diana ,  HAEFLIGER, Carolina ,  MURAKAMI, Masato ,  PALMER, Michael ,  WANG, Youzhen ,  WEISS, Andreas

Inventor： FAIRHURST, Robin, Alec ,  FURET, Pascal ,  KNÖPFEL, Thomas ,  LEBLANC, Catherine ,  LIAO, Lv ,  MAH, Robert ,  NIMSGERN, Pierre ,  RIPOCHE, Sebastien ,  XIONG, Jing ,  ZHAO, Xianglin ,  HAN, Bo ,  WANG, Can ,  PORTER, Dale ,  BUSCHMANN, Nicole ,  GRAUS PORTA, Diana ,  HAEFLIGER, Carolina ,  MURAKAMI, Masato ,  PALMER, Michael ,  WANG, Youzhen ,  WEISS, Andreas

IPC: A61K31/4375 ,  A61K31/437 ,  A61K31/4353 ,  A61K31/506 ,  A61K31/5383 ,  A61K31/5377 ,  A61K31/501 ,  A61P35/00

CPC classification number: A61K31/4375 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/55 ,  A61P35/00

Abstract: The present invention relates to therapeutic uses of compounds of formula (I) or a pharmaceutically acceptable salt thereof.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐的治疗用途。

公开(公告)号：WO1994011335A1

公开(公告)日：1994-05-26

申请号：PCT/JP1993001610

申请日：1993-11-05

Applicant: UBE INDUSTRIES, LTD. ,  MANADA, Noriaki ,  KURAFUJI, Toshio ,  YAMAMOTO, Yasushi ,  MURAKAMI, Masato

Inventor： UBE INDUSTRIES, LTD.

IPC: C07C69/96

CPC classification number: B01J23/8926 ,  B01J21/18 ,  C07C68/00 ,  C07C69/96

Abstract: A process for producing a carbonic diester by the catalytic reaction of carbon monoxide with a nitrous ester in the presence of a solid catalyst, characterized by adding a minute amount of a chloroformic ester to the feedstock gas comprising carbon monoxide and a nitrous ester, whereby the catalyst can be kept in a highly activated state for long and can provide the objective diester at a high reaction velocity and a high selectivity stably for long.

Abstract translation: 一种在固体催化剂存在下通过一氧化碳与亚硝酸酯的催化反应制备碳酸二酯的方法，其特征在于向含有一氧化碳和亚硝酸酯的原料气中加入少量的氯甲酸酯， 催化剂可以长时间保持在高活化状态，并且可以长时间稳定地提供目标二酯在高反应速度和高选择性。

公开(公告)号：WO1992017407A1

公开(公告)日：1992-10-15

申请号：PCT/JP1992000402

申请日：1992-04-01

Applicant: INTERNATIONAL SUPERCONDUCTIVITY TECHNOLOGY CENTER ,  HOKURIKU ELECTRIC POWER COMPANY ,  SUMITOMO ELECTRIC INDUSTRIES, LTD. ,  KAWASAKI JUKOGYO KABUSHIKI KAISHA ,  NIPPON STEEL CORPORATION ,  MURAKAMI, Masato; ,  TAKADA, Tsutomu; ,  YAMAGUCHI, Koji; ,  KONDO, Akihiro; ,  KOSHIZUKA, Naoki;

Inventor： INTERNATIONAL SUPERCONDUCTIVITY TECHNOLOGY CENTER ,  HOKURIKU ELECTRIC POWER COMPANY ,  SUMITOMO ELECTRIC INDUSTRIES, LTD. ,  KAWASAKI JUKOGYO KABUSHIKI KAISHA ,  NIPPON STEEL CORPORATION

IPC: C01G03/00

CPC classification number: C01G55/002 ,  C01G3/006 ,  C01P2004/03 ,  C01P2004/61 ,  C01P2004/62 ,  C01P2006/40 ,  C01P2006/42 ,  C01P2006/80 ,  C04B35/4504 ,  C04B35/4508 ,  Y10S505/78 ,  Y10S505/781 ,  Y10S505/785

Abstract: An oxide superconductor comprising Ln2BaCuO5 and PtBaCuO with a mean particle diameter of 0.1 to 10 νm finely dispersed in the crystal of LnBa2Cu3Oy, wherein Ln represents at least one rare earth element including Y; and a process for producing the same by melting a powdery raw material comprising composite oxides of Ln, Ba and Cu, rapidly cooling the melt to effect solidification, crushing the solid, adding thereto a Pt powder, molding the mixture, heating the molding into a semi-molten state, and cooling the resulting molding.

公开(公告)号：WO1989012028A1

公开(公告)日：1989-12-14

申请号：PCT/JP1989000577

申请日：1989-06-06

Applicant: NIPPON STEEL CORPORATION ,  MORITA, Mitsuru ,  MIYAMOTO, Katsuyoshi ,  MURAKAMI, Masato ,  MATSUDA, Shoichi

Inventor： NIPPON STEEL CORPORATION

IPC: C01G03/00

CPC classification number: H01L39/126 ,  C04B35/4508 ,  C04B35/653 ,  H01L39/2419

Abstract: An oxide superconductive material of a structure wherein RE2BaCuO5-phase particles of 20 mum or less in diameter are dispersed in an REBa2Cu3O7-y phase (wherein RE represents a rare earth element including Y) is disclosed. This superconductive material is obtained by melting a superconductive oxide composition of RE, Ba and Cu, rapidly quenching and solidifying it to obtain a platy or linear product, heating it to a temperature range of 1000 to 1350°C to make it half-molten, and gradually cooling it at a rate not higher than 200°C.

公开(公告)号：WO2016120828A1

公开(公告)日：2016-08-04

申请号：PCT/IB2016/050442

申请日：2016-01-28

Applicant: NOVARTIS AG ,  HACKL, Wolfgang ,  MURAKAMI, Masato ,  WIESMANN, Marion ,  JI, Yan ,  FJAELLSKOG, Marie-Louise ,  WHARTON, Keith

Inventor： HACKL, Wolfgang ,  MURAKAMI, Masato ,  WIESMANN, Marion ,  JI, Yan ,  FJAELLSKOG, Marie-Louise ,  WHARTON, Keith

IPC: A61K39/395 ,  A61K31/00 ,  C07K16/24 ,  G01N33/574

CPC classification number: C07K16/243 ,  A61K31/555 ,  A61K31/7068 ,  A61K33/24 ,  A61K39/39558 ,  A61K2039/505 ,  A61K2039/55 ,  C07K2317/24 ,  G01N33/57415 ,  G01N2333/70596 ,  G01N2333/7153 ,  G01N2800/52 ,  A61K2300/00

Abstract: The invention relates, in part, to a method of selectively treating a patient having breast cancer, comprising administering a therapeutically effective amount of a M-CSF antagonist to the patient on the basis of the patient having a level of CD 163 expression that is predictive that the patient will respond to an M-CSF antagonist. The invention relates, in part, to a method of treating a patient having triple negative breast cancer, comprising administering a therapeutically effective amount of an M-CSF antibody or fragment thereof to the patient, wherein the M-CSF antibody or fragment comprises 1, 2, 3, 4, 5, or 6 CDRs as shown in Table 1. The invention relates, in part, to a method of treating a patient having breast cancer, comprising administering a combination of a therapeutically effective amount of an M-CSF antagonist, a therapeutically effective amount of a second agent and a therapeutically effective amount of a third agent.

Abstract translation: 本发明部分地涉及选择性治疗患有乳腺癌的患者的方法，其包括基于具有预测性的CD163表达水平的患者向患者施用治疗有效量的M-CSF拮抗剂 患者将对M-CSF拮抗剂作出反应。 本发明部分涉及治疗患有三阴性乳腺癌的患者的方法，包括向患者施用治疗有效量的M-CSF抗体或其片段，其中所述M-CSF抗体或片段包含1， 2,3,4,5或6个CDR。本发明部分涉及治疗患有乳腺癌的患者的方法，包括给予治疗有效量的M-CSF拮抗剂的组合 ，治疗有效量的第二药剂和治疗有效量的第三药剂。

公开(公告)号：WO2006059415A8

公开(公告)日：2007-06-21

申请号：PCT/JP2005016200

申请日：2005-08-30

Applicant: UBE INDUSTRIES ,  YAMAGUCHI HIROAKI ,  MURAKAMI MASATO ,  KOHDA MASAFUMI

Inventor： YAMAGUCHI HIROAKI ,  MURAKAMI MASATO ,  KOHDA MASAFUMI

IPC: C08G73/10

CPC classification number: C08G73/1067 ,  C08G73/1042 ,  C08G73/1071 ,  H05K1/0346 ,  Y10T428/12569 ,  Y10T428/31678 ,  Y10T428/31681 ,  Y10T428/31721

Abstract: A novel polyimide wherein a tetracarboxylic dianhydride comprising 3,3',4,4'-biphenyltetracarboxylic dianhydride as the essential component is the starting tetracarboxylic dianhydride component, and an amine comprising between 0.5 and 30 mole percent of a diamine represented by the following general formula is the starting diamine component. (wherein A is a direct bond or a crosslinking group, and R1-R4 each represent a substituent). It is possible to obtain a polyimide, a polyimide film and a laminated body with an improved adhesion property and an improved moisture permeation rate, even without surface treatment, comprising, as the essential tetracarboxylic dianhydride, 3,3',4,4'-biphenyltetracarboxylic dianhydride which has conventionally only yielded polyimides with low adhesive strength.

Abstract translation: 一种新型的聚酰亚胺，其中包含3,3'，4,4'-联苯四羧酸二酐作为主要成分的四羧酸二酐是起始的四羧酸二酐组分，和含有0.5至30摩尔％的由以下通式表示的二胺的胺 是起始的二胺组分。 （其中A是直接键或交联基团，并且R 1 -R 4各自表示取代基）。 即使没有表面处理，也可以获得聚酰亚胺，聚酰亚胺膜和具有改进的粘附性和改善的透湿速率的层压体，其包含作为主要的四羧酸二酐的3,3'，4,4'- 联苯四羧酸二酐，其通常仅产生具有低粘合强度的聚酰亚胺。

公开(公告)号：WO2006059415A1

公开(公告)日：2006-06-08

申请号：PCT/JP2005/016200

申请日：2005-08-30

Applicant: UBE INDUSTRIES, LTD. ,  YAMAGUCHI, Hiroaki ,  MURAKAMI, Masato ,  KOHDA, Masafumi

Inventor： YAMAGUCHI, Hiroaki ,  MURAKAMI, Masato ,  KOHDA, Masafumi

IPC: C08G73/10

CPC classification number: C08G73/1067 ,  C08G73/1042 ,  C08G73/1071 ,  H05K1/0346 ,  Y10T428/12569 ,  Y10T428/31678 ,  Y10T428/31681 ,  Y10T428/31721

Abstract: A novel polyimide wherein a tetracarboxylic dianhydride comprising 3,3',4,4'-biphenyltetracarboxylic dianhydride as the essential component is the starting tetracarboxylic dianhydride component, and an amine comprising between 0.5 and 30 mole percent of a diamine represented by the following general formula is the starting diamine component. (wherein A is a direct bond or a crosslinking group, and R1-R4 each represent a substituent). It is possible to obtain a polyimide, a polyimide film and a laminated body with an improved adhesion property and an improved moisture permeation rate, even without surface treatment, comprising, as the essential tetracarboxylic dianhydride, 3,3',4,4'-biphenyltetracarboxylic dianhydride which has conventionally only yielded polyimides with low adhesive strength.

Abstract translation: 一种新型的聚酰亚胺，其中包含3,3'，4,4'-联苯四羧酸二酐作为主要成分的四羧酸二酐是起始的四羧酸二酐组分，和含有0.5至30摩尔％的由以下通式表示的二胺的胺 是起始的二胺组分。 （其中A是直接键或交联基团，并且R 1 -R 4各自表示取代基）。 即使没有表面处理，也可以获得聚酰亚胺，聚酰亚胺膜和具有改进的粘附性和改善的透湿速率的层压体，其包含作为主要的四羧酸二酐的3,3'，4,4'- 联苯四羧酸二酐，其通常仅产生具有低粘合强度的聚酰亚胺。

公开(公告)号：WO1992016471A1

公开(公告)日：1992-10-01

申请号：PCT/JP1992000315

申请日：1992-03-16

Applicant: INTERNATIONAL SUPERCONDUCTIVITY TECHNOLOGY CENTER ,  SHIKOKU ELECTRIC POWER CO., INC. ,  NIPPON STEEL CORPORATION ,  OYAMA, Terutsugu ,  MURAKAMI, Masato ,  KOSHIZUKA, Naoki ,  TANAKA, Shoji

Inventor： INTERNATIONAL SUPERCONDUCTIVITY TECHNOLOGY CENTER ,  SHIKOKU ELECTRIC POWER CO., INC. ,  NIPPON STEEL CORPORATION

IPC: C04B35/64

CPC classification number: H01L39/2419 ,  C04B35/45 ,  C04B35/4504 ,  C04B35/64 ,  C04B35/653

Abstract: A method of making an oxide superconductor comprising the steps of putting a powdery material to be molded into an oxide superconductor on silver or silver oxide in a pan, heating said pan to a temperature higher than the melting point of silver so as to bring said material into a half-melting state while said material is floating in said molten silver, and cooling said pan and taking out said material from re-solidified silver, whereby a bulky material 10 cm or more in diameter free of cracks can be obtained.