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    APPARATUS AND METHOD OF PERFORMING HIGH-THROUGHPUT CELL-CULTURE STUDIES ON BIOMATERIALS
    4.
    发明申请
    APPARATUS AND METHOD OF PERFORMING HIGH-THROUGHPUT CELL-CULTURE STUDIES ON BIOMATERIALS 审中-公开
    在生物材料上进行高通量细胞培养研究的装置和方法

    公开(公告)号：WO2008147783A3

    公开(公告)日：2009-01-22

    申请号：PCT/US2008064281

    申请日：2008-05-21

    申请人： BOSTON SCIENT SCIMED INC ,  FREDERICKSON GERALD ,  MCNAMARA ADRIAN ,  OHRI RACHIT ,  ROBIDA TODD R ,  WHALEN ANNE M

    发明人： FREDERICKSON GERALD ,  MCNAMARA ADRIAN ,  OHRI RACHIT ,  ROBIDA TODD R ,  WHALEN ANNE M

    IPC分类号： B01L3/00 ,  C12M1/20 ,  C12M1/22 ,  C12M3/06

    CPC分类号： C12M23/12 ,  B01L3/5085 ,  B01L3/50853 ,  B01L3/50855 ,  B01L2200/0689 ,  B01L2300/0822 ,  B01L2300/0829 ,  B01L2300/0851 ,  Y10T436/25

    摘要： In one embodiment, a kit includes a base and a specimen removably couplable to the base. A top plate defines a plurality of apertures and is removably couplable to the base such that at least two of the apertures are associated with a specimen and each aperture defines a well with that specimen. Each well is configured to receive a sample material therein in contact with the specimen. A method includes disposing a specimen within a recessed portion of a test apparatus and coupling a top plate of the test apparatus to a base of the test apparatus such that a sealing engagement is formed between the top plate and the specimen. The top plate defines a plurality of apertures, each of at least two of the apertures collectively with the specimen defines a well. A sample material can be disposed within at least one well.

    摘要翻译： 在一个实施例中，套件包括基部和可移除地联接到基部的样本。 顶板限定多个孔，并且可移除地联接到基部，使得至少两个孔与样本相关联，并且每个孔与该标本形成一个孔。 每个孔被构造成接收与样品接触的样品材料。 一种方法包括将样品设置在测试装置的凹陷部分内，并将测试装置的顶板连接到测试装置的底部，使得在顶板和样品之间形成密封接合。 顶板限定多个孔，与样本共同的至少两个孔中的每一个限定了孔。 样品材料可以设置在至少一个孔内。

    POLYMERIC THERAPEUTICS
    7.
    发明申请
    POLYMERIC THERAPEUTICS 审中-公开
    聚合物治疗

    公开(公告)号：WO2008089256A2

    公开(公告)日：2008-07-24

    申请号：PCT/US2008/051193

    申请日：2008-01-16

    申请人： CAPPELLA, INC. ,  OHRI, Rachit ,  STECKEL, Mark ,  RANADE, Shrirang

    发明人： OHRI, Rachit ,  STECKEL, Mark ,  RANADE, Shrirang

    IPC分类号： A61K47/48

    CPC分类号： A61K47/6957 ,  A61K47/59 ,  A61K47/593 ,  A61K47/60 ,  A61K47/605 ,  A61K47/62

    摘要： Disclosed herein are polymers comprising a chemical moiety linked through a covalent bond, where the chemical moiety forms a pharmaceutically active agent upon degradation of the covalent bond. The polymers can be chosen from star polymers, dendrimers, and hyperbranched polymers. Also disclosed are coatings for implantable medical device comprising such polymers.

    摘要翻译： 本文公开了包含通过共价键连接的化学部分的聚合物，其中化学部分在共价键降解时形成药物活性剂。 聚合物可以选自星形聚合物，树枝状聚合物和超支化聚合物。 还公开了包含这种聚合物的可植入医疗装置的涂层。

    POLYMERIC THERAPEUTICS
    9.
    发明申请
    POLYMERIC THERAPEUTICS 审中-公开
    聚合物治疗

    公开(公告)号：WO2008089256A3

    公开(公告)日：2009-12-30

    申请号：PCT/US2008051193

    申请日：2008-01-16

    申请人： CAPPELLA INC ,  OHRI RACHIT ,  STECKEL MARK ,  RANADE SHRIRANG

    发明人： OHRI RACHIT ,  STECKEL MARK ,  RANADE SHRIRANG

    IPC分类号： A61K47/48

    CPC分类号： A61K47/6957 ,  A61K47/59 ,  A61K47/593 ,  A61K47/60 ,  A61K47/605 ,  A61K47/62

    摘要： Disclosed herein are polymers comprising a chemical moiety linked through a covalent bond, where the chemical moiety forms a pharmaceutically active agent upon degradation of the covalent bond. The polymers can be chosen from star polymers, dendrimers, and hyperbranched polymers. Also disclosed are coatings for implantable medical device comprising such polymers.

    摘要翻译： 本文公开了包含通过共价键连接的化学部分的聚合物，其中化学部分在共价键降解时形成药物活性剂。 聚合物可以选自星形聚合物，树枝状聚合物和超支化聚合物。 还公开了包含这种聚合物的可植入医疗装置的涂层。

    SHEATH WITH RADIO-OPAQUE MARKERS FOR IDENTIFYING SPLIT PROPAGATION
    10.
    发明申请
    SHEATH WITH RADIO-OPAQUE MARKERS FOR IDENTIFYING SPLIT PROPAGATION 审中-公开
    用于识别分裂传播的无线电OPAQUE标记

    公开(公告)号：WO2009129199A1

    公开(公告)日：2009-10-22

    申请号：PCT/US2009/040421

    申请日：2009-04-14

    申请人： CAPPELLA, INC. ,  STECKEL, Mark ,  OHRI, Rachit

    发明人： STECKEL, Mark ,  OHRI, Rachit

    IPC分类号： A61F2/84

    CPC分类号： A61F2/97 ,  A61F2/958 ,  A61F2002/821 ,  A61F2002/9583 ,  A61F2250/0098

    摘要： A medical device delivery system includes a self-expanding medical device mounted on a balloon portion of a catheter. A sheath is provided around the medical device to hold the device in place with the device staying in a compressed state. The balloon portion is inflated to cause the sheath to rupture and release the self-expanding medical device. A number of radio- opaque markers in a pattern that will aid in determining whether or not the sheath has properly ruptured upon inflation of the balloon portion are provided on the sheath. The radio-opaque markers are positioned with respect to an expected sheath rupture propagation path along which the sheath is expected to rupture. The pattern of the markers changes as the sheath ruptures and this change is detected by an operator of the system.

    摘要翻译： 医疗装置输送系统包括安装在导管的球囊部分上的自扩张医疗装置。 在医疗装置周围设置护套，以将装置保持在处于压缩状态的装置的适当位置。 气囊部分被充气以使皮肤破裂并释放自膨胀的医疗装置。 许多不透射线的标记物将有助于确定在球囊部分膨胀时护套是否已经适当地破裂。 射线不透明标记物相对于期望的鞘破裂传播路径定位，预期护套穿过其将破裂。 标记的图案随着鞘破裂而变化，并且该变化由系统的操作者检测到。