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    MAGNESIUM-BASED ABSORBABLE IMPLANTS
    1.
    发明申请
    MAGNESIUM-BASED ABSORBABLE IMPLANTS 审中-公开

    公开(公告)号：WO2012075311A3

    公开(公告)日：2012-06-07

    申请号：PCT/US2011/062922

    申请日：2011-12-01

    申请人： ZORION MEDICAL, INC. ,  STECKEL, Mark ,  PANDELIDIS, Ioannis

    发明人： STECKEL, Mark ,  PANDELIDIS, Ioannis

    IPC分类号： A61L27/04 ,  A61L27/58 ,  A61L31/02 ,  A61L31/14

    摘要： A bioabsorbable implant including an elongated metallic element comprising an alloy of more than about 70% by weight magnesium and about 2 - 20% by weight lithium, substantially free of rare earth metals. An implantable tissue filler includes a particulate material suspended in a carrier, comprising more than about 70% by weight magnesium and about 2 - 20% by weight lithium, substantially free of rare earth metals. A bioabsorbable implant includes an elongated metallic element having a core and at least two layers of alternating compositions of magnesium, iron, and alloys thereof. A bioabsorbable implant includes at least three wires including magnesium and defining a cylindrical sheath surrounding at least one core wire including iron. A bioabsorbable implant includes a plurality of intertwined magnesium alloy wires defining a strand, with an Fe-rich layer formed by vapor, chemical and /or electro- deposition defined on a surface of at least one of the wires.

    MAGNESIUM-BASED ABSORBABLE IMPLANTS
    3.
    发明申请
    MAGNESIUM-BASED ABSORBABLE IMPLANTS 审中-公开
    基于MAGNESIUM的可吸收植入物

    公开(公告)号：WO2012075311A2

    公开(公告)日：2012-06-07

    申请号：PCT/US2011062922

    申请日：2011-12-01

    申请人： ZORION MEDICAL INC ,  STECKEL MARK ,  PANDELIDIS IOANNIS

    发明人： STECKEL MARK ,  PANDELIDIS IOANNIS

    IPC分类号： A61B17/03

    CPC分类号： A61F2/86 ,  A61B17/122 ,  A61B17/80 ,  A61B17/866 ,  A61B2017/00004 ,  A61B2017/0417 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61L27/04 ,  A61L27/58 ,  A61L31/022 ,  A61L31/148 ,  C25F3/18 ,  C25F3/24

    摘要： A bioabsorbable implant including an elongated metallic element comprising an alloy of more than about 70% by weight magnesium and about 2 - 20% by weight lithium, substantially free of rare earth metals. An implantable tissue filler includes a particulate material suspended in a carrier, comprising more than about 70% by weight magnesium and about 2 - 20% by weight lithium, substantially free of rare earth metals. A bioabsorbable implant includes an elongated metallic element having a core and at least two layers of alternating compositions of magnesium, iron, and alloys thereof. A bioabsorbable implant includes at least three wires including magnesium and defining a cylindrical sheath surrounding at least one core wire including iron. A bioabsorbable implant includes a plurality of intertwined magnesium alloy wires defining a strand, with an Fe-rich layer formed by vapor, chemical and /or electro- deposition defined on a surface of at least one of the wires.

    摘要翻译： 一种生物可吸收植入物，其包括细长的金属元素，其包含大于约70重量％的镁和约2-20重量％的锂的合金，基本上不含稀土金属。 可植入组织填料包括悬浮在载体中的颗粒材料，其包含大于约70重量％的镁和约2-20重量％的锂，基本上不含稀土金属。 生物可吸收植入物包括细长的金属元件，其具有芯和至少两层交替组成的镁，铁及其合金。 生物可吸收植入物包括至少三根包括镁的线，并限定围绕包括铁的至少一根芯线的圆柱形护套。 生物可吸收植入物包括限定线的多个缠结的镁合金线，其中​​至少一条导线的表面上限定有通过蒸气，化学和/或电沉积形成的富Fe层。

    POLYMERIC THERAPEUTICS
    6.
    发明申请
    POLYMERIC THERAPEUTICS 审中-公开
    聚合物治疗

    公开(公告)号：WO2008089256A2

    公开(公告)日：2008-07-24

    申请号：PCT/US2008/051193

    申请日：2008-01-16

    申请人： CAPPELLA, INC. ,  OHRI, Rachit ,  STECKEL, Mark ,  RANADE, Shrirang

    发明人： OHRI, Rachit ,  STECKEL, Mark ,  RANADE, Shrirang

    IPC分类号： A61K47/48

    CPC分类号： A61K47/6957 ,  A61K47/59 ,  A61K47/593 ,  A61K47/60 ,  A61K47/605 ,  A61K47/62

    摘要： Disclosed herein are polymers comprising a chemical moiety linked through a covalent bond, where the chemical moiety forms a pharmaceutically active agent upon degradation of the covalent bond. The polymers can be chosen from star polymers, dendrimers, and hyperbranched polymers. Also disclosed are coatings for implantable medical device comprising such polymers.

    摘要翻译： 本文公开了包含通过共价键连接的化学部分的聚合物，其中化学部分在共价键降解时形成药物活性剂。 聚合物可以选自星形聚合物，树枝状聚合物和超支化聚合物。 还公开了包含这种聚合物的可植入医疗装置的涂层。

    MEDICAL DEVICE DELIVERY SYSTEM WITH SHEATH HAVING BALLOON-RELATIVE POSITION
    8.
    发明申请
    MEDICAL DEVICE DELIVERY SYSTEM WITH SHEATH HAVING BALLOON-RELATIVE POSITION 审中-公开
    具有气孔相关位置的医疗装置输送系统

    公开(公告)号：WO2008157830A1

    公开(公告)日：2008-12-24

    申请号：PCT/US2008/067898

    申请日：2008-06-23

    申请人： CAPPELLA, INC. ,  SLATTERY, David ,  KELLY, Damian ,  O'CONNOR, Therese ,  KERINS, Joseph ,  GILMORE, Michael ,  STECKEL, Mark

    发明人： SLATTERY, David ,  KELLY, Damian ,  O'CONNOR, Therese ,  KERINS, Joseph ,  GILMORE, Michael ,  STECKEL, Mark

    IPC分类号： A61F2/84 ,  A61M25/10

    CPC分类号： A61M25/1038 ,  A61F2/958 ,  A61F2/97 ,  A61F2002/9583

    摘要： A delivery system for delivering a self- expanding medical device such as a stent (16) includes the stent mounted on a balloon portion (30) of a catheter. A sheath (18,40) is provided around the stent to hold the device in place in a compressed state. A portion of the sheath (42,44) is positioned at a predetermined location, or within a predetermined range of locations, on the circumference of the sheath. The predetermined location or range of locations are determined with respect to a configuration of the balloon portion. The sheath may be profiled or shaped to reduce instances of interference between a distal edge of the sheath and a vessel or with any lesion or lesions that might be present in the vessel. The sheath is formed by modifying a cylinder of sheath material to include three portions and an initiation slit (602) that controls the rupturing of the sheath to facilitate delivery of the medical device.

    摘要翻译： 用于递送诸如支架（16）的自扩张医疗装置的递送系统包括安装在导管的球囊部分（30）上的支架。 在支架周围设置护套（18,40），以将装置保持在压缩状态。 护套（42,44）的一部分位于护套的圆周上的预定位置或位于预定范围内的位置。 相对于球囊部分的构造来确定位置的预定位置或范围。 护套可以被成形或成形，以减少护套的远侧边缘与血管之间的干涉或与血管中可能存在的任何损伤或病变的干扰。 护套通过改变护套材料的圆筒以包括三个部分和起始狭缝（602）形成，起始狭缝（602）控制护套的破裂以促进医疗装置的传送。

    MEDICAL DEVICES HAVING BIODEGRADABLE POLYMERIC REGIONS
    9.
    发明申请
    MEDICAL DEVICES HAVING BIODEGRADABLE POLYMERIC REGIONS 审中-公开
    具有生物可降解聚合物区域的医疗设备

    公开(公告)号：WO2007111808A2

    公开(公告)日：2007-10-04

    申请号：PCT/US2007005654

    申请日：2007-03-05

    申请人： BOSTON SCIENT SCIMED INC ,  STECKEL MARK ,  SIKES COURTNEY

    发明人： STECKEL MARK ,  SIKES COURTNEY

    CPC分类号： A61L27/58 ,  A61F2210/0004 ,  A61L27/14

    摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more biodegradable polymeric regions. These biodegradable polymeric regions, in turn, contain one or more polymers, at least one of which is a biodegradable copolymer that includes: (a) one or More amorphous polymer blocks that displays a glass transition temperature below 37°C and (b) one or more amorphous polymer blocks displaying a glass transition temperature above 37°C.

    摘要翻译： 根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含一个或多个可生物降解的聚合物区域。 这些可生物降解的聚合物区域又包含一种或多种聚合物，其中至少一种是可生物降解的共聚物，其包括：（a）显示玻璃化转变温度低于37℃的一种或多种无定形聚合物嵌段和（b）一种 或更多的显示玻璃化转变温度高于37℃的无定形聚合物嵌段。