公开(公告)号：WO2018217104A1

公开(公告)日：2018-11-29

申请号：PCT/NZ2018/050073

申请日：2018-05-24

Applicant: OTAGO INNOVATION LIMITED

Inventor： MELEDANDRI, Carla Joy ,  COTTON, Gemma Claire ,  SCHWASS, Donald Royden

IPC: A61K6/083 ,  A61L24/12 ,  A61K33/38 ,  A61P31/04

CPC classification number: A61P31/04 ,  A61K6/046 ,  A61K6/0835 ,  A61L24/0089 ,  A61L24/12 ,  C08L33/10 ,  C08L33/08

Abstract: The present invention relates to a glass ionomer cement comprising: (i) nanoparticles of metallic silver (Ag); (ii) a polymer comprising carboxylate groups; (iii) bridging molecules comprising at least one group capable of binding to Ag; (iv) metal ions; and (v) aluminosilicate particles; wherein at least some of the aluminosilicate particles are bound to the polymer through a linking structure of the following general formula: polymer-M-B-Ag-B-M-aluminosilicate where M is a metal ion, B is a bridging molecule, and Ag is a silver nanoparticle. The invention further relates to a dental preparation product comprising a liquid phase and a solid phase separated from each other, wherein the liquid phase comprises: (i) nanoparticles of metallic silver; (ii) a polymer comprising carboxylate groups; and (iii) bridging molecules comprising at least one group capable of binding to Ag; and wherein the solid phase comprises particles of an aluminosilicate compound.

公开(公告)号：WO2014204327A1

公开(公告)日：2014-12-24

申请号：PCT/NZ2014/000123

申请日：2014-06-20

Applicant: OTAGO INNOVATION LIMITED

Inventor： MCLENNAN, Ian Stuart ,  PANKHURST, Michael William

IPC: G01N33/53

CPC classification number: G01N33/74

Abstract: The present invention provides assays, methods and kits for detection and measurement of the different species of AMH present in a sample, and in particular a biological sample such as a whole blood sample, plasma or serum. The species of AMH include, for example, proAMH and AMH N,C .

Abstract translation: 本发明提供用于检测和测量样品中存在的不同种类的AMH的测定，方法和试剂盒，特别是生物样品，例如全血样品，血浆或血清。 AMH的种类包括例如proAMH和AMHN，C。

公开(公告)号：WO2005056821A1

公开(公告)日：2005-06-23

申请号：PCT/NZ2004/000320

申请日：2004-12-13

Applicant: OTAGO INNOVATION LIMITED ,  POULTER, Russell, Tony ,  BUTLER, Margaret, Isobel

Inventor： POULTER, Russell, Tony ,  BUTLER, Margaret, Isobel

IPC: C12Q1/04

CPC classification number: C12Q1/6895 ,  C12Q1/04 ,  C12Q2600/156

Abstract: A method for the detection and/or assay of pathogenic Cryptococcus in a sample is provided. It involves detection or measurement of a polynucleotide in the sample encoding the intein of the PRP8 gene of a Cryptococcus pathogen.

Abstract translation: 提供了一种用于检测和/或测定样品中致病性隐球菌的方法。 其涉及检测或测量编码隐球菌病原体PRP8基因的内含肽的样品中的多核苷酸。

公开(公告)号：WO2017155416A1

公开(公告)日：2017-09-14

申请号：PCT/NZ2017/050023

申请日：2017-03-08

Applicant: COOK, Gregory Murray ,  LEE, Robyn Hellen ,  MACKNIGHT, Richard Colin ,  POULTER, George Taiaroa Maskell ,  POULTER, Russell Tony Maskell ,  OTAGO INNOVATION LIMITED

Inventor： COOK, Gregory Murray ,  LEE, Robyn Hellen ,  MACKNIGHT, Richard Colin ,  POULTER, George Taiaroa Maskell ,  POULTER, Russell Tony Maskell

IPC: C12Q1/68

CPC classification number: C12Q1/6827 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2521/301 ,  C12Q2521/319 ,  C12Q2525/125 ,  C12Q2537/113 ,  C12Q2545/101

Abstract: The present invention provides assays, methods and test kits for alternate genotyping methods, including nucleic acid sequence based diagnostics, and in particular for identifying genetic variation in a test sample.

Abstract translation: 本发明提供了用于替代基因分型方法的测定法，方法和测试试剂盒，包括基于核酸序列的诊断方法，特别是用于鉴定测试样品中的遗传变异。

公开(公告)号：WO2014137228A1

公开(公告)日：2014-09-12

申请号：PCT/NZ2014/000028

申请日：2014-03-06

Applicant: OTAGO INNOVATION LIMITED

Inventor： RAWLE, Christopher Bruce

IPC: G01N21/00 ,  B01L7/00 ,  H05B1/00

CPC classification number: B01L3/50851 ,  B01L7/52 ,  B01L2200/025 ,  B01L2300/12 ,  B01L2300/168 ,  B01L2300/1822 ,  B01L2300/1894 ,  G01N21/0332 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/0371 ,  H01L35/30

Abstract: A reaction vessel holder (120) receives a reaction vessel (110). The reaction vessel (110) has a portion that is substantially optically transparent to light of a first range of wavelengths. The reaction vessel holder (120) comprises a body having a high thermal conductivity that is thermally coupled to and supports the reaction vessel (120). The body is further thermally coupled to a thermal device (130) for heating or cooling the reaction vessel holder (120) and thereby the reaction vessel (110). The body comprises a transparent portion that is substantially optically transparent to the light of the first range of wavelengths. The optically transparent portion of the reaction vessel (110) faces the transparent portion of the body such that light of the first range of wavelengths to and/or from the sample in the reaction vessel (120) can pass through the transparent portion.

Abstract translation: 反应容器支架（120）容纳反应容器（110）。 反应容器（110）具有对第一波长范围的光基本上光学透明的部分。 反应容器保持器（120）包括与热反应容器（120）热耦合并支撑反应容器（120）的具有高热导率的主体。 本体进一步热耦合到热装置（130），用于加热或冷却反应容器保持器（120），从而加热或冷却反应容器（110）。 该主体包括对第一波长范围的光基本上光学透明的透明部分。 反应容器（110）的光学透明部分面向主体的透明部分，使得反应容器（120）中的第一波长范围和/或从样品的光可以通过透明部分。

公开(公告)号：WO2008153421A1

公开(公告)日：2008-12-18

申请号：PCT/NZ2008/000141

申请日：2008-06-13

Applicant: OTAGO INNOVATION LIMITED ,  BRAITHWAITE, Antony ,  ROYDS, Janice

Inventor： BRAITHWAITE, Antony ,  ROYDS, Janice

IPC: C12N7/01 ,  A61K31/70 ,  A61K35/76 ,  C12N1/10 ,  G01N33/50

CPC classification number: A61K35/76 ,  A01K2267/0331 ,  A61K38/00 ,  A61K45/06 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10332 ,  C12N2710/10343 ,  G01N33/57484 ,  Y02A50/467 ,  A61K2300/00

Abstract: The present invention relates to the treatment of cancer, including methods of therapy and diagnosis of cancer. More particularly it relates to the use of recombinant viruses in the therapy and diagnosis of neoplastic cells lacking p16 tumour suppressor gene function, optionally together with the use of one or more chemotherapeutic or radiotherapeutic agents.

Abstract translation: 本发明涉及癌症的治疗，包括癌症的治疗和诊断方法。 更具体地说，其涉及重组病毒在治疗和诊断缺乏p16肿瘤抑制基因功能的肿瘤细胞中的用途，任选地与使用一种或多种化学治疗剂或放射治疗剂一起使用。

公开(公告)号：WO2006098643A1

公开(公告)日：2006-09-21

申请号：PCT/NZ2006/000046

申请日：2006-03-14

Applicant: OTAGO INNOVATION LIMITED ,  QUICK, Andrew, Noel ,  BOYD, Dorothy, Helen

Inventor： QUICK, Andrew, Noel ,  BOYD, Dorothy, Helen

IPC: A61C19/06

CPC classification number: A61C19/06 ,  A61C7/22 ,  A61C7/28

Abstract: An apparatus (7) for localised application of a substance to a site within the oral cavity has a reservoir (9) for receipt of the substance to be applied, and a mounting arrangement (11) for mounting the apparatus within the oral cavity. The mounting arrangement (11) is configured to place the reservoir (9) in contact with the site to which the substance is to be applied to substantially form a seal between the reservoir and the site to which the substance is to be applied.

Abstract translation: 用于将物质局部应用于口腔内的部位的装置（7）具有用于接收待施用物质的储存器（9）和用于将该装置安装在口腔内的安装装置（11）。 安装装置（11）构造成将储存器（9）放置在与要被施加物质的位置接触的位置上，从而基本上形成在储存器和要被施加物质的位置之间的密封。

公开(公告)号：WO2022019786A1

公开(公告)日：2022-01-27

申请号：PCT/NZ2021/050113

申请日：2021-07-23

Applicant: OTAGO INNOVATION LIMITED

Inventor： GUÉVREMONT, Diane ,  WILLIAMS, Joanna Margaret ,  TATE, Warren Perry ,  ABRAHAM, Wickliffe Carson

IPC: C12Q1/6883

Abstract: Analysis of microRNA (miRNA) signatures to determine or predict stages of cognitive impairment and likelihood of Alzheimer's disease in an individual.

公开(公告)号：WO2021015625A1

公开(公告)日：2021-01-28

申请号：PCT/NZ2020/050069

申请日：2020-07-17

Applicant: OTAGO INNOVATION LIMITED ,  STITELY, Michael Lynn ,  PATERSON, Gwynneth Helen ,  MAY, Stuart ,  SMITH, Robert John ,  SAGGUS, Greta Isabella

Inventor： STITELY, Michael Lynn ,  PATERSON, Gwynneth Helen ,  MAY, Stuart ,  SMITH, Robert John ,  SAGGUS, Greta Isabella

IPC: A61F6/12 ,  A61F6/18

Abstract: An insertion device for an IUD. The insertion device comprises an introducer having an elongate hollow body and a first end and a second end, the hollow body defining an elongate passageway extending from the first end to the second end and defining openings at the first end and the second end, and a pusher provided or configured to be provided inside the elongate passageway such that the pusher is movable through or along the passageway. The passageway is sized to accommodate an IUD such that the IUD is slidable along the passageway. Further, the second end of the introducer that abuts the fundus of the uterus in use is configured to have an increased surface area relative to prior art devices so as to reduce the risk of injury, including perforation of the uterus.

公开(公告)号：WO2019125185A1

公开(公告)日：2019-06-27

申请号：PCT/NZ2018/050182

申请日：2018-12-20

Applicant: OTAGO INNOVATION LIMITED

Inventor： BRIMBLE, Margaret Anne ,  COOK, Greg Murray ,  FERGUSON, Scott Andrew ,  HEIKAL, Adam ,  RENNISON, David

IPC: C07D215/40 ,  C07D401/12 ,  C07D409/12 ,  C07D401/14 ,  C07D405/12 ,  C07D411/12 ,  A61P31/04 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/5377

Abstract: The invention provides novel quinoline sulfonamide compounds of Formula I: (Formula (I)) and their use for the treatment or prevention of bacterial infections caused by both Gram positive and Gram negative bacteria such as, for example, infections caused by one or more bacteria from the Enterobactericeae, Staphylococcaceae, or Streptococcaceae families. The compounds described and claimed herein may be formulated in one or more pharmaceutical or veterinary compositions for use in animal husbandry, and in particular in relation to the treatment of mastitis by directly targeting mastitis causing bacteria in a bovine herd. In certain embodiments described herein the pharmaceutical or veterinary compositions are formulated as a spray for direct administration to the udder of the bovine animal such as a cow.