公开(公告)号：WO2005077899A2

公开(公告)日：2005-08-25

申请号：PCT/US2005/003578

申请日：2005-02-04

Applicant: ABBOTT LABORATORIES ,  SCHRIMPF, Michael, R. ,  SIPPY, Kevin, B. ,  JI, Jianguo ,  LI, Tao ,  PACE, Jennifer, M. ,  BRIGGS, Clark, A. ,  BUNELLE, William, H.

Inventor： SCHRIMPF, Michael, R. ,  SIPPY, Kevin, B. ,  JI, Jianguo ,  LI, Tao ,  PACE, Jennifer, M. ,  BRIGGS, Clark, A. ,  BUNELLE, William, H.

IPC: C07D207/08

CPC classification number: C07D207/08 ,  C07C211/31 ,  C07C217/24 ,  C07C2603/18 ,  C07C2603/26 ,  C07D205/04 ,  C07D207/12 ,  C07D207/14 ,  C07D209/88 ,  C07D211/22 ,  C07D211/46 ,  C07D243/08 ,  C07D295/104 ,  C07D307/91 ,  C07D311/86 ,  C07D333/76 ,  C07D451/06 ,  C07D453/02 ,  C07D487/04 ,  C07D487/08

Abstract: Compounds of formula (I) wherein A and B are amine-substituted sidechains, Y 1 and Y 2 form various tricyclic cores, X a and X b are C, CH, or N, as defined herein, and R x is an optional substituent. Compounds and compositions of formula (I) are contemplated as well as methods for treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands that encompass compounds of formula (I) and other tricyclic derivatives. Methods of using amino-substituted tricyclic derivatives also are described herein.

Abstract translation: 其中A和B是胺取代的侧链，Y 1和Y 2形成各种三环核心的式（I）化合物， 如本文所定义，X和X是C，CH或N，并且R X是任选的取代基。 考虑式（I）化合物和组合物以及用于治疗由包含式（I）化合物和其他三环衍生物的α7nAChR配体阻止或改善的病症或障碍的方法。 本文还描述了使用氨基取代的三环衍生物的方法。

公开(公告)号：WO2006069196A1

公开(公告)日：2006-06-29

申请号：PCT/US2005/046480

申请日：2005-12-21

Applicant: ABBOTT LABORATORIES ,  PACE, Jennifer, M. ,  TIETJE, Karin ,  DART, Michael, J. ,  MEYER, Michael, D.

Inventor： PACE, Jennifer, M. ,  TIETJE, Karin ,  DART, Michael, J. ,  MEYER, Michael, D.

IPC: C07D417/06 ,  C07D413/06 ,  C07D409/06 ,  C07D405/06 ,  C07D401/06 ,  A61K31/404 ,  A61K31/55 ,  A61K31/496 ,  A61K31/454 ,  A61K31/435 ,  A61K31/428 ,  A61K31/422

CPC classification number: C07D403/06 ,  C07D209/12 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06

Abstract: The present invention provides novel compounds of Formula (I), which are CB 2 selective ligands useful for the treatment of pain.

Abstract translation: 本发明提供了新的式（I）化合物，其为可用于治疗疼痛的CB 2/2选择性配体。

公开(公告)号：WO2005077899A3

公开(公告)日：2005-12-01

申请号：PCT/US2005003578

申请日：2005-02-04

Applicant: ABBOTT LAB ,  SCHRIMPF MICHAEL R ,  SIPPY KEVIN B ,  JI JIANGUO ,  LI TAO ,  PACE JENNIFER M ,  BRIGGS CLARK A ,  BUNELLE WILLIAM H

Inventor： SCHRIMPF MICHAEL R ,  SIPPY KEVIN B ,  JI JIANGUO ,  LI TAO ,  PACE JENNIFER M ,  BRIGGS CLARK A ,  BUNELLE WILLIAM H

IPC: C07C211/25 ,  C07C211/31 ,  C07C217/24 ,  C07C217/42 ,  C07D205/04 ,  C07D207/08 ,  C07D207/12 ,  C07D207/14 ,  C07D209/88 ,  C07D211/22 ,  C07D211/46 ,  C07D243/08 ,  C07D295/104 ,  C07D307/91 ,  C07D311/86 ,  C07D333/76 ,  C07D451/06 ,  C07D453/02 ,  C07D487/04 ,  C07D487/08 ,  C07D519/00 ,  C07D295/10

CPC classification number: C07D207/08 ,  C07C211/31 ,  C07C217/24 ,  C07C2603/18 ,  C07C2603/26 ,  C07D205/04 ,  C07D207/12 ,  C07D207/14 ,  C07D209/88 ,  C07D211/22 ,  C07D211/46 ,  C07D243/08 ,  C07D295/104 ,  C07D307/91 ,  C07D311/86 ,  C07D333/76 ,  C07D451/06 ,  C07D453/02 ,  C07D487/04 ,  C07D487/08

Abstract: Compounds of formula (I) wherein A and B are amine-substituted sidechains, Y and Y form various tricyclic cores, X and X are C, CH, or N, as defined herein, and R is an optional substituent. Compounds and compositions of formula (I) are contemplated as well as methods for treating conditions or disorders prevented by or ameliorated by alpha7 nAChR ligands that encompass compounds of formula (I) and other tricyclic derivatives. Methods of using amino-substituted tricyclic derivatives also are described herein.

Abstract translation: 其中A和B是胺取代的侧链的式（I）化合物，Y 1和Y 2形成各种三环核，X a和X b是如本文所定义的C，CH或N ，R x是任选的取代基。 考虑式（I）的化合物和组合物以及用于治疗由包括式（I）化合物和其它三环衍生物的α7nAChR配体防止或改善的病症或病症的方法。 使用氨基取代的三环衍生物的方法也在本文中描述。

公开(公告)号：WO2005028477A1

公开(公告)日：2005-03-31

申请号：PCT/US2004/030735

申请日：2004-09-17

Applicant: ABBOTT LABORATORIES ,  LI, Tao ,  BASHA, Anwer ,  BUNNELLE, William, H. ,  DART, Michael, J. ,  GALLAGHER, Megan, E. ,  JI, Jianguo ,  PACE, Jennifer, M. ,  RYTHER, Keith, B. ,  TIETJE, Karin, R. ,  MORTELL, Kathleen, H. ,  NERSESIAN, Diana, L. ,  SCHRIMPF, Michael, R.

Inventor： BASHA, Anwer ,  BUNNELLE, William, H. ,  DART, Michael, J. ,  GALLAGHER, Megan, E. ,  JI, Jianguo ,  PACE, Jennifer, M. ,  RYTHER, Keith, B. ,  TIETJE, Karin, R. ,  MORTELL, Kathleen, H. ,  NERSESIAN, Diana, L. ,  SCHRIMPF, Michael, R.

IPC: C07D471/04

CPC classification number: C07D487/08 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04

Abstract: Compounds of formula (I) Z-Ar 1 -Ar 2 wherein Z is a diazabicyclic amine, Ar 1 is a 5- or 6-membered aromatic ring, and Ar 2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.

Abstract translation: 式（I）化合物Z-Ar 1 -Ar 2其中Z是二氮杂双环胺，Ar 1是5-或6-元芳环，Ar 2选自未取代或取代的5-或 6元杂芳基环; 未取代或取代的双环杂芳基环; 3,4-（亚甲二氧基）苯基; 咔唑; tetrahydrocarbazolyl; 萘; 和苯基; 其中苯基在间位或对位被0,1,2或3个取代基取代。 该化合物可用于治疗由α7nAChR配体预防或改善的病症或病症。 还公开了包含式（I）化合物和使用这些化合物和组合物的方法的药物组合物。