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公开(公告)号：WO2005016264A3
公开(公告)日：2005-11-17
申请号：PCT/US2004024775
申请日：2004-08-02
发明人： PADIA JANAK K , O'BRIEN SEAN , LU JIEMIN , PIKUL STANISLAW
IPC分类号： A61K20060101 , A61K31/165 , A61K31/47 , A61K31/498 , A61K31/517 , A61K31/52 , A61K31/535 , A61K31/538 , C07C237/04 , C07D203/14 , C07D207/14 , C07D207/16 , C07D211/46 , C07D211/58 , C07D211/60 , C07D211/62 , C07D213/38 , C07D213/74 , C07D215/12 , C07D215/38 , C07D217/04 , C07D231/06 , C07D237/26 , C07D239/42 , C07D241/42 , C07D265/30 , C07D265/36 , C07D295/112 , C07D295/185 , C07D307/68 , C07D307/79 , C07D333/54 , C07D491/10
CPC分类号： C07D203/14 , C07C237/04 , C07D207/14 , C07D207/16 , C07D211/46 , C07D211/58 , C07D211/60 , C07D211/62 , C07D213/38 , C07D213/74 , C07D215/38 , C07D217/04 , C07D231/06 , C07D239/42 , C07D241/42 , C07D295/112 , C07D295/185 , C07D307/68 , C07D307/79 , C07D333/54 , C07D491/10
摘要： Diamine derivatives of quinones, and related compounds, including salts thereof, that modulate the levels of gene expression in cellular systems, such as cancer cells, are disclosed, along with methods for preparing such compounds and derivatives, as well as pharmaceutical compositions containing these compounds and derivatives as active ingredients. Methods of using these as compounds and derivatives as therapeutic agents are also described.
摘要翻译： 公开了醌类的二胺衍生物和调节细胞系统如癌细胞中基因表达水平的相关化合物，包括其盐，以及制备这些化合物和衍生物的方法以及含有这些化合物的药物组合物 和衍生物作为活性成分。 还描述了将其用作化合物和衍生物作为治疗剂的方法。
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公开(公告)号：WO2005013903A3
公开(公告)日：2005-06-09
申请号：PCT/US2004025343
申请日：2004-08-05
发明人： PADIA JANAK K , O'BRIEN SEAN , LU JIEMIN , PIKUL STANISLAW
IPC分类号： A01N37/18 , A01N43/42 , A01N43/58 , A01N43/60 , A61K20060101 , A61K31/16 , A61K31/165 , A61K31/47 , A61K31/495 , A61K31/50 , C07D239/72 , C07D491/107 , C12N15/12
CPC分类号： C07D211/44 , C07C233/32 , C07C233/41 , C07C235/14 , C07D213/38 , C07D213/74 , C07D215/38 , C07D295/135 , C07D295/185 , C07D307/68 , C07D307/79 , C07D403/12 , C07D409/12 , C07D491/10
摘要： Chemical agents, such as derivatives of quinone, and including salts thereof, that modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.
摘要翻译： 公开了调节细胞系统（包括癌细胞）中基因表达水平的醌类衍生物的化学试剂，包括其盐，以及制备这些试剂的方法，以及含有这些试剂如活性成分的药物组合物 以及使用它们作为治疗剂的方法。
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公开(公告)号：WO2005016264A2
公开(公告)日：2005-02-24
申请号：PCT/US2004/024775
申请日：2004-08-02
发明人： PADIA, Janak, K. , O'BRIEN, Sean , LU, Jiemin , PIKUL, Stanislaw
IPC分类号： A61K
CPC分类号： C07D203/14 , C07C237/04 , C07D207/14 , C07D207/16 , C07D211/46 , C07D211/58 , C07D211/60 , C07D211/62 , C07D213/38 , C07D213/74 , C07D215/38 , C07D217/04 , C07D231/06 , C07D239/42 , C07D241/42 , C07D295/112 , C07D295/185 , C07D307/68 , C07D307/79 , C07D333/54 , C07D491/10
摘要： Diamine derivatives of quinones, and related compounds, including salts thereof, that modulate the levels of gene expression in cellular systems, such as cancer cells, are disclosed, along with methods for preparing such compounds and derivatives, as well as pharmaceutical compositions containing these compounds and derivatives as active ingredients. Methods of using these as compounds and derivatives as therapeutic agents are also described.
摘要翻译： 公开了调节细胞系统如癌细胞中基因表达水平的醌的二胺衍生物以及相关化合物及其盐，包括其盐，以及制备这些化合物和衍生物的方法， 以及含有这些化合物和衍生物作为活性成分的药物组合物。 还描述了使用这些化合物和衍生物作为治疗剂的方法。
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公开(公告)号：WO2005016000A1
公开(公告)日：2005-02-24
申请号：PCT/US2004/025038
申请日：2004-08-03
发明人： PADIA, Janak, K. , O'BRIEN, Sean , LU, Jiemin , PIKUL, Stanislaw
IPC分类号： A01N43/58
CPC分类号： C07D241/38 , C07D401/06 , C07D403/06 , C07D471/04 , C07D487/04 , C07D495/04
摘要： Chemical agents, such as derivatives of quinone, and including salts thereof, that modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.
摘要翻译： 公开了调节细胞系统（包括癌细胞）中基因表达水平的醌类衍生物的化学试剂，包括其盐，以及制备这些试剂的方法，以及含有这些试剂如活性成分的药物组合物 以及使用它们作为治疗剂的方法。
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公开(公告)号：WO2005013903A2
公开(公告)日：2005-02-17
申请号：PCT/US2004/025343
申请日：2004-08-05
发明人： PADIA, Janak, K. , O'BRIEN, Sean , LU, Jiemin , PIKUL, Stanislaw
IPC分类号： A61K
CPC分类号： C07D211/44 , C07C233/32 , C07C233/41 , C07C235/14 , C07D213/38 , C07D213/74 , C07D215/38 , C07D295/135 , C07D295/185 , C07D307/68 , C07D307/79 , C07D403/12 , C07D409/12 , C07D491/10
摘要： Chemical agents, such as derivatives of quinone, and including salts thereof, that modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.
摘要翻译： 公开了调节细胞系统（包括癌细胞）中的基因表达水平的化学试剂，例如醌的衍生物及其盐，以及制备这些试剂的方法，以及 含有这些试剂作为活性成分的药物组合物以及使用它们作为治疗剂的方法。
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