公开(公告)号：WO1994008968A1

公开(公告)日：1994-04-28

申请号：PCT/GB1993001990

申请日：1993-09-22

申请人： ZENECA LIMITED ,  DE FRAINE, Paul, John ,  PILKINGTON, Brian, Leslie

发明人： ZENECA LIMITED

IPC分类号： C07D217/14

CPC分类号： C07D239/26 ,  A01N43/40 ,  A01N43/42 ,  A01N43/54 ,  C07C251/60 ,  C07C2601/08 ,  C07C2601/14 ,  C07D213/64 ,  C07D217/14 ,  C07D239/90 ,  C07D401/04 ,  C07D487/04 ,  C07D495/04

摘要： A fungicidal compound having formula (I), wherein either: A is hydrogen, halogen, hydroxy, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, C1-4 alkylcarbonyl, C1-4 alkoxycarbonyl, phenoxy, nitro or cyano; and one of R and R is optionally substituted isoquinoline while the other is hydrogen, C1-4 alkyl, C1-4 haloalkyl, halogen or cyano; or A is hydrogen, R is methyl and R is 4-t &cir& _e &cir& _r &cir& _t &cir& _-butylpyrid-2-yl, 4t &cir& _e &cir& _r &cir& _t &cir& _-butylpyrimidin-2-yl, 5-methyl-6-i &cir& _s &cir& _o &cir& _-propoxypyrimidin-4-yl or 4-(C1-4 chlorofluoroalkyl)pyrid-2-yl.

摘要翻译： 具有式（I）的杀真菌化合物，其中：A是氢，卤素，羟基，C 1-4烷基，C 1-4烷氧基，C 1-4卤代烷基，C 1-4卤代烷氧基，C 1-4烷基羰基，C 1-4烷氧基羰基， 苯氧基，硝基或氰基; R 1和R 2之一是任选取代的异喹啉，而另一个是氢，C 1-4烷基，C 1-4卤代烷基，卤素或氰基; 或A为氢，R 2为甲基，R 1为4-叔丁基 - 吡啶-2-基，4'，“ - ” - “和” ，5-甲基-6-氨基嘧啶-4-基或4-（C1-4氯氟代烷基）吡啶-2-基。

公开(公告)号：WO1992018487A1

公开(公告)日：1992-10-29

申请号：PCT/GB1992000681

申请日：1992-04-14

申请人： IMPERIAL CHEMICAL INDUSTRIES PLC ,  DE FRAINE, Paul, John ,  CLOUGH, John, Martin ,  WORTHINGTON, Paul, Anthony ,  PILKINGTON, Brian, Leslie ,  MATTHEWS, Ian, Richard

发明人： IMPERIAL CHEMICAL INDUSTRIES PLC

IPC分类号： C07D239/26

CPC分类号： C07D213/64 ,  A01N37/36 ,  A01N43/06 ,  A01N43/36 ,  A01N43/38 ,  A01N43/40 ,  A01N43/54 ,  A01N43/60 ,  A01N43/66 ,  A01N43/707 ,  A01N43/74 ,  A01N43/80 ,  A01N43/84 ,  A01N57/22 ,  C07C251/60 ,  C07C255/13 ,  C07C259/02 ,  C07C259/06 ,  C07C259/18 ,  C07C317/28 ,  C07C323/47 ,  C07C327/48 ,  C07C2603/74 ,  C07D213/65 ,  C07D213/68 ,  C07D213/78 ,  C07D213/85 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D239/42 ,  C07D241/18 ,  C07D261/12 ,  C07D333/24 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D495/04 ,  C07F9/4006

摘要： Compounds having formula (I), wherein A is hydrogen, halogen, hydroxy, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy or cyano; and one of R?1 and R2¿ is methyl and the other is pyridyl or pyrimidinyl substituted by one or more substituents independently selected from halogen, hydroxy, C¿1-6? alkyl (itself optionally substituted by C1-6 alkoxy), C1-6 haloalkyl, C1-6 alkoxy (optionally substituted by halogen, R?3R4¿N, cyano, R?3C(O), R3¿OC(O), R3R4NC(O), R3SC(O), H¿2?N.NHC(O), R?3S(O)¿m wherein m is 0, 1 or 2, C3-6 cycloalkyl [itself optionally substituted by C1-4 alkyl] or a 5- or 6-membered heterocyclic ring containing one or two oxygen atoms, optionally being in the form of a lactone, the heterocyclic ring being optionally fused to a benzene ring and optionally substituted by C1-4 alkyl), R3S(O)n wherein n is 0, 1 or 2, C2-6 alkenyl, C2-6 alkynyl, C2-6 alkenyloxy, C2-6 alkynyloxy, nitro, cyano, CO2R?3, NR3R4, NR3R4¿C(O), NR?3R4C(S), R3R4¿C:NO, C¿3-6? cycloalkyl, C3-6 cycloalkyloxy (itself optionally substituted by C1-4 alkyl), C1-6 alkoxy(C1-6)alkoxy, an aromatic 5-membered ring containing 1, 2 or 3 nitrogen atoms (itself optionally substituted by C1-4 alkyl), C1-6 alkoxy(C1-6)haloalkoxy, phenoxy(C1-4)alkoxy, phenyl(C1-4)alkoxy(C1-6)alkoxy, C1-4alkoxy(C1-6)alkoxy(C1-6)alkoxy, di(C1-4alkoxy)-(C1-6)alkoxy, C2-6 alkenyloxy(C1-6)alkoxy, C2-6 alkenyloxy(C1-6)haloalkoxy, a 5- or 6-membered heterocyclic ring containing one or two heteromoieties independently selected form N, S, S(O), S(O)2 or O and optionally being fused to a benzene ring, the heterocyclic ring being optionally substituted by C1-4 alkyl and when it contains an oxygen atom it may be in the form of a lactone, the heterocyclic ring is linked directly to the pyridine or pyrimidine ring or is linked through an O, OCH2 or CH2O moiety, phenyl, phenoxy or phenyl(C1-4)alkoxy; wherein any of the foregoing phenyl moieties is optionally substituted by halogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, nitro or cyano, or the other of R?1 and R2¿ is a pyridine or pyrimidine ring optionally substituted with any of the moieties already listed as substitutents for pyridine and pyrimidine rings above and fused to an aromatic 5-membered ring containing one or two heteroatoms independently selected from nitrogen, oxygen and sulphur; and R?3 and R4¿ are independently hydrogen or C¿1-6? alkyl (itself optionally substituted by halogen or cyano); provided that when A is hydrogen and one of R?1 and R2¿ is methyl then the other is not: pyrid-2-yl monosubstituted with chloro, cyano, fluoro, bromo, methyl or 5-ethyl, or substituted with 3-5-difluoro or 3,4,5,6-tetrafluoro; pyrid-3-yl substituted with 6-methyl, 4-cyano, 5-cyano, 6-cyano or 2,6-dichloro; pyrid-4-yl monosubstituted with cyano; pyrimidin-2-yl substituted with 4-methyl, 4,6-dimethyl or 4,6-dimethoxy; pyrimidin-4-yl substituted with 2-chloro, 2-methoxy, 2-methyl, 2-cyano, 6-methyl, 6-chloro, 6-methoxy, 6-phenyl or 2,6-dimethyl; or pyrimidin-5-yl substituted with 2-methyl, 4-methyl or 2,4-dimethyl. The compounds of formula (I) are useful as fungicides.