-
1.发明申请
公开(公告)号：WO2010105094A1
公开(公告)日：2010-09-16
申请号：PCT/US2010/027038
申请日：2010-03-11
Applicant: MANNKIND CORPORATION , ADAMO, Benoit , MCLEAN, Scott , SMUTNEY, Chad, C. , POLIDORO, John, M. , SAHI, Carl, R.
Inventor： ADAMO, Benoit , MCLEAN, Scott , SMUTNEY, Chad, C. , POLIDORO, John, M. , SAHI, Carl, R.
CPC classification number: G01N7/00 , A61M15/00 , A61M15/0065 , A61M16/0003 , A61M16/0057 , A61M16/10 , A61M16/201 , A61M2016/0027 , A61M2016/0039 , A61M2202/064 , A61M2205/3334 , A61M2209/02 , G01F1/00 , G01L13/00
Abstract: The present disclosure relates to a device (10) and method for measuring the resistance of inhalers (20) to air flow. In particular, the device and method can be used to measure the resistance to air flow of dry powder inhalers (20), which are used for pulmonary drug delivery. The device (10) has a pair of chambers (12, 18) to mount and enclose an inhaler (20) within. Each chamber (12, 18) has a respective valve. The device (10) has further a pressure controller (22), a flow controller (24) and pressure and flow sensors and microprocessors configured to control opening and closing of the valves and to detect and analyze the corresponding signals.
Abstract translation: 本公开涉及一种用于测量吸入器（20）对气流的阻力的装置（10）和方法。 特别地，该装置和方法可用于测量用于肺部药物递送的干粉吸入器（20）的气流阻力。 装置（10）具有一对在其内安装和封闭吸入器（20）的腔室（12,18）。 每个室（12,18）具有相应的阀。 装置（10）还具有压力控制器（22），流量控制器（24）和压力和流量传感器和微处理器，其被配置为控制阀的打开和关闭并检测和分析对应的信号。
-
公开(公告)号：WO2010102148A3
公开(公告)日：2011-12-08
申请号：PCT/US2010026271
申请日：2010-03-04
Applicant: MANNKIND CORP , SMUTNEY CHAD C , ADAMO BENOIT , POLIDORO JOHN M , KINSEY P SPENCER , OVERFIELD DENNIS , SAHI CARL R , BILLINGS CHRISTINE , MARINO MARK T
Inventor： SMUTNEY CHAD C , ADAMO BENOIT , POLIDORO JOHN M , KINSEY P SPENCER , OVERFIELD DENNIS , SAHI CARL R , BILLINGS CHRISTINE , MARINO MARK T
CPC classification number: A61K38/29 , A61K31/495 , A61K38/1816 , A61K38/193 , A61K38/28 , A61M15/0021 , A61M15/0028 , A61M15/0035 , A61M2202/064
Abstract: A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of endocrine disease, for example, diabetes and/or obesity.
Abstract translation: 公开了一种肺部药物递送系统，包括呼吸驱动的干粉吸入器和用于递送干粉制剂的药筒。 吸入器和药筒可以设置有药物递送制剂，其包含例如二酮哌嗪和活性成分，包括肽和蛋白质，例如胰岛素和胰高血糖素样肽1，用于治疗内分泌疾病，例如糖尿病和 /或肥胖。
-
公开(公告)号：WO2011056889A1
公开(公告)日：2011-05-12
申请号：PCT/US2010/055323
申请日：2010-11-03
Applicant: MANNKIND CORPORATION , ADAMO, Benoit , POLIDORO, John, M. , OVERFIELD, Dennis , SAHI, Carl, R. , LAURENZI, Brendan , SMUTNEY, Chad, C. , KINSEY, P., Spencer
Inventor： ADAMO, Benoit , POLIDORO, John, M. , OVERFIELD, Dennis , SAHI, Carl, R. , LAURENZI, Brendan , SMUTNEY, Chad, C. , KINSEY, P., Spencer
CPC classification number: A61B5/08 , A61B5/4839 , A61B7/003 , A61K9/0075 , A61K31/496 , A61M15/0028 , A61M15/008 , A61M16/161 , A61M2016/0018 , A61M2016/0021 , A61M2016/0027 , A61M2016/003 , A61M2202/064 , A61M2205/3327 , A61M2205/3368 , A61M2205/3375 , A61M2205/3546 , A61M2205/3569 , A61M2205/3592 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2205/8206 , G09B19/003 , G09B23/28
Abstract: An inhalation simulation system is provided for use with inhalers in particular breath-powered dry powder inhalers. The simulation system can recreate a patient's inhalation profile obtained with an inhaler adapted with a sensing and monitoring device for the detection of characteristic signals generated from the inhaler in use, which signals are transmitted to a computer with an algorithm which is configured to analyze the signals and generate new signals via a transmitter to actuate the inhalation simulation system component parts so that a subject's inhalation profile is replicated simultaneously or in real-time, or stored for later use. Methods of measuring the performance of inhalers are also provided.
Abstract translation: 提供吸入模拟系统，用于吸入器，特别是呼吸动力干粉吸入器。 仿真系统可以重建患者的吸入曲线，该吸入曲线适用于具有感测和监测装置的吸入器，用于检测从使用中的吸入器产生的特征信号，哪些信号被传送到计算机，该算法被配置成分析信号 并通过发射器产生新的信号以致动吸入模拟系统组成部分，使得受试者的吸入曲线同时或实时复制，或存储以供以后使用。 还提供了测量吸入器性能的方法。
-
公开(公告)号：WO2006031500A3
公开(公告)日：2006-06-15
申请号：PCT/US2005031658
申请日：2005-09-07
Applicant: BECTON DICKINSON CO , SULLIVAN VINCENT J , JIANG GE , FERRITER MATTHEW S , POWELL KENNETH G , KINSEY SPENCER P , SAHI CARL R , POLIDORO JOHN M
Inventor： SULLIVAN VINCENT J , JIANG GE , FERRITER MATTHEW S , POWELL KENNETH G , KINSEY SPENCER P , SAHI CARL R , POLIDORO JOHN M
IPC: A61M5/142
CPC classification number: A61M5/145 , A61M5/1407 , A61M5/1409 , A61M5/14248 , A61M5/14566 , A61M5/14586 , A61M2005/14256
Abstract: A system and method for a patch-like, self-contained multi-component substance infusion device (1000) which provides one or more substantially hidden patient needles which can be placed in fluid communication with a fluid reservoir assembly that includes a rigid bladder portion used in conjunction with a non-distensible bladder film, such as a metallized film. The device can he attached to a skin surface via an adhesive contact and a pressurization system provides a pressure to the contents of a fluid reservoir assembly. Improvements to dry powdered formulations for reconstitution for preferred use in the device are also disclosed.
Abstract translation: 一种用于贴片状，独立的多组分物质输注装置（1000）的系统和方法，其提供一个或多个基本上隐藏的患者针，所述患者针可以与流体储存器组件流体连通，所述流体储存器组件包括使用的刚性囊部分 与不扩张的膀胱膜结合，例如金属化膜。 该装置可以通过粘合剂接触附着到皮肤表面，并且加压系统向流体储存器组件的内容物提供压力。 还公开了用于重构用于装置中优选使用的干燥粉末制剂的改进。
-
公开(公告)号：WO2011163272A1
公开(公告)日：2011-12-29
申请号：PCT/US2011/041303
申请日：2011-06-21
Applicant: MANNKIND CORPORATION , SMUTNEY, Chad, C. , ADAMO, Benoit , POLIDORO, John, M. , KINSEY, P., Spencer , OVERFIELD, Dennis , SAHI, Carl , BILLINGS, Christine , MARINO, Mark, T.
Inventor： SMUTNEY, Chad, C. , ADAMO, Benoit , POLIDORO, John, M. , KINSEY, P., Spencer , OVERFIELD, Dennis , SAHI, Carl , BILLINGS, Christine , MARINO, Mark, T.
IPC: A61M15/00
CPC classification number: A61M15/0091 , A61M11/06 , A61M15/0021 , A61M15/0025 , A61M15/0028 , A61M15/0043 , A61M2202/064 , A61M2205/6045 , A61M2205/6081
Abstract: A pulmonary drug delivery system Is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, Including, small organic molecules, peptides and proteins, including, insulin and g!ucagon-i!ke peptide (1) for the treatment of disease and disorders, for example, endocrine disease such as diabetes and/or obesity.
Abstract translation: 公开了一种肺部药物递送系统，包括呼吸动力的干粉吸入器和用于递送干粉配方的药筒。 吸入器和药筒可以设置有药物递送制剂，其包含例如二酮哌嗪和活性成分，包括小有机分子，肽和蛋白质，包括胰岛素和葛根uc酮肽（1），用于 疾病和病症的治疗，例如内分泌疾病如糖尿病和/或肥胖症。
-
Patent Agency Ranking
公开(公告)号：WO2010102148A2
公开(公告)日：2010-09-10
申请号：PCT/US2010/026271
申请日：2010-03-04
Applicant: MANNKIND CORPORATION , SMUTNEY, Chad, C. , ADAMO, Benoit , POLIDORO, John, M. , KINSEY, P., Spencer , OVERFIELD, Dennis , SAHI, Carl, R. , BILLINGS, Christine , MARINO, Mark, T.
Inventor： SMUTNEY, Chad, C. , ADAMO, Benoit , POLIDORO, John, M. , KINSEY, P., Spencer , OVERFIELD, Dennis , SAHI, Carl, R. , BILLINGS, Christine , MARINO, Mark, T.
IPC: A61K9/72
CPC classification number: A61K38/29 , A61K31/495 , A61K38/1816 , A61K38/193 , A61K38/28 , A61M15/0021 , A61M15/0028 , A61M15/0035 , A61M2202/064
Abstract: A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of endocrine disease, for example, diabetes and/or obesity.
Abstract translation: 公开了一种肺部药物递送系统，包括呼吸动力的干粉吸入器和用于递送干粉制剂的药筒。 吸入器和药筒可以配备药物递送制剂，其包含例如二酮哌嗪和活性成分，包括肽和蛋白质，例如胰岛素和胰高血糖素样肽1，用于治疗内分泌疾病，例如糖尿病和 /或肥胖。
-
公开(公告)号：WO2009121020A1
公开(公告)日：2009-10-01
申请号：PCT/US2009/038668
申请日：2009-03-27
Applicant: MANNKIND CORPORATION , SMUTNEY, Chad, C. , KINSEY, P., Spencer , POLIDORO, John, M. , SAHI, Carl, R. , ADAMO, Benoit , MCLEAN, Scott , OVERFIELD, Dennis , BRYANT, Anthony
Inventor： SMUTNEY, Chad, C. , KINSEY, P., Spencer , POLIDORO, John, M. , SAHI, Carl, R. , ADAMO, Benoit , MCLEAN, Scott , OVERFIELD, Dennis , BRYANT, Anthony
IPC: A61M15/00
CPC classification number: A61M15/0023 , A61M15/0015 , A61M15/002 , A61M15/0028 , A61M15/0043 , A61M2016/0021 , A61M2016/0027 , A61M2202/064 , A61M2202/07 , A61M2205/58 , A61M2205/581 , A61M2205/582
Abstract: Dry powder inhaler systems for pulmonary delivery of pharmaceuticals are disclosed. The dry powder inhalation systems comprise a dry powder inhalation device or inhaler ( 109) and a cartridge (1600) containing a pharmaceutical formulation comprising an active ingredient for delivery to the pulmonary circulation. The present devices provide rugged devices which are reusable, use pre-metered unit dose cartridges which deliver a medicament in a liner manner, and can be disassembled for cleaning. The devices also provide a high resistance inhalation system which enables deagglomeration of dry powder particles, have a consistent airflow, are easy to manufacture and are simple and relatively easy to use.
Abstract translation: 公开了用于肺部递送药物的干粉吸入器系统。 干粉吸入系统包括干粉吸入装置或吸入器（109）和含有药物制剂的药筒（1600），其包含用于递送至肺循环的活性成分。 本装置提供可重复使用的坚固的装置，使用预先计量的单位剂量药筒，其以衬垫方式递送药物，并且可以拆卸以进行清洁。 这些装置还提供了一种高阻力吸入系统，其能够使干粉颗粒解聚，具有一致的气流，易于制造并且简单且相对易于使用。
-
8.发明申请AN INTERACTIVE APPARATUS AND METHOD FOR REAL-TIME PROFILING OF INHALATION EFFORTS 审中-公开一种交互式设备和实时吸入吸烟分析方法
公开(公告)号：WO2009155581A1
公开(公告)日：2009-12-23
申请号：PCT/US2009/048059
申请日：2009-06-19
Applicant: MANNKIND CORPORATION , OVERFIELD, Dennis , SAHI, Carl, R. , ADAMO, Benoit , KINSEY, P., Spencer , MCLEAN, Scott , POLIDORO, John, M. , SMUTNEY, Chad, C.
Inventor： OVERFIELD, Dennis , SAHI, Carl, R. , ADAMO, Benoit , KINSEY, P., Spencer , MCLEAN, Scott , POLIDORO, John, M. , SMUTNEY, Chad, C.
IPC: A61M15/00
CPC classification number: A61M15/0065 , A61B5/087 , A61M15/0021 , A61M15/0025 , A61M15/008 , A61M2016/0027 , A61M2016/003 , A61M2202/064 , A61M2205/3375 , A61M2205/3569 , A61M2205/3592 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2206/10 , A61M2209/086 , A61M2230/40 , G06F19/00 , G09B23/28
Abstract: Described herein are interactive apparatus and methods for sensing and measuring real-time characteristic patterns of a subject's use of a dry powder inhalation system. The devices can be used in a wired or wireless communication mode to communicate with a display to assess the subject's usage of the inhalation system, to evaluate the performance of the inhalation system and/or to detect the characteristics profile of a dry powder formulation emitted from the inhalation system in use.
Abstract translation: 这里描述了用于感测和测量受试者使用干粉吸入系统的实时特征图案的交互式装置和方法。 这些装置可以在有线或无线通信模式下用于与显示器通信，以评估受试者对吸入系统的使用情况，评估吸入系统的性能和/或检测从 吸入系统正在使用。
-
公开(公告)号：WO2009152477A3
公开(公告)日：2009-12-17
申请号：PCT/US2009/047281
申请日：2009-06-12
Applicant: MANNKIND CORPORATION , SMUTNEY, Chad, C. , KINSEY, P., Spencer , SAHI, Carl, R. , ADAMO, Benoit , POLIDORO, John, M. , MCLEAN, Scott , OVERFIELD, Dennis , BRYANT, Anthony , HE, Tom , MANN, Alfred
Inventor： SMUTNEY, Chad, C. , KINSEY, P., Spencer , SAHI, Carl, R. , ADAMO, Benoit , POLIDORO, John, M. , MCLEAN, Scott , OVERFIELD, Dennis , BRYANT, Anthony , HE, Tom , MANN, Alfred
IPC: A61M15/00
Abstract: A breath-powered, dry powder inhaler (100), a cartridge (150), and a pulmonary- drug delivery system are provided. The dry powder inhaler (100) can be provided with or without a unit dose cartridge (150) for using with the inhaler (100). The inhaler (100) and/or cartridge (150) can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler (100) is compact; can be provided in various shapes and sizes, colors, and comprises a housing (120), a mouthpiece (130), a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.
-
公开(公告)号：WO2009152477A2
公开(公告)日：2009-12-17
申请号：PCT/US2009047281
申请日：2009-06-12
Applicant: MANNKIND CORP , SMUTNEY CHAD C , KINSEY P SPENCER , SAHI CARL R , ADAMO BENOIT , POLIDORO JOHN M , MCLEAN SCOTT , OVERFIELD DENNIS , BRYANT ANTHONY , HE TOM , MANN ALFRED
Inventor： SMUTNEY CHAD C , KINSEY P SPENCER , SAHI CARL R , ADAMO BENOIT , POLIDORO JOHN M , MCLEAN SCOTT , OVERFIELD DENNIS , BRYANT ANTHONY , HE TOM , MANN ALFRED
IPC: A61M15/00
CPC classification number: A61M15/0045 , A61K9/0075 , A61K38/00 , A61K38/1709 , A61K38/22 , A61K38/26 , A61K38/28 , A61K47/22 , A61M15/0021 , A61M15/0023 , A61M15/0028 , A61M15/0043 , A61M15/0048 , A61M15/0086 , A61M15/0091 , A61M2202/064 , A61M2205/6081 , A61M2206/20
Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.
Abstract translation: 提供了一种呼吸动力的干粉吸入器，药筒和肺部药物递送系统。 干粉吸入器可以配备有或不带有与吸入器一起使用的单位剂量盒。 吸入器和/或药筒可以具有药物递送制剂，其包含例如二酮哌嗪和活性成分，包括肽和蛋白质，例如用于治疗糖尿病和/或肥胖症的胰岛素和胰高血糖素样肽1。 干粉吸入器紧凑; 可以以各种形状和尺寸，颜色提供，并且包括壳体，接口管，盒放置区域和用于打开和关闭药剂盒的机构。 该设备易于制造，提供预单位单位剂量，相对易于使用，并且可重复使用或一次性使用。
-
-
-
-
-
-
-
-
-
Search Results
11
records
(took 0.015 seconds)
