公开(公告)号：WO2019060839A1

公开(公告)日：2019-03-28

申请号：PCT/US2018/052468

申请日：2018-09-24

Applicant: INSULET CORPORATION

Inventor： NAZZARO, David ,  MCLAUGHLIN, Ian ,  MCCAFFREY, Maureen ,  KOZIN, Simon ,  MAC, Jackie

IPC: A61M5/142

CPC classification number: A61M5/2033 ,  A61M5/001 ,  A61M5/14244 ,  A61M5/14248 ,  A61M5/1454 ,  A61M5/288 ,  A61M5/3157 ,  A61M2005/14256 ,  A61M2005/1581 ,  A61M2005/2006 ,  A61M2005/2073 ,  A61M2005/2474 ,  A61M2005/31518 ,  A61M2205/581 ,  A61M2205/582

Abstract: A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can be controlled to provide the liquid drug to the patient in a single dose or over multiple doses.

公开(公告)号：WO2017072333A1

公开(公告)日：2017-05-04

申请号：PCT/EP2016/076156

申请日：2016-10-28

Applicant: NNE PHARMAPLAN A/S

Inventor： KNUDSEN, Hans Stenberg ,  PLAMBECH, Christian ,  ØHLENSCHLÆGER, Rasmus ,  JØRGENSEN, Jørgen

IPC: A61M5/145 ,  A61M5/20 ,  A61M5/32 ,  A61M5/315 ,  A61M5/142

CPC classification number: A61M5/1454 ,  A61M5/2033 ,  A61M5/3204 ,  A61M5/326 ,  A61M2005/14256 ,  A61M2005/14506 ,  A61M2005/206 ,  A61M2005/31518 ,  A61M2005/3267

Abstract: The present invention relates to a single-use auto-injector for injection of a dosage of a drug into a human body, comprising a housing, and a dosing unit arranged in at least part of the housing, the dosing unit comprising, a needle, a drug container comprising the drug, a piston movable in the container, a first mechanical power supply for supplying a first mechanical force for moving the piston to deliver a drug to the human body, an activation mechanism configured to release the first mechanical power of the first mechanical power supply, and a mechanical escapement mechanism for controlling the movement of the piston, wherein the auto-injector comprises a second mechanical power supply for supplying a second mechanical force, the auto-injector having, a first state in which the needle is protected from needle damage or contamination, a second state in which the needle is ready to penetrate the human body for dosing the drug, a third state in which the needle has penetrated the human body and is ready to dose, and a fourth state in which the needle is shielded to avoid unintended needle sticks, wherein the second mechanical power supply is configured to shift state of the auto-injector from the third state to the fourth state by releasing the second mechanical power.

Abstract translation: 本发明涉及一种用于将剂量的药物注射到人体内的单次使用的自动注射器，其包括壳体和设置在壳体的至少一部分中的给药单元， 所述给药单元包括针头，包括所述药物的药物容器，在所述容器中可移动的活塞，用于供应第一机械力的第一机械动力源，所述第一机械动力供应用于移动所述活塞以将药物递送至人体，配置的致动机构 以释放所述第一机械动力源的第一机械动力，以及用于控制所述活塞的运动的机械擒纵机构，其中所述自动注射器包括用于供应第二机械力的第二机械动力源， 第一状态和第二状态，在第一状态中针保护免受针损伤或污染，第二状态中针准备好穿透人体用于给药;第三状态，针具有双侧 训练人体并且准备好剂量;以及第四状态，在所述第四状态中针被屏蔽以避免意外针刺，其中第二机械电源被配置为将自动注射器的状态从第三状态转变到第四状态 通过释放第二个机械动力。

公开(公告)号：WO2016041870A1

公开(公告)日：2016-03-24

申请号：PCT/EP2015/070868

申请日：2015-09-11

Applicant: SANOFI

Inventor： SCHIENDZIELORZ, Eva ,  WENDLAND, Stefan

IPC: A61M5/142

CPC classification number: A61M5/14248 ,  A61M5/1452 ,  A61M5/158 ,  A61M5/1684 ,  A61M2005/14256 ,  A61M2005/1585 ,  A61M2205/581 ,  A61M2205/583

Abstract: A medicament delivery device (10) comprises a medicament delivery mechanism including an injection needle (23). A housing (11) contains at least one component of the medicament delivery mechanism. A base plate (12) includes a contact surface (12b) for placement against a patient's body. The housing (11) is moveably connected to the base plate (12) and is moveable relative to the base plate (12) between a first position and a second position. The medicament delivery mechanism is operative upon movement of the housing (11) from the first position to the second position.

Abstract translation: 药物输送装置（10）包括药物输送机构，其包括注射针（23）。 壳体（11）包含药物输送机构的至少一个部件。 基板（12）包括用于放置在患者身体上的接触表面（12b）。 壳体（11）可移动地连接到基板（12）并且可在第一位置和第二位置之间相对于基板（12）移动。 药物输送机构在壳体（11）从第一位置移动到第二位置时操作。

公开(公告)号：WO2013155153A1

公开(公告)日：2013-10-17

申请号：PCT/US2013/035925

申请日：2013-04-10

Applicant: BECTON, DICKINSON AND COMPANY

Inventor： CRONENBERG, Richard

IPC: A61M5/145

CPC classification number: A61M5/14248 ,  A61M5/1454 ,  A61M5/20 ,  A61M5/2033 ,  A61M2005/14252 ,  A61M2005/14256 ,  A61M2005/206 ,  A61M2205/582 ,  A61M2205/584 ,  A61M2205/585

Abstract: A device (10) for delivering a fluid includes a housing (12) defining an interior space (22) and having a bottom surface (18) configured for contacting a patient. The bottom surface (18) defines a needle opening (56). The device (10)also includes a reservoir (26) disposed within the interior space (22) of the housing (12) for containing a fluid therein, a needle carrier (30) disposed within the housing (12), and an injection needle (28) supported by the needle carrier (30) and defining a lumen. The lumen of the injection needle (28) is configured to be placed in fluid communication with the reservoir (26). The injection needle (28) is transitionable from an initial position in which the injection needle is disposed within the housing (12), to a use position in which the injection needle extends through the needle opening (56), and a substantially shielded position in which the injection needle (28) is disposed within the housing (12) and the lumen of the needle (28) is blocked by a portion of the housing (12).

Abstract translation: 用于输送流体的装置（10）包括限定内部空间（22）的壳体（12），并且具有构造成用于接触患者的底部表面（18）。 底表面（18）限定针孔（56）。 所述装置（10）还包括设置在所述壳体（12）的内部空间（22）内用于容纳流体的储存器（26），设置在所述壳体（12）内的针架（30），以及注射针 （28），其由所述针架（30）支撑并限定管腔。 注射针（28）的管腔构造成与贮液器（26）流体连通。 注射针（28）可从其中注射针设置在壳体（12）内的初始位置转移到注射针穿过针孔（56）延伸的使用位置，并且基本上屏蔽位置 其中注射针（28）设置在壳体（12）内并且针（28）的内腔被壳体（12）的一部分阻挡。

公开(公告)号：WO2013114221A2

公开(公告)日：2013-08-08

申请号：PCT/IB2013/000659

申请日：2013-01-30

Applicant: PRECIFLEX SA

Inventor： VOUILLAMOZ, Lucien ,  ROSEN, Melissa ,  WALISH, Judy, L. ,  YASEVAC, Daniel ,  BRUEHWILER, Michel

CPC classification number: A61M5/172 ,  A61B17/3496 ,  A61B2017/00132 ,  A61B2017/00212 ,  A61M5/14248 ,  A61M5/1454 ,  A61M5/152 ,  A61M5/155 ,  A61M5/2033 ,  A61M5/2053 ,  A61M5/2066 ,  A61M5/31531 ,  A61M5/3202 ,  A61M5/3234 ,  A61M5/326 ,  A61M5/3273 ,  A61M5/3291 ,  A61M5/3293 ,  A61M5/3294 ,  A61M2005/14252 ,  A61M2005/14256 ,  A61M2005/1426 ,  A61M2005/14268 ,  A61M2005/14506 ,  A61M2005/1581 ,  A61M2005/1583 ,  A61M2005/1585 ,  A61M2005/206 ,  A61M2005/2073 ,  A61M2005/2086 ,  A61M2005/3022 ,  A61M2005/3142 ,  A61M2205/3561 ,  A61M2205/3569 ,  A61M2205/3592 ,  A61M2205/8218 ,  A61M2205/8293 ,  A61M2209/01 ,  A61M2209/088 ,  A61M2210/12

Abstract: An active agent injecting device dispenses a measured amount of active agent into a living organism. The injecting device includes a main housing, an injection assembly and a trigger mechanism. The main housing houses the operative components of the device. The needle encloses a carrier having an active agent disposed thereon. The trigger mechanism triggers the injection assembly to release the needle to inject the active agent into the living organism.

Abstract translation: 活性剂注入装置将测定量的活性剂分配到活体内。 注射装置包括主壳体，注射组件和触发机构。 主壳体容纳设备的操作部件。 针包围其上布置有活性剂的载体。 触发机构触发注射组件以释放针以将活性剂注入生物体内。

公开(公告)号：WO2005018704A2

公开(公告)日：2005-03-03

申请号：PCT/US2004/026110

申请日：2004-08-12

Applicant: BECTON, DICKINSON AND COMPANY ,  VEDRINE, Lionel

Inventor： VEDRINE, Lionel

IPC: A61M

CPC classification number: A61M5/158 ,  A61M5/14248 ,  A61M5/145 ,  A61M5/16804 ,  A61M2005/14256 ,  A61M2005/1426 ,  A61M2005/14506 ,  A61M2005/1583 ,  A61M2005/1585 ,  A61M2209/06

Abstract: A packaging system and method which provides at least one tray or nest (1170), having a number of wells (1171) and ribs (1196) and (1195) to position and secure a patch-like, self-contained substance infusion device having one or more patient needles which can be placed in fluid communication with a fluid reservoir assembly within the device and upon which a disk, or Belleville spring assembly applies an essentially even and constant pressure to the contents. The device further provides for the release of one or more spring-loaded patient needles into a patient's skin surface to establish a fluid communication path between the patient needles and the pressurized fluid reservoir contents.

Abstract translation: 一种提供至少一个具有多个孔（1171）和肋（1196）和（1195）的托盘或巢（1170）的包装系统和方法，用于定位和固定具有片状的独立物质输注装置，其具有 一个或多个患者针，其可以被放置成与装置内的流体储存器组件流体连通，并且盘或贝氏弹簧组件对其施加基本均匀且恒定的压力。 该装置进一步提供将一个或多个弹簧加载的患者针释放到患者的皮肤表面中以在患者针和加压流体储存器内容物之间建立流体连通路径。

公开(公告)号：WO2016053954A8

公开(公告)日：2016-06-30

申请号：PCT/US2015052815

申请日：2015-09-29

Applicant: UNITRACT SYRINGE PTY LTD ,  DESTEFANO MARK

Inventor： DESTEFANO MARK ,  HANSON IAN ,  BENTE PAUL ,  LAURENCE LAWTON

IPC: A61M5/158 ,  A61M5/142

CPC classification number: A61M5/158 ,  A61M5/142 ,  A61M5/14248 ,  A61M2005/14252 ,  A61M2005/14256 ,  A61M2005/1585

Abstract: An insertion mechanism (200, 2200) and methods of assembly and operation of a drag pump (1) may include an insertion mechanism housing (202, 2202); a housing cap (203); a manifold guide (220, 2220); an insertion biasing member (210, 2210) initially held in an energized state; a retraction biasing member (216, 2216) connected to a hub (212, 2212) connected to a proximal end of a needle (214, 2214); and optionally, a clip retainer (219, 2219). The retraction biasing member is held initially in an energized state between the hub and manifold guide. A manifold has a manifold body (240B, 2240B) and one or more septa (230A, 230B, 2230A, 2230B) defining a manifold header (242, 2242). The retraction biasing member may be held initially in an energized state between the hub and the clip retainer. The needle is advanced by the insertion biasing member(s) from the initial configuration to an administration configuration, opening a fluid pathway from the manifold header to the target. The drug delivery pump may include an activation mechanism (14), a dreive mechanism (100), a fluid pathway connection (300), and the insertion mechanism (200).

Abstract translation: 插入机构（200,2200）以及牵引泵（1）的组装和操作的方法可以包括插入机构壳体（202,2202）; 壳体盖（203）; 歧管引导件（220,2220）; 最初保持在通电状态的插入偏置构件（210,2210）; 连接到连接到针的近端的轮毂（212,2222）的回缩偏置构件（216,2216）; 和可选的夹子保持器（219,2219）。 回缩偏压构件最初保持在轮毂和歧管引导件之间的通电状态。 歧管具有歧管主体（240B，2240B）和限定歧管集管（242,2242）的一个或多个隔片（230A，230B，2230A，2230B）。 回缩偏压构件可以初始地保持在轮毂和夹子保持器之间的通电状态。 针通过插入偏置构件从初始构型推进到管理构型，打开从歧管歧管到目标的流体通道。 药物输送泵可以包括激活机构（14），脱气机构（100），流体通路连接（300）和插入机构（200）。

公开(公告)号：WO2015091758A1

公开(公告)日：2015-06-25

申请号：PCT/EP2014/078410

申请日：2014-12-18

Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH

Inventor： SCHABBACH, Michael ,  ZECKAI, Olaf ,  WERNER, Meinolf

IPC: A61M5/14 ,  A61M5/142

CPC classification number: A61M5/148 ,  A61M5/14232 ,  A61M5/14244 ,  A61M5/14248 ,  A61M5/162 ,  A61M2005/14252 ,  A61M2005/14256 ,  A61M2005/14268

Abstract: The present invention relates to a disposable delivery assembly for a drug delivery device to dispense a liquid medicament, the delivery assembly comprising: a disposable injector (60) comprising an injection needle(65), a flexible tube (64) and an injector fluid coupling (68), wherein the injection needle (65) is in fluid communication with the fluid coupling (68) via the flexible tube (64), a disposable cartridge (70) comprising a reservoir (80) at least partially filled with the liquid medicament and comprising a cartridge fluid coupling (90) in fluid communication with the reservoir (80), wherein the injector (60) and the cartridge (70) are mechanically interconnected in an undeployed configuration (4), in which the injector fluid coupling (68) and the cartridge fluid coupling (90) are disconnected, and - wherein the cartridge (70) is displaceable relative to the injector (60) into a deployed configuration (6), in which the injector fluid coupling (68) and the cartridge fluid coupling (90) are in fluid communication.

Abstract translation: 本发明涉及用于药物输送装置分配液体药物的一次性输送组件，所述输送组件包括：一次性注射器（60），其包括注射针（65），柔性管（64）和注射器流体联接 （68），其中所述注射针（65）经由所述柔性管（64）与所述流体联接器（68）流体连通，所述一次性药筒（70）包括至少部分地填充有所述液体药物 并且包括与所述储存器（80）流体连通的盒式液体联接器（90），其中所述注射器（60）和所述药筒（70）在未部署的构型（4）中机械地互连，其中所述注射器流体联接器 ）和所述墨盒流体联接器（90）被断开，并且其中所述墨盒（70）可相对于所述喷射器（60）移位成展开构型（6），其中所述喷射器流体联接器（68）和所述墨盒流体 coupl （90）流体连通。

公开(公告)号：WO2015059192A1

公开(公告)日：2015-04-30

申请号：PCT/EP2014/072655

申请日：2014-10-22

Applicant: CAREBAY EUROPE LTD

Inventor： KOCH, Eugen ,  YANG, Cheng-Yung ,  SCHOLZE, Laura

IPC: A61M5/145 ,  A61M5/142 ,  A61M5/315

CPC classification number: A61M5/3204 ,  A61M5/1424 ,  A61M5/14248 ,  A61M5/1454 ,  A61M5/14566 ,  A61M5/168 ,  A61M2005/14256 ,  A61M2005/31518 ,  A61M2005/3247

Abstract: The present invention relates to a medicament delivery device comprising a housing (10, 12), a compartment (102) inside said housing for positioning a medicament container (70), an injection needle (184) arranged to said housing, being connectable to said medicament container (70) for delivering a dose of medicament, a manually operated activation mechanism (129) for activating said device, an actuation mechanism (165) operably connected to said activation mechanism (129) and arranged to, upon activation of said activation mechanism (129), extend said injection needle (184) from a first position inside said housing to a second position wherein a penetration of a patient is performed, a plunger rod (66) arranged in said housing capable of acting on said medicament container (70) for delivering a dose of medicament through said injection needle (184), a driver (50) capable of acting on said plunger rod (66) for delivering a dose of medicament. The invention is characterised in that said device comprises a needle cover (188) operably arranged in said housing from a first position inside said housing to a second extended position outside said housing for shielding said injection needle (184) when said injection needle (184) is in said second position.

Abstract translation: 本发明涉及一种药物输送装置，其包括壳体（10,12），位于所述壳体内部的用于定位药物容器（70）的隔室（102），布置到所述壳体上的注射针（184），可连接到所述壳体 用于输送药剂的药物容器（70），用于启动所述装置的手动操作的致动机构（129），可操作地连接到所述致动机构（129）并且被布置成在激活所述致动机构 （129）将所述注射针（184）从所述壳体内的第一位置延伸到进行患者穿透的第二位置;布置在所述壳体中的能够作用在所述药物容器（70）上的柱塞杆（66） ），用于通过所述注射针（184）输送剂量的药物;驱动器（50），其能够作用在所述柱塞杆（66）上用于递送一定剂量的药物。 本发明的特征在于，所述装置包括针盖（188），其可操作地布置在所述壳体中，从所述壳体内的第一位置到所述壳体外部的第二延伸位置，用于当所述注射针头（184）时屏蔽所述注射针头（184） 处于第二位置。

公开(公告)号：WO2014179774A4

公开(公告)日：2014-12-24

申请号：PCT/US2014036701

申请日：2014-05-02

Applicant: BECTON DICKINSON CO

Inventor： WU HAIMING ,  FERREIRA DANIAL P

IPC: A61M5/32

CPC classification number: A61M5/1413 ,  A61M5/14248 ,  A61M5/145 ,  A61M5/1454 ,  A61M5/162 ,  A61M5/1626 ,  A61M5/16813 ,  A61M5/3134 ,  A61M39/20 ,  A61M39/22 ,  A61M2005/14252 ,  A61M2005/14256 ,  A61M2005/2073 ,  A61M2005/2474 ,  A61M2205/195 ,  A61M2205/70 ,  A61M2207/00 ,  B65B55/04

Abstract: A drug delivery device for injecting medicament, the device including a main body having a surface for contacting a patient, an actuation button (110, 420, 436) movably disposed relative to the main body, and a reservoir disposed within the main body for containing a medicament. The device also includes a needle having a distal end for insertion into a patient, and a lumen extending proximally from the distal end, wherein said lumen is fluidly connectable with the reservoir. The device further includes a removable needle cover (114, 400) for selectively covering the distal end of the needle and selectively preventing movement of the actuation button relative to the main body that initiates activation of the device.

Abstract translation: 一种用于注射药物的药物输送装置，所述装置包括具有用于接触患者的表面的主体，相对于主体可移动地设置的致动按钮（110,420,436）和设置在主体内的容纳物 药物。 该装置还包括具有用于插入患者的远端的针和从远端向近端延伸的内腔，其中所述内腔与储液器可流体连接。 该装置还包括可移除的针头盖（114,400），用于选择性地覆盖针的远端并且选择性地防止致动按钮相对于主体的移动，从而启动装置的启动。