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1.发明申请7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS 审中-公开7-（异 - 氨基）-6,7,8,9-四氢吡咯并[1,2-A]吲哚乙酸衍生物及其作为前列腺素D2受体调节剂的用途
公开(公告)号：WO2012140612A1
公开(公告)日：2012-10-18
申请号：PCT/IB2012/051831
申请日：2012-04-13
Applicant: ACTELION PHARMACEUTICALS LTD , AISSAOUI, Hamed , BOSS, Christoph , GABILLET, Jerome , RICHARD-BILDSTEIN, Sylvia , SIEGRIST, Romain
Inventor： AISSAOUI, Hamed , BOSS, Christoph , GABILLET, Jerome , RICHARD-BILDSTEIN, Sylvia , SIEGRIST, Romain
IPC: C07D471/04 , A61K31/437 , A61P37/08
CPC classification number: C07D471/04 , A61K31/437
Abstract: The present invention relates to 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives of the formula (I), wherein R 1 , R 2 , R 3 and R 4 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D 2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.
Abstract translation: 本发明涉及式（I）的7-（杂芳基 - 氨基）-6,7,8,9-四氢吡啶并[1,2-a]吲哚乙酸衍生物，其中R 1，R 2，R 3和R 4为 描述及其作为前列腺素受体调节剂的用途，最特别地作为前列腺素D2受体调节剂用于治疗各种前列腺素介导的疾病和病症，含有这些化合物的药物组合物及其制备方法。
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公开(公告)号：WO2007099509A2
公开(公告)日：2007-09-07
申请号：PCT/IB2007/050671
申请日：2007-03-01
Applicant: ACTELION PHARMACEUTICALS LTD , BEZENCON, Olivier , BUR, Daniel , CORMINBOEUF, Olivier , GRISOSTOMI, Corinna , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , WELLER, Thomas
Inventor： BEZENCON, Olivier , BUR, Daniel , CORMINBOEUF, Olivier , GRISOSTOMI, Corinna , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , WELLER, Thomas
CPC classification number: C07D277/34 , C07D213/64 , C07D401/04 , C07D417/04
Abstract: The invention relates to novel primary amine derivatives and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
Abstract translation: 本发明涉及新型伯胺衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为肾素抑制剂的用途的相关方面。
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3.发明申请
公开(公告)号：WO2005040165A1
公开(公告)日：2005-05-06
申请号：PCT/EP2004/011186
申请日：2004-10-07
Applicant: ACTELION PHARMACEUTICALS LTD , BEZENCON, Olivier , SIFFERLEN, Thierry , BUR, Daniel , FISCHLI, Walter , WELLER, Thomas , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia
Inventor： BEZENCON, Olivier , SIFFERLEN, Thierry , BUR, Daniel , FISCHLI, Walter , WELLER, Thomas , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia
IPC: C07D471/08
CPC classification number: C07D471/08
Abstract: The invention relates to novel derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
Abstract translation: 本发明涉及新型衍生物和相关化合物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为肾素抑制剂的用途的相关方面。
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4.发明申请DIAZABICYCLONONENE AND TETRAHYDROPYRIDINE DERIVATIVES AS RENIN INHIBITORS 审中-公开作为RININ抑制剂的二氮杂萘酮和四氢吡啶衍生物
公开(公告)号：WO2004096804A1
公开(公告)日：2004-11-11
申请号：PCT/EP2004/004373
申请日：2004-04-26
Applicant: ACTELION PHARMACEUTICALS LTD , BEZENCON, Olivier , BUR, Daniel , FISCHLI, Walter , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , WELLER, Thomas
Inventor： BEZENCON, Olivier , BUR, Daniel , FISCHLI, Walter , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , WELLER, Thomas
IPC: C07D471/08
CPC classification number: C07D471/08
Abstract: The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives, tetrahydropyridine derivatives, and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
Abstract translation: 本发明涉及新型的3,9-二氮杂双环[3.3.1]壬烯衍生物，四氢吡啶衍生物及其相关化合物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为肾素抑制剂的用途的相关方面。
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5.发明申请9-AZABICYCLO’3.3.1!NON-6-EE DERIVATIVES WITH A HETEROATOM AT THE 3-POSITION AS RENIN INHIBITORS 审中-公开9-AZABICYCLO'3.3.1！作为RENIN抑制剂在3-位上具有异位的非-6-EE衍生物
公开(公告)号：WO2004096366A1
公开(公告)日：2004-11-11
申请号：PCT/EP2004/004371
申请日：2004-04-26
Applicant: ACTELION PHARMACEUTICALS LTD , BEZENCON, Oliver , BUR, Daniel , FISCHLI, Walter , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , WELLER, Thomas , SIFFERLEN, Thierry
Inventor： BEZENCON, Oliver , BUR, Daniel , FISCHLI, Walter , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , WELLER, Thomas , SIFFERLEN, Thierry
IPC: A61P9/00
CPC classification number: C07D513/08
Abstract: The invention relates to novel 9-azabicyclo[3.3.1]nonene derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
Abstract translation: 本发明涉及新型9-氮杂双环[3.3.1]壬烯衍生物及其相关化合物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为肾素抑制剂的用途的相关方面。
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Patent Agency Ranking6.发明申请7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES 审中-公开7-ARYL-3,9-DIAZABICYCLO（3.3.1）非6-环己酮衍生物及其作为治疗高血压，心血管病或肾病的瑞恩抑制剂使用
公开(公告)号：WO2003093267A1
公开(公告)日：2003-11-13
申请号：PCT/EP2003/003721
申请日：2003-04-08
Applicant: ACTELION PHARMACEUTICALS LTD , BEZENCON, Olivier , BUR, Daniel , FISCHLI, Walter , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , WEBER, Hans-Peter , WELLER, Thomas
Inventor： BEZENCON, Olivier , BUR, Daniel , FISCHLI, Walter , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , WEBER, Hans-Peter , WELLER, Thomas
IPC: C07D471/08
CPC classification number: C07D471/08 , A61K31/4995 , A61K45/06 , Y02A50/411 , A61K2300/00
Abstract: The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors or renin.
Abstract translation: 本发明涉及式（I）的新的3,9-二氮杂双环[3.3.1]壬烯衍生物及其相关化合物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为抑制剂或肾素的用途的相关方面。
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公开(公告)号：WO2012077049A1
公开(公告)日：2012-06-14
申请号：PCT/IB2011/055487
申请日：2011-12-06
Applicant: ACTELION PHARMACEUTICALS LTD , BUR, Daniel , CORMINBOEUF, Olivier , CREN, Sylvaine , GRISOSTOMI, Corinna , LEROY, Xavier , RICHARD-BILDSTEIN, Sylvia
Inventor： BUR, Daniel , CORMINBOEUF, Olivier , CREN, Sylvaine , GRISOSTOMI, Corinna , LEROY, Xavier , RICHARD-BILDSTEIN, Sylvia
IPC: C07D413/14 , A61K31/422 , A61P29/00
CPC classification number: C07D413/14
Abstract: The invention relates to oxazolyl-methylether derivatives of formula (I), wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the description, their preparation and their use as pharmaceutically active compounds.
Abstract translation: 本发明涉及式（I）的恶唑基 - 甲基醚衍生物，其中R1，R2，R3，R4和R5如说明书中所定义，它们的制备及其作为药物活性化合物的用途。
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8.发明申请3-(HETEROARYL-AMINO)-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS 审中-公开3-（异丁基氨基）-1,2,3,4-四氢-9H-卡波醇衍生物及其作为PROSTAGLANDIN D2受体调节剂的用途
公开(公告)号：WO2011117798A1
公开(公告)日：2011-09-29
申请号：PCT/IB2011/051165
申请日：2011-03-21
Applicant: ACTELION PHARMACEUTICALS LTD , AISSAOUI, Hamed , FRETZ, Heinz , HAZEMANN, Julien , RICHARD-BILDSTEIN, Sylvia , SIEGRIST, Romain
Inventor： AISSAOUI, Hamed , FRETZ, Heinz , HAZEMANN, Julien , RICHARD-BILDSTEIN, Sylvia , SIEGRIST, Romain
IPC: C07D209/88 , A61K31/403 , A61P11/06
CPC classification number: C07D209/88
Abstract: The present invention relates to 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9H-carbazole derivatives of the formula (I), wherein R 1 , R 2 and R 3 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D 2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.
Abstract translation: 本发明涉及式（I）的3-（杂芳基 - 氨基）-1,2,3,4-四氢-9H-咔唑衍生物，其中R1，R2和R3如说明书中所述及其用途 前列腺素受体调节剂，最特别是前列腺素D2受体调节剂，用于治疗各种前列腺素介导的疾病和病症，含有这些化合物的药物组合物及其制备方法。
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9.发明申请BRIDGED SPIRO [2.4] HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS 审中-公开BRIDGED SPIRO [2.4]作为ALX受体和/或FPRL2激动剂的HEPTANE衍生物
公开(公告)号：WO2010134014A1
公开(公告)日：2010-11-25
申请号：PCT/IB2010/052170
申请日：2010-05-17
Applicant: ACTELION PHARMACEUTICALS LTD , BUR, Daniel , CORMINBOEUF, Olivier , CREN, Sylvaine , GRISOSTOMI, Corinna , LEROY, Xavier , RICHARD-BILDSTEIN, Sylvia
Inventor： BUR, Daniel , CORMINBOEUF, Olivier , CREN, Sylvaine , GRISOSTOMI, Corinna , LEROY, Xavier , RICHARD-BILDSTEIN, Sylvia
IPC: C07C233/58 , C07C233/60 , C07C233/63 , C07D207/09 , C07D211/26 , C07D213/40 , C07D231/12 , C07D233/64 , C07D235/14 , C07D239/30 , C07D249/08 , C07D277/28 , C07D277/62 , C07D307/52 , C07D319/12
CPC classification number: C07D295/13 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/61 , C07C233/63 , C07C255/29 , C07C2603/94 , C07D205/04 , C07D207/14 , C07D211/26 , C07D211/56 , C07D211/58 , C07D213/40 , C07D213/75 , C07D231/12 , C07D233/36 , C07D233/64 , C07D235/14 , C07D239/30 , C07D249/08 , C07D261/08 , C07D271/08 , C07D275/04 , C07D277/46 , C07D277/58 , C07D277/62 , C07D285/08 , C07D295/125 , C07D295/185 , C07D307/14 , C07D307/52 , C07D333/28 , C07D417/12
Abstract: The present invention relates to bridged spiro[2.4]heptane derivatives of formula (I), wherein W, Y, Z, R 1 and R 2 are as defined in the description, their preparation and their use as pharmaceutically active compounds as ALX receptor and/or FPRL2 agonists for the treatment of inflammatory and obstructive airways diseases.
Abstract translation: 本发明涉及式（I）的桥连螺[2.4]庚烷衍生物，其中W，Y，Z，R 1和R 2如说明书中所定义，它们的制备及其作为药物活性化合物作为ALX受体和/或 FPRL2激动剂用于治疗炎性和阻塞性气道疾病。
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10.发明申请NOVEL PIPERAZINE DERIVATIVES AS RENIN INHIBITORS FOR CARDIOVASCULAR EVENTS AND RENAL INSUFFICIENCY 审中-公开新颖的哌嗪衍生物作为心血管事件和肾功能不全的RININ抑制剂
公开(公告)号：WO2007034445A3
公开(公告)日：2008-11-20
申请号：PCT/IB2006053445
申请日：2006-09-22
Applicant: ACTELION PHARMACEUTICALS LTD , BEZENCON OLIVIER , BOSS CHRISTOPH , BUR DANIEL , CORMINBOEUF OLIVIER , GRISOSTOMI CORINNA , REMEN LUBOS , RICHARD-BILDSTEIN SYLVIA , WELLER THOMAS
Inventor： BEZENCON OLIVIER , BOSS CHRISTOPH , BUR DANIEL , CORMINBOEUF OLIVIER , GRISOSTOMI CORINNA , REMEN LUBOS , RICHARD-BILDSTEIN SYLVIA , WELLER THOMAS
IPC: C07D241/08 , A61K31/496 , A61P9/00 , A61P13/12 , C07D413/12
CPC classification number: C07D413/12 , C07D241/08
Abstract: The invention relates to novel piperazine derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin. In particular, the present invention relates to novel compounds of the formula (I),
Abstract translation: 本发明涉及新型哌嗪衍生物及其相关化合物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为肾素抑制剂的用途的相关方面。 特别地，本发明涉及新的式（I）化合物，
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