公开(公告)号：WO2008058709A1

公开(公告)日：2008-05-22

申请号：PCT/EP2007/009816

申请日：2007-11-13

Applicant: DSM IP ASSETS B.V. ,  SCHALCH, Wolfgang ,  BARBUR, John, Lazar

Inventor： SCHALCH, Wolfgang ,  BARBUR, John, Lazar

IPC: A61B3/06 ,  A23L1/302

CPC classification number: A23L33/155 ,  A23L5/44 ,  A23L33/15 ,  A23V2002/00 ,  A61B3/12 ,  A23V2200/302 ,  A23V2250/211 ,  A23V2250/702 ,  A23V2250/708 ,  A23V2250/712

Abstract: A novel method of assessing visual performance is provided, which can simulate the effect of pigment absorption on visual acuity and indicate macular pigment optical density (MPOD). The method can simulate the amounts of pigment in the eye and assess e.g. the response of the eye, (or the reaction of an individual) to different levels of blue light. The individual can be asked to detect a specific feature (a gap in Landolt rings) at decreasing contrast levels, the Landolt rings (and background) both being blue. This can provide an indication of the density or concentration of levels of macular pigments in an individual's eye which can help determine treatments or substances to be administered (carotenoids, such as lutein or zeaxanthin) to improve the individual's visual performance.

Abstract translation: 提供了一种评估视觉表现的新方法，可以模拟颜料吸收对视力的影响，并指示黄斑色素光密度（MPOD）。 该方法可以模拟眼睛中颜料的量， 眼睛的反应（或个人的反应）对不同水平的蓝光。 可以要求个人在对比度降低的情况下检测出特定的特征（Landolt戒指的间隙），兰德乐环（和背景）均为蓝色。 这可以提供个人眼睛中黄斑色素的浓度或浓度的指示，其可以帮助确定待施用的处理或物质（类胡萝卜素，例如叶黄素或玉米黄质）以改善个体的视觉表现。

公开(公告)号：WO2006084687A1

公开(公告)日：2006-08-17

申请号：PCT/EP2006/001128

申请日：2006-02-09

Applicant: DSM IP ASSETS B.V. ,  GORALCZYK, Regina ,  SCHALCH, Wolfgang

Inventor： GORALCZYK, Regina ,  SCHALCH, Wolfgang

IPC: A61K31/047 ,  A61P27/02

CPC classification number: A61K31/047 ,  A23L33/105 ,  A23V2002/00 ,  A23V2250/211 ,  A23V2250/708 ,  A23V2250/712 ,  A23V2250/1842 ,  A23V2250/1642

Abstract: Zeaxanthin is useful for the treatment or prevention of diseases of the peripheral retina, and/or for improvement of peripheral vision.

Abstract translation: 玉米黄质可用于治疗或预防周围视网膜的疾病，和/或用于改善周边视力。

公开(公告)号：WO2008110824A3

公开(公告)日：2009-03-26

申请号：PCT/GB2008000917

申请日：2008-03-14

Applicant: DSM IP ASSETS BV ,  WRIGHT SIMON MARK ,  BENDIK IGOR ,  SANCAK OZGUER ,  SCHALCH WOLFGANG ,  WITTWER JONAS

Inventor： BENDIK IGOR ,  SANCAK OZGUER ,  SCHALCH WOLFGANG ,  WITTWER JONAS

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/172

Abstract: A method of prevention of age-related macular degeneration (AMD) is provided where a sample is taken from an individual and the presence of a polymorphism associated with a dehydrogenase, oxygenase, acyltransferase, dismutase or a macular or retinal pigment, or an SNP as shown in Table 1 of the specification, is detected. The individual can then be provided with a substance that can prevent or treat AMD, or can mitigate or alleviate symptoms of AMD. The substance is a medication comprising lutein and/or zeaxanthin and/or certain antioxidants (or a mixture thereof) is tailored to that individual.

Abstract translation: 提供了一种预防年龄相关性黄斑变性（AMD）的方法，其中取自个体的样品和与脱氢酶，加氧酶，酰基转移酶，岐化酶或黄斑或视网膜色素或SNP相关的多态性的存在或作为 检测了表1中所示的规格。 然后可以向个体提供可以预防或治疗AMD的物质，或者可以减轻或缓解AMD的症状。 该物质是包含叶黄素和/或玉米黄质的药物和/或某些抗氧化剂（或其混合物）适合于该个体。

公开(公告)号：WO2008110283A2

公开(公告)日：2008-09-18

申请号：PCT/EP2008/001688

申请日：2008-03-04

Applicant: DSM IP ASSETS B.V. ,  BENDIK, Igor ,  SANCAK, Özgür ,  SCHALCH, Wolfgang ,  WITTWER, Jonas

Inventor： BENDIK, Igor ,  SANCAK, Özgür ,  SCHALCH, Wolfgang ,  WITTWER, Jonas

CPC classification number: C12Q1/6886 ,  C12Q2600/172

Abstract: A method of prevention of age-related macular degeneration (AMD) involves, in a first step, taking a sample from an individual and detecting the presence of a polymorphism (rsl 1200638 or rs 10490924, or an SNP related to or associated with a (high temperature requirement) serine protease). In a second step the individual is provided with a substance that can prevent AMD, or can mitigate or alleviate symptoms of AMD. The substance is a medication comprising lutein and/or zeaxanthin and/or certain antioxidants (or a mixture thereof) is tailored to that individual. The invention also provides a method of determining the substance to be administered to an individual, which individual may be susceptible of having age-related macular degeneration (or an age-related macular degeneration-related disorder) by detecting the presence of the polymorphism and identifying a substance capable of preventing or treating age-related macular degeneration in that individual. The method may additionally comprise providing (such as administering or communicating) the substance (or its identity) to the individual.

Abstract translation: 预防年龄相关性黄斑变性（AMD）的方法涉及在第一步中从个体取样并检测多形性（rs1200638或rs10490924，或与（或 高温要求）丝氨酸蛋白酶）。 在第二步中，个体被提供可以预防AMD的物质，或者可以减轻或缓解AMD的症状。 该物质是包含叶黄素和/或玉米黄质的药物和/或某些抗氧化剂（或其混合物）适合于该个体。 本发明还提供了一种确定要给予个体的物质的方法，该个体可能通过检测多态性的存在并鉴定其可能具有年龄相关性黄斑变性（或年龄相关性黄斑变性相关病症） 能够预防或治疗该个体年龄相关性黄斑变性的物质。 该方法可以另外包括向个体提供（例如管理或通信）物质（或其身份）。

公开(公告)号：WO2010037857A1

公开(公告)日：2010-04-08

申请号：PCT/EP2009/062848

申请日：2009-10-02

Applicant: DSM IP Assets B.V. ,  HUG, Hubert ,  KILPERT, Claus ,  MAIR, Peter ,  SCHALCH, Wolfgang ,  SIMON, Werner ,  WYSS, Adrian

Inventor： HUG, Hubert ,  KILPERT, Claus ,  MAIR, Peter ,  SCHALCH, Wolfgang ,  SIMON, Werner ,  WYSS, Adrian

IPC: H01G9/20 ,  H01L51/00

CPC classification number: H01G9/2059 ,  H01G9/2031 ,  H01L51/0064 ,  Y02E10/542 ,  Y02E10/549

Abstract: Use of specific carotenoids in dye sensitized solar cells. Preferred carotenoids according to the present invention are listed in the following : Bixin (A), Canthaxanthin (B), Astaxanthin (C), Zeaxanthin (D), Torularhodin (E).

Abstract translation: 在染料敏化太阳能电池中使用特定的类胡萝卜素。 根据本发明的优选的类胡萝卜素列举如下：Bixin（A），Canthaxanthin（B），虾青素（C），玉米黄质（D），Torrohodin（E）。

公开(公告)号：WO2008119544A1

公开(公告)日：2008-10-09

申请号：PCT/EP2008/002563

申请日：2008-04-01

Applicant: DSM IP ASSETS B.V. ,  PRUDENCE, Kevin ,  RIEGGER, Christoph ,  SCHALCH, Wolfgang

Inventor： PRUDENCE, Kevin ,  RIEGGER, Christoph ,  SCHALCH, Wolfgang

IPC: A61K31/352 ,  A61P27/02

CPC classification number: A61K31/352 ,  A23L33/105

Abstract: Use of genistein for the treatment and prevention of dry eye syndrome or LKC and corresponding compositions containing it.

Abstract translation: 使用染料木素治疗和预防干眼综合征或LKC及含有它的相应组合物。

公开(公告)号：WO2008128552A1

公开(公告)日：2008-10-30

申请号：PCT/EP2007/003405

申请日：2007-04-18

Applicant: DSM IP ASSETS B.V. ,  LIU, Jiankang ,  SCHALCH, Wolfgang ,  WANG-SCHMIDT, Ying ,  WERTZ, Karin

Inventor： LIU, Jiankang ,  SCHALCH, Wolfgang ,  WANG-SCHMIDT, Ying ,  WERTZ, Karin

IPC: A61K31/05

CPC classification number: A61K31/05 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/30 ,  A23V2250/2132

Abstract: The present invention is directed to the use of (a composition comprising) hydroxytyrosol for treating or preventing age-related macular degeneration in humans, for maintaining the eye health in animals (preferably in humans), especially in elderly animals (preferably elderly humans), for improving the vision of animals (preferably of humans), for maintaining the high resolution vision in animals (preferably in humans) and/or for maintaining the visual acuity in animals (preferably in humans), as well as for maintaining the visual performance in animals (preferably in humans) and/or the visual function in animals (preferably in humans).

Abstract translation: 本发明涉及用于治疗或预防人类年龄相关性黄斑变性的（含有羟基酪氨酸的组合物）用于维持动物（优选人）中的眼睛健康的用途，特别是在老年动物（优选老年人）中， 为了维持动物（优选人类）中的高分辨率视觉和/或维持动物（优选人类）中的视力，以及维持动物（优选人类）的视力，以及维持动物 动物（优选人）和/或动物（优选人类）中的视觉功能。

公开(公告)号：WO2008110824A2

公开(公告)日：2008-09-18

申请号：PCT/GB2008/000917

申请日：2008-03-14

Applicant: DSM IP ASSETS B.V. ,  WRIGHT, Simon, Mark ,  BENDIK, Igor ,  SANCAK, Ozgür ,  SCHALCH, Wolfgang ,  WITTWER, Jonas

Inventor： BENDIK, Igor ,  SANCAK, Ozgür ,  SCHALCH, Wolfgang ,  WITTWER, Jonas

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/172

Abstract: A method of prevention of age-related macular degeneration (AMD) is provided where a sample is taken from an individual and the presence of a polymorphism associated with a dehydrogenase, oxygenase, acyltransferase, dismutase or a macular or retinal pigment, or an SNP as shown in Table 1 of the specification, is detected. The individual can then be provided with a substance that can prevent or treat AMD, or can mitigate or alleviate symptoms of AMD. The substance is a medication comprising lutein and/or zeaxanthin and/or certain antioxidants (or a mixture thereof) is tailored to that individual.

Abstract translation: 提供了一种预防年龄相关性黄斑变性（AMD）的方法，其中取自个体的样品和与脱氢酶，加氧酶，酰基转移酶，岐化酶或黄斑或视网膜色素或SNP相关的多态性的存在或作为 检测了表1中所示的规格。 然后可以向个体提供可以预防或治疗AMD的物质，或者可以减轻或缓解AMD的症状。 该物质是包含叶黄素和/或玉米黄质的药物和/或某些抗氧化剂（或其混合物）适合于该个体。

公开(公告)号：WO2003063848A1

公开(公告)日：2003-08-07

申请号：PCT/EP2003/000656

申请日：2003-01-23

Applicant: ROCHE VITAMINS AG ,  BARKER, Felix ,  GORALCZYK, Regina ,  SCHALCH, Wolfgang

Inventor： BARKER, Felix ,  GORALCZYK, Regina ,  SCHALCH, Wolfgang

IPC: A61K31/07

CPC classification number: A61K31/047 ,  A61K31/015 ,  A61K31/07 ,  A61K31/355 ,  A61K31/375 ,  A61K33/04 ,  A61K33/30 ,  A61K36/06 ,  A61K2300/00

Abstract: The invention relates to the improvement of visual performance, particularly of visual performance in the darkness, by administration of a colorant that is capable of being incorporated into eye tissue and/or causing yellowing of eye tissue, especially carotenoids, such as lutein and zeaxanthin.

Abstract translation: 本发明涉及通过施用能够引入眼睛组织和/或引起眼组织，特别是类胡萝卜素如叶黄素和玉米黄质的黄化的着色剂来改善视觉表现，特别是在黑暗中的视觉表现。

公开(公告)号：WO2008110828A1

公开(公告)日：2008-09-18

申请号：PCT/GB2008/000925

申请日：2008-03-14

Applicant: DSM IP ASSETS B.V. ,  WRIGHT, Simon, Mark ,  BENDIK, Igor ,  SANCAK, Özgür ,  SCHALCH, Wolfgang ,  WITTWER, Jonas

Inventor： BENDIK, Igor ,  SANCAK, Özgür ,  SCHALCH, Wolfgang ,  WITTWER, Jonas

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/172

Abstract: A method of prevention of age-related macular degeneration (AMD) involves, in a first step, taking a sample from an individual and detecting the presence of a polymorphism (rsl 1200638 or rs 10490924, or an SNP related to or associated with a (high temperature requirement) serine protease). In a second step the individual is provided with a substance that can prevent AMD, or can mitigate or alleviate symptoms of AMD. The substance is a medication comprising lutein and/or zeaxanthin and/or certain antioxidants (or a mixture thereof) is tailored to that individual. The invention also provides a method of determining the substance to be administered to an individual, which individual may be susceptible of having age-related macular degeneration (or an age-related macular degeneration-related disorder) by detecting the presence of the polymorphism and identifying a substance capable of preventing or treating age-related macular degeneration in that individual. The method may additionally comprise providing (such as administering or communicating) the substance (or its identity) to the individual.

Abstract translation: 预防年龄相关性黄斑变性（AMD）的方法包括，在第一步中，从个体取样品并检测多态性（rs1112638或rs10490924或 与（高温需求）丝氨酸蛋白酶相关或相关的SNP）。 在第二步中，向个体提供能够预防AMD的物质，或者可以缓解或缓解AMD的症状。 该物质是含有叶黄素和/或玉米黄质和/或某种抗氧化剂（或其混合物）的个体的药物。 本发明还提供了测定待施用于个体的物质的方法，所述个体可能通过检测多态性的存在并鉴定出与年龄相关的黄斑变性（或与年龄相关的黄斑变性有关的病症） 能够预防或治疗该个体的年龄相关性黄斑变性的物质。 该方法可以另外包括向个体提供（例如给予或传递）物质（或其身份）。