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公开(公告)号：WO2007139948A3
公开(公告)日：2008-01-24
申请号：PCT/US2007012516
申请日：2007-05-25
申请人： EISAI R&D MAN CO LTD , SPYVEE MARK , SELETSKY BORIS M , SCHILLER SHAWN , SHAFFER CHRISTINA J , LIU JIA , LI XIANG-YI , CHEN QIAN , BOIVIN ROCH
发明人： SPYVEE MARK , SELETSKY BORIS M , SCHILLER SHAWN , SHAFFER CHRISTINA J , LIU JIA , LI XIANG-YI , CHEN QIAN , BOIVIN ROCH
CPC分类号： A61K31/55 , A61K31/435
摘要： The present invention provides an enantiomerically pure compound of formula I: along with pharmaceutical formulations containing the same and methods of use thereof the treatment of autoimmune disease.
摘要翻译： 本发明提供了对映异构体纯的式I化合物以及含有其的药物制剂及其使用方法治疗自身免疫性疾病。
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公开(公告)号：WO2009070305A1
公开(公告)日：2009-06-04
申请号：PCT/US2008/013162
申请日：2008-11-26
申请人： EISAI E & D MANAGEMENT CO., LTD. , SPYVEE, Mark , SELETSKY, Boris M. , SCHILLER, Shawn , FANG, Francis
IPC分类号： A01N43/00
CPC分类号： C07D471/20 , C07D513/04
摘要： A method of making a compound of Formula I: is carried out by (a) providing a compound of Formula (II) or (III): wherein ring A is C3-14 aryl or C3-14 heteroaryl such as phenyl or furanyl, and then (b) combining the compound of Formula (II) or (III) with an acid to produce a compound of Formula I.
摘要翻译： 通过（a）提供式（II）或（III）的化合物来进行制备式I化合物的方法：其中环A为C 3-8芳基或C 3-14杂芳基，例如苯基或呋喃基，和 然后（b）将式（II）或（III）的化合物与酸组合以制备式I的化合物。
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公开(公告)号：WO2007139948A2
公开(公告)日：2007-12-06
申请号：PCT/US2007/012516
申请日：2007-05-25
申请人： EISAI R & D MANAGEMENT CO., LTD , SPYVEE, Mark , SELETSKY, Boris, M. , SCHILLER, Shawn , SHAFFER, Christina, J. , LIU, Jia , LI, Xiang-Yi , CHEN, Qian , BOIVIN, Roch
发明人： SPYVEE, Mark , SELETSKY, Boris, M. , SCHILLER, Shawn , SHAFFER, Christina, J. , LIU, Jia , LI, Xiang-Yi , CHEN, Qian , BOIVIN, Roch
CPC分类号： A61K31/55 , A61K31/435
摘要： The present invention provides an enantiomerically pure compound of formula I: along with pharmaceutical formulations containing the same and methods of use thereof the treatment of autoimmune disease.
摘要翻译： 本发明提供了对映异构体纯的式I化合物以及含有其的药物制剂及其使用方法治疗自身免疫性疾病。
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公开(公告)号：WO2005030794A2
公开(公告)日：2005-04-07
申请号：PCT/US2004030921
申请日：2004-09-22
申请人： EISAI CO LTD , KOWALCZYK JAMES J , KUZNETSOV GALINA , SCHILLER SHAWN , SELETSKY BORIS M , SPYVEE MARK , YANG HU , CAMPAGNA SILVIO A , FANG FRANCIS G
发明人： KOWALCZYK JAMES J , KUZNETSOV GALINA , SCHILLER SHAWN , SELETSKY BORIS M , SPYVEE MARK , YANG HU , CAMPAGNA SILVIO A , FANG FRANCIS G
IPC分类号： A61K31/395 , A61K38/04 , A61K38/05 , C07D207/04 , C07D207/12 , C07D207/16 , C07D207/42 , C07D209/20 , C07D211/60 , C07D217/26 , C07D223/06 , C07D233/84 , C07D237/04 , C07D241/04 , C07D265/30 , C07D277/06 , C07D279/12 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/12 , C07D471/04 , C07K1/06 , C07K5/00 , C07K5/02 , C07K5/04 , C07K5/06 , C07K5/097
CPC分类号： C07D207/04 , C07D207/12 , C07D207/16 , C07D207/42 , C07D209/20 , C07D211/60 , C07D217/26 , C07D223/06 , C07D233/84 , C07D237/04 , C07D241/04 , C07D265/30 , C07D277/06 , C07D279/12 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/12 , C07D471/04 , C07K5/0205 , C07K5/0207 , C07K5/0821
摘要： The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
摘要翻译： 本发明提供了具有式（I）的化合物：并且另外提供了用于其合成的方法以及其用于治疗癌症的方法，其中R 1 -R 7，X 1，X 2，R，Q和n如本文所定义 。
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公开(公告)号：WO03082268A2
公开(公告)日：2003-10-09
申请号：PCT/US0308888
申请日：2003-03-21
申请人： EISAI CO LTD , KOWALCZYK JAMES J , KUZNETSOV GALINA , SCHILLER SHAWN , SELETSKY BORIS M , SPYVEE MARK , YANG HU
发明人： KOWALCZYK JAMES J , KUZNETSOV GALINA , SCHILLER SHAWN , SELETSKY BORIS M , SPYVEE MARK , YANG HU
IPC分类号： C07D295/18 , A61K31/16 , A61K31/165 , A61K31/197 , A61K31/40 , A61K31/401 , A61K31/426 , A61K31/427 , A61K31/4465 , A61K31/454 , A61P1/00 , A61P9/00 , A61P11/00 , A61P13/00 , A61P35/00 , C07C237/12 , C07D207/08 , C07D207/16 , C07D211/60 , C07D277/20 , C07D277/56 , C07D295/185 , C07D401/12 , C07D401/14 , C07K5/062 , C07K5/065 , C07K5/078 , C07K5/083 , C07K5/087 , C07K5/097 , C07K5/107 , C07K7/02 , C07K7/06 , A61K38/05 , A61K38/06 , C07K5/027 , C07K5/033
CPC分类号： C07K7/06 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/08 , C07C237/22 , C07D207/08 , C07D207/16 , C07D211/60 , C07D295/185 , C07D401/14 , C07K5/06078 , C07K5/06156 , C07K5/06165 , C07K5/0808 , C07K5/0821 , C07K5/0823 , C07K5/1016
摘要： The present invention provides compounds having formula (I): (I) and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
摘要翻译： 本发明提供具有式（I）：（I）的化合物，另外提供其合成方法及其用于治疗癌症的方法，其中R1-R7，X1，X2，R，Q和n为 如本文所定义。
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公开(公告)号：WO2005030794B1
公开(公告)日：2005-10-20
申请号：PCT/US2004030921
申请日：2004-09-22
申请人： EISAI CO LTD , KOWALCZYK JAMES J , KUZNETSOV GALINA , SCHILLER SHAWN , SELETSKY BORIS M , SPYVEE MARK , YANG HU , CAMPAGNA SILVIO A , FANG FRANCIS G
发明人： KOWALCZYK JAMES J , KUZNETSOV GALINA , SCHILLER SHAWN , SELETSKY BORIS M , SPYVEE MARK , YANG HU , CAMPAGNA SILVIO A , FANG FRANCIS G
IPC分类号： A61K31/395 , A61K38/04 , A61K38/05 , C07D207/04 , C07D207/12 , C07D207/16 , C07D207/42 , C07D209/20 , C07D211/60 , C07D217/26 , C07D223/06 , C07D233/84 , C07D237/04 , C07D241/04 , C07D265/30 , C07D277/06 , C07D279/12 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/12 , C07D471/04 , C07K1/06 , C07K5/00 , C07K5/02 , C07K5/04 , C07K5/06 , C07K5/097
CPC分类号： C07D207/04 , C07D207/12 , C07D207/16 , C07D207/42 , C07D209/20 , C07D211/60 , C07D217/26 , C07D223/06 , C07D233/84 , C07D237/04 , C07D241/04 , C07D265/30 , C07D277/06 , C07D279/12 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/12 , C07D471/04 , C07K5/0205 , C07K5/0207 , C07K5/0821
摘要： The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
摘要翻译： 本发明提供具有式（I）的化合物：另外提供其合成方法及其用于治疗癌症的方法，其中R1-R7，X1，X2，R，Q和n如本文所定义 。
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公开(公告)号：WO2005030794A3
公开(公告)日：2005-04-07
申请号：PCT/US2004/030921
申请日：2004-09-22
申请人： EISAI CO. LTD. , KOWALCZYK, James, J. , KUZNETSOV, Galina , SCHILLER, Shawn , SELETSKY, Boris, M. , SPYVEE, Mark , YANG, Hu , CAMPAGNA, Silvio, A. , FANG, Francis, G.
发明人： KOWALCZYK, James, J. , KUZNETSOV, Galina , SCHILLER, Shawn , SELETSKY, Boris, M. , SPYVEE, Mark , YANG, Hu , CAMPAGNA, Silvio, A. , FANG, Francis, G.
IPC分类号： C07K5/00
摘要： The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R 1 -R 7 , X 1 , X 2 , R, Q, and n are as defined herein.
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公开(公告)号：WO2009064274A1
公开(公告)日：2009-05-22
申请号：PCT/US2007/024011
申请日：2007-11-15
申请人： EISAI R & D MANAGEMENT CO., LTD. , SPYVEE, Mark , SHAFFER, Christina J. , SELETSKY, Boris M. , SCHILLER, Shawn , LIU, Jia , LI, Xiang-Yi Li , CHEN, Qian , BOIVIN, Roch
发明人： SPYVEE, Mark , SHAFFER, Christina J. , SELETSKY, Boris M. , SCHILLER, Shawn , LIU, Jia , LI, Xiang-Yi Li , CHEN, Qian , BOIVIN, Roch
IPC分类号： C07D471/20
CPC分类号： C07D471/20
摘要： The present invention provides an enantiomerically pure compound of Formula (I) along with pharmaceutical formulations containing the same and methods of use thereof.
摘要翻译： 本发明提供对映异构体纯的式（I）化合物以及含有其的药物制剂及其使用方法。
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公开(公告)号：WO2003082268A3
公开(公告)日：2003-10-09
申请号：PCT/US2003/008888
申请日：2003-03-21
申请人： EISAI CO. LTD , KOWALCZYK, James, J. , KUZNETSOV, Galina , SCHILLER, Shawn , SELETSKY, Boris, M. , SPYVEE, Mark , YANG, Hu
发明人： KOWALCZYK, James, J. , KUZNETSOV, Galina , SCHILLER, Shawn , SELETSKY, Boris, M. , SPYVEE, Mark , YANG, Hu
IPC分类号： A61K31/40
摘要： The present invention provides compounds having formula (I): (I) and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R 1 -R 7 , X 1 , X 2 , R, Q, and n are as defined herein.
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公开(公告)号：WO2003057696A1
公开(公告)日：2003-07-17
申请号：PCT/US2003/000366
申请日：2003-01-07
申请人： EISAI CO. LTD. , DAUN, Jane , DAVIS, Heather, A. , GUSOVSKY, Fabian , HISHINUMA, Ieharu , JIANG, Yimin , KANEKO, Toshihiko , KIKUCHI, Kouichi , KOBAYASHI, Seiichi , LESCARBEAU, Andre , LI, Xiang-Li , MURAMOTO, Kenzo , OHI, Norihito , PESANT, Marc , SELETSKY, Boris, M. , SOEJIMA, Motohiko , YAO, Ye , YOKOHAMA, Hiromitsu , ZHAO, Janet, Y. , ZHENG, Wanjun , TREMBLAY, Lynda
发明人： DAUN, Jane , DAVIS, Heather, A. , GUSOVSKY, Fabian , HISHINUMA, Ieharu , JIANG, Yimin , KANEKO, Toshihiko , KIKUCHI, Kouichi , KOBAYASHI, Seiichi , LESCARBEAU, Andre , LI, Xiang-Li , MURAMOTO, Kenzo , OHI, Norihito , PESANT, Marc , SELETSKY, Boris, M. , SOEJIMA, Motohiko , YAO, Ye , YOKOHAMA, Hiromitsu , ZHAO, Janet, Y. , ZHENG, Wanjun , TREMBLAY, Lynda
IPC分类号： C07D471/04
CPC分类号： A61K31/437 , C07D471/04
摘要： The present invention provides compounds having formula (I), wherein R 1 , R 2 , R 3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally.
摘要翻译： 本发明提供了具有式（I）的化合物，其中R 1，R 2，R b，R b，S 3和n如通式和类别所述 并且另外提供其药物组合物，以及其用于治疗炎症或自身免疫和增殖性疾病的方法，以及作为细胞粘附分子表达和炎性细胞因子信号转导的抑制剂。
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