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公开(公告)号：WO2012006072A9
公开(公告)日：2012-01-12
申请号：PCT/US2011/042144
申请日：2011-06-28
申请人： VIRGINIA COMMONWEALTH UNIVERSITY , BOWLIN, Gary, L. , MCCLURE, Michael, J. , SIMPSON, David, G. , YANG, Hu
摘要： Electrospun materials are fabricated using air-flow impedance technology, which results in the production of scaffolds in which some regions are dense with low porosity and others regions are less dense and more porous. The dense regions provide structural support for the scaffold while the porous regions permit entry of cells and other materials into the scaffold, e.g. when used for tissue engineering.
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2.发明申请A FACILE METHOD FOR CROSSLINKING AND INCORPORATING BIOACTIVE MOLECULES INTO ELECTROSPUN FIBER SCAFFOLDS 审中-公开用于交联和将生物活性分子掺入电纺纤维片的方法
公开(公告)号：WO2012088059A2
公开(公告)日：2012-06-28
申请号：PCT/US2011/066071
申请日：2011-12-20
CPC分类号： A61K47/42 , A61L27/222 , A61L27/26 , A61L27/54 , A61L2300/258 , D04H1/587 , D04H1/728 , D06M13/2246 , D06M15/27 , D06M15/59 , C08L89/00 , C08L101/005 , C08L79/02
摘要： Electrospun scaffolds crosslinked with acrylates and methods of making the same are provided. Because the crosslinking is carried out under mild conditions, biologically active agents are incorporated into the scaffolds in a facile manner.
摘要翻译： 提供了与丙烯酸酯交联的电纺丝支架及其制备方法。 因为交联在温和条件下进行，生物活性剂以容易的方式并入支架中。
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公开(公告)号：WO2012006072A2
公开(公告)日：2012-01-12
申请号：PCT/US2011042144
申请日：2011-06-28
发明人： BOWLIN GARY L , MCCLURE MICHAEL J , SIMPSON DAVID G , YANG HU
CPC分类号： A61F2/02 , D01D5/0061 , D01D5/0076 , D01F6/62 , D01F6/625 , D04H1/728
摘要： Electrospun materials are fabricated using air-flow impedance technology, which results in the production of scaffolds in which some regions are dense with low porosity and others regions are less dense and more porous. The dense regions provide structural support for the scaffold while the porous regions permit entry of cells and other materials into the scaffold, e.g. when used for tissue engineering.
摘要翻译： 电纺材料使用气流阻抗技术制造，这导致生产支架，其中一些区域是致密的，具有低孔隙率，而另一些区域则不那么致密并且更多孔。 致密区域为支架提供结构支撑，而多孔区域允许细胞和其他材料进入支架， 当用于组织工程。
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公开(公告)号：WO2007050746A1
公开(公告)日：2007-05-03
申请号：PCT/US2006/041768
申请日：2006-10-26
发明人： BARALT, Eduardo, J. , YANG, Hu
CPC分类号： C10L1/1808 , C09K8/524 , C10L10/16
摘要： An oxidized olefin wax useful as a pour point depressant for hydrocarbon compositions and/or additive to reduce the wax particle size of wax precipitates in hydrocarbon compositions is described. Method for reducing the pour point and/or wax particle size of hydrocarbon composition with an oxidized olefin wax are described.
摘要翻译： 描述了用作烃组合物和/或添加剂的用于降低烃组合物中蜡沉淀物的蜡粒度的倾点下降剂的氧化烯烃蜡。 描述了用氧化烯烃蜡降低烃组合物的倾点和/或蜡粒度的方法。
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公开(公告)号：WO2005030794A2
公开(公告)日：2005-04-07
申请号：PCT/US2004030921
申请日：2004-09-22
申请人： EISAI CO LTD , KOWALCZYK JAMES J , KUZNETSOV GALINA , SCHILLER SHAWN , SELETSKY BORIS M , SPYVEE MARK , YANG HU , CAMPAGNA SILVIO A , FANG FRANCIS G
发明人： KOWALCZYK JAMES J , KUZNETSOV GALINA , SCHILLER SHAWN , SELETSKY BORIS M , SPYVEE MARK , YANG HU , CAMPAGNA SILVIO A , FANG FRANCIS G
IPC分类号： A61K31/395 , A61K38/04 , A61K38/05 , C07D207/04 , C07D207/12 , C07D207/16 , C07D207/42 , C07D209/20 , C07D211/60 , C07D217/26 , C07D223/06 , C07D233/84 , C07D237/04 , C07D241/04 , C07D265/30 , C07D277/06 , C07D279/12 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/12 , C07D471/04 , C07K1/06 , C07K5/00 , C07K5/02 , C07K5/04 , C07K5/06 , C07K5/097
CPC分类号： C07D207/04 , C07D207/12 , C07D207/16 , C07D207/42 , C07D209/20 , C07D211/60 , C07D217/26 , C07D223/06 , C07D233/84 , C07D237/04 , C07D241/04 , C07D265/30 , C07D277/06 , C07D279/12 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/12 , C07D471/04 , C07K5/0205 , C07K5/0207 , C07K5/0821
摘要： The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
摘要翻译： 本发明提供了具有式（I）的化合物：并且另外提供了用于其合成的方法以及其用于治疗癌症的方法，其中R 1 -R 7，X 1，X 2，R，Q和n如本文所定义 。
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公开(公告)号：WO03082268A2
公开(公告)日：2003-10-09
申请号：PCT/US0308888
申请日：2003-03-21
申请人： EISAI CO LTD , KOWALCZYK JAMES J , KUZNETSOV GALINA , SCHILLER SHAWN , SELETSKY BORIS M , SPYVEE MARK , YANG HU
发明人： KOWALCZYK JAMES J , KUZNETSOV GALINA , SCHILLER SHAWN , SELETSKY BORIS M , SPYVEE MARK , YANG HU
IPC分类号： C07D295/18 , A61K31/16 , A61K31/165 , A61K31/197 , A61K31/40 , A61K31/401 , A61K31/426 , A61K31/427 , A61K31/4465 , A61K31/454 , A61P1/00 , A61P9/00 , A61P11/00 , A61P13/00 , A61P35/00 , C07C237/12 , C07D207/08 , C07D207/16 , C07D211/60 , C07D277/20 , C07D277/56 , C07D295/185 , C07D401/12 , C07D401/14 , C07K5/062 , C07K5/065 , C07K5/078 , C07K5/083 , C07K5/087 , C07K5/097 , C07K5/107 , C07K7/02 , C07K7/06 , A61K38/05 , A61K38/06 , C07K5/027 , C07K5/033
CPC分类号： C07K7/06 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/08 , C07C237/22 , C07D207/08 , C07D207/16 , C07D211/60 , C07D295/185 , C07D401/14 , C07K5/06078 , C07K5/06156 , C07K5/06165 , C07K5/0808 , C07K5/0821 , C07K5/0823 , C07K5/1016
摘要： The present invention provides compounds having formula (I): (I) and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
摘要翻译： 本发明提供具有式（I）：（I）的化合物，另外提供其合成方法及其用于治疗癌症的方法，其中R1-R7，X1，X2，R，Q和n为 如本文所定义。
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7.发明申请A FACILE METHOD FOR CROSSLINKING AND INCORPORATING BIOACTIVE MOLECULES INTO ELECTROSPUN FIBER SCAFFOLDS 审中-公开用于交联和将生物活性分子掺入电纺纤维片的方法
公开(公告)号：WO2012088059A3
公开(公告)日：2013-01-17
申请号：PCT/US2011066071
申请日：2011-12-20
发明人： YANG HU , BOWLIN GARY L , DONGARGAONKAR ALPANA
CPC分类号： A61K47/42 , A61L27/222 , A61L27/26 , A61L27/54 , A61L2300/258 , D04H1/587 , D04H1/728 , D06M13/2246 , D06M15/27 , D06M15/59 , C08L89/00 , C08L101/005 , C08L79/02
摘要： Electrospun scaffolds crosslinked with acrylates and methods of making the same are provided. Because the crosslinking is carried out under mild conditions, biologically active agents are incorporated into the scaffolds in a facile manner.
摘要翻译： 提供了与丙烯酸酯交联的电纺丝支架及其制备方法。 因为交联在温和条件下进行，生物活性剂以容易的方式并入支架中。
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公开(公告)号：WO2010017184A2
公开(公告)日：2010-02-11
申请号：PCT/US2009052678
申请日：2009-08-04
发明人： YANG HU , DESAI POOJA N
IPC分类号： C08G65/325 , C08G65/28 , C08G65/32 , C08L71/00 , G03F7/004
CPC分类号： C08G65/3326 , C08G65/33379 , C08G83/003 , G03F7/0388
摘要： Photoactivatable dendrimers and hydrogels formed therefrom are provided. The photoactivatable dendrimers comprise a dendrimer to which polymer chains (e.g. polyethylene glycol, PEG) have been conjugated; and reactive photoactivatable groups attached to terminal functional groups of the polymer chains (e.g. hydroxyls of PEG). Exposure to a suitable wavelength of light activates the photoactivatable groups, which then crosslink with one another, thereby forming a hydrogel.
摘要翻译： 提供可光活化的树枝状大分子和由其形成的水凝胶。 可光活化的树枝状大分子包含聚合物链（例如聚乙二醇，PEG）已经共轭的树枝状大分子; 和连接到聚合物链的末端官能团（例如PEG的羟基）上的活性可光活化基团。 暴露于适当波长的光激活可光活化的基团，然后其彼此交联，从而形成水凝胶。
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公开(公告)号：WO2003082268A3
公开(公告)日：2003-10-09
申请号：PCT/US2003/008888
申请日：2003-03-21
申请人： EISAI CO. LTD , KOWALCZYK, James, J. , KUZNETSOV, Galina , SCHILLER, Shawn , SELETSKY, Boris, M. , SPYVEE, Mark , YANG, Hu
发明人： KOWALCZYK, James, J. , KUZNETSOV, Galina , SCHILLER, Shawn , SELETSKY, Boris, M. , SPYVEE, Mark , YANG, Hu
IPC分类号： A61K31/40
摘要： The present invention provides compounds having formula (I): (I) and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R 1 -R 7 , X 1 , X 2 , R, Q, and n are as defined herein.
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公开(公告)号：WO2012006072A3
公开(公告)日：2012-04-12
申请号：PCT/US2011042144
申请日：2011-06-28
发明人： BOWLIN GARY L , MCCLURE MICHAEL J , SIMPSON DAVID G , YANG HU
CPC分类号： A61F2/02 , D01D5/0061 , D01D5/0076 , D01F6/62 , D01F6/625 , D04H1/728
摘要： Electrospun materials are fabricated using air-flow impedance technology, which results in the production of scaffolds in which some regions are dense with low porosity and others regions are less dense and more porous. The dense regions provide structural support for the scaffold while the porous regions permit entry of cells and other materials into the scaffold, e.g. when used for tissue engineering.
摘要翻译： 使用气流阻抗技术制造电纺丝材料，这导致支架的生产，其中一些区域是致密的，具有低孔隙率，而其它区域较不致密且更多孔。 致密区域为支架提供结构支撑，而多孔区域允许细胞和其它材料进入支架，例如， 用于组织工程。
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