公开(公告)号：WO2011031637A3

公开(公告)日：2011-06-23

申请号：PCT/US2010047852

申请日：2010-09-03

Applicant: MUSCULOSKELETAL TRANSPLANT ,  SEMLER ERIC J ,  GERTZMAN ARTHUR A ,  HUANG YEN-CHEN ,  YANNARIELLO-BROWN JUDITH ,  TRUNCALE KATHERINE GOMES

Inventor： SEMLER ERIC J ,  GERTZMAN ARTHUR A ,  HUANG YEN-CHEN ,  YANNARIELLO-BROWN JUDITH ,  TRUNCALE KATHERINE GOMES

IPC: A61L27/46 ,  A61F2/38 ,  A61K35/32 ,  A61L27/36 ,  A61L27/38 ,  A61L27/48 ,  A61L27/54

CPC classification number: A61L27/3654 ,  A61F2/3872 ,  A61K35/32 ,  A61K35/34 ,  A61L27/3612 ,  A61L27/3834 ,  A61L27/48 ,  A61L2430/06

Abstract: A meniscus repair composition for application to a meniscus defect site to promote growth of new tissue at the meniscus defect site is provided. The composition comprises: from about 10 to about 50 percent by weight of allograft meniscus particles having an average particle size of from about 10 µm to about 500 µm; a carrier selected from the group consisting of sodium hyaluronate, gelatin, collagen, polyethylene glycol, glycerin, carboxymethylcellulose, dextrose, blood derivatives, aqueous solutions thereof, and mixtures thereof; and a curing agent. The curing agent may be the carrier where the carrier is cross-linkable. When introduced to a defect site in a meniscus and cured, the composition will not flow away from the defect site, and the composition is non-adhering to the defect site after it is cured.

Abstract translation: 提供了一种应用于弯月面缺损部位以促进新月组织在半月板缺损部位生长的半月板修复组合物。 该组合物包含：约10至约50重量％的平均粒度为约10μm至约500μm的同种异体移植物半月板颗粒; 选自透明质酸钠，明胶，胶原，聚乙二醇，甘油，羧甲基纤维素，右旋糖，血液衍生物，其水溶液及其混合物的载体; 和固化剂。 固化剂可以是载体可以交联的载体。 当被引入到弯月面中的缺陷部位并被固化时，组合物不会从缺陷部位流走，并且组合物在固化后不会粘附到缺陷部位。

公开(公告)号：WO2010083051A2

公开(公告)日：2010-07-22

申请号：PCT/US2010/000108

申请日：2010-01-14

Applicant: PROCHON BIOTECH, LTD. ,  MUSCULOSKELETAL TRANSPLANT FOUNDATION ,  YAYON, Avner ,  TRUNCALE, Katherine, G. ,  BARKAY-OLAMI, Hilla ,  CALLAHAN, Alex, B. ,  GERTZMAN, Arthur, A. ,  HUANG, Yen-chen ,  JACOBS, Morris, L. ,  MUNSON, John, C. ,  SEMLER, Eric, J. ,  SHIKHANOVICH, Roman ,  STERN, Baruch ,  SUNWOO, Moon, Hae ,  TOMFORD, William, W. ,  YANNARIELLO-BROWN, Judith, I.

Inventor： YAYON, Avner ,  TRUNCALE, Katherine, G. ,  BARKAY-OLAMI, Hilla ,  CALLAHAN, Alex, B. ,  GERTZMAN, Arthur, A. ,  HUANG, Yen-chen ,  JACOBS, Morris, L. ,  MUNSON, John, C. ,  SEMLER, Eric, J. ,  SHIKHANOVICH, Roman ,  STERN, Baruch ,  SUNWOO, Moon, Hae ,  TOMFORD, William, W. ,  YANNARIELLO-BROWN, Judith, I.

IPC: A61K38/18

CPC classification number: A61K9/19 ,  A61K35/32 ,  A61K38/1825 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/602

Abstract: Mixtures, such as gels or pastes, comprising freeze-milled cartilage particles and exogenous growth factors are used for repairing chondral defects. Such mixtures may be applied to constructs comprising cancellous bone for implantation at the defect site. Suitable growth factors include variants of FGF-2, particularly variants that include a sole amino acid substitution for asparagine at amino acid 111 of the β8-β9 loop of the FGF-2 peptide. Such FGF-2 variants are released slowly and continuously at a constant rate from cartilage pastes. In other embodiments, the amino acid substituted for asparigine is glycine. Other variants that may be used include FGF-9 variants having truncated chains and a sole amino acid substitution in the β8-β9 loop of the FGF-9 peptide either for tryptophan at amino acid 144 or for asparagine at amino acid 143.

Abstract translation: 使用包含冷冻研磨的软骨颗粒和外源生长因子的混合物，例如凝胶或糊剂来修复软骨缺陷。 可以将这样的混合物施用于包含用于在缺损部位植入的松质骨的构建体。 合适的生长因子包括FGF-2的变体，特别是在FGF-2肽的β8-β9环的氨基酸111处包括天冬酰胺的唯一氨基酸取代的变体。 这样的FGF-2变体以软骨糊剂的恒定速率缓慢且连续地释放。 在其它实施方案中，取代天冬酰胺的氨基酸是甘氨酸。 可以使用的其它变体包括在FGF-9肽的β8-β9环中具有截短链的FGF-9变体和在氨基酸144处的色氨酸或在氨基酸143处的天冬酰胺的唯一氨基酸取代。

公开(公告)号：WO2009111069A1

公开(公告)日：2009-09-11

申请号：PCT/US2009/001459

申请日：2009-03-05

Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATION ,  TRUNCALE, Katherine, G. ,  SEMLER, Eric, J. ,  GERTZMAN, Arthur, A. ,  SUNWOO, Moon, Hae ,  TOMFORD, William, W. ,  SHIKHANOVICH, Roman ,  CALLAHAN, Alex, B. ,  YANNARIELLO-BROWN, Judith, I. ,  HUANG, Yen-chen ,  JACOBS, Morris, L. ,  MUNSON, John, C.

Inventor： TRUNCALE, Katherine, G. ,  SEMLER, Eric, J. ,  GERTZMAN, Arthur, A. ,  SUNWOO, Moon, Hae ,  TOMFORD, William, W. ,  SHIKHANOVICH, Roman ,  CALLAHAN, Alex, B. ,  YANNARIELLO-BROWN, Judith, I. ,  HUANG, Yen-chen ,  JACOBS, Morris, L. ,  MUNSON, John, C.

IPC: A61F2/28 ,  A61F2/30

CPC classification number: A61F2/30756 ,  A61B17/00491 ,  A61F2/28 ,  A61F2/3094 ,  A61F2/3859 ,  A61F2/3872 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/2842 ,  A61F2002/30057 ,  A61F2002/30059 ,  A61F2002/30062 ,  A61F2002/30224 ,  A61F2002/30225 ,  A61F2002/30227 ,  A61F2002/30233 ,  A61F2002/30235 ,  A61F2002/30327 ,  A61F2002/30331 ,  A61F2002/30354 ,  A61F2002/30387 ,  A61F2002/30448 ,  A61F2002/30459 ,  A61F2002/30461 ,  A61F2002/30492 ,  A61F2002/30604 ,  A61F2002/30759 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/30772 ,  A61F2002/30785 ,  A61F2002/30789 ,  A61F2002/30795 ,  A61F2002/3085 ,  A61F2002/30932 ,  A61F2002/3096 ,  A61F2002/4635 ,  A61F2002/4646 ,  A61F2002/4649 ,  A61F2210/0004 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2220/0066 ,  A61F2220/0075 ,  A61F2230/0069 ,  A61F2250/0039 ,  A61F2310/00365 ,  A61L27/3608 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/48 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/43 ,  A61L2430/06 ,  C08L89/00

Abstract: Constructs that are at least partially constructed of allograft cancellous bone are disclosed, along with cartilage particles that may be used with the constructs for repairing articular cartilage defects. A multi-piece construct (20) includes a base member (22), a cap member (30) and at least one pin (40) that secures the cap member (30) to the base member (20). The base member (22) may be constructed of mineralized cancellous bone, and is used to replace the subchondral bone removed when a surgeon cuts a bore in the area of an adjacent cartilage defect. The base member (22) includes a blind bore (23) and first and second through-going transverse bores (28, 29) in opposite sides of a wall of the base member (22). The cap member (30) includes an upper section (32) that has a thickness that is similar to that of a patient's surrounding articular cartilage layer and a stem (36) depending from the upper section (32) that is dimensioned to be received in and by the blind bore (23) of the base member (22). The stem (36) includes a transverse through-going bore (37), which may be aligned with the transverse through-going bores (28, 29) of the base member (22) to receive the pin (40) therein when the construct (20) has been assembled. The cap member (30) is at least partially formed of demineralized allograft cancellous bone, into which a mixture containing lyophilized, freeze-milled allograft cartilage particles may be infused for the repair of articular cartilage defects. The cartilage particles have a size within a range of from about 10 microns to about 210 microns.

Abstract translation: 公开了至少部分由同种异体移植松质骨构成的构造物，以及可用于修复关节软骨缺损的构建体的软骨颗粒。 多件式构件（20）包括基座构件（22），盖构件（30）和将盖构件（30）固定到基座构件（20）的至少一个销（40）。 基部构件（22）可以由矿化的松质骨构成，并且当外科医生切割相邻软骨缺损区域中的孔时，用于替代去除的软骨下骨。 基部构件（22）在基部构件（22）的壁的相对侧中包括盲孔（23）以及第一和第二穿过横向孔（28,29）。 盖构件（30）包括具有与患者周围的关节软骨层的厚度相似的厚度的上部部分（32），以及从上部（32）悬垂的杆（36），其尺寸设计成被接收在 并且通过基部构件（22）的盲孔（23）。 杆（36）包括横向通孔（37），其可以与基部构件（22）的横向贯穿孔（28,29）对准，以在构件（36）内容纳其中的销（40） （20）已经组装。 盖构件（30）至少部分地由脱矿质的同种异体移植松质骨形成，其中可以注入含有冻干的冷冻研磨的同种异体移植软骨颗粒的混合物用于修复关节软骨缺损。 软骨颗粒的尺寸在约10微米至约210微米的范围内。

公开(公告)号：WO2008013763A2

公开(公告)日：2008-01-31

申请号：PCT/US2007016528

申请日：2007-07-23

Applicant: MUSCULOSKELETAL TRANSPLANT ,  SEMLER ERIC J ,  YANNARIELLO-BROWN JUDITH I ,  JACOBS MORRIS L

Inventor： SEMLER ERIC J ,  YANNARIELLO-BROWN JUDITH I ,  JACOBS MORRIS L

IPC: A61F2/44

CPC classification number: A61F2/442 ,  A61F2/28 ,  A61F2/441 ,  A61F2/4644 ,  A61F2002/30059 ,  A61F2002/3008 ,  A61F2002/30225 ,  A61F2002/30242 ,  A61F2002/30263 ,  A61F2002/30588 ,  A61F2002/30677 ,  A61F2002/444 ,  A61F2002/4495 ,  A61F2002/4649 ,  A61F2230/0069 ,  A61F2230/0071 ,  A61F2230/0084 ,  A61F2250/0098 ,  A61L27/3608 ,  A61L27/3654 ,  A61L27/3658 ,  A61L27/3683 ,  A61L27/56 ,  A61L2430/38

Abstract: A composition for spinal disc repair comprising a plurality of uniformly shaped demineralized cancellous bone pieces ranging in size from about 2.0mm to about 4.0mm loaded into a porous mesh container with the cancellous bone pieces being treated so that they are not osteoinductive and are packed in the porous mesh container under compression forces.

Abstract translation: 一种用于脊椎椎间盘修复的组合物，其包含多个均匀形状的脱矿质松质骨片，其尺寸范围为约2.0mm至约4.0mm，其装载到多孔网状容器中，其中松质骨片被处理，使得它们不是骨诱导性的并且包装在 多孔网状容器受压力。

公开(公告)号：WO2006113586A3

公开(公告)日：2006-10-26

申请号：PCT/US2006/014342

申请日：2006-04-17

Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATION ,  GERTZMAN, Arthur, A. ,  MERBOTH, Barbara, L. ,  SCHULER, Michael, J. ,  STEINER, Anton, J. ,  SEMLER, Eric, J. ,  YANNARIELLO-BROWN, Judith, L.

Inventor： GERTZMAN, Arthur, A. ,  MERBOTH, Barbara, L. ,  SCHULER, Michael, J. ,  STEINER, Anton, J. ,  SEMLER, Eric, J. ,  YANNARIELLO-BROWN, Judith, L.

IPC: A61F2/44

Abstract: A sterile implant for treatment of a spinal disc defect comprising an allograft cortical bone demineralized to a Type I collagen having a specific shape which is treated to eliminate osteoinductivity. The implant is lyophilized and compressed into smaller first shape which 20 to 80% from its original shape in at least one dimension and hardened. The implant expanding when hydrated into a second shape having the shape memory of the first shape and expanded in dimensional size from the first compressed shape.

公开(公告)号：WO2012061024A1

公开(公告)日：2012-05-10

申请号：PCT/US2011/057011

申请日：2011-10-20

Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATION ,  SPINEOLOGY INC. ,  SEMLER, Eric, J. ,  BOYLAN, Clint ,  ROCHE, Karen

Inventor： SEMLER, Eric, J. ,  BOYLAN, Clint ,  ROCHE, Karen

IPC: A61L27/36 ,  A61F2/30

CPC classification number: A61F2/28 ,  A61B17/7095 ,  A61F2/0063 ,  A61F2/441 ,  A61F2/4601 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/30057 ,  A61F2002/30062 ,  A61F2002/30224 ,  A61F2002/30242 ,  A61F2002/30252 ,  A61F2002/30253 ,  A61F2002/30261 ,  A61F2002/30273 ,  A61F2002/30588 ,  A61F2002/30677 ,  A61F2002/444 ,  A61F2002/4635 ,  A61F2002/4646 ,  A61F2002/4649 ,  A61F2310/00976 ,  A61L27/3608 ,  A61L27/3658 ,  A61L27/3683 ,  A61L27/48 ,  A61L27/54 ,  A61L2300/44

Abstract: Implants comprising a plurality of separate cortical bone units (10). which have been at least partially demineralized and are osteoinductive, are described herein. The implants can be used in methods for treating bone. Also, disclosed are methods for treating spinal conditions using these implants. The spinal conditions include but are not limited to repairing damage to or defects in the spine, such as fractures in a vertebral (30) body or degeneration of spinal discs.

Abstract translation: 植入物包括多个分离的皮质骨单元（10）。 其至少部分脱矿质并且是骨诱导的。 植入物可用于治疗骨的方法。 还公开了使用这些植入物治疗脊柱病症的方法。 脊柱病症包括但不限于修复脊柱损伤或脊柱缺损，例如椎体（30）骨折或脊椎椎间盘退变。

公开(公告)号：WO2010083051A9

公开(公告)日：2010-10-28

申请号：PCT/US2010000108

申请日：2010-01-14

Applicant: PROCHON BIOTECH LTD ,  MUSCULOSKELETAL TRANSPLANT ,  YAYON AVNER ,  TRUNCALE KATHERINE G ,  BARKAY-OLAMI HILLA ,  CALLAHAN ALEX B ,  GERTZMAN ARTHUR A ,  HUANG YEN-CHEN ,  JACOBS MORRIS L ,  MUNSON JOHN C ,  SEMLER ERIC J ,  SHIKHANOVICH ROMAN ,  STERN BARUCH ,  SUNWOO MOON HAE ,  TOMFORD WILLIAM W ,  YANNARIELLO-BROWN JUDITH I

Inventor： YAYON AVNER ,  TRUNCALE KATHERINE G ,  BARKAY-OLAMI HILLA ,  CALLAHAN ALEX B ,  GERTZMAN ARTHUR A ,  HUANG YEN-CHEN ,  JACOBS MORRIS L ,  MUNSON JOHN C ,  SEMLER ERIC J ,  SHIKHANOVICH ROMAN ,  STERN BARUCH ,  SUNWOO MOON HAE ,  TOMFORD WILLIAM W ,  YANNARIELLO-BROWN JUDITH I

IPC: A61K35/32 ,  A61K38/18 ,  A61L27/36 ,  A61L27/54

CPC classification number: A61K9/19 ,  A61K35/32 ,  A61K38/1825 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/602

Abstract: Mixtures, such as gels or pastes, comprising freeze-milled cartilage particles and exogenous growth factors are used for repairing chondral defects. Such mixtures may be applied to constructs comprising cancellous bone for implantation at the defect site. Suitable growth factors include variants of FGF-2, particularly variants that include a sole amino acid substitution for asparagine at amino acid 111 of the ß8-ß9 loop of the FGF-2 peptide. Such FGF-2 variants are released slowly and continuously at a constant rate from cartilage pastes. In other embodiments, the amino acid substituted for asparigine is glycine. Other variants that may be used include FGF-9 variants having truncated chains and a sole amino acid substitution in the ß8-ß9 loop of the FGF-9 peptide either for tryptophan at amino acid 144 or for asparagine at amino acid 143.

Abstract translation: 包含冷冻研磨的软骨颗粒和外源生长因子的混合物如凝胶或糊剂用于修复软骨缺陷。 这样的混合物可以应用于包含松质骨的构建体以植入缺损部位。 合适的生长因子包括FGF-2的变体，特别是在FGF-2肽的β8-β9环的氨基酸111处包含天冬酰胺的单一氨基酸取代的变体。 这种FGF-2变体从软骨膏以恒定速率缓慢和连续释放。 在其他实施方案中，取代天冬氨酸的氨基酸是甘氨酸。 可以使用的其他变体包括在FGF-9肽的β8-β9环中具有截短的链和唯一的氨基酸取代的FGF-9变体，其在第144位的氨基酸为色氨酸或第143位的氨基酸为天冬酰胺。

公开(公告)号：WO2009076164A2

公开(公告)日：2009-06-18

申请号：PCT/US2008/085522

申请日：2008-12-04

Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATION ,  SEMLER, Eric, J. ,  TRUNCALE, Katherine, G. ,  CALLAHAN, Alex, B. ,  SHIKHANOVICH, Roman

Inventor： SEMLER, Eric, J. ,  TRUNCALE, Katherine, G. ,  CALLAHAN, Alex, B. ,  SHIKHANOVICH, Roman

IPC: A61F2/30

CPC classification number: A61F2/28 ,  A61F2/30756 ,  A61F2/3859 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/30057 ,  A61F2002/30059 ,  A61F2002/30225 ,  A61F2002/30227 ,  A61F2002/30233 ,  A61F2002/30235 ,  A61F2002/30327 ,  A61F2002/30354 ,  A61F2002/30448 ,  A61F2002/30492 ,  A61F2002/30604 ,  A61F2002/30616 ,  A61F2002/30759 ,  A61F2002/30764 ,  A61F2002/30766 ,  A61F2002/30772 ,  A61F2002/30789 ,  A61F2002/30795 ,  A61F2002/30932 ,  A61F2002/3096 ,  A61F2002/4635 ,  A61F2002/4646 ,  A61F2002/4649 ,  A61F2002/4681 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2230/0069 ,  A61F2250/0039 ,  A61F2310/00017 ,  A61F2310/00179 ,  A61F2310/00365 ,  A61L27/3608 ,  A61L27/3654 ,  A61L27/3683 ,  A61L27/3804 ,  A61L27/3852 ,  A61L27/54 ,  A61L2300/25 ,  A61L2300/414

Abstract: The invention is directed toward a cartilage repair assembly (10) comprising a shaped allograft construct comprising a cylindrical mineralized cancellous bone base member (12) and a demineralized cancellous bone cap member (20) having a cylindrical top portion (22) and a stem (26) extending from the top portion (22) mounted to the bone base member (12). The base member (12) has a central bore (14) and a transverse bore (16) which intersects the central bore (14) and the cap member stem (26) has a through-going bore (28) which is aligned with the base member transverse bore (16) when the stem (26) is mounted in the central bore (14) to receive a pin member (30). Milled cartilage particles having a size ranging from 10 to 212 microns are mixed with a biocompatible carrier and a cartilage growth factor, with the mixture being infused in the cap member (20) to generate cartilage growth.

Abstract translation: 本发明涉及一种软骨修复组件（10），其包括成形的同种异体移植物构建体，其包括圆柱形矿化的松质骨基底构件（12）和具有圆柱形顶部部分（22）和茎（22）的软化软骨骨盖构件（20） 26），其从安装到所述骨基部构件（12）的顶部（22）延伸。 基部构件（12）具有与中心孔（14）相交的中心孔（14）和横向孔（16），并且盖构件杆（26）具有贯穿孔（28），其与 当杆（26）安装在中心孔（14）中以接收销构件（30）时，基部构件横向孔（16）。 具有10至212微米尺寸的研磨软骨颗粒与生物相容性载体和软骨生长因子混合，将混合物注入盖构件（20）中以产生软骨生长。

公开(公告)号：WO2011031642A3

公开(公告)日：2011-03-17

申请号：PCT/US2010/047881

申请日：2010-09-03

Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATION INC. ,  SEMLER, Eric, J. ,  GERTZMAN, Arthur, A. ,  HUANG, Yen-chen ,  YANNARIELLO-BROWN, Judith ,  TRUNCALE, Katherine, Gomes

Inventor： SEMLER, Eric, J. ,  GERTZMAN, Arthur, A. ,  HUANG, Yen-chen ,  YANNARIELLO-BROWN, Judith ,  TRUNCALE, Katherine, Gomes

IPC: A61L27/22 ,  A61L27/36 ,  A61L27/38 ,  A61L27/48 ,  A61F2/38 ,  A61K35/32

Abstract: A meniscus repair composition for application to a meniscus injury to promote growth of new tissue at the meniscus injury site is provided. The composition comprises: from about 10 to about 50 percent by weight of allograft meniscus particles having an average particle size of from about 10 μm to about 500 μm; and a carrier comprising a solid fibrin web matrix. When introduced to a defect site in a meniscus, the composition is non-adhering to the defect site. A method for repairing a meniscus injury comprises administering a meniscus repair composition to the injury site.

Abstract translation: 提供了用于半月板损伤以促进半月板损伤部位新组织生长的半月板修复组合物。 该组合物包含：约10至约50重量％的平均粒度为约10μm至约500μm的同种异体移植物半月板颗粒; 和包含固体纤维蛋白网基质的载体。 当被引入到半月板中的缺陷部位时，组合物不粘附到缺陷部位。 修复半月板损伤的方法包括将半月板修复组合物给予损伤部位。

公开(公告)号：WO2011031642A2

公开(公告)日：2011-03-17

申请号：PCT/US2010047881

申请日：2010-09-03

Applicant: MUSCULOSKELETAL TRANSPLANT ,  SEMLER ERIC J ,  GERTZMAN ARTHUR A ,  HUANG YEN-CHEN ,  YANNARIELLO-BROWN JUDITH ,  TRUNCALE KATHERINE GOMES

Inventor： SEMLER ERIC J ,  GERTZMAN ARTHUR A ,  HUANG YEN-CHEN ,  YANNARIELLO-BROWN JUDITH ,  TRUNCALE KATHERINE GOMES

IPC: A61L27/22

CPC classification number: A61L27/3616 ,  A61F2/30756 ,  A61F2/3872 ,  A61F2002/30762 ,  A61K35/32 ,  A61K38/1841 ,  A61L27/225 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/38 ,  A61L27/3817 ,  A61L27/48 ,  A61L2430/06 ,  A61K2300/00

Abstract: A meniscus repair composition for application to a meniscus injury to promote growth of new tissue at the meniscus injury site is provided. The composition comprises: from about 10 to about 50 percent by weight of allograft meniscus particles having an average particle size of from about 10 µm to about 500 µm; and a carrier comprising a solid fibrin web matrix. When introduced to a defect site in a meniscus, the composition is non-adhering to the defect site. A method for repairing a meniscus injury comprises administering a meniscus repair composition to the injury site.

Abstract translation: 提供一种用于应用于半月板损伤以促进半月板损伤部位新组织生长的半月板修复组合物。 组合物包含：约10至约50重量％的平均粒度为约10μm至约500μm的同种异体移植物弯月面颗粒; 和包含固体纤维蛋白网状基质的载体。 当引入弯液面中的缺陷部位时，组合物不粘附于缺陷部位。 修复半月板损伤的方法包括向损伤部位施用半月板修复组合物。