公开(公告)号：WO2013029009A1

公开(公告)日：2013-02-28

申请号：PCT/US2012/052350

申请日：2012-08-24

Applicant: NOVAN, INC. ,  THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL ,  SCHOENFISCH, Mark ,  LU, Yuan ,  STASKO, Nathan ,  BAO, Jian

Inventor： SCHOENFISCH, Mark ,  LU, Yuan ,  STASKO, Nathan ,  BAO, Jian

IPC: C07C245/00

CPC classification number: C07C281/20 ,  A61K31/655 ,  C07C247/10 ,  C07C291/02 ,  Y10T428/2982

Abstract: Provided here are nitric oxide-releasing compounds that include at least two different NO donor functional groups of the same class. In some embodiments, such nitric oxide-releasing compounds are macromolecules such as dendrimer and co-condensed silica. Pharmaceutical compositions, wound dressings, kits and methods of treatments are also provided herein.

Abstract translation: 这里提供一氧化氮释放化合物，其包括相同类别的至少两个不同的NO供体官能团。 在一些实施方案中，这种释放氧化氮的化合物是大分子如树枝状聚合物和共缩合二氧化硅。 本文还提供药物组合物，伤口敷料，试剂盒和治疗方法。

公开(公告)号：WO2012082976A1

公开(公告)日：2012-06-21

申请号：PCT/US2011/065043

申请日：2011-12-15

Applicant: NOVAN, INC. ,  BAUMAN, Susanne ,  STASKO, Nathan

Inventor： BAUMAN, Susanne ,  STASKO, Nathan

IPC: A61K8/30

CPC classification number: A61K38/063 ,  A61K31/131 ,  A61K31/197 ,  A61K31/80 ,  A61K33/00 ,  A61K45/06 ,  A61K2300/00

Abstract: Provided herein are methods of using gaseous nitric oxide and/or at least one nitric oxide source to or decrease sebum production in the skin of a subject. In some embodiments, the nitric oxide source includes small molecule and/or macromolecular NO-releasing compounds.

Abstract translation: 本文提供了使用气体一氧化氮和/或至少一种一氧化氮源来或减少受试者皮肤中产生皮脂的方法。 在一些实施方案中，一氧化氮源包括小分子和/或大分子释放NO的化合物。

公开(公告)号：WO2013006613A1

公开(公告)日：2013-01-10

申请号：PCT/US2012/045390

申请日：2012-07-03

Applicant: NOVAN, INC. ,  KOUGOULOS, Eleftherios ,  STASKO, Nathan

Inventor： KOUGOULOS, Eleftherios ,  STASKO, Nathan

IPC: A61K9/00

CPC classification number: A61K31/655 ,  A61K9/0014 ,  A61K47/10 ,  A61K47/20 ,  A61K47/34 ,  A61K47/38 ,  B01F7/00008 ,  B01F7/164 ,  B01F15/00012 ,  B01F15/00071 ,  B01F15/02 ,  B01F15/06

Abstract: Provided according to some embodiments of the invention are methods of manufacturing a pharmaceutical composition. In some embodiments, such methods include homogenizing at a first excipient composition that includes a viscosity agent and at least one solvent to form a first premix composition; separately homogenizing at least one active pharmaceutical ingredient (API) and a second excipient composition to form a second premix composition; and combining the first premix composition and the second premix composition to form the composition. The pre-mixing of constituents may increase the stability of the API and provide uniformity of the dispersion of the constituents throughout the final topical composition.

Abstract translation: 根据本发明的一些实施方案提供的是制备药物组合物的方法。 在一些实施方案中，这些方法包括在包含粘度剂和至少一种溶剂的第一赋形剂组合物上均化以形成第一预混物组合物; 分别均化至少一种活性药物成分（API）和第二赋形剂组合物以形成第二预混物组合物; 以及组合第一预混组合物和第二预混物组合物以形成组合物。 组分的预混合可以增加API的稳定性并提供组分在整个最终局部组合物中的分散体的均匀性。

公开(公告)号：WO2012118819A2

公开(公告)日：2012-09-07

申请号：PCT/US2012/026960

申请日：2012-02-28

Applicant: NOVAN, INC. ,  THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL ,  SCHOENFISCH, Mark ,  RICCIO, Daniel ,  NUGENT, Julia ,  STASKO, Nathan

Inventor： SCHOENFISCH, Mark ,  RICCIO, Daniel ,  NUGENT, Julia ,  STASKO, Nathan

IPC: C09D183/08 ,  C07F7/10

CPC classification number: A61L2/18 ,  C07F7/0874 ,  C07F7/10 ,  C07F7/1836 ,  C08G77/26 ,  C08G77/28 ,  C08K3/28 ,  C08K3/30 ,  C08K2003/023 ,  Y10T428/2982

Abstract: Provided according to some embodiments of the invention are methods of forming co-condensed silica particles. In some embodiments, the methods include reacting a thiol-containing silane and a backbone alkoxysilane in a reaction solution that comprises water to form thiol-functionalized co-condensed silica particles, wherein the thiol-functionalized co-condensed silica particles include a polysiloxane matrix and at least some of thiol groups are present within the polysiloxane matrix; and reacting the thiol-functionalized co-condensed silica particles with a nitrosating agent to provide the S-nitrosothiol-functionalized co-condensed silica particles. In some embodiments, provided are S-nitrosothiol-functionalized co-condensed silica particles.

Abstract translation: 根据本发明的一些实施方案提供了形成共缩合二氧化硅颗粒的方法。 在一些实施方案中，所述方法包括在包含水以形成硫醇官能化的共缩合二氧化硅颗粒的反应溶液中使含硫醇的硅烷和骨架烷氧基硅烷反应，其中硫醇官能化的共缩合二氧化硅颗粒包括聚硅氧烷基质和 至少一些硫醇基团存在于聚硅氧烷基质内; 并使硫醇官能化的共缩合二氧化硅颗粒与亚硝化剂反应以提供S-亚硝基硫醇官能化的共缩合二氧化硅颗粒。 在一些实施方案中，提供了S-亚硝基硫醇官能化的共缩合二氧化硅颗粒。

公开(公告)号：WO2012118819A3

公开(公告)日：2014-04-17

申请号：PCT/US2012026960

申请日：2012-02-28

Applicant: NOVAN INC ,  UNIV NORTH CAROLINA ,  SCHOENFISCH MARK ,  RICCIO DANIEL ,  NUGENT JULIA ,  STASKO NATHAN

Inventor： SCHOENFISCH MARK ,  RICCIO DANIEL ,  NUGENT JULIA ,  STASKO NATHAN

IPC: A01N59/00

CPC classification number: A61L2/18 ,  C07F7/0874 ,  C07F7/10 ,  C07F7/1836 ,  C08G77/26 ,  C08G77/28 ,  C08K3/28 ,  C08K3/30 ,  C08K2003/023 ,  Y10T428/2982

Abstract: Provided according to some embodiments of the invention are methods of forming co-condensed silica particles. In some embodiments, the methods include reacting a thiol-containing silane and a backbone alkoxysilane in a reaction solution that comprises water to form thiol-functionalized co-condensed silica particles, wherein the thiol-functionalized co-condensed silica particles include a polysiloxane matrix and at least some of thiol groups are present within the polysiloxane matrix; and reacting the thiol-functionalized co-condensed silica particles with a nitrosating agent to provide the S-nitrosothiol-functionalized co-condensed silica particles. In some embodiments, provided are S-nitrosothiol-functionalized co-condensed silica particles.

Abstract translation: 根据本发明的一些实施方案提供了形成共缩合二氧化硅颗粒的方法。 在一些实施方案中，所述方法包括在包含水以形成硫醇官能化的共缩合二氧化硅颗粒的反应溶液中使含硫醇的硅烷和骨架烷氧基硅烷反应，其中硫醇官能化的共缩合二氧化硅颗粒包括聚硅氧烷基质和 至少一些硫醇基团存在于聚硅氧烷基质内; 并使硫醇官能化的共缩合二氧化硅颗粒与亚硝化剂反应以提供S-亚硝基硫醇官能化的共缩合二氧化硅颗粒。 在一些实施方案中，提供了S-亚硝基硫醇官能化的共缩合二氧化硅颗粒。

公开(公告)号：WO2013006608A1

公开(公告)日：2013-01-10

申请号：PCT/US2012/045384

申请日：2012-07-03

Applicant: NOVAN, INC. ,  DOXEY, Ryan ,  STASKO, Nathan

Inventor： DOXEY, Ryan ,  STASKO, Nathan

IPC: A61K9/16

CPC classification number: A61K31/695 ,  A61K8/34 ,  A61K8/345 ,  A61K8/368 ,  A61K8/40 ,  A61K8/585 ,  A61K8/731 ,  A61K8/891 ,  A61K9/0014 ,  A61K9/143 ,  A61K47/10 ,  A61K47/20 ,  A61K47/34 ,  A61K47/38 ,  A61K2800/22 ,  A61K2800/31 ,  A61K2800/56 ,  A61K2800/592 ,  A61Q19/00

Abstract: Provided herein are anhydrous compositions that include at least one viscosity increasing agent, at least one organic solvent and at least one humectant. Such compositions may also include at least one active pharmaceutical ingredient (API) and/or at least one water repellant. Related compositions, methods and kits are also provided.

Abstract translation: 本文提供的是包含至少一种增粘剂，至少一种有机溶剂和至少一种湿润剂的无水组合物。 这样的组合物还可以包括至少一种活性药物成分（API）和/或至少一种防水剂。 还提供了相关的组合物，方法和试剂盒。

公开(公告)号：WO2012100174A1

公开(公告)日：2012-07-26

申请号：PCT/US2012/022048

申请日：2012-01-20

Applicant: NOVAN, INC. ,  BAO, Jian ,  STASKO, Nathan

Inventor： BAO, Jian ,  STASKO, Nathan

IPC: C08G77/26

CPC classification number: C08G77/26 ,  C08G77/06

Abstract: Provided according to some embodiments of the invention are methods of making co-condensed macromolecules that include forming a reaction mixture by combining at least one reactant and at least one reagent at a first temperature at which the at least one reactant is substantially unreactive in the presence of the at least one reagent; raising the temperature of the reaction mixture to a second temperature at which the at least one reactant is reactive in the presence of the at least one reagent, wherein the reaction of the at least one reactant in the presence of the at least one reagent produces co-condensed macromolecules such as co-condensed silica macromolecules.

Abstract translation: 根据本发明的一些实施方案提供的是制备共缩合大分子的方法，其包括通过在至少一种反应物在存在下基本上不反应的第一温度下组合至少一种反应物和至少一种试剂来形成反应混合物 的所述至少一种试剂; 将所述反应混合物的温度升高至所述至少一种反应物在所述至少一种试剂存在下具有反应性的第二温度，其中所述至少一种反应物在所述至少一种试剂存在下的反应产生共聚物 稠化大分子如共缩合二氧化硅大分子。

公开(公告)号：WO2006128121A2

公开(公告)日：2006-11-30

申请号：PCT/US2006020781

申请日：2006-05-30

Applicant: UNIV NORTH CAROLINA ,  SCHOENFISCH MARK H ,  HO SHIN JAE ,  STASKO NATHAN

Inventor： SCHOENFISCH MARK H ,  HO SHIN JAE ,  STASKO NATHAN

IPC: A61K31/198

CPC classification number: C07F7/10 ,  A61K9/14 ,  A61K9/167 ,  A61K9/5115 ,  A61K31/695 ,  A61K41/0042 ,  A61K47/59 ,  A61K47/6923 ,  A61K47/6929 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y30/00 ,  C07F7/18

Abstract: The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.

Abstract translation: 目前公开的主题涉及用于输送一氧化氮的一氧化氮释放颗粒及其在生物医学和药物应用中的用途。

公开(公告)号：WO2011022680A2

公开(公告)日：2011-02-24

申请号：PCT/US2010046209

申请日：2010-08-20

Applicant: NOVAN INC ,  STASKO NATHAN ,  BAUMAN SUSANNE ,  JOSHI PRANAV R

Inventor： STASKO NATHAN ,  BAUMAN SUSANNE ,  JOSHI PRANAV R

IPC: A61L15/22

CPC classification number: A61L15/44 ,  A61L15/225 ,  A61L15/425 ,  A61L2300/114 ,  A61L2300/45 ,  A61L2300/602 ,  C08L83/04 ,  C08L75/04

Abstract: Provided according to some embodiments of the invention are wound dressings that include a polymer matrix and nitric oxide-releasing polysiloxane macromolecules within and/or on the polymer matrix. Also provided are wound dressing kits and methods of using and forming such wound dressings.

Abstract translation: 根据本发明的一些实施方式提供了伤口敷料，其包括聚合物基质内和/或聚合物基质上的聚合物基质和释放一氧化氮的聚硅氧烷大分子。 还提供了伤口敷料套件以及使用和形成这种伤口敷料的方法。

公开(公告)号：WO2011022652A1

公开(公告)日：2011-02-24

申请号：PCT/US2010/046173

申请日：2010-08-20

Applicant: NOVAN, INC. ,  STASKO, Nathan ,  BAUMAN, Susanne ,  JOSHI, Pranav R.

Inventor： STASKO, Nathan ,  BAUMAN, Susanne ,  JOSHI, Pranav R.

IPC: A61K9/06 ,  A61P17/02 ,  A61P17/10 ,  A61K31/655 ,  A61K33/00 ,  A61K47/34 ,  A61K47/48

CPC classification number: A61K31/80 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/655 ,  A61K33/00 ,  A61K47/24 ,  A61K47/48192 ,  A61K47/48784 ,  A61K47/59 ,  A61K47/6903 ,  A61K2300/00

Abstract: Provided according to some embodiments of the invention are topical gels that may release nitric oxide. Also provided are methods of using such topical gels in the treatment of wounds and other skin ailments. The topical gels comprise diazeniutndiolate-functionalized polysiloxane macromolecules.

Abstract translation: 根据本发明的一些实施方案提供的是可释放一氧化氮的局部凝胶。 还提供了使用这种局部凝胶来治疗伤口和其它皮肤疾病的方法。 局部凝胶包含二氮烯二硬脂酸官能化聚硅氧烷大分子。