公开(公告)号：WO2008039186A3

公开(公告)日：2009-04-23

申请号：PCT/US2006037483

申请日：2006-09-26

Applicant: PLENSAT LLC ,  STERLING BERNHARD B

Inventor： STERLING BERNHARD B ,  MILLS ALEXANDER K

IPC: A61K9/12 ,  A61K9/20 ,  A61K9/46

CPC classification number: A61F5/0036

Abstract: The invention comprises a gastric device having an outer region and a gas producing material. The gastric device hydrates within a patient's stomach and the gas producing material expands the device to a greater volume. Accordingly, the volume of the hydrated, expanded gastric devices occupy space in the stomach cavity and reduce the amount of food the patient will ingest before reaching the feeling of fullness. Preferably, the gastric device is made from food grade materials. The gastric device is configured to expand to a desired volume and then degrade after a residence time, allowing the device to be passed by the patient's normal digestive process.

Abstract translation: 本发明包括具有外部区域和气体产生材料的胃装置。 胃装置中的胃装置在患者的胃中水化，并且气体生成材料将装置扩大到更大的体积。 因此，水合，扩张的胃装置的体积占据胃腔中的空间，并减少患者在达到饱腹感之前摄取的食物量。 优选地，胃装置由食品级材料制成。 胃装置被配置为扩张到期望的体积，然后在停留时间后降解，允许装置通过患者的正常消化过程。

公开(公告)号：WO2009032073A1

公开(公告)日：2009-03-12

申请号：PCT/US2008/009925

申请日：2008-08-20

Applicant: WOOLSTHORPE, LLC ,  STERLING, Bernhard, B. ,  VOSS, Gregory, I. ,  PERRY, James, M. ,  CLINTON, Rankin, A., III ,  LAWRENCE, Andrew, R.

Inventor： STERLING, Bernhard, B. ,  VOSS, Gregory, I. ,  PERRY, James, M. ,  CLINTON, Rankin, A., III ,  LAWRENCE, Andrew, R.

IPC: A61B5/00

CPC classification number: A61B5/6838 ,  A61B5/14551 ,  A61B5/1491 ,  A61B5/6816 ,  A61B5/6826

Abstract: A non-invasive method of determining a physiological characteristic, comprising providing at least one physiological sensor that is adapted to measure at least one physiological characteristic at a target measurement site on a subject's body, heating an extended tissue region on the subject's body, whereby blood perfusion of the tissue region is enhanced, and measuring at least one physiological characteristic with the physiological sensor during or within a predetermined period after heating the extended tissue region.

Abstract translation: 一种确定生理特征的非侵入性方法，包括提供至少一个生理传感器，其适于测量受试者身体上的目标测量部位上的至少一种生理特征，加热受试者身体上延伸的组织区域，由此血液 增强组织区域的灌注，并且在加热延伸的组织区域之后或期间的预定时间段内测量与生理传感器的至少一个生理特征。

公开(公告)号：WO2008064130A3

公开(公告)日：2008-08-14

申请号：PCT/US2007085001

申请日：2007-11-16

Applicant: BLOOM MATTHEW B ,  STERLING BERNHARD B

Inventor： BLOOM MATTHEW B ,  STERLING BERNHARD B

IPC: A61B5/00 ,  G01N21/35

CPC classification number: A61B5/0075 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/444 ,  A61B5/445 ,  A61B5/7275 ,  G01N21/35

Abstract: Disclosed are methods of determining long-term deposition pattern of a compound in tissue. The following steps can be followed: placing tissue against a receptor; directing mid- infrared electromagnetic radiation onto the tissue; quantifying the electromagnetic radiation that is reflected from the tissue to obtain a reflected amount; using a calibration equation to calculate the concentration of a compound from the reflected amount; and using the concentration of the compound to evaluate presence of a clinical condition in the tissue.

Abstract translation: 公开了确定组织中化合物的长期沉积模式的方法。 可以遵循以下步骤：将组织贴靠在受体上; 将中红外电磁辐射引导到组织上; 量化从组织反射的电磁辐射以获得反射量; 使用校准方程从反射量计算化合物的浓度; 并使用该化合物的浓度来评估组织中临床病症的存在。

公开(公告)号：WO2008039187A1

公开(公告)日：2008-04-03

申请号：PCT/US2006/037484

申请日：2006-09-26

Applicant: WOOLSTHORPE TECHNOLOGIES, LLC ,  STERLING, Bernhard, B.

Inventor： STERLING, Bernhard, B.

IPC: A61B5/00 ,  A61B5/02

CPC classification number: A61B5/14551 ,  A61B5/7207

Abstract: The invention comprises a method and apparatus for processing signals reflecting a physiological characteristic by detecting the intensity of light following tissue absorption at two wavelengths and subtracting the best estimate of the desired signal from the difference between the signals. Corrected first and second intensity signals are determined by applying a residual derived from a combination of the first and second intensity signals as multiplied by a residual factor and subtracted from a difference between the first and second intensity signals to the first and second intensity signals. In one embodiment, the method and apparatus are used to determine arterial oxygen saturation.

Abstract translation: 本发明包括一种用于通过检测在两个波长的组织吸收之后的光的强度来处理反映生理特征的信号的方法和装置，并且从信号之间的差中减去所需信号的最佳估计。 通过将从第一和第二强度信号的组合导出的残差乘以残差因子并从第一和第二强度信号之间的差减去第一和第二强度信号来确定校正的第一和第二强度信号。 在一个实施例中，使用该方法和装置来确定动脉血氧饱和度。

公开(公告)号：WO2007044492A2

公开(公告)日：2007-04-19

申请号：PCT/US2006/039058

申请日：2006-10-04

Applicant: OPTISCAN BIOMEDICAL CORPORATION ,  STERLING, Bernhard, B. ,  GABLE, Jennifer, H. ,  BRAIG, James, R. ,  WECHSLER, Mark ,  ZHENG, Peng ,  RULE, Peter ,  KEENAN, Richard

Inventor： STERLING, Bernhard, B. ,  GABLE, Jennifer, H. ,  BRAIG, James, R. ,  WECHSLER, Mark ,  ZHENG, Peng ,  RULE, Peter ,  KEENAN, Richard

IPC: A61B5/15 ,  A61M5/172

CPC classification number: A61B5/14546 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/4839 ,  A61M5/14212 ,  A61M2230/20 ,  G01N35/1095

Abstract: In certain embodiments, a method samples a body fluid of a patient. The method includes providing a fluid handling system having one or more fluid passageways. The method further includes infusing an infusion fluid by way of a fluid handling system into a patient through one or more fluid passageways. The method further includes obtaining a sample of body fluid by way of a fluid handling system from a patient through one or more fluid passageways. The obtained sample is no more than 5 milliliters in volume. The method further includes analyzing at least an analyzed portion of the obtained sample by way of an analyte detection system operatively associated with the fluid handling system to determine a concentration of at least one analyte.

Abstract translation: 在某些实施方案中，方法对患者的体液进行取样。 该方法包括提供具有一个或多个流体通道的流体处理系统。 该方法还包括通过流体处理系统通过一个或多个流体通道将输注流体输入患者体内。 该方法还包括通过来自患者的流体处理系统通过一个或多个流体通道获得体液样品。 所得样品的体积不超过5毫升。 该方法还包括通过可操作地与流体处理系统相关联的分析物检测系统分析所获得的样品的至少一部分分析物，以确定至少一种分析物的浓度。

公开(公告)号：WO2006088792A3

公开(公告)日：2007-03-01

申请号：PCT/US2006005027

申请日：2006-02-13

Applicant: OPTISCAN BIOMEDICAL CORP ,  STERLING BERNHARD B ,  HALL W DALE ,  CALLICOAT DAVID N ,  GABLE JENNIFER H ,  BRAIG JAMES R ,  WITTE KENNETH G ,  WECHSLER MARK ,  ZHENG PENG ,  RULE PETER ,  KEENAN RICHARD ,  KING RICHARD A

Inventor： STERLING BERNHARD B ,  HALL W DALE ,  CALLICOAT DAVID N ,  GABLE JENNIFER H ,  BRAIG JAMES R ,  WITTE KENNETH G ,  WECHSLER MARK ,  ZHENG PENG ,  RULE PETER ,  KEENAN RICHARD ,  KING RICHARD A

IPC: A61B5/15

CPC classification number: A61M5/1723 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M2205/12 ,  A61M2230/20 ,  A61M2230/201 ,  G01N1/14 ,  G01N21/05 ,  G01N21/274 ,  G01N21/35 ,  G01N2021/0346

Abstract: An apparatus (10) for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end (11) configured to maintain fluid communication with a bodily fluid in a patient and at least one pump (203) intermittently operable to draw a sample of bodily fluid from the patient. The apparatus further comprises a fluid analyzer (140) positioned to analyze at least a portion of the sample and measure the presence of two or more analytes . Also disclosed is a method for analyzing the composition of a bodily fluid in a patient. The method comprises drawing a sample of the bodily fluid of the patient through a fluid handling network configured to maintain fluid communication with a bodily fluid in a patient. The method further comprises analyzing the at least a portion of the sample in a fluid analyzer to estimate the concentration of two or more analytes in the sample. Disclosed are further means for separating plasma and serum and a spectroscopic analyzer.

Abstract translation: 一种用于分析体液组成的装置（10）。 该装置包括流体处理网络，其包括被配置为保持与患者体内的体液的流体连通的患者端部（11），以及间歇地可操作以从患者抽取体液样本的至少一个泵（203）。 该装置还包括流体分析器（140），其定位成分析样品的至少一部分并测量两种或多种分析物的存在。 还公开了一种用于分析患者体液组成的方法。 该方法包括通过流体处理网络来绘制患者的体液样本，流体处理网络被配置为保持患者体内与体液的流体连通。 该方法还包括在流体分析仪中分析样品的至少一部分以估计样品中两种或多种分析物的浓度。 公开了用于分离血浆和血清和光谱分析仪的进一步手段。

公开(公告)号：WO2004092715A1

公开(公告)日：2004-10-28

申请号：PCT/US2004/011693

申请日：2004-04-15

Applicant: OPTISCAN BIOMEDICAL CORPORATION ,  BRAIG, James, R. ,  LI, Ken, I. ,  STERLING, Bernhard, B. ,  RULE, Peter ,  HARTSTEIN, Philip, C.

Inventor： BRAIG, James, R. ,  LI, Ken, I. ,  STERLING, Bernhard, B. ,  RULE, Peter ,  HARTSTEIN, Philip, C.

IPC: G01N21/86

CPC classification number: G01N21/8483 ,  G01N21/03 ,  G01N21/0303 ,  G01N21/3577 ,  G01N2021/0346

Abstract: A system and method are provided for determining a concentration of an analyte in a material sample. The method includes providing a sample element with a sample chamber at least partially defined by at least one window formed from a material having greater than about 1% wavelength-domain variation in absorbtivity of electromagnetic radiation incident thereon. The methot further includes employing the sample element with an analyte detection system which determines the concentration of the analyte with clinically acceptable accuracy.

Abstract translation: 提供了用于确定材料样品中分析物浓度的系统和方法。 所述方法包括提供样品室，所述样品室至少部分地由至少一个窗口形成，所述至少一个窗口由从其入射的电磁辐射的吸收率具有大于约1％的波长域的变化的材料形成。 甲基还包括使用样品元件分析物检测系统，其以临床可接受的精度确定分析物的浓度。

公开(公告)号：WO2003016865A2

公开(公告)日：2003-02-27

申请号：PCT/US2002/026190

申请日：2002-08-15

Applicant: OPTISCAN BIOMEDICAL CORPORATION ,  BRAIG, James, R. ,  RULE, Peter ,  STERLING, Bernhard, B. ,  SMITH, Heidi, M. ,  CORTELLA, Julian, M. ,  GABLE, Jennifer, H.

Inventor： BRAIG, James, R. ,  RULE, Peter ,  STERLING, Bernhard, B. ,  SMITH, Heidi, M. ,  CORTELLA, Julian, M. ,  GABLE, Jennifer, H.

IPC: G01N

CPC classification number: A61B5/1495 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1491

Abstract: A method calibrates a monitor (100) that comprises a non-invasive blood constituent monitor (102) and a traditional measurement system (116). The non-invasive blood constituent monitor includes a thermal gradient inducing element (110) an analyzer window (108). A traditional monitor output representing a property of a blood constituent is generated by the traditional measurement system. A non-invasive monitor output representing the property of the whole blood constituent is generated by the non-invasive constituent monitor. The traditional monitor output and the non-invasive monitor output are compared to estimate an amount of error. The non-invasive monitor output is corrected by the amount of error.

Abstract translation: 一种校准包括非侵入性血液成分监测器（102）和传统测量系统（116）的监测器（100）。 非侵入性血液成分监测器包括热梯度诱导元件（110）分析器窗口（108）。 由传统的测量系统产生代表血液成分属性的传统监视器输出。 代表全血成分的性质的非侵入性监测输出是由非侵入性成分监测器产生的。 将传统的监视器输出和非侵入式监视器输出进行比较，以估计误差量。 非侵入性监视器输出由误差量校正。

公开(公告)号：WO2008039195A1

公开(公告)日：2008-04-03

申请号：PCT/US2006/037914

申请日：2006-09-27

Applicant: WOOLSTHORPE TECHNOLOGIES, LLC ,  STERLING, Bernhard, B.

Inventor： STERLING, Bernhard, B.

IPC: A61B5/00

CPC classification number: A61B5/14551 ,  A61B5/1495 ,  A61B2560/0223

Abstract: The invention is method and apparatus for determining a physiological characteristic by detecting the intensity of light following tissue absorption at two wavelengths, estimating the pulse amplitude and indexing a calculated physiological characteristic to the estimated pulse amplitude. In one embodiment, the ratio of logarithms of absorbance signal amplitude is indexed to the pulse amplitude to improve the accuracy of arterial oxygen saturation as determined by a pulse oximeter.

Abstract translation: 本发明是通过检测在两个波长的组织吸收之后的光的强度来确定生理特性的方法和装置，估计脉冲幅度并将计算的生理特征指数与估计的脉冲幅度相关。 在一个实施例中，将吸光度信号幅度的对数比率指数为脉冲幅度，以提高由脉搏血氧计确定的动脉血氧饱和度的准确度。

公开(公告)号：WO2008039186A2

公开(公告)日：2008-04-03

申请号：PCT/US2006/037483

申请日：2006-09-26

Applicant: PLENSAT, LLC ,  STERLING, Bernhard, B.

Inventor： STERLING, Bernhard, B.

IPC: A61F2/02

CPC classification number: A61F5/0036

Abstract: The invention comprises a gastric device having an outer region and a gas producing material. The gastric device hydrates within a patient's stomach and the gas producing material expands the device to a greater volume. Accordingly, the volume of the hydrated, expanded gastric devices occupy space in the stomach cavity and reduce the amount of food the patient will ingest before reaching the feeling of fullness. Preferably, the gastric device is made from food grade materials. The gastric device is configured to expand to a desired volume and then degrade after a residence time, allowing the device to be passed by the patient's normal digestive process.

Abstract translation: 本发明包括具有外部区域和气体产生材料的胃装置。 胃装置中的胃装置在患者的胃中水化，并且气体生成材料将装置扩大到更大的体积。 因此，水合，扩张的胃装置的体积占据胃腔中的空间，并减少患者在达到饱腹感之前摄取的食物量。 优选地，胃装置由食品级材料制成。 胃装置被配置为扩张到期望的体积，然后在停留时间后降解，允许装置通过患者的正常消化过程。