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公开(公告)号：WO2008064130A3
公开(公告)日：2008-08-14
申请号：PCT/US2007085001
申请日：2007-11-16
Applicant: BLOOM MATTHEW B , STERLING BERNHARD B
Inventor： BLOOM MATTHEW B , STERLING BERNHARD B
CPC classification number: A61B5/0075 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/444 , A61B5/445 , A61B5/7275 , G01N21/35
Abstract: Disclosed are methods of determining long-term deposition pattern of a compound in tissue. The following steps can be followed: placing tissue against a receptor; directing mid- infrared electromagnetic radiation onto the tissue; quantifying the electromagnetic radiation that is reflected from the tissue to obtain a reflected amount; using a calibration equation to calculate the concentration of a compound from the reflected amount; and using the concentration of the compound to evaluate presence of a clinical condition in the tissue.
Abstract translation: 公开了确定组织中化合物的长期沉积模式的方法。 可以遵循以下步骤：将组织贴靠在受体上; 将中红外电磁辐射引导到组织上; 量化从组织反射的电磁辐射以获得反射量; 使用校准方程从反射量计算化合物的浓度; 并使用该化合物的浓度来评估组织中临床病症的存在。
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公开(公告)号：WO2008039193A2
公开(公告)日：2008-04-03
申请号：PCT/US2006037754
申请日：2006-09-26
Applicant: PLENSAT LLC , MILLS DONNA , STERLING BERNHARD B
Inventor： STERLING BERNHARD B , MILLS ALEXANDER K
IPC: A61F2/02
CPC classification number: A61F5/003 , A61B17/12022 , A61B17/12099 , A61B17/1219 , A61F5/0036 , A61K45/06
Abstract: The invention comprises a gastric device having a pouch formed from a degradable film. Preferably, the pouch contains a gas producing material. The gastric device hydrates within a patient's stomach and the gas producing material expands the device to a greater volume. Accordingly, the volume of the hydrated, expanded gastric devices occupy space in the stomach cavity and reduce the amount of food the patient will ingest before reaching the feeling of fullness. Preferably, the gastric device is made from food grade materials. The gastric device is configured to expand to a desired volume and then degrade after a residence time, allowing the device to be passed by the patient's normal digestive process.
Abstract translation: 本发明包括具有由可降解膜形成的袋的胃装置。 优选地，袋包含产气材料。 胃装置中的胃装置在患者的胃中水化，并且气体生成材料将装置扩大到更大的体积。 因此，水合，扩张的胃装置的体积占据胃腔中的空间，并减少患者在达到饱腹感之前摄取的食物量。 优选地，胃装置由食品级材料制成。 胃装置被配置为扩张到期望的体积，然后在停留时间后降解，允许装置通过患者的正常消化过程。
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公开(公告)号：WO2007044492A3
公开(公告)日：2007-07-26
申请号：PCT/US2006039058
申请日：2006-10-04
Applicant: OPTISCAN BIOMEDICAL CORP , STERLING BERNHARD B , GABLE JENNIFER H , BRAIG JAMES R , WECHSLER MARK , ZHENG PENG , RULE PETER , KEENAN RICHARD
Inventor： STERLING BERNHARD B , GABLE JENNIFER H , BRAIG JAMES R , WECHSLER MARK , ZHENG PENG , RULE PETER , KEENAN RICHARD
CPC classification number: A61B5/14546 , A61B5/145 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/14212 , A61M2230/20 , G01N35/1095
Abstract: Disclosed is a system that samples a body fluid of a patient. The system includes a fluid handling system (10) having one or more fluid passageways. The system further includes a pump system for infusing an infusion fluid by way of a fluid handling system into a patient (P) through one or more fluid passageways . The system further includes a pump system for obtaining a sample of body fluid by way of a fluid handling system from a patient through one or more fluid passageways. The obtained sample is no more than 5 milliliters in volume. The system further includes an analyzer (140) for analyzing at least an analyzed portion of the obtained sample by way of an analyte detection system operatively associated with the fluid handling system to determine a concentration of at least one analyte.
Abstract translation: 公开了一种对患者的体液进行采样的系统。 该系统包括具有一个或多个流体通道的流体处理系统（10）。 该系统还包括一个泵系统，用于通过流体处理系统将输液通过一个或多个流体通道输入患者（P）。 该系统还包括泵系统，用于通过来自患者的流体处理系统通过一个或多个流体通道获得体液样本。 所得样品的体积不超过5毫升。 该系统还包括分析器（140），用于通过可操作地与流体处理系统相关联的分析物检测系统来分析至少所获得的样品的分析部分，以确定至少一种分析物的浓度。
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公开(公告)号：WO2006127724A3
公开(公告)日：2007-03-29
申请号：PCT/US2006019952
申请日：2006-05-23
Applicant: OPTISCAN BIOMEDICAL CORP , BRAIG JAMES R , WITTE KENNETH G , MAGARIAN MARGARET , SHEILL JANE J , STERLING BERNHARD B
Inventor： BRAIG JAMES R , WITTE KENNETH G , MAGARIAN MARGARET , SHEILL JANE J , STERLING BERNHARD B
Abstract: An apparatus is presented for estimating the concentration of an analyte using a combined enzyme-spectroscopic method. Examples are provided for the detection of glucose and lactate. A sample of biological fluid is mixed or contacted with an enzyme specific to the analyte of interest, and the reacting fluid is probed with an optical system at wavelengths that includes at least one wavelength that is sensitive to the analyte concentration and at least one wavelength that is not sensitive to the analyte concentration. The optical system measures properties, such as optical density, and relates the measurements to concentration through a calibration of the system. A method is also provided for analyzing the data obtained from optical measurements of reactions of enzymes with biological fluids. These technologies may be applied to continuous or periodic patient sampling systems or to test strip type devices.
Abstract translation: 提出了使用组合酶分光法估计分析物浓度的装置。 提供葡萄糖和乳酸盐检测的实例。 将生物流体样品与特定于目标分析物的酶混合或接触，并且用包括至少一种对分析物浓度敏感的波长的波长的光学系统探测反应流体，并且至少一个波长 对分析物浓度不敏感。 光学系统测量诸如光密度的性质，并通过校准系统将测量值与浓度相关联。 还提供了一种用于分析从酶与生物流体的反应的光学测量获得的数据的方法。 这些技术可以应用于连续或周期性的患者取样系统或测试条型装置。
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Patent Agency Ranking5.发明申请
公开(公告)号：WO2008022225A2
公开(公告)日：2008-02-21
申请号：PCT/US2007076046
申请日：2007-08-15
Applicant: OPTISCAN BIOMEDICAL CORP , STERLING BERNHARD B , HALL DALE W
Inventor： STERLING BERNHARD B , HALL DALE W
CPC classification number: A61B5/1495 , A61B5/14532 , A61B2560/0223 , G01N21/3577
Abstract: Method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement The method reduces the error in the analyte concentration in the presence of interferents The method includes the use of a set of measurements obtained for a large population having a range of known analyte and interfering compound concentrations From a sample measurement, which may or may not be one of the population, interferents likely to be present are identified, and a calibration coefficient is calculated The calibration coefficient may be applied to the measurement to estimate the analyte concentration In some implementations, the calibration coefficient may be determined as a weighted average of single interferent calibration coefficients In some embodiments, the sample measurement includes a spectroscopic measurement.
Abstract translation: 描述了允许在干扰测量的化合物存在下从测量估计分析物浓度的方法和装置。该方法减少了在存在干扰物的情况下分析物浓度的误差。该方法包括使用一组测量 对于具有一定范围的已知分析物和干扰化合物浓度的大群体获得，从可能或可能不是其中一个群体的样本测量中鉴定可能存在的干扰物，并且计算校准系数校准系数可以是 应用于测量以估计分析物浓度。在一些实施方式中，校准系数可以被确定为单个干扰物校准系数的加权平均值。在一些实施例中，样本测量包括光谱测量。
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公开(公告)号：WO2004091387A3
公开(公告)日：2005-04-21
申请号：PCT/US2004011432
申请日：2004-04-14
Applicant: OPTISCAN BIOMEDICAL CORP , BRAIG JAMES R , RULE PETER , WITTE KENNETH G , HARTSTEIN PHILIP C , STERLING BERNHARD B
Inventor： BRAIG JAMES R , RULE PETER , WITTE KENNETH G , HARTSTEIN PHILIP C , STERLING BERNHARD B
IPC: A61B5/00
CPC classification number: A61B5/1455 , A61B5/14532 , A61B5/14546
Abstract: An analyte detection system (10) is configured to measure concentrations of at least first and second analytes in a single material sample supported by a sample element (120, 302, 402, 602). The measurement of a second analyte can be conditioned on a quantitative or qualitative result of the first measurement. In one embodiment, the first analyte is glucose and the second analyte is a ketone. According to such an embodiment the ketone is measured if the result of the glucose measurement exceeds a previously-specified value or falls outside of a previously-specified range.
Abstract translation: 分析物检测系统（10）被配置为测量由样品元件（120,302,402,602）支撑的单个材料样品中的至少第一和第二分析物的浓度。 第二分析物的测量可以对第一次测量的定量或定性结果进行调节。 在一个实施方案中，第一分析物是葡萄糖，第二分析物是酮。 根据这样的实施方案，如果葡萄糖测量结果超过预先规定的值或者超出预先规定的范围，则测量酮。
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7.发明申请METHOD OF DETERMINING AN ANALYTE CONCENTRATION IN A SAMPLE FROM AN ABSORPTION SPECTRUM 审中-公开从吸收光谱中测定样品中分析物浓度的方法
公开(公告)号：WO03069308A2
公开(公告)日：2003-08-21
申请号：PCT/US0304548
申请日：2003-02-12
Applicant: OPTISCAN BIOMEDICAL CORP , STERLING BERNHARD B , BRAIG JAMES R , GOLDBERGER DANIEL S , HARTSTEIN PHILIP C , GAFFNEY ROBERT D
Inventor： STERLING BERNHARD B , BRAIG JAMES R , GOLDBERGER DANIEL S , HARTSTEIN PHILIP C , GAFFNEY ROBERT D
IPC: G01N33/483 , A61B5/00 , G01N21/27 , G01N21/31 , G01N21/35 , G01N33/487 , G01N33/66 , G01N
CPC classification number: A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B2562/0295 , G01N21/274 , G01N21/314 , G01N21/35 , G01N27/3271
Abstract: A method determines an analyte concentration in a sample including the analyte and a substance. The method includes providing an absorption spectrum of the sample. The absorption spectrum has an absorption baseline. The method further includes shifting the absorption spectrum so that the absorption baseline approximately equals a selected absorption value in a selected absorption wavelength range. The method further includes subtracting a substance contribution from the absorption spectrum. Thus, the method provides a corrected absorption spectrum substantially free of a contribution from the substance.
Abstract translation: 一种方法确定包含分析物和物质的样品中的分析物浓度。 该方法包括提供样品的吸收光谱。 吸收光谱具有吸收基线。 该方法还包括移动吸收光谱，使得吸收基线大约等于所选吸收波长范围内的选定吸收值。 该方法还包括从吸收光谱中减去物质贡献。 因此，该方法提供基本上不含该物质的贡献的校正吸收光谱。
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公开(公告)号：WO2008039186A3
公开(公告)日：2009-04-23
申请号：PCT/US2006037483
申请日：2006-09-26
Applicant: PLENSAT LLC , STERLING BERNHARD B
Inventor： STERLING BERNHARD B , MILLS ALEXANDER K
CPC classification number: A61F5/0036
Abstract: The invention comprises a gastric device having an outer region and a gas producing material. The gastric device hydrates within a patient's stomach and the gas producing material expands the device to a greater volume. Accordingly, the volume of the hydrated, expanded gastric devices occupy space in the stomach cavity and reduce the amount of food the patient will ingest before reaching the feeling of fullness. Preferably, the gastric device is made from food grade materials. The gastric device is configured to expand to a desired volume and then degrade after a residence time, allowing the device to be passed by the patient's normal digestive process.
Abstract translation: 本发明包括具有外部区域和气体产生材料的胃装置。 胃装置中的胃装置在患者的胃中水化，并且气体生成材料将装置扩大到更大的体积。 因此，水合，扩张的胃装置的体积占据胃腔中的空间，并减少患者在达到饱腹感之前摄取的食物量。 优选地，胃装置由食品级材料制成。 胃装置被配置为扩张到期望的体积，然后在停留时间后降解，允许装置通过患者的正常消化过程。
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公开(公告)号：WO2006088792A3
公开(公告)日：2007-03-01
申请号：PCT/US2006005027
申请日：2006-02-13
Applicant: OPTISCAN BIOMEDICAL CORP , STERLING BERNHARD B , HALL W DALE , CALLICOAT DAVID N , GABLE JENNIFER H , BRAIG JAMES R , WITTE KENNETH G , WECHSLER MARK , ZHENG PENG , RULE PETER , KEENAN RICHARD , KING RICHARD A
Inventor： STERLING BERNHARD B , HALL W DALE , CALLICOAT DAVID N , GABLE JENNIFER H , BRAIG JAMES R , WITTE KENNETH G , WECHSLER MARK , ZHENG PENG , RULE PETER , KEENAN RICHARD , KING RICHARD A
IPC: A61B5/15
CPC classification number: A61M5/1723 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M2205/12 , A61M2230/20 , A61M2230/201 , G01N1/14 , G01N21/05 , G01N21/274 , G01N21/35 , G01N2021/0346
Abstract: An apparatus (10) for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end (11) configured to maintain fluid communication with a bodily fluid in a patient and at least one pump (203) intermittently operable to draw a sample of bodily fluid from the patient. The apparatus further comprises a fluid analyzer (140) positioned to analyze at least a portion of the sample and measure the presence of two or more analytes . Also disclosed is a method for analyzing the composition of a bodily fluid in a patient. The method comprises drawing a sample of the bodily fluid of the patient through a fluid handling network configured to maintain fluid communication with a bodily fluid in a patient. The method further comprises analyzing the at least a portion of the sample in a fluid analyzer to estimate the concentration of two or more analytes in the sample. Disclosed are further means for separating plasma and serum and a spectroscopic analyzer.
Abstract translation: 一种用于分析体液组成的装置（10）。 该装置包括流体处理网络，其包括被配置为保持与患者体内的体液的流体连通的患者端部（11），以及间歇地可操作以从患者抽取体液样本的至少一个泵（203）。 该装置还包括流体分析器（140），其定位成分析样品的至少一部分并测量两种或多种分析物的存在。 还公开了一种用于分析患者体液组成的方法。 该方法包括通过流体处理网络来绘制患者的体液样本，流体处理网络被配置为保持患者体内与体液的流体连通。 该方法还包括在流体分析仪中分析样品的至少一部分以估计样品中两种或多种分析物的浓度。 公开了用于分离血浆和血清和光谱分析仪的进一步手段。
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