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    MESH COMPRISING ECM
    1.
    发明申请
    MESH COMPRISING ECM 审中-公开
    包含ECM的MESH

    公开(公告)号：WO2008107483A2

    公开(公告)日：2008-09-12

    申请号：PCT/EP2008/052782

    申请日：2008-03-07

    Applicant: COLOPLAST A/S ,  NIELSEN, Lene Feldskov ,  TRUELSEN, Jens Hoeg ,  EVERLAND, Hanne

    Inventor： NIELSEN, Lene Feldskov ,  TRUELSEN, Jens Hoeg ,  EVERLAND, Hanne

    IPC: A61L31/00 ,  A61L31/04 ,  A61L31/10

    CPC classification number: A61L31/10 ,  A61L27/34 ,  A61L27/3633 ,  A61L27/3641 ,  A61L27/48 ,  A61L27/56 ,  A61L27/58 ,  A61L31/005 ,  A61L31/129 ,  A61L31/146 ,  A61L31/148

    Abstract: Herein is disclosed the utility of discontinuous regions of Extraceullar Matrix Proteins (ECM) in promoting cell growth in a Mesh. When the described scaffolds are applied on top of inert materials, cell in-growth is promoted and the attachment of the mesh is properly secured. In one aspect, the mesh has a side with reduced cellular in-growth and a side with enhanced in-growth. Combining inert materials with cell attractive materials such as ECM can do this. This is particularly advantageous for use as hernia implant. Here, the mesh should adhere only to the abdominal wall (on one side of the mesh) without adhering to the intestines. In one aspect of the invention, the inert material is elongated and coated on both ends. This is particularly advantageous for use as slings. Here, the mesh will adhere to the anchorage points in the ends of the sling, and still allow urethral redistribution as a consequence of bladder emptying.

    Abstract translation: 本文公开了Extraceullar Matrix Proteins（ECM）的不连续区域在促进网状细胞生长中的用途。 当将所述支架应用于惰性材料的顶部时，促进细胞生长并适当地固定网状物的附着。 在一个方面，网状物具有减少的细胞生长中的侧面和具有增强的生长增长的一侧。 将惰性材料与细胞吸引材料如ECM结合可以实现。 这对于用作疝植入物是特别有利的。 这里，网状物只能粘附于腹壁（网状物的一侧）而不粘附在肠上。 在本发明的一个方面，惰性材料是细长的并涂覆在两端。 这对于用作吊索是特别有利的。 在这里，网状物将粘附在吊索末端的锚固点上，并且由于膀胱排空仍然允许尿道再分布。

    MESH COMPRISING ECM
    2.
    发明申请
    MESH COMPRISING ECM 审中-公开
    包括ECM的MESH

    公开(公告)号：WO2008107483A3

    公开(公告)日：2009-08-27

    申请号：PCT/EP2008052782

    申请日：2008-03-07

    Applicant: COLOPLAST AS ,  NIELSEN LENE FELDSKOV ,  TRUELSEN JENS HOEG ,  EVERLAND HANNE

    Inventor： NIELSEN LENE FELDSKOV ,  TRUELSEN JENS HOEG ,  EVERLAND HANNE

    IPC: A61L27/36 ,  A61L27/34 ,  A61L27/48 ,  A61L27/56 ,  A61L27/58 ,  A61L31/00 ,  A61L31/10 ,  A61L31/12 ,  A61L31/14

    CPC classification number: A61L31/10 ,  A61L27/34 ,  A61L27/3633 ,  A61L27/3641 ,  A61L27/48 ,  A61L27/56 ,  A61L27/58 ,  A61L31/005 ,  A61L31/129 ,  A61L31/146 ,  A61L31/148

    Abstract: Herein is disclosed the utility of discontinuous regions of Extraceullar Matrix Proteins (ECM) in promoting cell growth in a Mesh. When the described scaffolds are applied on top of inert materials, cell in-growth is promoted and the attachment of the mesh is properly secured. In one aspect, the mesh has a side with reduced cellular in-growth and a side with enhanced in-growth. Combining inert materials with cell attractive materials such as ECM can do this. This is particularly advantageous for use as hernia implant. Here, the mesh should adhere only to the abdominal wall (on one side of the mesh) without adhering to the intestines. In one aspect of the invention, the inert material is elongated and coated on both ends. This is particularly advantageous for use as slings. Here, the mesh will adhere to the anchorage points in the ends of the sling, and still allow urethral redistribution as a consequence of bladder emptying.

    Abstract translation: 本文公开了Extraceullar Matrix Proteins（ECM）的不连续区域在网状物中促进细胞生长的效用。 当将所述支架应用于惰性材料的顶部时，促进细胞生长并适当地固定网状物的附着。 在一个方面，网状物具有减少的细胞生长中的侧面和具有增强的生长增长的一侧。 将惰性材料与细胞吸引材料如ECM结合可以实现。 这对于用作疝植入物是特别有利的。 这里，网状物只能粘附于腹壁（网状物的一侧）而不粘附在肠上。 在本发明的一个方面，惰性材料是细长的并涂覆在两端。 这对于用作吊索是特别有利的。 这里，网状物将粘附在吊索末端的锚固点上，并且仍然允许由于膀胱排空而导致的尿道再分布。

    ATTACHMENT DEVICE FOR WOUND DRAINAGE SYSTEM
    4.
    发明申请
    ATTACHMENT DEVICE FOR WOUND DRAINAGE SYSTEM 审中-公开
    创伤排水系统附件装置

    公开(公告)号：WO2009068666A3

    公开(公告)日：2009-11-12

    申请号：PCT/EP2008066466

    申请日：2008-11-28

    Applicant: COLOPLAST AS ,  LARSEN TRUELS STERM ,  BUDIG KLAUS ,  NIELSEN BRIAN ,  FREDERIKSEN JESPER MADS BARTRO ,  TRUELSEN JENS HOEG

    Inventor： LARSEN TRUELS STERM ,  BUDIG KLAUS ,  NIELSEN BRIAN ,  FREDERIKSEN JESPER MADS BARTROFF ,  TRUELSEN JENS HOEG

    IPC: A61M39/10 ,  A61M1/00

    CPC classification number: A61M1/0088 ,  A61M39/1055

    Abstract: System for draining fluid from a wound site at a skin surface of a living being. The system comprises a suction source, a drainage tube (112) for conveying wound exudate away from a wound at the wound site, the drainage tube being in fluid communication with the suction source at one end thereof and with the wound site at the other end thereof, and an attachment device (100) for connecting the drainage tube (112) to the wound site, the attachment device (100) forming or being part of a sealing enclosure at the wound site. The attachment device comprises a stationary part (102) arranged to be fixed to the living being's body, a rotary part (104) interconnecting the tube (112) and the stationary part (102), the rotary part (104) being rotatable relative to the stationary part (102).

    Abstract translation: 从活体皮肤表面的伤口部位排出液体的系统。 该系统包括抽吸源，用于将伤口渗出物远离伤口部位的伤口输送的引流管（112），所述引流管在其一端与吸入源流体连通，另一端与伤口部位流体连通 以及用于将引流管（112）连接到伤口部位的附接装置（100），所述附接装置（100）在伤口部位处形成或者是密封外壳的一部分。 所述附接装置包括被布置成固定到所述活体的固定部分（102），将所述管（112）和所述固定部分（102）互连的旋转部分（104），所述旋转部分（104）可相对于 固定部分（102）。

    PRESSURE-DISTRIBUTING ELEMENT OF CLOSED CELL FOAM
    6.
    发明申请
    PRESSURE-DISTRIBUTING ELEMENT OF CLOSED CELL FOAM 审中-公开
    封闭细胞泡沫的压力分布元件

    公开(公告)号：WO2009021523A1

    公开(公告)日：2009-02-19

    申请号：PCT/DK2008/050200

    申请日：2008-08-14

    Applicant: COLOPLAST A/S ,  TRUELSEN, Jens Hoeg

    Inventor： TRUELSEN, Jens Hoeg

    IPC: A61F13/02 ,  A61L15/42 ,  A61M1/00

    CPC classification number: A61M1/0088 ,  A61F13/0203

    Abstract: When using negative pressure therapy in connection with wound treatment, a pressure-distributing element is preferably used. The invention provides a system for use in connection with negative pressure therapy, which system comprises a pump, a tube, a wound covering and a wound-packing material. A pressure-distributing element is used as a wound-packing material, which element comprises an element of closed cell foam, which is flexible and resilient so as to provide a comfortable wound-packing material. The porosity of the element is only slightly changed during the influence of negative pressure. This gives an improved control over the therapy, as the pressure across the wound packing material will only alter slightly during the therapy. A pressure-distributing element of closed cell foam having perforations in at least two directions is also provided. Perforating in more directions provides more diffuse path-ways for the exudate, which may be advantageous in some situations. Finally a method of treating a wound using a negative therapy system is provided.

    Abstract translation: 当使用与伤口治疗相关的负压治疗时，优选使用压力分配元件。 本发明提供了一种用于负压治疗的系统，该系统包括泵，管，伤口覆盖物和伤口包装材料。 使用压力分配元件作为缠绕包装材料，该元件包括密闭泡沫元件，其是柔性和弹性的，以便提供舒适的卷绕包装材料。 元素的孔隙度在负压的影响下仅稍微改变。 这提供了对治疗的改进的控制，因为在治疗期间，伤口包装材料上的压力将仅稍微改变。 还提供了具有至少两个方向的穿孔的闭孔泡沫的压力分配元件。 在更多方向穿孔为渗出液提供了更多的扩散路径，这在某些情况下可能是有利的。 最后，提供了使用阴性治疗系统治疗伤口的方法。

    CROSS-LINKING OF FOAMS OF S-SULFONATED KERATIN
    8.
    发明申请
    CROSS-LINKING OF FOAMS OF S-SULFONATED KERATIN 审中-公开
    S-SULFONATED KERATIN的交叉关系

    公开(公告)号：WO2008040357A1

    公开(公告)日：2008-04-10

    申请号：PCT/DK2007/050134

    申请日：2007-10-02

    Applicant: COLOPLAST A/S ,  TRUELSEN, Jens Hoeg ,  NIELSEN, Pia

    Inventor： TRUELSEN, Jens Hoeg ,  NIELSEN, Pia

    IPC: C08J9/36 ,  C08J3/24 ,  C08H1/06

    CPC classification number: C08J9/36 ,  A61L27/227 ,  A61L27/56 ,  C08H1/06 ,  C08J3/24 ,  C08J2389/04

    Abstract: The present invention relates to a process for cross-linking of highly porous foams of S- sulfonated keratin, and to highly porous, cross-linked keratin foams (e.g. scaffolds) as such. Such scaffolds (foams) are particularly useful for wound care applications. Such porous keratin foams can be obtained through exchanging the aqueous solution of the reductant as the cross-linking media with an alcohol solution of the same reductant, and by exchanging the aqueous washing procedures with a similar alcohol washing procedure.

    Abstract translation: 本发明涉及S-磺化角蛋白的高度多孔泡沫交联和高度多孔的交联角蛋白泡沫（例如支架）的方法。 这种支架（泡沫）对伤口护理应用特别有用。 这种多孔角蛋白泡沫可以通过将还原剂的水溶液作为交联介质与相同的还原剂的醇溶液进行交换，并且通过用类似的醇洗涤方法更换含水洗涤程序来获得。

    SPATIALLY ENCODED POLYMER MATRIX
    9.
    发明申请
    SPATIALLY ENCODED POLYMER MATRIX 审中-公开
    空间编码聚合物矩阵

    公开(公告)号：WO2004028682A3

    公开(公告)日：2004-08-05

    申请号：PCT/DK0300635

    申请日：2003-09-26

    Applicant: CARLSBERG AS ,  CHRISTENSEN SOEREN FLYGENRING ,  TRUELSEN JENS HOEG ,  MELDAL MORTEN ,  MICHAEL ROICE ,  JOHANNSEN IB

    Inventor： CHRISTENSEN SOEREN FLYGENRING ,  TRUELSEN JENS HOEG ,  MELDAL MORTEN ,  MICHAEL ROICE ,  JOHANNSEN IB

    IPC: B01J19/00 ,  G01N15/14 ,  G01N21/05

    CPC classification number: B01J19/0046 ,  B01J2219/005 ,  B01J2219/0054 ,  B01J2219/00551 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B01J2219/0074

    Abstract: The invention relates to a spatially encoded polymer matrix in the form of a bead or a granule for combinatorial solid phase synthesis, assaying, functional proteomics and diagnostic use. Compositions of such beads or granules are also provided. Each beaded polymer matrix of the composition comprises a plurality of spatially immobilised particles. The spatial immobilisation of the particles confers on each beaded polymer matrix a "fingerprint" which enables identification of unique beads in a population of beads. The unique identification of individual beads makes it possible to perform combinatorial chemistry strategies while logging individual chemical transformation. Also provided are methods for detection of relative positions in space of particles, methods for generating matrices, methods for distance matrix determination, methods for identifying individual matrices and devices for recording and storing images of matrices.

    Abstract translation: 本发明涉及用于组合固相合成，测定，功能蛋白质组学和诊断用途的珠粒或颗粒形式的空间编码聚合物基质。 还提供了这种珠粒或颗粒的组合物。 组合物的每个串珠聚合物基质包含多个空间固定的颗粒。 颗粒的空间固定赋予每个珠光聚合物基质上的“指纹”，其使得能够鉴定珠粒群中的独特珠粒。 单独珠粒的独特鉴定使得可以在记录单个化学转化的同时执行组合化学策略。 还提供了用于检测颗粒空间中的相对位置的方法，用于生成矩阵的方法，用于距离矩阵确定的方法，用于识别各个矩阵的方法以及用于记录和存储矩阵的图像的设备。

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