COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    2.
    发明申请
    COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR 审中-公开
    化合物及其调节方法及其适应症

    公开(公告)号:WO2011133637A3

    公开(公告)日:2012-02-09

    申请号:PCT/US2011033192

    申请日:2011-04-20

    CPC classification number: C07D487/04 C07D471/04

    Abstract: Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on one or more of Fms, Kit, Flt3, TrkA, TrkB and TrkC kinase protein. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of one or more of Fms, Kit, Flt3, TrkA, TrkB and TrkC, including rheumatoid arthiritis, osteoarthritis, osteoporosis, peri-prosthetic osteolysis, systemic sclerosis, demyelinating disorders, multiple sclerosis, Charcot Marie Tooth syndrome, amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, global ischemia, ulcerative colitis, Crohn's disease, immune thrombocytopenic purpura, atherosclerosis, systemic lupus erythematosis, myelopreparation for autologous transplantation, transplant rejection, glomerulonephritis, interstitial nephritis, Lupus nephritis, tubular necrosis, diabetic nephropathy, renal hypertrophy, type I diabetes, acute pain, inflammatory pain, neuropathic pain, acute myeloid leukemia, melanoma, multiple myeloma, breast cancer, prostate cancer, pancreatic cancer, lung cancer, ovarian cancer, gliomas, glioblastoma, neurofibromatosis, osteolytic bone metastases, brain metasteses, gastrointestinal stromal tumors, and giant cell tumors.

    Abstract translation: 其化合物及其盐,其制剂,其缀合物,其衍生物,其形式及用途。 在某些方面和实施方案中,所述的化合物或其盐,其制剂,其缀合物,其衍生物,其形式在Fms,Kit,Flt3,TrkA,TrkB和TrkC激酶蛋白中的一种或多种上是有活性的。 还描述了其用于治疗疾病和病症的方法,包括与Fms,Kit,Flt3,TrkA,TrkB和TrkC中的一种或多种的活性相关的疾病和病症,包括类风湿性关节炎,骨关节炎,骨质疏松症,假体周围骨质溶解, 系统性硬化症,脱髓鞘疾病,多发性硬化症,Charcot玛丽牙综合征,肌萎缩性侧索硬化症,阿尔茨海默氏病,帕金森病,全球缺血,溃疡性结肠炎,克罗恩病,免疫性血小板减少性紫癜,动脉粥样硬化,系统性红斑狼疮,自体移植骨髓造血,移植排斥 肾小球肾炎,间质性肾炎,狼疮性肾炎,肾小管坏死,糖尿病性肾病,肾肥大,I型糖尿病,急性疼痛,炎性疼痛,神经性疼痛,急性骨髓性白血病,黑素瘤,多发性骨髓瘤,乳腺癌,前列腺癌,胰腺癌,肺癌 癌症,卵巢癌,神经胶质瘤,成胶质细胞瘤,神经 纤维瘤病,溶骨性骨转移,脑转移,胃肠道间质瘤和巨细胞瘤。

    COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    4.
    发明申请
    COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR 审中-公开
    化合物及其调节方法及其适应症

    公开(公告)号:WO2011133637A2

    公开(公告)日:2011-10-27

    申请号:PCT/US2011/033192

    申请日:2011-04-20

    CPC classification number: C07D487/04 C07D471/04

    Abstract: Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on one or more of Fms, Kit, Flt3, TrkA, TrkB and TrkC kinase protein. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of one or more of Fms, Kit, Flt3, TrkA, TrkB and TrkC, including rheumatoid arthiritis, osteoarthritis, osteoporosis, peri-prosthetic osteolysis, systemic sclerosis, demyelinating disorders, multiple sclerosis, Charcot Marie Tooth syndrome, amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, global ischemia, ulcerative colitis, Crohn's disease, immune thrombocytopenic purpura, atherosclerosis, systemic lupus erythematosis, myelopreparation for autologous transplantation, transplant rejection, glomerulonephritis, interstitial nephritis, Lupus nephritis, tubular necrosis, diabetic nephropathy, renal hypertrophy, type I diabetes, acute pain, inflammatory pain, neuropathic pain, acute myeloid leukemia, melanoma, multiple myeloma, breast cancer, prostate cancer, pancreatic cancer, lung cancer, ovarian cancer, gliomas, glioblastoma, neurofibromatosis, osteolytic bone metastases, brain metasteses, gastrointestinal stromal tumors, and giant cell tumors.

    Abstract translation: 其化合物及其盐,其制剂,其缀合物,其衍生物,其形式及用途。 在某些方面和实施方案中,所述的化合物或其盐,其制剂,其缀合物,其衍生物,其形式在Fms,Kit,Flt3,TrkA,TrkB和TrkC激酶蛋白中的一种或多种上是有活性的。 还描述了其用于治疗疾病和病症的方法,包括与Fms,Kit,Flt3,TrkA,TrkB和TrkC中的一种或多种的活性相关的疾病和病症,包括类风湿性关节炎,骨关节炎,骨质疏松症,假体周围骨质溶解, 系统性硬化症,脱髓鞘疾病,多发性硬化症,Charcot玛丽牙综合征,肌萎缩性侧索硬化症,阿尔茨海默氏病,帕金森病,全球缺血,溃疡性结肠炎,克罗恩病,免疫性血小板减少性紫癜,动脉粥样硬化,系统性红斑狼疮,自体移植骨髓造血,移植排斥 肾小球肾炎,间质性肾炎,狼疮性肾炎,肾小管坏死,糖尿病性肾病,肾肥大,I型糖尿病,急性疼痛,炎性疼痛,神经性疼痛,急性骨髓性白血病,黑素瘤,多发性骨髓瘤,乳腺癌,前列腺癌,胰腺癌,肺癌 癌症,卵巢癌,神经胶质瘤,成胶质细胞瘤,神经 纤维瘤病,溶骨性骨转移,脑转移,胃肠道间质瘤和巨细胞瘤。

    WAKE-ON-WLAN FOR STATIONARY WIRELESS STATIONS
    5.
    发明申请
    WAKE-ON-WLAN FOR STATIONARY WIRELESS STATIONS 审中-公开
    WAVE-ON-WLAN用于静态无线站

    公开(公告)号:WO2008109413A1

    公开(公告)日:2008-09-12

    申请号:PCT/US2008/055451

    申请日:2008-02-29

    Abstract: Stationary wireless network stations are woken up using Wake-on- WLAN functionality. Wake -on- WLAN is provided by paging stations in a wireless network. Paging may support mobile stations across multiple access points. Paging may also support stationary nodes with reduced overhead. Wake-on- WLAN is also provided to stationary stations in idle mode by signifying a wake-on event in a traffic indication map (TIM). Wake-on events may occur when a station is associated or disassociated with an access point. Upon receiving a wake-on event, a station associates or reassociates with an AP if necessary.

    Abstract translation: 使用Wake-WLAN功能唤醒固定无线网络站。 唤醒WLAN由无线网络中的寻呼站提供。 寻呼可能支持多个接入点的移动台。 分页也可以支持固定节点,减少开销。 唤醒WLAN也通过表示交通指示图(TIM)中的唤醒事件提供给空闲模式的固定站。 当站点与接入点关联或取消关联时,可能会发生唤醒事件。 在接收到唤醒事件后,如果需要,站与AP关联或重新联系。

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