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    ELECTRON TUNNELING DEVICE
    1.
    发明申请
    ELECTRON TUNNELING DEVICE 审中-公开
    电子隧道设备

    公开(公告)号：WO2002095920A1

    公开(公告)日：2002-11-28

    申请号：PCT/US2002/015417

    申请日：2002-05-17

    Applicant: UNIVERSITY TECHNOLOGY CORPORATION ,  ELIASSON, Blake, J. ,  MODDEL, Garret

    Inventor： ELIASSON, Blake, J. ,  MODDEL, Garret

    IPC: H02N6/00

    CPC classification number: H01L31/06 ,  B82Y20/00 ,  H01L31/035236 ,  H01L31/101 ,  H01L45/00 ,  Y02E10/50

    Abstract: The electron tunneling device (110) includes first and second non-insulating layers (112 and 114) spaced apart such that a given voltage can be provided therebetween. The device also includes an arrangement disposed between the non-insulating layers and configured to serve as a transport of electrons between the non-insulating layers. This arrangement includes a first layer (116) of an amorphous material such that using only the first layer of amorphous material in the arrangement would result in a given value of a parameter in the transport of electrons, with respect to the given voltage. The arrangement further includes a second layer (118) of material, which is configured to cooperate with the first layer (116) of amorphous material such that the transport of electrons includes, at least in part, transport by tunneling, and such that the parameter, with respect to the given voltage, is increased above the given value of the parameter.

    Abstract translation: 电子隧穿装置（110）包括间隔开的第一和第二非绝缘层（112和114），使得可以在其间提供给定的电压。 该装置还包括设置在非绝缘层之间并被配置为用作非绝缘层之间的电子传输的布置。 这种布置包括非晶材料的第一层（116），使得仅使用该布置中的第一非晶材料层将导致相对于给定电压的电子传输中的参数的给定值。 该装置还包括材料的第二层（118），其被配置为与非晶材料的第一层（116）协作，使得电子的传输至少部分地包括通过隧道传输，并且使得参数 ，相对于给定的电压，增加到高于参数的给定值。

    DEVICES AND METHODS FOR THE PRODUCTION OF PARTICLES
    4.
    发明申请
    DEVICES AND METHODS FOR THE PRODUCTION OF PARTICLES 审中-公开
    用于生产颗粒的装置和方法

    公开(公告)号：WO2003006223A1

    公开(公告)日：2003-01-23

    申请号：PCT/US2002/022300

    申请日：2002-07-10

    Applicant: UNIVERSITY TECHNOLOGY CORPORATION ,  GROTHE, Willy ,  JARMER, Daniel ,  LENGSFELD, Corinne ,  RANDOLPH, Theodore

    Inventor： GROTHE, Willy ,  JARMER, Daniel ,  LENGSFELD, Corinne ,  RANDOLPH, Theodore

    IPC: B29B9/00

    CPC classification number: B01J2/04 ,  B01D11/0403 ,  B01D11/0407 ,  B01D11/0473 ,  B01F5/0057 ,  B01F2003/0064

    Abstract: The present invention provides methods and devices for producing particles with an average diameter less than about 15μm using the precipitation with compressed fluid-antisolvent (PCA) process and the carbon-dioxide assisted nebulization with a bubble dryer (CAN-BD) process. In the methods and nozzles of the invention, at least one jet of supercritical or near-supercritical fluid and at least one jet of solution interact to mix the supercritical or near-supercritical fluid and the solution within a chamber. The solution contains at least one solvent and at least one solute. At least one of the jets is a swirling jet. To form particles, the solvent and supercritical or near-supercritical fluid are then injected into a PCA or a CAN-BD process chamber. The degree of mixing depends in part on the power input into the mixing chamber. Power inputs of about 6.5xl0 9 W/m 3 enhance the degree of mixing and allow production of nanoscale particles with the PCA process. The nanoscale particles have a size distribution so that polydispersity is less than about 1.75.

    Abstract translation: 本发明提供了使用压缩流体 - 反溶剂（PCA）沉淀法和用气泡干燥器（CAN-BD）方法进行二氧化碳辅助雾化来生产平均直径小于约15μm的颗粒的方法和装置。 在本发明的方法和喷嘴中，至少一个超临界或近超临界流体射流和至少一个溶液射流相互作用以将超临界或近超临界流体和溶液混合在腔室内。 该溶液含有至少一种溶剂和至少一种溶质。 至少有一架喷气式飞机是旋流式飞机。 为了形成颗粒，然后将溶剂和超临界或近临界流体注入PCA或CAN-BD处理室中。 混合程度部分取决于输入混合室的功率。 约6.5×10 9 W / m 3的功率输入增强了混合的程度，并允许用PCA工艺生产纳米级颗粒。 纳米级颗粒具有尺寸分布，使得多分散性小于约1.75。

    METHODS FOR TREATING MIDDLE AND INNER EAR DISORDERS
    7.
    发明申请
    METHODS FOR TREATING MIDDLE AND INNER EAR DISORDERS 审中-公开
    用于治疗中度和内脏疾病的方法

    公开(公告)号：WO1997038698A1

    公开(公告)日：1997-10-23

    申请号：PCT/US1997006507

    申请日：1997-04-18

    Applicant: UNIVERSITY TECHNOLOGY CORPORATION ,  MANNING, Mark, C. ,  SHEFTER, Eli ,  HART, Michael, J.

    Inventor： UNIVERSITY TECHNOLOGY CORPORATION

    IPC: A61K31/715

    CPC classification number: A61K9/0046 ,  A61K31/7036 ,  A61K47/36

    Abstract: Provided are methods to deliver drugs to the middle or inner ear of a mammal in need of such drug comprising inserting a composition comprising a biocompatible polymer and at least one pharmacologically active agent. More particularly, the invention relates to a method for treating Meniere's disease using a composition of hyaluronic acid and gentamicin.

    Abstract translation: 提供了将药物递送到需要这种药物的哺乳动物的中耳或内耳的方法，包括插入包含生物相容性聚合物和至少一种药理活性剂的组合物。 更具体地，本发明涉及使用透明质酸和庆大霉素组合物治疗梅尼埃病的方法。

    EXTENDED DEPTH FIELD OPTICS FOR HUMAN VISION
    9.
    发明申请
    EXTENDED DEPTH FIELD OPTICS FOR HUMAN VISION 审中-公开
    用于人类视觉的扩展深度场光学

    公开(公告)号：WO2003052492A2

    公开(公告)日：2003-06-26

    申请号：PCT/US2001/026126

    申请日：2001-08-20

    Applicant: UNIVERSITY TECHNOLOGY CORPORATION

    Inventor： CATHEY, Wade, Thomas, Jr.

    IPC: G02C7/04

    CPC classification number: G02C7/024 ,  A61F2/1624 ,  A61F2002/1699 ,  A61F2250/0036 ,  G02B3/00 ,  G02C7/028 ,  G02C7/04 ,  G02C7/042

    Abstract: The present invention provides extended depth of focus (EDF) to human eyes by modifying contact lenses, interocular implants, or the surface of the eye itself. This is accomplished by applying selected phase variations to the optical element in question (for example, by varying surface thickness). The phase variations EDF-code the wavefront and cause the optical transfer function to remain essentially constant within some range away from the in-focus position. This provides a coded image on the retina. The human brain decodes this coded image, resulting in an in-focus image over an increased depth of focus.

    Abstract translation: 本发明通过改变隐形眼镜，眼内植入物或眼睛本身的表面来提供对人眼的扩展的深度焦点（EDF）。 这通过将所选择的相位变化应用于所讨论的光学元件来实现（例如，通过改变表面厚度）。 相位变化EDF-编码波前，并使光学传递函数在远离对焦位置的某个范围内保持基本恒定。 这提供了视网膜上的编码图像。 人类大脑解码这个编码图像，导致焦点上的图像越来越深。

    PROTECTION-OF-TELOMERE-1 (POT-1) PROTEIN AND ENCODING POLYNUCLEOTIDES
    10.
    发明申请
    PROTECTION-OF-TELOMERE-1 (POT-1) PROTEIN AND ENCODING POLYNUCLEOTIDES 审中-公开
    TOTOMERE-1（POT-1）蛋白和编码多核苷酸

    公开(公告)号：WO2002077156A2

    公开(公告)日：2002-10-03

    申请号：PCT/US2002/011107

    申请日：2002-03-26

    Applicant: UNIVERSITY TECHNOLOGY CORPORATION ,  BAUMANN, Peter ,  CECH, Thomas, R.

    Inventor： BAUMANN, Peter ,  CECH, Thomas, R.

    IPC: C12N

    CPC classification number: C12N9/1241 ,  A61K38/00 ,  A61K48/00 ,  C07K14/39 ,  C07K14/4703

    Abstract: Pot1p, a protein identified in humans, Schizosaccharomyces pombe , and mouse, binds single-stranded telomeric DNA and both stabilizes chromosome ends and regulates telomerase activity. Compounds that stabilize or disrupt the Pot1p-DNA interaction will be useful in regulating the telomere length of a cell. Because telomere length is involved in the regulation of cellular life-span, the life-span of useful cell populations may be prolonged or undesirable cells may be caused to cease proliferation. The identification of a Pot1 protein and its encoding DNA provides methods of screening useful compounds or diagnosing illnesses that involve altered expression or structure of a Pot1 protein or gene.

    Abstract translation: Pot1p，一种在人类中鉴定的蛋白质，粟酒裂殖酵母（Schizosaccharomyces pombe）和小鼠，结合单链端粒DNA，并稳定染色体末端并调节端粒酶活性。 稳定或破坏Pot1p-DNA相互作用的化合物可用于调节细胞的端粒长度。 由于端粒长度参与细胞寿命的调节，因此可能延长有用细胞群体的寿命或者可能导致不希望的细胞停止增殖。 Pot1蛋白及其编码DNA的鉴定提供了筛选有用化合物或诊断涉及改变Pot1蛋白或基因表达或结构的疾病的方法。

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