公开(公告)号：WO0076489A3

公开(公告)日：2002-05-30

申请号：PCT/US0015071

申请日：2000-05-31

Applicant: WARNER LAMBERT CO ,  YAMANOUCHI PHARMA CO LTD ,  AUGELLI SZAFRAN CORINNE ELIZAB ,  BARVIAN MARK ROBERT ,  BIGGE CHRISTOPHER FRANKLIN ,  GLASE SHELLY ANN ,  HACHIYA SHUNICHIRO ,  KEILY JOHN STEVEN ,  KIMURA TAKENORI ,  LAI YINGJIE ,  SAKKAB ANNETTE THERESA ,  SUTO MARK JAMES ,  WALKER LARY CRASWELL ,  YASUNAGA TOMOYUKI ,  ZHUANG NIAN

Inventor： AUGELLI-SZAFRAN CORINNE ELIZAB ,  BARVIAN MARK ROBERT ,  BIGGE CHRISTOPHER FRANKLIN ,  GLASE SHELLY ANN ,  HACHIYA SHUNICHIRO ,  KEILY JOHN STEVEN ,  KIMURA TAKENORI ,  LAI YINGJIE ,  SAKKAB ANNETTE THERESA ,  SUTO MARK JAMES ,  WALKER LARY CRASWELL ,  YASUNAGA TOMOYUKI ,  ZHUANG NIAN

IPC: C07D233/61 ,  A61K9/08 ,  A61K9/70 ,  A61K31/00 ,  A61K31/18 ,  A61K31/196 ,  A61K31/343 ,  A61K31/402 ,  A61K31/4164 ,  A61K31/427 ,  A61K31/4453 ,  A61K31/455 ,  A61K31/4709 ,  A61K31/472 ,  A61K47/10 ,  A61K47/32 ,  A61K49/00 ,  A61K51/00 ,  A61P25/28 ,  C07C229/58 ,  C07C229/60 ,  C07C229/62 ,  C07C229/64 ,  C07C233/43 ,  C07C237/30 ,  C07C311/51 ,  C07D207/04 ,  C07D207/325 ,  C07D209/44 ,  C07D211/14 ,  C07D213/80 ,  C07D213/82 ,  C07D217/02 ,  C07D217/04 ,  C07D231/12 ,  C07D233/54 ,  C07D233/88 ,  C07D257/04 ,  C07D295/135 ,  C07D317/58 ,  C07D413/06 ,  C07D417/06 ,  A61K31/195 ,  A61K31/36 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/425 ,  A61K31/445 ,  A61K31/47 ,  C07D207/327 ,  C07D277/36 ,  C07D295/12 ,  C07D317/60

CPC classification number: C07D213/82 ,  A61K31/196 ,  A61K31/402 ,  A61K31/4164 ,  C07C229/58 ,  C07C229/62 ,  C07C229/64 ,  C07C233/43 ,  C07C311/51 ,  C07D209/44 ,  C07D217/02 ,  C07D233/88 ,  C07D257/04 ,  C07D295/135 ,  C07D317/58 ,  C07D413/06

Abstract: The present invention provides a method of treating Alzheimer's disease using a compound of Formula (I). Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of the Formula (I) and a method of imaging amyloid deposits, as well as new compounds of Formula (I).

Abstract translation: 本发明提供使用式（I）的化合物治疗阿尔茨海默病的方法。 还提供了使用式（I）化合物和淀粉样沉积物成像方法以及式（I）的新化合物抑制淀粉样蛋白聚集的方法。

公开(公告)号：WO1998009940A1

公开(公告)日：1998-03-12

申请号：PCT/US1997014852

申请日：1997-08-22

Applicant: WARNER-LAMBERT COMPANY ,  PURCHASE, Claude, Forsey, Jr. ,  ROTH, Bruce, David ,  WHITE, Andrew, David ,  SCHIELKE, Gerald, Paul ,  WALKER, Lary, Craswell

Inventor： WARNER-LAMBERT COMPANY

IPC: C07C251/48

CPC classification number: C07C323/63 ,  C07C59/56 ,  C07C59/84 ,  C07C59/88 ,  C07C59/90 ,  C07C69/738 ,  C07C251/48 ,  C07C251/86 ,  C07C255/64

Abstract: Biphenyl butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, treatment of burns, decubital ulcers, wound healing, cancer, inflammation, pain, arthritis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells, acute and chronic neurodegenerative disorders including stroke, head trauma, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion diseases, myasthenia gravis, and Duchenne's muscular dystrophy.

Abstract translation: 描述了联苯丁酸化合物和衍生物以及用于制备的酸法和其药物组合物，其可用作基质金属蛋白酶抑制剂，特别是明胶酶A（72kD明胶酶）和基质溶素-1和用于治疗多发性硬化症 ，动脉粥样硬化斑块破裂，主动脉瘤，心力衰竭，再狭窄，牙周病，角膜溃疡，烧伤治疗，褥疮性溃疡，伤口愈合，癌症，炎症，疼痛，关节炎或依赖于白细胞组织侵袭的其他自身免疫性或炎性病症， 其他活化的迁移细胞，急性和慢性神经变性疾病，包括中风，头部创伤，脊髓损伤，阿尔茨海默病，肌萎缩性侧索硬化，脑淀粉样血管病，艾滋病，帕金森病，亨廷顿病，朊病毒疾病，重症肌无力和杜氏肌营养不良症。