公开(公告)号：WO2012084659A3

公开(公告)日：2012-06-28

申请号：PCT/EP2011/072823

申请日：2011-12-14

Applicant: ELEMENT SIX LIMITED ,  CULLEN, Alexander Lamb ,  DODSON, Joseph Michael ,  WILLIAMS, Stephen David ,  BRANDON, John Robert

Inventor： CULLEN, Alexander Lamb ,  DODSON, Joseph Michael ,  WILLIAMS, Stephen David ,  BRANDON, John Robert

IPC: H01J37/32 ,  C23C16/27 ,  C23C16/511

Abstract: A microwave plasma reactor for manufacturing a synthetic diamond material via chemical vapour deposition, the microwave plasma reactor comprising: a plasma chamber (2); a substrate holder (4) disposed in the plasma chamber for supporting a substrate on which the synthetic diamond material is to be deposited in use; a microwave coupling configuration (12) for feeding microwaves from a microwave generator (8) into the plasma chamber; and a gas flow system (13,16) for feeding process gases into the plasma chamber and removing them therefrom, wherein the microwave coupling configuration for feeding microwaves from the microwave generator into the plasma chamber comprises: an annular dielectric window (18) formed in one or several sections; a coaxial waveguide (14) having a central inner conductor (20) and an outer conductor (22) for feeding microwaves to the annular dielectric window; and a waveguide plate (24) comprising a plurality of apertures (28) disposed in an annular configuration with a plurality of arms (26) extending between the apertures, each aperture forming a waveguide for coupling microwaves towards the plasma chamber.

公开(公告)号：WO2012025743A1

公开(公告)日：2012-03-01

申请号：PCT/GB2011/051576

申请日：2011-08-19

Applicant: JAB SAILING LTD ,  ABRAHAMS, Jonathan Keith Anderson ,  WILLIAMS, Stephen Puleston

Inventor： ABRAHAMS, Jonathan Keith Anderson ,  WILLIAMS, Stephen Puleston

IPC: G06G1/00 ,  G06G1/08 ,  G01C21/20

CPC classification number: G06G1/0052 ,  G06G1/08

Abstract: A wind direction indicator comprises a base (1/1') on which is mounted a rotatable disc (2/2') with an anticlockwise scale (SC). Indicia in the form of sectors (S1 to S5) and sail plan diagrams (6, 6') indicate the points of sail for a given bearing. The device is used by rotating the disc so as to set the scale to indicate the wind direction and then simply reading off the bearing of the boat on the scale to find the wind direction experienced by the boat. Indicia such as sail plan diagrams (6, 6') show the points of sail needed for various wind directions. The wind direction indicator may be implemented electronically in a mobile device.

Abstract translation: 风向指示器包括基座（1/1'），在基座上安装有具有逆时针刻度尺（SC）的可旋转盘（2/2'）。 扇形（S1至S5）和帆平面图（6,6'）形式的标记表示给定轴承的航程。 通过旋转盘来使用该装置，以便设置刻度以指示风向，然后简单地读取船上的船的轴承以找到船所经历的风向。 诸如帆平面图（6,6'）的标记显示了各种风向所需的航程。 风向指示器可以在移动设备中以电子方式实现。

公开(公告)号：WO2010010382A3

公开(公告)日：2010-05-06

申请号：PCT/GB2009050889

申请日：2009-07-20

Applicant: AIRBUS OPERATIONS LTD ,  WILLIAMS STEPHEN

Inventor： WILLIAMS STEPHEN

IPC: B64C3/18 ,  B64F5/00

CPC classification number: B64C3/187 ,  B64F5/10 ,  Y10T29/49622

Abstract: A method of stiffening a rib (19, 20) during the assembly of an aircraft wing is described. A stiffener panel (40, 41) is attached to a face of the rib (19, 20). The rib is aligned with one or more wing components with the stiffener panel (40, 41) attached. An assembly operation such as drilling (16) is performed with the rib aligned and the stiffener panel attached. The stiffener panel (40, 41) is removed from the rib after the assembly operation. The stiffener panel has a resilient external sealing ring which is mounted on a face of the panel and forms an external perimeter of a vacuum cavity; and at least one resilient internal sealing ring which is mounted on the panel (20, 21) within the perimeter defined by the external sealing ring and forms an internal perimeter of the vacuum cavity. The stiffener can be attached to the rib by a vacuum clamping force, the vacuum being sealed by the external and internal sealing rings. The internal sealing ring(s) seal any holes which are present in the rib. The stiffener (40, 41) can support the rib (20, 21) during alignment to give it the required flatness.

Abstract translation: 描述了在飞行器机翼的组装期间加强肋（19,20）的方法。 加强板（40,41）附接到肋（19,20）的表面。 肋与一个或多个机翼部件对准，并且加强板（40,41）连接在一起。 执行诸如钻孔（16）的组装操作，其中肋对准并且加强板连接。 在组装操作之后，加强板（40,41）从肋上移除。 加强板具有弹性的外部密封环，其安装在面板的表面上并形成真空腔的外周; 以及至少一个弹性内部密封环，其安装在由外部密封环限定的周边内的面板（20,21）上并形成真空腔的内部周边。 加强件可以通过真空夹紧力连接到肋上，真空由外部和内部密封环密封。 内密封环密封肋中存在的任何孔。 加强件（40,41）可以在对准期间支撑肋（20,21），以使其成为所需的平整度。

公开(公告)号：WO2009032071A3

公开(公告)日：2010-01-14

申请号：PCT/US2008009912

申请日：2008-08-20

Applicant: SPINEMEDICA CORP ,  SALUMEDICA LLC ,  BETZ RANDAL R ,  BROWN REBECCAH ,  WILLIAMS STEPHEN

Inventor： BETZ RANDAL R ,  BROWN REBECCAH ,  WILLIAMS STEPHEN

IPC: A61L24/06 ,  A61L24/00 ,  A61L27/16 ,  A61L27/44 ,  A61L27/50

CPC classification number: A61K6/083 ,  A61K6/06 ,  A61L24/0063 ,  A61L27/425 ,  A61L2430/02 ,  C08L29/04

Abstract: Orthopaedic bone cement mixtures include a primary material that has a flowable state and a solid mass state and a low weight percent amount of polyvinyl alcohol (PVA) material. The PVA material is distributed in the primary material.

Abstract translation: 矫形骨水泥混合物包括具有可流动状态和固体质量状态的主要材料以及低重量百分比的聚乙烯醇（PVA）材料。 PVA材料分布在主材料中。

公开(公告)号：WO2007128953A1

公开(公告)日：2007-11-15

申请号：PCT/GB2007/000983

申请日：2007-03-21

Applicant: AIRBUS UK LIMITED ,  WILLIAMS, Stephen

Inventor： WILLIAMS, Stephen

IPC: B64D37/02

CPC classification number: H01R13/73 ,  H01R13/533 ,  H02G3/22

Abstract: An aircraft wiring installation connecting a set of fuel side wires in an aircraft fuel tank to a set of airside wires outside the fuel tank, the installation comprising: a connector box having a fuel side wall (22) and an airside wall (21); one or more connectors (40, 43) carried by the fuel side wall (22) which connect the fuel side wires to the airside wires; a fairing (6) partially covering the airside wall (21); and one or more holes (30) in the airside wall through which the airside wires pass from the connector box into the fairing (6).

Abstract translation: 一种将飞机燃料箱中的一组燃料侧电线连接到燃料箱外部的一组空气侧电线的飞行器接线装置，该装置包括：具有燃料侧壁（22）和空气侧壁（21）的连接器盒; 一个或多个由燃料侧壁（22）承载的连接器（40,43），其将燃料侧电线连接到空气侧电线; 部分覆盖空气侧壁（21）的整流罩（6）; 和空气侧壁中的一个或多个孔（30），空气侧线通过该孔从连接器盒穿过整流罩（6）。

公开(公告)号：WO2006136929A2

公开(公告)日：2006-12-28

申请号：PCT/IB2006/001694

申请日：2006-06-22

Applicant: ELEMENT SIX LIMITED ,  DONALD, Heather June ,  WILLIAMS, Stephen David ,  TWITCHEN, Daniel James ,  MARTINEAU, Philip Maurice ,  SCARSBROOK, Geoffrey Alan ,  FRIEL, Ian

Inventor： WILLIAMS, Stephen David ,  TWITCHEN, Daniel James ,  MARTINEAU, Philip Maurice ,  SCARSBROOK, Geoffrey Alan ,  FRIEL, Ian

IPC: C23C16/27 ,  C30B25/10 ,  C30B29/04

CPC classification number: C23C16/278 ,  C23C16/006 ,  C23C16/27 ,  C30B25/02 ,  C30B25/105 ,  C30B29/04 ,  Y10T428/26 ,  Y10T428/30

Abstract: A method of producing CVD diamond having a high colour, which is suitable for optical applications, for example. The method includes adding a gaseous source comprising a second impurity atom type to counter the detrimental effect on colour caused by the presence in the CVD synthesis atmosphere of a first impurity atom type. The described method applies to the production of both single crystal diamond and polycrystalline diamond.

Abstract translation: 例如，适用于光学应用的具有高颜色的CVD金刚石的方法。 该方法包括添加包含第二杂质原子类型的气态源，以抵消由于在第一杂质原子类型的CVD合成气氛中的存在引起的对颜色的不利影响。 所描述的方法适用于单晶金刚石和多晶金刚石的生产。

公开(公告)号：WO2005082299A2

公开(公告)日：2005-09-09

申请号：PCT/US2005/006334

申请日：2005-02-25

Applicant: FEMASYS INC. ,  LEE-SEPSICK, Kathy ,  PAXTON, Lani L. L. ,  MARCUS, Jeffrey A. ,  WILLIAMS, Stephen N.

Inventor： LEE-SEPSICK, Kathy ,  PAXTON, Lani L. L. ,  MARCUS, Jeffrey A. ,  WILLIAMS, Stephen N.

IPC: A61F6/00

CPC classification number: A61B17/42 ,  A61B17/12186 ,  A61B2017/1205 ,  A61B2017/4225 ,  A61B2017/4233 ,  A61F2/954 ,  A61F6/225 ,  A61M25/01

Abstract: The present invention comprises systems, methods and devices for the delivery of compositions for occluding or of means for opening conduits. The implantable occlusive material may be delivered pre-formed or in situ cured and, may be a resorbable material that supports tissue ingrowth that eventually replaces the material leaving little or no original material in place. The delivery system is positioned to allow for placement of the occlusive material into the body conduit. Use of delivery systems, methods and devices for re-opening an occluded body conduit are also included.

Abstract translation: 本发明包括用于输送用于闭塞的组合物或用于打开管道的装置的系统，方法和装置。 可植入的闭塞性材料可以被预先输送或原位固化，并且可以是支持组织向内生长的可吸收材料，其最终取代原材料而使原来的材料很少或不存在。 输送系统定位成允许将闭塞性材料放入身体导管中。 还包括使用输送系统，方法和设备来重新打开堵塞身体导管。

公开(公告)号：WO2003028543A3

公开(公告)日：2003-04-10

申请号：PCT/US2002/031642

申请日：2002-10-03

Applicant: PFIZER PRODUCTS INC. ,  OXFORD GLYCOSCIENCES (UK) LTD. ,  DURHAM, L., Kathryn ,  FRIEDMAN, David, L. ,  HERATH, Herath, Mudiyanselage, Athula, Chandrasiri ,  KIMMEL, Lida, H. ,  PAREKH, Rajesh, Bhikhu ,  POTTER, David, M. ,  ROHLFF, Christian ,  SILBER, B., Michael ,  SNYDER, Peter, Jeffrey ,  SOARES, Holly, Daria ,  STIGER, Thomas, R. ,  SUNDERLAND, P., Trey ,  TOWNSEND, Robert, Reid ,  WHITE, W., Frost ,  WILLIAMS, Stephen, A.

Inventor： DURHAM, L., Kathryn ,  FRIEDMAN, David, L. ,  HERATH, Herath, Mudiyanselage, Athula, Chandrasiri ,  KIMMEL, Lida, H. ,  PAREKH, Rajesh, Bhikhu ,  POTTER, David, M. ,  ROHLFF, Christian ,  SILBER, B., Michael ,  SNYDER, Peter, Jeffrey ,  SOARES, Holly, Daria ,  STIGER, Thomas, R. ,  SUNDERLAND, P., Trey ,  TOWNSEND, Robert, Reid ,  WHITE, W., Frost ,  WILLIAMS, Stephen, A.

IPC: C07K5/00

Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs antibodies immunospecific for APIs, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.

公开(公告)号：WO2002077034A3

公开(公告)日：2002-10-03

申请号：PCT/EP2002/001171

申请日：2002-02-05

Applicant: MERK PATENT GMBH ,  CARR, Francis, J. ,  CARTER, Graham ,  JONES, Tim ,  WILLIAMS, Stephen

Inventor： CARR, Francis, J. ,  CARTER, Graham ,  JONES, Tim ,  WILLIAMS, Stephen

IPC: C07K14/535

Abstract: The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of granulocyte colony stimulating factor (G-CSF) to result in granulocyte colony stimulating factor (G-CSF) proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo .

公开(公告)号：WO2002066514A2

公开(公告)日：2002-08-29

申请号：PCT/EP2002/001690

申请日：2002-02-18

Applicant: MERCK PATENT GMBH ,  GILLIES, Stephen ,  CARR, Francis, J. ,  JONES, Tim ,  CARTER, Graham ,  HAMILTON, Anita ,  WILLIAMS, Stephen ,  HANLON, Marian ,  WATKINS, John ,  BAKER, Matthew ,  WAY, Jeffrey, C.

Inventor： GILLIES, Stephen ,  CARR, Francis, J. ,  JONES, Tim ,  CARTER, Graham ,  HAMILTON, Anita ,  WILLIAMS, Stephen ,  HANLON, Marian ,  WATKINS, John ,  BAKER, Matthew ,  WAY, Jeffrey, C.

IPC: C07K16/00

CPC classification number: C07K16/30 ,  C07K16/28 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/30

Abstract: The invention relates to artificial modified proteins, preferably fusion proteins, having a reduced immunogenicity compared to the parent non-modified molecule when exposed to a species in vivo . The invention relates, above all, to novel immunoglobulin fusion proteins which essentially consist of an immunoglobulin molecule or a fragment thereof covalently fused via its C-terminus to the N-terminus of a biologically active non-immunoglobulin molecule, preferably a polypeptide or protein or a biologically active fragment thereof. In a specific embodiment, the invention relates to fusion proteins consisting of an Fc portion of an antibody which is fused as mentioned to the non-immunological target molecule which elicits biological or pharmacological efficacy. The molecules of the invention have amino acid sequences which are altered in one or more amino acid residue positions but have in principal the same biological activity as compared with the non-altered molecules. The changes are made in regions of the molecules which are identified as T-cell epitopes, which contribute to an immune reaction in a living host. Thus, the invention also relates to a novel method of making such fusion proteins by identifying said epitopes comprising calculation of T-cell epitope values for MHC Class II molecule binding sites in a peptide by computer-aided methods.

Abstract translation: 本发明涉及人体修饰蛋白，优选融合蛋白，当与体内物种暴露时，与亲本非修饰分子相比具有降低的免疫原性。 本发明首先涉及新的免疫球蛋白融合蛋白，其基本上由免疫球蛋白分子或其通过C末端与生物活性非免疫球蛋白分子，优选多肽或蛋白质的N末端共价融合的片段组成，或 其生物活性片段。 在一个具体的实施方案中，本发明涉及由抗体的Fc部分组成的融合蛋白，所述Fc部分如提及的非免疫靶标分子融合而引起生物学或药理学功效。 本发明的分子具有氨基酸序列，其在一个或多个氨基酸残基位置被改变，但与未改变的分子相比具有相同的生物学活性。 在被鉴定为T细胞表位的分子的区域中进行改变，其有助于在宿主中的免疫反应。 因此，本发明还涉及通过鉴定所述表位来制备此类融合蛋白的新方法，包括通过计算机辅助方法计算肽中MHC II类分子结合位点的T细胞表位值。