公开(公告)号：WO2011084341A1

公开(公告)日：2011-07-14

申请号：PCT/US2010/059624

申请日：2010-12-09

Applicant: MEDTRONIC, INC. ,  MOLNAR, Gabriela, C. ,  WU, Jianping

Inventor： MOLNAR, Gabriela, C. ,  WU, Jianping

IPC: A61B5/048 ,  A61N1/36

CPC classification number: A61B5/048 ,  A61B5/4082 ,  A61N1/0534 ,  A61N1/36139 ,  A61N1/36171 ,  A61N1/36185

Abstract: Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition can be selected based on a frequency domain characteristic of the sensed bioelectrical signals. In some examples, a stimulation electrode combination is selected based on a determination of which of the sense electrodes are located closest to a target tissue site, as indicated by the one or more sense electrodes that sensed a bioelectrical brain signal with a relatively highest value of the frequency domain characteristic. In some examples, determining which of the sense electrodes are located closest to the target tissue site may include executing an algorithm using relative values of the frequency domain characteristic.

Abstract translation: 可以在具有多个感测电极组合的患者的脑内感测生物电信号。 可以基于感测的生物电信号的频域特性来选择用于将刺激递送到患者以管理患者状况的刺激电极组合。 在一些示例中，基于确定哪个感测电极位于最靠近目标组织位置的位置来选择刺激电极组合，如感测出具有相对较高值的生物电脑信号的一个或多个感测电极所示 频域特性。 在一些示例中，确定哪个感测电极位于最靠近目标组织位置的位置可以包括使用频域特性的相对值来执行算法。

公开(公告)号：WO2010106437A1

公开(公告)日：2010-09-23

申请号：PCT/IB2010/000829

申请日：2010-03-19

Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA ,  WU, Jianping ,  MAJUMDER, Kaustav

Inventor： WU, Jianping ,  MAJUMDER, Kaustav

IPC: C40B40/10 ,  A23J1/00 ,  A61K38/01 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61P9/12 ,  C07K1/107 ,  C07K14/79 ,  C07K7/06 ,  C07K7/08 ,  C12N15/12 ,  C12P21/06

CPC classification number: C07K5/1024 ,  A23J3/34 ,  A23L33/18 ,  A23V2002/00 ,  A61K38/00 ,  C07K1/1133 ,  C07K5/0808 ,  C07K5/0821 ,  C07K5/1008 ,  C07K5/101 ,  C07K14/79 ,  C12P21/06 ,  C12Y304/15001 ,  Y02P20/52

Abstract: Described herein are methods of identifying and releasing bioactive peptides from ovotransferrin The method involves (a) contacting ovotransferrin with a reducing agent, a sonication step, a high pressure processing step, a heating step, a fermentation step, or any combination thereof, and (b) contacting the ovotransferrin after step (a) with a hydrolytic enzyme to produce bioactive peptides that exhibit angiotensin converting enzyme inhibitory activity or antioxidant activity when compared to the parent protein. The bioactive peptides may be added to foodstuffs, a medication, or to any potable, ingestible, or edible compositions.

Abstract translation: 本文描述了从转铁蛋白鉴定和释放生物活性肽的方法。该方法包括（a）将转铁蛋白与还原剂接触，超声处理步骤，高压加工步骤，加热步骤，发酵步骤或其任何组合，和（ b）在步骤（a）之后使转铁蛋白与水解酶接触以产生与亲本蛋白相比显示血管紧张素转化酶抑制活性或抗氧化活性的生物活性肽。 生物活性肽可以添加到食品，药物或任何可饮用的，可摄取的或可食用的组合物中。

公开(公告)号：WO2018191861A1

公开(公告)日：2018-10-25

申请号：PCT/CN2017/080891

申请日：2017-04-18

Applicant: GENERAL ELECTRIC COMPANY ,  GAO, Yibo ,  ZHOU, Hong ,  ZHANG, Liming ,  LIU, Yong ,  WU, Yingna ,  WU, Jianping

Inventor： GAO, Yibo ,  ZHOU, Hong ,  ZHANG, Liming ,  LIU, Yong ,  WU, Yingna ,  WU, Jianping

IPC: C23G5/00

CPC classification number: C23G5/00

Abstract: A method for removing oxide materials from a crack of a metallic workpiece comprises: infiltrating an alkali solution into the crack in a pressurized atmosphere or an ultrasonic environment; applying an energy to the crack to react the oxide materials with the alkali solution and form a resultant material; and rinsing the resultant material with an acid solution to remove the resultant material from the crack. The method is easier to penetrate into the inside of the cracks, in particular suitable for cleaning narrow and deep cracks.

公开(公告)号：WO2017016498A1

公开(公告)日：2017-02-02

申请号：PCT/CN2016/092001

申请日：2016-07-28

Applicant: COMMSCOPE TECHNOLOGIES LLC ,  WU, Jianping

Inventor： WU, Jianping ,  ZHANG, Yujun ,  AN, Hongjuan ,  ZHOU, Huifang

IPC: H01R9/05 ,  H02G15/02

CPC classification number: H01R9/0524 ,  H01R9/0527 ,  H02G15/085

Abstract: A connector (20) for a coaxial cable(10). The cable comprises an outer conductor (11), an inner conductor (12) and an insulating medium (13) located between the outer and the inner conductors, wherein the connector comprises a connector front body (21) and a connector rear body (22) inserted therein; the connector front body comprises a hollow shell(30); the connector rear body comprises a flare ring(50), a slot finger and a lock nut(70) which are inserted into the shell, wherein the flare ring at one end thereof rests against a shoulder (37) in the shell, the slot finger is mounted on the flare ring, and the lock nut is mounted on the slot finger and engages the inner surface of the shell; the flare ring is provided with adjacent the first incline(54) and the fist plane(55), and the slot finger is provided with adjacent the second incline(67) and the second plane(66), wherein the first incline is used for insertion between the outer conductor and the insulating medium of the coaxial cable, and the first incline and the first plane respectively cooperate with the second incline and the second plane, so as to simultaneously flare and crush the outer conductor of the coaxial cable. The cable connector can gain excellent third order intermodulation performance and high frequency transmission performance.

Abstract translation: 一种用于同轴电缆（10）的连接器（20）。 所述电缆包括位于所述外导体和所述内导体之间的外导体（11），内导体（12）和绝缘介质（13），其中所述连接器包括连接器前主体（21）和连接器后主体 ）插入; 连接器前体包括中空壳体（30）; 连接器后体包括插入壳体中的扩口环（50），狭槽指状物和锁定螺母（70），其中一端的扩口环抵靠壳体中的肩部（37），槽 手指安装在喇叭环上，锁紧螺母安装在槽指上并与外壳的内表面接合; 所述喇叭环设置有与所述第一倾斜部（54）和所述第一平面（55）相邻，并且所述狭槽指状物设置有与所述第二倾斜部（67）和所述第二平面（66）相邻，其中所述第一倾斜部用于 外部导体和同轴电缆的绝缘介质之间的插入以及第一倾斜面和第一平面分别与第二倾斜面和第二平面配合，以同时使同轴电缆的外部导体发光和挤压。 电缆连接器可以获得良好的三阶互调性能和高频率传输性能。

公开(公告)号：WO2011097210A1

公开(公告)日：2011-08-11

申请号：PCT/US2011/023307

申请日：2011-02-01

Applicant: MEDTRONIC, INC. ,  WU, Jianping ,  NELSON, Dwight E. ,  GUPTA, Rahul

Inventor： WU, Jianping ,  NELSON, Dwight E. ,  GUPTA, Rahul

IPC: A61N1/36 ,  A61B5/048 ,  A61B5/04

CPC classification number: A61N1/36067 ,  A61B5/048 ,  A61N1/0534 ,  A61N1/36171

Abstract: This disclosure describes techniques for delivering electrical stimulation to the brain of a patient at a frequency greater than a selected frequency. The techniques may reestablish gamma frequency band activity within the brain of a patient, and thus improve the patient's movements and cognitive states. In one example, the disclosure is directed to a device comprising a processor configured to select a frequency within a gamma frequency band and delivering electrical stimulation at a frequency greater than the selected frequency.

Abstract translation: 本公开描述了以大于所选频率的频率向患者的大脑递送电刺激的技术。 这些技术可能会重新建立患者脑内的伽马频带活动，从而改善患者的运动和认知状态。 在一个示例中，本公开涉及包括处理器的设备，该处理器被配置为选择伽马频带内的频率并以大于所选择的频率的频率递送电刺激。

公开(公告)号：WO2004057976A1

公开(公告)日：2004-07-15

申请号：PCT/CA2003/002020

申请日：2003-12-24

Applicant: HER MAJESTY THE QUEEN IN RIGHT OF CANADA as represented by THE MINISTER OF AGRICULTURE AND AGRI-FOOD CANADA ,  WU, Jianping ,  MUIR, Alister, D. ,  ALUKO, Rotimi, E.

Inventor： WU, Jianping ,  MUIR, Alister, D. ,  ALUKO, Rotimi, E.

IPC: A23J1/14

CPC classification number: A61K36/31 ,  A23J1/142 ,  A23J1/148 ,  A23J3/346 ,  A23L33/18 ,  A23V2002/00 ,  A23V2300/34 ,  A61K36/55 ,  A61K38/00 ,  C07K5/06078 ,  C07K5/0808 ,  C12P21/06 ,  A23V2250/0638 ,  A23V2250/0628 ,  A23V2250/0654 ,  A23V2250/0642

Abstract: Improved processes are provided for preparing ACE inhibitory peptide containing hydrolysates from a plant material such as a seed meal or flour. In one embodiment, the seed meal or flour is extracted with an organic solvent prior to digestion. Also provided are ACE inhibitory peptides Val-Ser-Val and Phe-Leu.

Abstract translation: 提供改进的方法用于从植物材料如种子粉或面粉制备含有ACE抑制肽的水解产物。 在一个实施方案中，种子粉或面粉在消化之前用有机溶剂萃取。 还提供ACE抑制肽Val-Ser-Val和Phe-Leu。

公开(公告)号：WO2012027286A1

公开(公告)日：2012-03-01

申请号：PCT/US2011/048663

申请日：2011-08-22

Applicant: MEDTRONIC, INC. ,  WU, Jianping ,  NELSON, Dwight E.

Inventor： WU, Jianping ,  NELSON, Dwight E.

IPC: A61B5/00 ,  A61B5/0496 ,  A61B5/0476 ,  A61N1/36

CPC classification number: A61N1/36067 ,  A61B5/04001 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/1104 ,  A61B5/1116 ,  A61B5/4812 ,  A61B5/4815 ,  A61B5/4836 ,  A61B5/6868 ,  A61B2562/0219 ,  A61N1/36003 ,  A61N1/36078

Abstract: Systems for delivering electrical stimulation to a patient via a medical device to manage or treat rapid eye movement behavior disorder (RBD) are described. A system comprises a therapy module and a processor that determines whether a patient is in a rapid eye movement (REM) sleep stage, and delivers electrical stimulation therapy to the patient based on the determination that the patient is in the REM sleep stage, where the electrical stimulation therapy is delivered to inhibit movement of the patient during the REM sleep stage. The electrical stimulation therapy may be delivered to the brain of the patient.

Abstract translation: 描述了通过医疗装置向患者传递电刺激以管理或治疗快速眼睛运动行为障碍（RBD）的系统。 系统包括治疗模块和处理器，其确定患者是否处于快速眼动（REM）睡眠阶段，并且基于患者处于REM睡眠阶段的确定，向患者传送电刺激治疗，其中 输送电刺激治疗以在REM睡眠阶段期间抑制患者的运动。 电刺激治疗可以递送到患者的大脑。

公开(公告)号：WO2009094050A1

公开(公告)日：2009-07-30

申请号：PCT/US2008/077720

申请日：2008-09-25

Applicant: MEDTRONIC, INC. ,  WU, Jianping ,  MOLNAR, Gregory, F. ,  MIYAZAWA, Gabriela, C. ,  DENISON, Timothy, J.

Inventor： WU, Jianping ,  MOLNAR, Gregory, F. ,  MIYAZAWA, Gabriela, C. ,  DENISON, Timothy, J.

IPC: A61M21/00 ,  A61B5/0476

CPC classification number: A61B5/4812 ,  A61B5/0031 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/024 ,  A61B5/04014 ,  A61B5/04015 ,  A61B5/0402 ,  A61B5/0478 ,  A61B5/048 ,  A61B5/1116 ,  A61B5/1118 ,  A61B5/4082 ,  A61B5/4839 ,  A61M5/1723 ,  A61M21/02 ,  A61M2005/1726 ,  A61M2021/0072 ,  A61M2205/3523 ,  A61M2205/3553 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/04 ,  A61M2230/08 ,  A61M2230/10 ,  A61M2230/205 ,  A61M2230/30 ,  A61M2230/42 ,  A61M2230/50 ,  A61M2230/60 ,  A61M2230/63 ,  A61M2230/65 ,  A61N1/36078 ,  A61N1/36139 ,  G06F19/3481 ,  G16H40/63

Abstract: Therapy delivery to a patient may be controlled based on a determined sleep stage of the patient. In examples, the sleep stage may be determined based on a frequency characteristic of a biosignal indicative of brain activity of the patient. A frequency characteristic may include, for example, a power level within one or more frequency bands of the biosignal, a ratio of the power level in two or more frequency bands, or a pattern in the power level of one or more frequency bands over time. A therapy program may be selected or modified based on the sleep stage determination. Therapy may be delivered during the sleep stage according to the selected or modified therapy program. In some examples, therapy delivery may be controlled after making separate determinations of a sleep stage based on the biosignal and another physiological parameter, and confirming that the sleep stage determinations are consistent.

Abstract translation: 可以基于患者的确定的睡眠阶段来控制对患者的治疗递送。 在实施例中，睡眠阶段可以基于指示患者的大脑活动的生物信号的频率特性来确定。 频率特性可以包括例如生物信号的一个或多个频带内的功率电平，两个或更多个频带中的功率电平的比率，或者一个或多个频带的功率电平中的模式随时间的变化 。 可以基于睡眠阶段确定来选择或修改治疗程序。 根据所选择或修改的治疗方案，治疗可以在睡眠阶段期间递送。 在一些实例中，可以在基于生物信号和另一生理参数进行睡眠阶段的单独测定以及确认睡眠阶段确定是一致的之后控制治疗递送。

公开(公告)号：WO2008088489A2

公开(公告)日：2008-07-24

申请号：PCT/US2007/024897

申请日：2007-12-04

Applicant: DANISCO US, INC., GENENCOR DIVISION ,  IOWA STATE UNIVERSITY ,  BIRSCHBACH, Peter ,  GLATZ, Charles, E. ,  JOHNSON, Lawrence, A. ,  JUNG, Stephanie ,  LAMSAL, Buddhi, Prasad ,  PENET, Christopher ,  WU, Jianping ,  ZHANG, Cheng

Inventor： BIRSCHBACH, Peter ,  GLATZ, Charles, E. ,  JOHNSON, Lawrence, A. ,  JUNG, Stephanie ,  LAMSAL, Buddhi, Prasad ,  PENET, Christopher ,  WU, Jianping ,  ZHANG, Cheng

IPC: B01D17/04 ,  B01D11/02 ,  C11B1/06 ,  C11B1/12 ,  C11B3/00

CPC classification number: C11B1/108 ,  B01D11/0492 ,  B01D17/0217 ,  B01D17/047 ,  C11B1/10

Abstract: Compositions and processes for destabilizing an oil-in-water emulsion resulting from the aqueous solvent extraction of plant oils are disclosed. The processes comprise the use of one or more enzyme activities including phospholipase and protease activity. The processes are useful for improving the extraction of oil from oilseeds, as well as for obtaining more desirable proteins from those oilseeds.

Abstract translation: 公开了用于使由植物油的含水溶剂提取产生的水包油乳液去稳定化的组合物和方法。 该方法包括使用一种或多种酶活性，包括磷脂酶和蛋白酶活性。 这些方法可用于改进从油籽中提取油，以及从这些油籽中获得更理想的蛋白质。

公开(公告)号：WO2008077242A1

公开(公告)日：2008-07-03

申请号：PCT/CA2007/002310

申请日：2007-12-18

Applicant: EXCEL-TECH LTD. ,  WU, Jianping ,  KURTZ, Ronald Leon ,  WEINROTH, Aaron Phillip

Inventor： WU, Jianping ,  KURTZ, Ronald Leon ,  WEINROTH, Aaron Phillip

IPC: A61B5/04 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0496

CPC classification number: A61B5/0492 ,  A61B5/0478 ,  A61B5/0496 ,  A61B5/4812 ,  A61B5/6814

Abstract: The described embodiments relate generally to methods, systems and devices for sleep stage determination using frontal electrodes. Certain embodiments relate to a system for sleep stage determination comprising a sensing unit and a processing unit. The sensing unit is positioned over a forehead area of a patient and has first, second and third electrodes for positioning at locations on or adjacent the forehead area for detecting electrical potentials of a human head. The processing unit is coupled to the sensing unit for receiving biological signals corresponding to the detected electrical potentials and processing the biological signals to determine a sleep stage of the patient. The processing of the biological signals is based on a plurality of rules.

Abstract translation: 所描述的实施例一般涉及使用正面电极进行睡眠阶段确定的方法，系统和装置。 某些实施例涉及一种用于睡眠阶段确定的系统，包括感测单元和处理单元。 感测单元位于患者的前额区域上方，并且具有第一，第二和第三电极，用于定位在前额区上或邻近前额区的位置，用于检测人头的电位。 处理单元耦合到感测单元，用于接收对应于检测到的电位的生物信号并处理生物信号以确定患者的睡眠阶段。 生物信号的处理是基于多个规则的。