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1.发明申请
公开(公告)号：WO2009089454A1
公开(公告)日：2009-07-16
申请号：PCT/US2009/030603
申请日：2009-01-09
Applicant: ARRAY BIOPHARMA INC. , BANKA, Anna , BENCSIK, Josef R. , BLAKE, James F. , FONG, Kin Chiu , HENTEMANN, Martin F. , MITCHELL, Ian S. , SAMMOND, Douglas McCord , TANG, Tony P. , WALLACE, Eli M. , XU, Rui
Inventor： BANKA, Anna , BENCSIK, Josef R. , BLAKE, James F. , FONG, Kin Chiu , HENTEMANN, Martin F. , MITCHELL, Ian S. , SAMMOND, Douglas McCord , TANG, Tony P. , WALLACE, Eli M. , XU, Rui
IPC: C07D471/10 , C07D487/10 , A61K31/517 , A61K31/438 , A61P35/00
CPC classification number: C07D471/10 , C07D487/10
Abstract: The present invention provides compounds of Formula (I) including tautomers, resolved enantiomers, resolved diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as Akt protein kinase inhibitors and for the treatment of Akt-mediated diseases, for example, hyperproliferative diseases such as cancer.
Abstract translation: 本发明提供式（I）化合物，其包括互变异构体，拆分的对映异构体，拆分的非对映体，溶剂合物，代谢物，盐和药学上可接受的前药。 还提供了使用本发明化合物作为Akt蛋白激酶抑制剂和治疗Akt介导的疾病例如过度增殖性疾病如癌症的方法。
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2.发明申请HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS 审中-公开羟基和甲氧基环丙氨酸[D]嘧啶酮作为AKT蛋白激酶抑制剂
公开(公告)号：WO2008006040A1
公开(公告)日：2008-01-10
申请号：PCT/US2007/072885
申请日：2007-07-05
Applicant: ARRAY BIOPHARMA INC. , GENENTECH, INC. , MITCHELL, Ian, S. , BLAKE, James, F. , XU, Rui , KALLAN, Nicholas, C. , XIAO, Dengming , SPENCER, Keith, Lee , BENCSIK, Josef, R. , LIANG, Jun , SAFINA, Brian , ZHANG, Birong , CHABOT, Christine , DO, Steven
Inventor： MITCHELL, Ian, S. , BLAKE, James, F. , XU, Rui , KALLAN, Nicholas, C. , XIAO, Dengming , SPENCER, Keith, Lee , BENCSIK, Josef, R. , LIANG, Jun , SAFINA, Brian , ZHANG, Birong , CHABOT, Christine , DO, Steven
IPC: C07D239/70 , C07D401/12 , C07D403/04 , C07D403/12 , C07D407/12 , C07D409/12 , C07D409/14 , A61K31/517 , A61P35/00
CPC classification number: C07D239/70 , C07D401/12 , C07D403/04 , C07D403/12 , C07D407/12 , C07D409/12 , C07D409/14
Abstract: The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula (I). Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
Abstract translation: 本发明提供了包含式（I）的化合物，包括拆分的对映体，拆分的非对映异构体，溶剂化物和药学上可接受的盐。 还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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3.发明申请
公开(公告)号：WO2008006025A1
公开(公告)日：2008-01-10
申请号：PCT/US2007/072863
申请日：2007-07-05
Applicant: ARRAY BIOPHARMA INC. , MITCHELL, Ian, S. , BLAKE, James, F. , XU, Rui , KALLAN, Nicholas, C. , XIAO, Dengming , SPENCER, Keith, Lee , BENCSIK, Josef, R.
Inventor： MITCHELL, Ian, S. , BLAKE, James, F. , XU, Rui , KALLAN, Nicholas, C. , XIAO, Dengming , SPENCER, Keith, Lee , BENCSIK, Josef, R.
IPC: C07D493/04 , A61K31/519 , A61P35/00
CPC classification number: C07D493/04
Abstract: The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula (I): Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
Abstract translation: 本发明提供包含式（I）的分解的对映体，非对映异构体，溶剂化物和药学上可接受的盐的化合物：还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和用于治疗过度增殖性疾病 作为癌症。
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4.发明申请AMINOPIPERIDINE AMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF 审中-公开氨基肽酰胺衍生物作为VLA-1整合拮抗剂及其用途
公开(公告)号：WO2005019177A1
公开(公告)日：2005-03-03
申请号：PCT/US2004/026207
申请日：2004-08-12
Applicant: ICOS CORPORATION , BOYD, Steven, A. , MILLER, Scott , THOMAS, Allen , XU, Rui , LEHUEROU, Yvan , GUNAWARDANA, Indrani , ZHANG, Gan , DEMEESE, Jason , MCLAUGHLIN, Martin , YANIK, Matthew , LUPHER, Mark, L., Jr. , JACOBSON, Irina, C. , THORSETT, Eugene
Inventor： BOYD, Steven, A. , MILLER, Scott , THOMAS, Allen , XU, Rui , LEHUEROU, Yvan , GUNAWARDANA, Indrani , ZHANG, Gan , DEMEESE, Jason , MCLAUGHLIN, Martin , YANIK, Matthew , LUPHER, Mark, L., Jr. , JACOBSON, Irina, C. , THORSETT, Eugene
IPC: C07D211/58
CPC classification number: C07D211/62 , C04B35/632 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
Abstract: Compounds of formula (I) that are VLA-1 integrin antagonists are disclosed. Also disclosed are compositions containing such compounds and methods of using such compounds in treating diseases mediated, at least in part, by the VLA-1 integrin.
Abstract translation: 公开了作为VLA-1整联蛋白拮抗剂的式（I）化合物。 还公开了含有这些化合物的组合物和使用这些化合物治疗由至少部分由VLA-1整联蛋白介导的疾病的方法。
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5.发明申请ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF 审中-公开丙烯酰胺衍生物作为VLA-1 INTEGRIN ANTAGONISTS及其用途
公开(公告)号：WO2005016883A2
公开(公告)日：2005-02-24
申请号：PCT/US2004026653
申请日：2004-08-12
Applicant: ICOS CORP , BOYD STEVEN A , MILLER SCOTT , THOMAS ALLEN , XU RUI , LEHUEROU YVAN , GUNAWARDANA INDRANI , ZHANG GAN , DEMEESE JASON , MCLAUGHLIN MARTIN , YANIK MATTHEW , LUPHER MARK L JR , JACOBSON IRINA C , THORSETT EUGENE D , FAROUZ FRANCINE S , KASAR RAMESH A
Inventor： BOYD STEVEN A , MILLER SCOTT , THOMAS ALLEN , XU RUI , LEHUEROU YVAN , GUNAWARDANA INDRANI , ZHANG GAN , DEMEESE JASON , MCLAUGHLIN MARTIN , YANIK MATTHEW , LUPHER MARK L JR , JACOBSON IRINA C , THORSETT EUGENE D , FAROUZ FRANCINE S , KASAR RAMESH A
IPC: A61K31/397 , A61K31/4178 , A61K31/4535 , A61K31/4709 , A61K31/4725 , A61K31/506 , C07D205/04 , C07D211/00 , C07D211/58 , C07D211/62 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
CPC classification number: C07D211/62 , C04B35/632 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
Abstract: Compounds that are VLA-1 integrin antagonists are disclosed. Also disclosed are compositions containing such compounds, and methods of using such compounds in treating diseases mediated, at least in part, by the VLA-1 integrin.
Abstract translation: 公开了作为VLA-1整联蛋白拮抗剂的化合物。 还公开了含有这些化合物的组合物，以及使用这些化合物治疗由至少部分由VLA-1整联蛋白介导的疾病的方法。
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Patent Agency Ranking6.发明申请WET LIMESTONE FLUE GAS DESULFURIZATION SLURRY STABILIZER AND METHOD OF USING SAME 审中-公开湿蒙脱石烟气脱硫浆料稳定剂及其使用方法
公开(公告)号：WO2013082856A8
公开(公告)日：2013-07-25
申请号：PCT/CN2012000580
申请日：2012-05-02
Applicant: JIANGXI ELECTRIC POWER SCIENCE RES INST , XU RUI , MEI CHONGMIN , WU FAYUAN , DENG YONGQIANG , MAO RONGJUN , TAN XU
Inventor： XU RUI , MEI CHONGMIN , WU FAYUAN , DENG YONGQIANG , MAO RONGJUN , TAN XU
CPC classification number: B01D53/502 , B01D2251/404 , B01D2251/606
Abstract: A wet limestone flue gas desulfurization slurry stabilizer and a method of using same. The stabilizer consists of lime, sodium formate, and an antifoaming agent. The components and the mass percentages thereof are as follows: lime, 30-70%, sodium formate, 15-40%, antifoaming agent, 15-40%. The method of using a desulfurization slurry stabilizer comprises preparing the slurry stabilizer and water or a desulfurization slurry into a homogeneous liquid with the mass concentration of 10-30% outside a desulfurization tower, and by using a pump and a slurry atomization and spraying device, spraying the desulfurization slurry into the absorption area and the reaction area of the desulfurization tower.
Abstract translation: 一种湿式石灰石烟气脱硫浆液稳定剂及其使用方法。 稳定剂由石灰，甲酸钠和消泡剂组成。 组分及其质量百分比如下：石灰，30-70％，甲酸钠，15-40％，消泡剂，15-40％。 使用脱硫浆液稳定剂的方法是将脱硫浆液稳定剂和水或脱硫浆液制成质量浓度为10-30％的均质液体在脱硫塔外，使用泵和浆液雾化喷淋装置， 将脱硫浆液喷入脱硫塔的吸收区和反应区。
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公开(公告)号：WO2013049147A3
公开(公告)日：2013-07-18
申请号：PCT/US2012057255
申请日：2012-09-26
Applicant: FORMFACTOR INC , FAN LI , XU RUI
CPC classification number: G01R1/06727 , G01R1/06744
Abstract: An electrically conductive probe can comprise a post to which a beam structure is attached. The beam structure can comprise a cantilevered portion that extends away from the post to a free end to which a contact structure can be attached. The cantilevered portion of the beam can include both a solid section and a hollow section. Multiple such probes can be used in a test contactor to make electrical connections with an electronic device such as a semiconductor die or dies to be tested.
Abstract translation: 导电探针可以包括梁结构附接到的柱。 梁结构可以包括悬臂部分，该悬臂部分从柱延伸到自由端，接触结构可以附接到该自由端。 梁的悬臂部分可以包括实心部分和中空部分。 可以在测试接触器中使用多个这样的探针以与待测试的诸如半导体管芯或管芯的电子器件进行电连接。
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公开(公告)号：WO2013049147A2
公开(公告)日：2013-04-04
申请号：PCT/US2012/057255
申请日：2012-09-26
Applicant: FORMFACTOR, INC. , FAN, Li , XU, Rui
CPC classification number: G01R1/06727 , G01R1/06744
Abstract: An electrically conductive probe can comprise a post to which a beam structure is attached. The beam structure can comprise a cantilevered portion that extends away from the post to a free end to which a contact structure can be attached. The cantilevered portion of the beam can include both a solid section and a hollow section. Multiple such probes can be used in a test contactor to make electrical connections with an electronic device such as a semiconductor die or dies to be tested.
Abstract translation: 导电探针可以包括梁结构附接到的柱。 梁结构可以包括悬臂部分，该悬臂部分从支柱延伸到可以连接接触结构的自由端。 梁的悬臂部分可以包括固体部分和中空部分。 多个这样的探针可以用于测试接触器中，以与电子设备（例如半导体管芯或要测试的管芯）形成电连接。
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9.发明申请
公开(公告)号：WO2009006569A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/069147
申请日：2008-07-03
Applicant: ARRAY BIOPHARMA INC. , GENENTECH, INC. , BENCSIK, Josef, R. , BLAKE, James, F. , KALLAN, Nicholas, C. , MITCHELL, Ian, S. , SPENCER, Keith, L. , XIAO, Dengming , XU, Rui , CHABOT, Christine , LIANG, Jun , SAFINA, Brian, S.
Inventor： BENCSIK, Josef, R. , BLAKE, James, F. , KALLAN, Nicholas, C. , MITCHELL, Ian, S. , SPENCER, Keith, L. , XIAO, Dengming , XU, Rui , CHABOT, Christine , LIANG, Jun , SAFINA, Brian, S.
IPC: C07D239/70 , A61K31/517 , A61P35/00
CPC classification number: C07D239/70 , C07D401/12 , C07D403/12 , C07D409/12
Abstract: The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
Abstract translation: 本发明提供了式I化合物，包括互变异构体，拆分的对映异构体，非对映异构体，溶剂合物，代谢物，盐和药学上可接受的前药。 还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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10.发明申请ARYL PIPERIDINE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF 审中-公开ARYL PIPERIDINE衍生物作为VLA-1整合拮抗剂及其用途
公开(公告)号：WO2005019200A3
公开(公告)日：2008-01-03
申请号：PCT/US2004026206
申请日：2004-08-12
Applicant: ICOS CORP , BOYD STEVEN A , DEMEESE JASON , GUNAWARDANA INDRANI , JACOBSON IRINA C , LEHUEROU YVAN , LUPHER MARK L JR , MCLAUGHLIN MARTIN , MILLER SCOTT , THOMAS ALLEN , THORSETT EUGENE , XU RUI , YANIK MATTHEW , ZHANG GAN
Inventor： BOYD STEVEN A , DEMEESE JASON , GUNAWARDANA INDRANI , JACOBSON IRINA C , LEHUEROU YVAN , LUPHER MARK L JR , MCLAUGHLIN MARTIN , MILLER SCOTT , THOMAS ALLEN , THORSETT EUGENE , XU RUI , YANIK MATTHEW , ZHANG GAN
IPC: C07D401/04 , A61K31/451 , A61K31/4545 , A61K31/4709 , A61P19/04 , A61P35/00 , C07D211/62 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/04 , C07D417/14 , C07K5/02
CPC classification number: C04B35/632 , C07D211/62 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/04 , C07D417/14
Abstract: Aryl piperidine that are VLA-1 integrin antagonists are disclosed. Also disclosed are compositions containing such compounds and methods of using such compounds in treating diseases mediated, at least in part, by the VLA-I integrin.
Abstract translation: 公开了作为VLA-1整联蛋白拮抗剂的芳基哌啶。 还公开了含有这些化合物的组合物和使用这些化合物治疗由至少部分由VLA-1整合素介导的疾病的方法。
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