公开(公告)号：WO2016044788A2

公开(公告)日：2016-03-24

申请号：PCT/US2015/051054

申请日：2015-09-18

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  HARRINGTON, Joel

Inventor： HARRINGTON, Joel ,  LUMAUIG, Rommel ,  PACETTI, Stephen D. ,  DING, Ni ,  MA, Xiao ,  OBERHAUSER, James ,  MCCOY, Jill ,  ABUNASSAR, Chad J. ,  ESWARAN, Senthil ,  TA, Diem

IPC: A61L31/06

CPC classification number: A61F2/915 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2210/0004 ,  A61F2230/0069 ,  A61L31/06 ,  A61L31/14 ,  A61L31/148 ,  B29C71/02 ,  B29C2035/046 ,  B29C2035/048 ,  B29C2035/0811 ,  B29C2035/0822 ,  B29C2035/0855 ,  B29C2035/0861 ,  B29C2071/022 ,  B29K2067/046 ,  B29K2995/006 ,  B29L2031/7534 ,  C08G63/08 ,  C08L67/04

Abstract: Method is disclosed including thermally processing a scaffold to increase the radial strength of the scaffold when the scaffold is deployed from a crimped state to a deployed state such as a nominal deployment diameter. The thermal processing may further maintain or increase the expansion capability of the scaffold when expanded beyond the nominal diameter.

Abstract translation: 公开了包括热处理支架以在支架从卷曲状态展开到展开状态（例如标称展开直径）时增加支架的径向强度的方法。 当热膨胀超过公称直径时，热处理可进一步保持或增加支架的膨胀能力。

公开(公告)号：WO2011011241A2

公开(公告)日：2011-01-27

申请号：PCT/US2010/041996

申请日：2010-07-14

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  WANG, Yunbing ,  OBERHAUSER, James ,  GADA, Manish ,  GLAUSER, Thierry ,  GUERIGUIAN, Vincent ,  STEICHEN, Bethany ,  KLEINER, Lothar ,  MA, Xiao

Inventor： WANG, Yunbing ,  OBERHAUSER, James ,  GADA, Manish ,  GLAUSER, Thierry ,  GUERIGUIAN, Vincent ,  STEICHEN, Bethany ,  KLEINER, Lothar ,  MA, Xiao

IPC: A61L31/06

CPC classification number: A61L31/14 ,  A61L31/06 ,  C08L67/04

Abstract: The present invention relates to implantable medical devices comprising a L-lactide-constitutional unit-containing copolymer having a wt% percent crystallinity of 40% or less.

Abstract translation: 本发明涉及包含具有40％或更低的重量百分比％结晶度的含L-丙交酯结构单元的共聚物的可植入医疗器械。

公开(公告)号：WO2010019478A1

公开(公告)日：2010-02-18

申请号：PCT/US2009/053182

申请日：2009-08-07

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  WANG, Yunbing ,  OBERHAUSER, James

Inventor： WANG, Yunbing ,  OBERHAUSER, James

IPC: A61L31/14 ,  B29C55/24 ,  B29C47/00

CPC classification number: A61L31/148 ,  A61L31/041 ,  B29C47/0004 ,  B29C47/0023 ,  B29C47/0026 ,  B29C47/882 ,  B29C47/8895 ,  B29C55/24 ,  B29D23/001 ,  B29K2067/00 ,  B29K2067/046 ,  B29K2995/006 ,  B29L2023/007 ,  B29L2031/7534 ,  C08L67/04

Abstract: Methods of fabricating a polymeric implantable device from a PLLA/PDLA blend such as a stent with improved fracture toughness are disclosed. The blend is melt processed to allow formation of stereocomplex crystallites, which are nucleation sites for crystal growth. A polymer construct is formed from the melt processed blend and device is formed from the polymer construct. The stereocomplex crystallites result in an in increase in nucleation density and reduced crystal size, which increases fracture toughness of the formed device.

Abstract translation: 公开了从具有改进的断裂韧性的支架的PLLA / PDLA共混物制造聚合物可植入装置的方法。 将共混物熔融加工以形成立体复合晶体，其是用于晶体生长的成核位点。 由熔融加工的共混物形成聚合物构件，并且由聚合物构造体形成装置。 立体络合物微晶导致成核密度增加和晶体尺寸减小，这增加了所形成的器件的断裂韧性。

公开(公告)号：WO2014158261A1

公开(公告)日：2014-10-02

申请号：PCT/US2013/076302

申请日：2013-12-18

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： WANG, Yunbing ,  OBERHAUSER, James ,  GADA, Manish

IPC: A61L31/14 ,  A61L31/16 ,  A61L31/04

CPC classification number: A61F2/06 ,  A61L31/041 ,  A61L31/129 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/422 ,  C08L67/04

Abstract: A medical device implantable within a peripheral vessel of the body composed of a bioresorbable polymer is disclosed. The device has a high resistance to fracture, is very flexible, and has a high crush recovery when subjected to crushing, axial, or torsional forces.

Abstract translation: 公开了一种可植入在由生物可再吸收的聚合物组成的身体的外周血管内的医疗装置。 该装置具有高抗断裂性，非常柔软，并且当受到破碎，轴向或扭转力时具有高的压碎恢复性。

公开(公告)号：WO2010019448A2

公开(公告)日：2010-02-18

申请号：PCT/US2009/053029

申请日：2009-08-06

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  WANG, Yunbing ,  OBERHAUSER, James

Inventor： WANG, Yunbing ,  OBERHAUSER, James

IPC: A61L31/06 ,  A61L31/14

CPC classification number: B29C51/002 ,  A61L31/06 ,  A61L31/14 ,  Y10T29/49 ,  C08L67/04

Abstract: Methods of fabricating a polymeric implantable device with improved fracture toughness through annealing are disclosed herein. A polymeric construct is annealed with no or substantially no crystal growth to increase nucleation density. After the annealing, crystallites are grown around the formed nuclei. An implantable medical device, such as a stent, can be fabricated from the polymer construct after the crystallite growth.

Abstract translation: 本文公开了通过退火制造具有改善的断裂韧性的聚合物可植入装置的方法。 将聚合物构件退火，没有或基本上没有晶体生长以增加成核密度。 退火后，在形成的核周围生长微晶。 在微晶生长之后，可由聚合物构造体制造诸如支架的可植入医疗装置。

公开(公告)号：WO2015195794A2

公开(公告)日：2015-12-23

申请号：PCT/US2015/036216

申请日：2015-06-17

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： MA, Xiao ,  KOSSUTH, Mary, Beth ,  OBERHAUSER, James ,  PACETTI, Stephen, D. ,  GADA, Manish

IPC: A61L31/04

CPC classification number: A61F2/90 ,  A61F2/91 ,  A61L31/041 ,  A61L31/06 ,  A61L31/148

Abstract: Bioresorbable polymer vascular scaffolds made of combinations of polylactide and polycaprolactone having thin struts in a selected range and sufficient radial strength to support a vessel upon deployment are disclosed. The scaffolds have degradation behavior of molecular weight, radial strength, and mass that are conducive to healing of a vessel including providing patency to a vessel, reduction of radial strength, breaking up, and resorbing to allow return of the vessel to a natural state.

Abstract translation: 公开了由具有选定范围的薄支柱的聚丙交酯和聚己内酯的组合制成的生物再吸收聚合物血管支架，并具有足够的径向强度以在展开时支撑血管。 支架具有有助于血管愈合的分子量，径向强度和质量的降解行为，包括向容器提供通畅性，降低径向强度，分解和再吸收以允许血管返回到自然状态。

公开(公告)号：WO2012051195A1

公开(公告)日：2012-04-19

申请号：PCT/US2011/055792

申请日：2011-10-11

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  WANG, Yunbing ,  OBERHAUSER, James

Inventor： WANG, Yunbing ,  OBERHAUSER, James

IPC: A61L31/06 ,  A61L31/14

CPC classification number: A61F2/82 ,  A61F2/958 ,  A61F2002/9583 ,  A61L31/06 ,  A61L31/148 ,  H01J2237/31 ,  C08L67/04

Abstract: Methods of fabricating an implantable medical devices such as stents made from biodegradable polymers are disclosed that reduce or minimize chain scission and monomer generation during processing steps. The method includes processing a poly(L-lactide) resin having an number average molecular weight between 150 to 200 kD in an extruder in a molten state. A poly(L-lactide) tube is formed from the processed resin and a stent is fabricated from the tube. The number average molecular weight of the poly(L-lactide) of the stent after sterilization is 70 to 100 kD.

Abstract translation: 公开了制造可植入医疗装置的方法，例如由可生物降解的聚合物制成的支架，其可减少或最小化加工步骤期间的链断裂和单体产生。 该方法包括在熔融状态的挤出机中加工数均分子量为150〜200kD的聚（L-丙交酯）树脂。 由处理后的树脂形成聚（L-丙交酯）管，由管制造支架。 灭菌后支架的聚（L-丙交酯）的数均分子量为70〜100kD。

公开(公告)号：WO2011031872A2

公开(公告)日：2011-03-17

申请号：PCT/US2010/048287

申请日：2010-09-09

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  GLAUSER, Thierry ,  GUERIGUIAN, Vincent J. ,  STEICHEN, Bethany ,  OBERHAUSER, James ,  GADA, Manish ,  KLEINER, Lothar

Inventor： GLAUSER, Thierry ,  GUERIGUIAN, Vincent J. ,  STEICHEN, Bethany ,  OBERHAUSER, James ,  GADA, Manish ,  KLEINER, Lothar

IPC: B29C49/08

CPC classification number: B29D22/00 ,  A61F2/91 ,  B29C49/0005 ,  B29C49/02 ,  B29C49/04 ,  B29C49/08 ,  B29C49/78 ,  B29C55/26 ,  B29C2793/009 ,  B29K2995/004 ,  B29K2995/0041 ,  B29K2995/0046 ,  B29K2995/0056 ,  B29K2995/006 ,  B29K2995/0077 ,  B29K2995/0089 ,  B29L2031/7542

Abstract: Methods to expand polymer tubing with desirable or optimum morphology and mechanical properties for stent manufacture and fabrication of a stent therefrom are disclosed.

Abstract translation: 公开了扩展聚合物管的方法，其具有用于支架制造和制造支架的所需或最佳形态和机械性能。

公开(公告)号：WO2013148860A1

公开(公告)日：2013-10-03

申请号：PCT/US2013/034139

申请日：2013-03-27

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  GILLICK, Matthew ,  WANG, Yunbing ,  MANN, Justin ,  WILSON, Bruce ,  OBERHAUSER, James

Inventor： GILLICK, Matthew ,  WANG, Yunbing ,  MANN, Justin ,  WILSON, Bruce ,  OBERHAUSER, James

IPC: A61F2/958 ,  A61M25/10

CPC classification number: A61F2/958 ,  A61F2250/0013 ,  A61M25/10181 ,  A61M25/10185

Abstract: A fluid accumulator (130) for controlling inflation pressure and pressurization rate of a stent delivery balloon catheter (120) during deployment of a stent or scaffold (126) are disclosed. The fluid accumulator comprises a chamber (136) connected with an inflation lumen of a balloon (125). A movable wall (138) inside the chamber allows the volume of the chamber to vary in response to pressure of inflation fluid that flows into the chamber. The wall moves against a biasing force that opposes a volume increase of the chamber and thus attenuates the pressure in the chamber.

Abstract translation: 公开了一种用于在展开支架或支架（126）期间控制支架输送球囊导管（120）的充气压力和加压速率的流体蓄积器（130）。 流体蓄积器包括与球囊（125）的充气腔连接的腔室（136）。 室内的可移动壁（138）允许室的体积响应于流入室的充气流体的压力而变化。 壁抵抗与室的体积增加相反的偏压力并因此衰减室中的压力。

公开(公告)号：WO2012145326A1

公开(公告)日：2012-10-26

申请号：PCT/US2012/033955

申请日：2012-04-17

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  WANG, Yunbing ,  LUMAUIG, Rommel ,  OBERHAUSER, James ,  ROBERTS, Lily Ayo ,  MCNIVEN, Sean A. ,  YAN, Kathleen ,  KNOTT, Boyd V. ,  BEER, Jeremy B. ,  JOHNSON, Mark C.

Inventor： WANG, Yunbing ,  LUMAUIG, Rommel ,  OBERHAUSER, James ,  ROBERTS, Lily Ayo ,  MCNIVEN, Sean A. ,  YAN, Kathleen ,  KNOTT, Boyd V. ,  BEER, Jeremy B. ,  JOHNSON, Mark C.

IPC: A61F2/84

CPC classification number: A61F2/958 ,  A61F2/915 ,  A61F2002/9522 ,  A61F2210/0014 ,  A61L31/06 ,  C08L67/04

Abstract: A medical device includes a scaffold crimped to a catheter having an expansion balloon. The scaffold is crimped to the balloon by a process that includes one or more balloon pressurization steps. The balloon pressurization steps are selected to enhance scaffold retention to the balloon and maintain a relatively uniform arrangement of balloon folds about the inner surface of the crimped scaffold so that the scaffold expands in a uniform manner when the balloon is inflated.

Abstract translation: 医疗装置包括卷曲到具有膨胀气囊的导管的支架。 支架通过包括一个或多个气囊加压步骤的过程卷曲到气囊。 选择球囊加压步骤以增强对球囊的支架保持性，并且保持围绕卷曲的支架的内表面的气球折叠的相对均匀的布置，使得当气囊膨胀时，支架以均匀的方式膨胀。