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公开(公告)号：WO2016044788A2
公开(公告)日：2016-03-24
申请号：PCT/US2015/051054
申请日：2015-09-18
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. , HARRINGTON, Joel
Inventor： HARRINGTON, Joel , LUMAUIG, Rommel , PACETTI, Stephen D. , DING, Ni , MA, Xiao , OBERHAUSER, James , MCCOY, Jill , ABUNASSAR, Chad J. , ESWARAN, Senthil , TA, Diem
IPC: A61L31/06
CPC classification number: A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2210/0004 , A61F2230/0069 , A61L31/06 , A61L31/14 , A61L31/148 , B29C71/02 , B29C2035/046 , B29C2035/048 , B29C2035/0811 , B29C2035/0822 , B29C2035/0855 , B29C2035/0861 , B29C2071/022 , B29K2067/046 , B29K2995/006 , B29L2031/7534 , C08G63/08 , C08L67/04
Abstract: Method is disclosed including thermally processing a scaffold to increase the radial strength of the scaffold when the scaffold is deployed from a crimped state to a deployed state such as a nominal deployment diameter. The thermal processing may further maintain or increase the expansion capability of the scaffold when expanded beyond the nominal diameter.
Abstract translation: 公开了包括热处理支架以在支架从卷曲状态展开到展开状态（例如标称展开直径）时增加支架的径向强度的方法。 当热膨胀超过公称直径时，热处理可进一步保持或增加支架的膨胀能力。
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2.发明申请DRUG DELIVERY SCAFFOLD OR STENT WITH A NOVOLIMUS AND LACTIDE BASED COATING SUCH THAT NOVOLIMUS HAS A MINIMUM AMOUNT OF BONDING TO THE COATING 审中-公开药物递送SCAFFOL或STENT与NOVOLIMUS和LACTIDE这样的涂料，如果NOVOLIMUS具有最少量的粘合到涂层
公开(公告)号：WO2015119653A1
公开(公告)日：2015-08-13
申请号：PCT/US2014/041398
申请日：2014-06-06
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： DING, Ni , PACETTI, Stephen , KAMBERI, Marika , KERRIGAN, Cameron
CPC classification number: A61L31/16 , A61K31/436 , A61K47/593 , A61K47/6957 , A61L31/10 , A61L31/148 , A61L2300/416 , A61L2420/02 , C08L67/04
Abstract: Disclosed herein are drug delivery medical devices. A polymer coating for a medical device is provided which comprises a minimum amount of a drug bonded to the polymer in the coating.
Abstract translation: 本文公开了药物递送医疗装置。 提供了一种用于医疗装置的聚合物涂层，其包括与涂层中的聚合物结合的最少量的药物。
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3.发明申请METHOD OF FABRICATION OF IMPLANTABLE MEDICAL DEVICE COMPRISING MACROCYCLIC TRIENE ACTIVE AGENT AND ANTIOXIDANT 审中-公开包含大环三磷酸活性剂和抗氧化剂的可植入医疗装置的制造方法
公开(公告)号：WO2014062339A1
公开(公告)日：2014-04-24
申请号：PCT/US2013/060468
申请日：2013-09-18
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： PACETTI, Stephen D. , DING, Ni
IPC: A61L31/16
CPC classification number: A61L31/08 , A61L31/16 , A61L2300/416 , A61L2300/428 , A61L2300/608 , A61L2300/61 , A61L2420/08
Abstract: This invention relates to methods of including an oxygen-sensitive macrocyclic triene on an implantable medical device wherein the device includes separate antioxidant-containing layers above, below or both above and below the drug reservoir layer containing the macrocyclic triene.
Abstract translation: 本发明涉及在可植入医疗装置上包含氧敏感性大环三烯的方法，其中该装置在含有大环三烯的药物贮存层上方，下方或两者以上含有分离的抗氧化剂层。
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4.发明申请CONTROLLING MOISTURE IN AND PLASTICIZATION OF BIORESORBABLE POLYMER FOR MELT PROCESSING 审中-公开控制用于熔融加工的可生物降解聚合物的水分和塑化
公开(公告)号：WO2013022851A2
公开(公告)日：2013-02-14
申请号：PCT/US2012/049775
申请日：2012-08-06
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. , STEICHEN, Bethany , PACETTI, Stephen, D. , GADA, Manish , GLAUSER, Thierry , KLEINER, Lothar, W. , WANG, Yunbing , OBERHAUSER, James, P. , DING, Ni
Inventor： STEICHEN, Bethany , PACETTI, Stephen, D. , GADA, Manish , GLAUSER, Thierry , KLEINER, Lothar, W. , WANG, Yunbing , OBERHAUSER, James, P. , DING, Ni
CPC classification number: B29C47/0078 , B29B13/06 , B29B13/065 , B29C47/0014 , B29C47/0021 , B29C47/0023 , B29C47/1018 , B29C47/1072 , B29C47/76 , B29C47/92 , B29C2947/922 , B29C2947/92228 , B29C2947/92342 , B29C2947/92695 , B29C2947/92704 , B29C2947/92723 , B29K2995/006
Abstract: Methods and systems for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon.
Abstract translation: 公开了用于在挤出之前控制可生物降解和生物可再吸收的聚合物树脂的含水量的方法和系统，其允许聚合物树脂熔体增塑并低于上限以降低或防止分子量损失。 进一步公开的方法涉及用二氧化碳和氟利昂进料到挤出机中的聚合物树脂的增塑。
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5.发明申请
公开(公告)号：WO2009117398A2
公开(公告)日：2009-09-24
申请号：PCT/US2009/037375
申请日：2009-03-17
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. , HSU, Shaw, Ling , TANG, Yiwen , KLEINER, Lothar, W. , TANG, Fuh-Wei , DING, Ni , HOSSAINY, Syed, Faiyaz Ahmed
Inventor： HSU, Shaw, Ling , TANG, Yiwen , KLEINER, Lothar, W. , TANG, Fuh-Wei , DING, Ni , HOSSAINY, Syed, Faiyaz Ahmed
CPC classification number: A61L27/34 , A61L31/10 , A61L2420/08 , C08L67/04
Abstract: Implantable medical device coatings that have improved mechanical stability and medical devices coated with such coatings are disclosed.
Abstract translation: 公开了具有改善的机械稳定性的植入式医疗装置涂层和涂覆有这种涂层的医疗装置。
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Patent Agency Ranking
公开(公告)号：WO2015119976A1
公开(公告)日：2015-08-13
申请号：PCT/US2015/014330
申请日：2015-02-03
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. , MORTISEN, Derek
Inventor： MORTISEN, Derek , DING, Ni , PACETTI, Stephen , TANG, Fuh-Wei , MA, Xiao
CPC classification number: A61L31/06 , A61F2/82 , A61F2/91 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , A61K47/593 , A61L2/087 , A61L31/10 , A61L31/148 , A61L2300/606 , B29B13/08 , B29C71/04 , B29C2035/0827 , B29C2035/085 , B29C2035/0877 , C08G63/08 , C08G63/912
Abstract: It is provided herein modified polylactide (PLA) polymers comprising biocompatibile functional group(s) on the polymers and methods of making and using the modified PLA polymers.
Abstract translation: 提供了在聚合物上包含生物相容性官能团的改性聚丙交酯（PLA）聚合物以及制备和使用改性PLA聚合物的方法。
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公开(公告)号：WO2014182542A1
公开(公告)日：2014-11-13
申请号：PCT/US2014/036427
申请日：2014-05-01
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： PACETTI, Stephen D. , DING, Ni
CPC classification number: A61L31/16 , A61F2/82 , A61F2250/0067 , A61F2250/0068 , A61L27/50 , A61L27/505 , A61L27/54 , A61L31/022 , A61L31/143 , A61L2300/00 , A61L2300/416 , A61L2300/426 , A61L2300/604 , A61L2300/802 , B65B3/003 , Y10T29/49993
Abstract: A composition for loading into a structural element of a stent, where the structural element is defined by a lumen and at least one opening to access the lumen. The composition may comprise a therapeutic agent, and a chelator, a precipitation agent, or a combination thereof. Medical devices, such as stents, with a structural element defined by a lumen and at least one opening to access the lumen, filled with the compositions are also described.
Abstract translation: 用于装载到支架的结构元件中的组合物，其中所述结构元件由内腔和至少一个开口限定以进入所述内腔。 组合物可以包含治疗剂，螯合剂，沉淀剂或其组合。 还描述了填充有组合物的医疗装置，例如具有由内腔限定的结构元件和用于进入内腔的至少一个开口的支架。
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公开(公告)号：WO2008002632A2
公开(公告)日：2008-01-03
申请号：PCT/US2007/014981
申请日：2007-06-25
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. , DING, Ni , MICHAL, Gene , PACETTI, Stephen D.
Inventor： DING, Ni , MICHAL, Gene , PACETTI, Stephen D.
CPC classification number: A61L31/16 , A61L31/084 , A61L2300/606
Abstract: A carbon coating on a stent having a bioactive agent covalently attached thereto and methods of making the same are described.
Abstract translation: 描述了具有共价连接于其上的生物活性剂的支架上的碳涂层及其制备方法。
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公开(公告)号：WO2012148452A1
公开(公告)日：2012-11-01
申请号：PCT/US2011/057932
申请日：2011-10-26
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. , WANG, Yunbing , MA, Xiao , TANG, Fuh-Wei , DING, Ni
Inventor： WANG, Yunbing , MA, Xiao , TANG, Fuh-Wei , DING, Ni
CPC classification number: B29C71/02 , A61F2/82 , A61F2/915 , A61F2002/91558 , A61F2002/91583 , A61F2210/0004 , A61F2240/001 , A61L2/007 , A61L2/08 , A61L2/087 , A61L31/06 , A61L31/148 , A61L2202/21 , A61L2202/24 , A61L2400/18 , B29C35/02 , B29C2035/0877 , B29C2071/022 , B29L2031/753 , C08J7/08 , C08J7/123 , C08J2367/04 , C08L67/04
Abstract: Methods are disclosed for conditioning a polymeric stent after sterilization, and/or after crimping and before packaging, such that the properties of the polymeric stent fall within a narrower range of values. The stent is exposed to a controlled temperature at or above ambient for a period of time after radiation sterilization and/or after crimping and before sterilization. As a result, the polymeric stent properties, particularly radial strength and number- average molecular weight of the polymer of the polymeric stent, fall within a narrower range.
Abstract translation: 公开了用于在灭菌后和/或在卷曲之后和包装之前调节聚合物支架的方法，使得聚合物支架的性质落在较窄的值范围内。 在辐射灭菌后和/或在压接之后和灭菌之前将支架暴露于等于或高于环境的受控温度一段时间。 结果，聚合物支架的聚合物支架性质，特别是聚合物支架的聚合物的径向强度和数均分子量在更窄的范围内。
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公开(公告)号：WO2015191758A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/035171
申请日：2015-06-10
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： PACETTI, Stephen D. , DING, Ni
IPC: A61L31/06
Abstract: Methods of making polymeric devices, such as stents, using solvent based processes. More particularly, methods of making bioabsorbable stents.
Abstract translation: 使用基于溶剂的方法制造聚合物装置例如支架的方法。 更具体地，制备生物可吸收支架的方法。
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