公开(公告)号：WO2011123209A1

公开(公告)日：2011-10-06

申请号：PCT/US2011/026794

申请日：2011-03-02

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  KLEINER, Lothar W. ,  HOSSAINY, Syed F.A. ,  TROLLSAS, Mikael ,  PACETTI, Stephen D.

Inventor： KLEINER, Lothar W. ,  HOSSAINY, Syed F.A. ,  TROLLSAS, Mikael ,  PACETTI, Stephen D.

IPC: A61L31/10 ,  A61L31/16

CPC classification number: A61L31/148 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2420/02 ,  A61L2420/08 ,  C08L67/04

Abstract: The present invention provides an absorbable coating for an implantable device and the methods of making and using the same.

Abstract translation: 本发明提供了一种用于可植入装置的可吸收涂层及其制造和使用方法。

公开(公告)号：WO2011123306A1

公开(公告)日：2011-10-06

申请号：PCT/US2011/029656

申请日：2011-03-23

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  PACETTI, Stephen D.

Inventor： PACETTI, Stephen D.

IPC: A61F2/90 ,  A61F2/00 ,  A61F2/02

CPC classification number: A61F2/90 ,  A61F2/915 ,  A61F2002/91575 ,  A61F2210/0004 ,  A61F2230/0054 ,  A61F2240/001 ,  A61F2250/0068 ,  B33Y80/00

Abstract: A prosthesis (10) for intraluminal drug delivery can comprise a plurality of interconnected struts and links (12, 14) that form a tubular structure. The struts and links can have luminal surfaces facing radially inward, abluminal surfaces facing radially outward, and side surfaces connecting the luminal surfaces to the abluminal surfaces. At least some of the struts and links have through-holes (50T) in the side surfaces. At least some of the through-holes contain a drug, which can be carried in a polymer matrix.

Abstract translation: 用于腔内药物递送的假体（10）可以包括形成管状结构的多个互连的支柱和连杆（12,14）。 支柱和连杆可以具有朝向径向向内的腔表面，面向径向外侧的腹膜表面以及将管腔表面连接到腔外表面的侧表面。 至少一些支柱和连杆在侧面具有通孔（50T）。 至少一些通孔含有可以在聚合物基质中携带的药物。

公开(公告)号：WO2011123282A1

公开(公告)日：2011-10-06

申请号：PCT/US2011/029305

申请日：2011-03-22

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  PACETTI, Stephen D. ,  KERRIGAN, Cameron K.

Inventor： PACETTI, Stephen D. ,  KERRIGAN, Cameron K.

IPC: A61F2/82 ,  A61F2/90 ,  A61F2/00

CPC classification number: A61F2/91 ,  A61F2/915 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2230/0013 ,  A61F2250/0068 ,  B33Y80/00 ,  Y10T29/49826

Abstract: A prosthesis for intraluminal drug delivery can comprise a plurality of interconnected struts that form a tubular scaffold structure. The struts include through-holes (50) with an inner surface configured to retain a bioabsorbable depot. The bioabsorbable depot includes a drug-polymer composition that hydrolytically degrades upon implantation. The inner surface of the through-hole can be an entirely smooth and continuous area that is concave or convex, with no geometric discontinuities. The inner surface of the through-hole can include any number of constricted and distended regions to form grooves of a size and shape carefully selected to engage a corresponding geometric feature of the bioabsorbable depot.

Abstract translation: 用于管腔内药物递送的假体可以包括形成管状支架结构的多个互连的支柱。 支柱包括通孔（50），其内表面构造成保持生物可吸收储库。 生物可吸收贮库包括在植入时水解降解的药物 - 聚合物组合物。 通孔的内表面可以是一个完全平滑和连续的凹或凸的区域，没有几何不连续。 通孔的内表面可以包括任何数量的收缩和扩张的区域，以形成仔细选择以接合生物可吸收贮库的相应几何特征的尺寸和形状的凹槽。

公开(公告)号：WO2013173127A1

公开(公告)日：2013-11-21

申请号：PCT/US2013/039980

申请日：2013-05-07

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  PACETTI, Stephen D. ,  WANG, Yunbing

Inventor： PACETTI, Stephen D. ,  WANG, Yunbing

IPC: A61F2/958 ,  A61M25/10

CPC classification number: A61F2/958 ,  A61M5/16877 ,  A61M25/10184 ,  A61M25/10185 ,  A61M25/104 ,  A61M39/24 ,  A61M2039/2413

Abstract: An apparatus and method for controlling inflation pressure, pressurization rate, and volumetric flow rate of a balloon during deployment of a stent or scaffold is disclosed. The apparatus includes a valve (200, 300) that has a flow restrictor (228, 328) that limits flow of inflation fluid into the balloon to a maximum value and provides essentially no resistance upon deflation of the baloon.

Abstract translation: 公开了一种用于在展开支架或支架期间控制气囊的充气压力，加压速率和体积流量的装置和方法。 该装置包括具有限流器（228,328）的阀门（200,300），该限流器限制膨胀流体进入球囊的流量达到最大值，并且在气球放气时基本上不产生阻力。

公开(公告)号：WO2007117435A3

公开(公告)日：2007-10-18

申请号：PCT/US2007/008265

申请日：2007-03-29

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  CHEN, Yung-Ming ,  TANG, Yiwen ,  PACETTI, Stephen D. ,  KLEINER, Lothar Walter

Inventor： CHEN, Yung-Ming ,  TANG, Yiwen ,  PACETTI, Stephen D. ,  KLEINER, Lothar Walter

IPC: A61L31/10 ,  A61L31/16 ,  A61K9/16

Abstract: A coating comprising a stimulus-responsive material and a bioactive agent for controlled release of the bioactive agent and methods of making and using the same are disclosed.

公开(公告)号：WO2013009466A2

公开(公告)日：2013-01-17

申请号：PCT/US2012/044260

申请日：2012-06-26

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  PACETTI, Stephen D.

Inventor： PACETTI, Stephen D.

IPC: A61F2/82

CPC classification number: A61F2/82 ,  A61F2/91 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  B29C47/0023 ,  B29L2031/7542 ,  Y10T29/49865 ,  Y10T29/49885 ,  Y10T29/49925 ,  Y10T29/49927

Abstract: Methods of making bioabsorbable stents with grooved lumenal surfaces for enhanced re-endothelialization are disclosed. Methods include molding grooves on the lumenal surface of coated bioresorbable and durable stents. Methods further include molding grooves on lumenal surfaces of a bioresorbable tube and forming a scaffold from the tube.

Abstract translation: 公开了制造具有沟槽腔表面的生物可​​吸收支架以增强再内皮化的方法。 方法包括在涂覆的生物可吸收且耐用的支架的腔表面上模制凹槽。 方法还包括在生物可再吸收管的内腔表面上模制凹槽并从管形成支架。

公开(公告)号：WO2012036812A1

公开(公告)日：2012-03-22

申请号：PCT/US2011/047574

申请日：2011-08-12

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  PACETTI, Stephen D.

Inventor： PACETTI, Stephen D.

IPC: A61F2/90

CPC classification number: A61F2/915 ,  A61F2002/826 ,  A61F2002/91533 ,  A61F2002/9155 ,  A61F2210/0004 ,  A61F2230/0054 ,  A61F2230/0065 ,  A61F2250/0036 ,  A61F2250/0071

Abstract: Bioabsorbable polymeric stent patterns with linking struts between rings that are designed to fail upon deployment of the stent are disclosed.

Abstract translation: 公开了在设计为在展开支架时失败的环之间具有连接支柱的生物可吸收聚合物支架图案。

公开(公告)号：WO2013151576A2

公开(公告)日：2013-10-10

申请号：PCT/US2012/053969

申请日：2012-09-06

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  PAPP, John E. ,  NGUYEN, Hung T. ,  ELERATH, Justin K. ,  HERABADI, Dion I. ,  MARTINS, Michael T. ,  KING, Kirsten S. ,  MUELLER, Scott H. ,  PELOQUIN, Coeta K. ,  PACETTI, Stephen D.

Inventor： PAPP, John E. ,  NGUYEN, Hung T. ,  ELERATH, Justin K. ,  HERABADI, Dion I. ,  MARTINS, Michael T. ,  KING, Kirsten S. ,  MUELLER, Scott H. ,  PELOQUIN, Coeta K. ,  PACETTI, Stephen D.

IPC: A61F2/84 ,  A61F2/82

CPC classification number: A61F2/958 ,  A61F2/844 ,  A61F2/91 ,  A61F2/915 ,  A61F2/966 ,  A61F2002/826 ,  A61F2002/9583 ,  A61F2210/0076 ,  A61F2250/0019 ,  A61F2250/0039

Abstract: Segmented scaffolds composed of disconnected scaffold segments are disclosed. System of and methods for delivery of the segmented scaffolds are disclosed.

Abstract translation: 公开了由断开的支架段组成的分段支架。 公开了用于递送分段支架的系统和方法。

公开(公告)号：WO2008002632A2

公开(公告)日：2008-01-03

申请号：PCT/US2007/014981

申请日：2007-06-25

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  DING, Ni ,  MICHAL, Gene ,  PACETTI, Stephen D.

Inventor： DING, Ni ,  MICHAL, Gene ,  PACETTI, Stephen D.

IPC: A61L31/08 ,  A61L31/16

CPC classification number: A61L31/16 ,  A61L31/084 ,  A61L2300/606

Abstract: A carbon coating on a stent having a bioactive agent covalently attached thereto and methods of making the same are described.

Abstract translation: 描述了具有共价连接于其上的生物活性剂的支架上的碳涂层及其制备方法。

公开(公告)号：WO2017003746A1

公开(公告)日：2017-01-05

申请号：PCT/US2016/038418

申请日：2016-06-20

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： PACETTI, Stephen D. ,  SHEEHY, Alexander J. ,  ABUNASSAR, Chad J.

IPC: A61L31/06 ,  A61L31/10 ,  A61L31/16

CPC classification number: A61F2/915 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/02 ,  A61L2420/08 ,  C08L67/04

Abstract: Stents including a poly(D,L-lactide)(PDLLA)-based scaffold and PDLLA based therapeutic layer are disclosed. The PDLLA based scaffold may be amorphous and may include a primer layer. Methods of applying the PDLLA-based coating to the scaffold are disclosed with solvent processing methods using a solvent blend are also disclosed. Methods of removing residual solvent from a PDLLA-base coating that also condition the scaffold are disclosed. Methods of treating restenosis that release drugs to prevent restenosis without interfering with the natural positive remodeling of a vessel are disclosed.

Abstract translation: 公开了包含基于聚（D，L-丙交酯）（PDLLA）的支架和基于PDLLA的治疗层的支架。 基于PDLLA的支架可以是无定形的，并且可以包括底漆层。 公开了使用溶剂共混物的溶剂处理方法将基于PDLLA的涂层施用于支架的方法。 公开了从处于支架状态的PDLLA基底涂层除去残余溶剂的方法。 公开了治疗释放药物以预防再狭窄而不干扰血管的天然阳性重塑的再狭窄的方法。