公开(公告)号：WO2012072684A3

公开(公告)日：2013-06-13

申请号：PCT/EP2011071393

申请日：2011-11-30

Applicant: ALFA LAVAL CORP AB ,  ZHENG JIE

Inventor： ZHENG JIE

IPC: C23C18/16 ,  C23C18/18 ,  C23C18/32 ,  F28F19/00

CPC classification number: F28F19/06 ,  C23C18/1616 ,  C23C18/1669 ,  C23C18/1676 ,  C23C18/1824 ,  C23C18/1831 ,  C23C18/32 ,  F28F21/089 ,  F28F2245/00

Abstract: A method of coating an internal surface of an assembled heat exchanger is provided. The heat exchanger (2) comprising a first passage for a first heat exchange fluid, and a second passage for a second heat exchange fluid. The first and second passages are separated by at least one heat transfer element. The heat transfer element has a first surface facing the first passage. The method comprises; pre-treating the first surface by circulating at least one pre-treatment liquid through the first passage of the heat exchanger (2) and a pre-treatment liquid storage (38) separate from the heat exchanger, and electroless nickel plating the first surface by circulating a solution comprising nickel ions through the first passage of the heat exchanger (2) and a solution container (40) separate from the heat exchanger (2). A heat exchanger comprising a nickel plating is also disclosed.

Abstract translation: 提供了一种涂覆组装的热交换器的内表面的方法。 所述热交换器（2）包括用于第一热交换流体的第一通道和用于第二热交换流体的第二通道。 第一和第二通道被至少一个传热元件隔开。 传热元件具有面向第一通道的第一表面。 该方法包括： 通过循环至少一个预处理液体通过热交换器（2）的第一通道和与热交换器分离的预处理液体储存器（38）来预处理第一表面，以及通过 通过热交换器（2）的第一通道和与热交换器（2）分离的溶液容器（40）循环包含镍离子的溶液。 还公开了一种包括镀镍的热交换器。

公开(公告)号：WO2012025416A3

公开(公告)日：2012-04-26

申请号：PCT/EP2011064032

申请日：2011-08-15

Applicant: ALFA LAVAL CORP AB ,  ZHENG JIE ,  WASE CLAES ,  RIDDERSTRAALE ROLF

Inventor： ZHENG JIE ,  WASE CLAES ,  RIDDERSTRAALE ROLF

IPC: B04B1/20 ,  B04B7/12

CPC classification number: B04B1/2008 ,  B04B2001/2066

Abstract: The present invention relates to a centrifugal separator (1) comprising a rotor (2) which is rotatable around an axis of rotation (R), the rotor (2) comprising a separation chamber (10) with an inlet (7, 9, 11) for a liquid mixture containing solid particles, at least one liquid outlet (18, 19, 20) for a separated liquid from the liquid mixture, and a solids outlet (22, 26, 27) for the separated solid particles, wherein a screw conveyor (3) is arranged to rotate inside the rotor (2) around the axis of rotation (R), at a different speed than the rotor (2), the screw conveyor (3) having at least one conveyor flight (3c) for transporting the separated solid particles in the separation chamber (10) towards and out of the solids outlet (22), wherein the conveyor flight (3c) is provided with wear resistant elements (23) arranged along its edge and the wear resistant elements (23) are spaced apart with an interspace (23a) between mutually adjacent wear resistant elements (23).

Abstract translation: 本发明涉及一种离心分离器（1），其包括可围绕旋转轴线（R）旋转的转子（2），转子（2）包括具有入口（7,9,11）的分离室 ），用于含有固体颗粒的液体混合物，用于从液体混合物分离的液体的至少一个液体出口（18,19,20）和用于分离的固体颗粒的固体出口（22,26,27），其中螺杆 输送机（3）布置成以与转子（2）不同的速度围绕转动轴线（R）围绕转子（2）旋转，螺旋输送机（3）具有至少一个输送机飞行（3c），用于 将所述分离室（10）中的分离的固体颗粒输送到所述固体出口（22）中并且离开所述固体出口（22），其中所述输送机飞行物（3c）设置有沿其边缘布置的耐磨元件（23）和所述耐磨元件（23） ）与相互相邻的耐磨元件（23）之间的间隙（23a）间隔开。

公开(公告)号：WO2005086830A3

公开(公告)日：2005-12-29

申请号：PCT/US2005007649

申请日：2005-03-10

Applicant: GEORGIA TECH RES INST ,  DICKSON ROBERT MARTIN ,  ZHENG JIE ,  CAPADONA LYNN ANNE ,  PETTY JEFFREY THOMAS ,  PATEL SANDEEP AJIT ,  WECK MARCUS

Inventor： DICKSON ROBERT MARTIN ,  ZHENG JIE ,  CAPADONA LYNN ANNE ,  PETTY JEFFREY THOMAS ,  PATEL SANDEEP AJIT ,  WECK MARCUS

IPC: C07K1/00 ,  C12Q1/68 ,  G01N33/20 ,  G01N33/53 ,  G01N33/532 ,  G01N33/533 ,  G01N33/543 ,  G01N33/553 ,  G01N33/58

CPC classification number: G01N33/588 ,  A61K49/0065 ,  A61K49/0067 ,  A61K49/0093 ,  B82Y15/00 ,  G01N33/532 ,  G01N33/54346 ,  G01N33/5436 ,  G01N33/582 ,  Y10T436/107497

Abstract: A composition is disclosed which is capable of being used for detection, comprising an encapsulated noble metal nanocluster. Methods for preparing the encapsulated noble metal nanoclusters, and methods of using the encapsulated noble metal nanoclusters are also disclosed. In certain embodiments, the noble metal nanoclusters are encapsulated by a dendrimer, a peptide, a small organic or inorganic molecule, or an oligonucleotide. The encapsulated noble metal nanoclusters have a characteristic spectral emission, wherein said spectral emission is varied by controlling the nature of the encapsulating material, such as by controlling the size of the nanocluster, the generation of a dendrimer, the incorporation of a functional group, and wherein said emission is used to provide information about a biological state. The emission is selected from the group consisting of nanocluster fluorescence, multiphoton excited nanocluster fluorescence, Stokes or Anti-Stokes Raman emission from the encapsulating material, and second harmonic generation.

Abstract translation: 公开了能够用于检测的组合物，其包含包封的贵金属纳米簇。 还公开了制备包封的贵金属纳米簇的方法，以及使用包封的贵金属纳米团簇的方法。 在某些实施方案中，贵金属纳米簇被树枝状聚合物，肽，小有机或无机分子或寡核苷酸包封。 封装的贵金属纳米团簇具有特征光谱发射，其中通过控制封装材料的性质来改变所述光谱发射，例如通过控制纳米簇的尺寸，树枝状聚合物的产生，官能团的结合，和 其中所述发射用于提供关于生物学状态的信息。 发射选自纳米团簇荧光，多光子激发纳米团簇荧光，来自封装材料的斯托克斯或反斯托克斯拉曼发射以及二次谐波产生。

公开(公告)号：WO2009155055A3

公开(公告)日：2010-05-27

申请号：PCT/US2009045485

申请日：2009-05-28

Applicant: ENZO BIOCHEM INC ,  ZHENG JIE

Inventor： ZHENG JIE

IPC: A61K38/00 ,  C12N5/00

CPC classification number: C07K14/705 ,  A61K31/00 ,  A61K38/00 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/32 ,  G01N33/5041 ,  G01N33/68 ,  G01N2333/495 ,  G01N2333/705 ,  A61K2300/00

Abstract: Compositions and methods related to Wnt signaling regulation by Dickkopf (Dkk) polypeptides and Wnt-related diseases are disclosed. For example, compounds that Kind a Dkk or LRP polypeptide are disclosed. Compounds that disrupt binding of a Dkk polypeptide to an LRP polypeptide are also disclosed. Methods for using the described compounds and compositions are also disclosed.

Abstract translation: 公开了与Dickkopf（Dkk）多肽和Wnt相关疾病的Wnt信号调节相关的组合物和方法。 例如，公开了Dkk或LRP多肽的化合物。 还公开了破坏Dkk多肽与LRP多肽的结合的化合物。 还公开了使用所述化合物和组合物的方法。

公开(公告)号：WO2004089850A3

公开(公告)日：2005-02-03

申请号：PCT/EP2004050367

申请日：2004-03-26

Applicant: SKELETON TECHNOLOGIES AG ,  SVENDSEN LENA ,  ZHENG JIE ,  MEURLING FREDRIK ,  ROSTVALL TOMAS

Inventor： SVENDSEN LENA ,  ZHENG JIE ,  MEURLING FREDRIK ,  ROSTVALL TOMAS

IPC: C04B20060101 ,  C04B35/52 ,  C04B35/573 ,  C04B41/50 ,  C22C26/00

CPC classification number: C04B35/52 ,  C04B35/6316 ,  C04B2235/3821 ,  C04B2235/3826 ,  C04B2235/3843 ,  C04B2235/40 ,  C04B2235/404 ,  C04B2235/405 ,  C04B2235/407 ,  C04B2235/408 ,  C04B2235/421 ,  C04B2235/425 ,  C04B2235/427 ,  C04B2235/428 ,  C04B2235/5436 ,  C04B2235/80

Abstract: The present invention relates to a method for manufacturing a diamond composite, comprising the steps of: a) mixing diamonds with additives, the mixture comprising at least 50 wt% and less than 95 wt% of diamonds and more than 5 wt% additives; b) forming a work piece from the mixture using a pressure of at least 100 Mpa; c) heating the formed work piece to at least 300°C for removing possible water and wholly or partially removing additives; d) heating the work piece and controlling the heating temperature and heatin time so that a certain desired amount of graphite is created by graphitization of diamonds, wherein the amount of graphite created by graphitization is 3-50 wt% of the amount of diamond; e) infiltrating silicon or silicon alloy into the work piece, the infiltration of silicon or silicon alloy being performed at a temperature below 1900°C and a pressure less than 50 bars; and f) heating the infiltrated work piece to form silicon carbide, or other carbides, (and silicides), thereby creating a final diamond composite.

Abstract translation: 金刚石复合材料的制造方法技术领域本发明涉及金刚石复合材料的制造方法，包括以下步骤：a）将金刚石与添加剂混合，所述混合物包含至少50wt％且小于95wt％的金刚石和5wt％以上的添加剂; b）使用至少100Mpa的压力从混合物形成工件; c）将形成的工件加热至至少300℃，以除去可能的水并全部或部分除去添加剂; d）加热工件并控制加热温度和加热时间，使得通过石墨化石墨化产生一定的所需量的石墨，其中由石墨化产生的石墨的量为金刚石量的3-50wt％; e）将硅或硅合金渗透到工件中，在低于1900℃的温度和低于50巴的压力下进行硅或硅合金的渗透; 和f）加热渗透的工件以形成碳化硅或其他碳化物（和硅化物），从而形成最终的金刚石复合材料。

公开(公告)号：WO0242240A3

公开(公告)日：2002-10-10

申请号：PCT/EP0110439

申请日：2001-09-10

Applicant: FRENTON LTD ,  EKSTROEM THOMMY ,  ZHENG JIE ,  KLOUB KAUTHAR ,  GORDEEV SERGEY K ,  DANCHUKOVA LIYA V

Inventor： EKSTROEM THOMMY ,  ZHENG JIE ,  KLOUB KAUTHAR ,  GORDEEV SERGEY K ,  DANCHUKOVA LIYA V

IPC: C01B31/06 ,  C01B31/36 ,  C04B35/52 ,  H01L23/373

CPC classification number: C04B35/52 ,  H01L23/3732 ,  H01L2924/0002 ,  Y10T428/25 ,  Y10T428/252 ,  Y10T428/31678 ,  H01L2924/00

Abstract: This invention relates to diamond-containing composite materials that have high thermal conductivity and thermal diffusivity, and to the use of said materials in heat sinks, heat spreading and other heat conductive applications. The material comprises diamond particles, silicone carbide and silicon, and has a thermal conductivity of at least 400 W/mK and a thermal diffusivity of at least 2.1 cm /s.

Abstract translation: 本发明涉及具有高导热性和热扩散性的含金刚石复合材料，以及所述材料在散热片，散热和其它导热应用中的用途。 该材料包括金刚石颗粒，碳化硅和硅，并且具有至少400W / mK的热导率和至少2.1cm 2 / s的热扩散率。

公开(公告)号：WO2006107719A2

公开(公告)日：2006-10-12

申请号：PCT/US2006011754

申请日：2006-03-31

Applicant: ENZO BIOCHEM INC ,  ZHENG JIE ,  SHAN JUFANG ,  WU DIANQING

Inventor： ZHENG JIE ,  SHAN JUFANG ,  WU DIANQING

IPC: A61K38/17

CPC classification number: A61K31/00 ,  A61K31/164 ,  C07K1/00 ,  C40B30/02

Abstract: The Wnt signaling pathways are involved in embryo development as well as in M tumorigenesis. Dishevelled (DvI) tra®'duces Wnt signals from the receptor Frizzled (Fz) to downstream components in canonical and non-canonical Wnt signaling pathways, and the DvI , PDZ domain plays an essential role in both pathways, and the DvI PDZ .domain binds directly to Fz receptors. In the present invention using NMR-assisted virtual ligand screening, several compounds were identified and were found to bind to the DvI PDZ domain. Molecular dynamics simulation was used to analyze the binding between the PDZ domain and these compounds in detail. These compounds provide a basis for rational design of high-affinity inhibitors of the PDZ domain, which can block Wnt signaling by interrupting the Fz-DvI interaction.

Abstract translation: Wnt信号通路参与胚胎发育以及M肿瘤发生。 不规则（DvI）tra®将Wnt信号从受体卷曲（Fz）引发到规范和非规范Wnt信号通路中的下游组分，DvI，PDZ结构域在两个途径中起重要作用，DvI PDZ。 直接与Fz受体结合。 在使用NMR辅助的虚拟配体筛选的本发明中，鉴定出几种化合物，并且发现其与DvI PDZ结构域结合。 分子动力学模拟用于详细分析PDZ结构域与这些化合物的结合。 这些化合物为PDZ结构域的高亲和力抑制剂的合理设计提供了依据，可以通过中断Fz-DvI相互作用来阻断Wnt信号。