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    USE OF ELECTRICALLY CONDUCTIVE MATERIALS FOR ELECTROPHYSIOLOGY
    1.
    发明申请
    USE OF ELECTRICALLY CONDUCTIVE MATERIALS FOR ELECTROPHYSIOLOGY 审中-公开
    用于电生理学的导电材料

    公开(公告)号：WO2015039112A2

    公开(公告)日：2015-03-19

    申请号：PCT/US2014/055893

    申请日：2014-09-16

    Applicant: WILLIAM MARSH RICE UNIVERSITY ,  BAYLOR COLLEGE OF MEDICINE ,  TEXAS HEART INSTITUTE

    Inventor： PASQUALI, Matteo ,  RAZAVI, Mehdi ,  VITALE, Flavia ,  YOUNG, Colin, Christopher ,  MCCAULEY, Mark, David

    CPC classification number: A61N1/0587 ,  A61B17/06166 ,  A61N1/05 ,  A61N1/0551 ,  A61N1/056

    Abstract: Some embodiments of the present disclosure pertain to methods of improving electrical conduction across an impaired region of a tissue (e.g., myocardial tissue) by applying an electrically conductive material (e.g., carbon nanotube fibers) across the impaired region. The electrically conductive materials can become associated with non-impaired regions of the tissue on opposite sides of the impaired region by suturing. Such methods can also be utilized to treat or prevent cardiac arrhythmia in a subject (e.g., ventricular arrhythmia). Additional embodiments of the present disclosure pertain to electrical wirings that include carbon nanotubes, such as carbon nanotube fibers. Such electrical wirings can be used to transmit electrical signals to a tissue or sense electrical signals from the tissue. In some embodiments, the present disclosure also pertains to suture threads that include carbon nanotubes, such as carbon nanotube fibers.

    Abstract translation: 本公开的一些实施方式涉及通过跨过受损伤的组织（例如碳纳米管纤维）施加导电材料（例如，碳纳米管纤维）来改善穿过组织（例如心肌组织）的受损区域的电传导的方法 地区。 通过缝合，导电材料可以与受损区域的相对侧上的组织的非受损区域相关联。 这样的方法也可以用于治疗或预防受试者的心律失常（例如室性心律失常）。 本公开的另外的实施例涉及包括碳纳米管的电布线，例如碳纳米管纤维。 这样的电线可以用于将电信号传输到组织或感测来自组织的电信号。 在一些实施例中，本公开还涉及包括碳纳米管的缝合线，例如碳纳米管纤维。

    SYSTEMS AND METHODS FOR WIRELESS TREATMENT OF ARRHYTHMIAS
    2.
    发明申请
    SYSTEMS AND METHODS FOR WIRELESS TREATMENT OF ARRHYTHMIAS 审中-公开
    用于无痛治疗心律失常的系统和方法

    公开(公告)号：WO2018039162A2

    公开(公告)日：2018-03-01

    申请号：PCT/US2017/047901

    申请日：2017-08-22

    Applicant: WILLIAM MARSH RICE UNIVERSITY ,  TEXAS HEART INSTITUTE ,  BAYLOR COLLEGE OF MEDICINE

    Inventor： SUN, Yuxiang ,  BABAKHANI, Aydin ,  RAZAVI, Mehdi ,  BURKLAND, David ,  GREET, Brian ,  JOHN, Mathews ,  LYU, Hongming

    IPC: A61N1/02 ,  A61N1/05 ,  A61N1/39 ,  A61N1/372 ,  A61N1/375 ,  A61N1/378

    CPC classification number: A61N1/0563 ,  A61N1/025 ,  A61N1/0573 ,  A61N1/059 ,  A61N1/37217 ,  A61N1/37223 ,  A61N1/37229 ,  A61N1/37288 ,  A61N1/37516 ,  A61N1/37518 ,  A61N1/3787 ,  A61N1/39622 ,  A61N1/3968 ,  A61N1/3975

    Abstract: Wireless treatment of arrhythmias. At least some of the example embodiments are methods including: charging a capacitor of a first microchip device abutting heart tissue, the charging by harvesting ambient energy; charging a capacitor of a second microchip device abutting the heart tissue, the charging of the capacitor of the second microchip device by harvesting ambient energy; sending a command wirelessly from a communication device outside the rib cage to the microchip devices; applying electrical energy to the heart tissue by the first microchip device responsive to the command, the electrical energy applied from the capacitor of the first microchip device; and applying electrical energy to the heart tissue by the second microchip device responsive to the command to the second microchip device, the electrical energy applied from the capacitor of the second microchip device.

    Abstract translation:

    无线治疗心律失常。 示例实施例中的至少一些是这样的方法，包括：对邻接心脏组织的第一微芯片装置的电容器充电，通过收集环境能量进行充电; 对靠近心脏组织的第二微芯片装置的电容器充电，通过收集环境能量对第二微芯片装置的电容器充电; 从肋骨外部的通信装置向微芯片器件无线发送命令; 响应于所述命令，由所述第一微型芯片设备向所述心脏组织施加电能，所述电能从所述第一微型芯片设备的所述电容器施加; 以及响应于对第二微型芯片设备的命令，由第二微型芯片设备向心脏组织施加电能，从第二微型芯片设备的电容器施加电能。

    SYSTEMS AND METHODS FOR ATTACHING FLEXIBLE CONDUCTIVE FILAMENTS, NETWORKS, OR PATCHES TO TISSUE VIA CATHETER DELIVERY
    3.
    发明申请
    SYSTEMS AND METHODS FOR ATTACHING FLEXIBLE CONDUCTIVE FILAMENTS, NETWORKS, OR PATCHES TO TISSUE VIA CATHETER DELIVERY 审中-公开
    用于连接柔性导电膜，网络或通过导管输送组装的配线的系统和方法

    公开(公告)号：WO2015127243A1

    公开(公告)日：2015-08-27

    申请号：PCT/US2015/016869

    申请日：2015-02-20

    Applicant: WILLIAM MARSH RICE UNIVERSITY ,  BAYLOR COLLEGE OF MEDICINE ,  TEXAS HEART INSTITUTE

    Inventor： VITALE, Flavia ,  TSENTALOVICH, Dimitri ,  MIRRI, Francesca ,  PASQUALI, Matteo ,  RAZAVI, Mehdi ,  McCAULEY, Mark, D. ,  YOUNG, Colin, C.

    IPC: A61N1/05

    CPC classification number: A61N1/0573 ,  A61N2001/058

    Abstract: Systems and methods for deploying and securing conductive materials to a region of tissue may utilize a catheter. The catheter may provide a tip with one or more detachable sections or may provide an adjustable opening. A lumen of the catheter may provide a conductive material, such as a filament, fiber, network or patch of carbon nanotubes (CNTs) or carbon nanofibers (CNFs). In some embodiments, the conductive materials may be coupled to securing mechanisms, such as screws, clips, anchors, alligator clips, or anchors with barbs, which can be actuated to attach the conductive materials to desired regions of tissue. In some embodiments, the catheter may provide a needle tip that allows the conductive material to be embedded into desired regions of tissue by inserting the needle into the tissue.

    Abstract translation: 用于将导电材料部署和固定到组织区域的系统和方法可以利用导管。 导管可以提供具有一个或多个可拆卸部分的尖端，或者可以提供可调节的开口。 导管的内腔可以提供导电材料，例如丝，纤维，碳纳米管（CNT）或碳纳米纤维（CNF）的网状或贴片。 在一些实施例中，导电材料可以联接到固定机构，例如螺钉，夹子，锚定器，鳄鱼夹或具有倒钩的锚固件，其可以被致动以将导电材料附着到组织的期望区域。 在一些实施例中，导管可以提供针尖，其允许通过将针插入组织中将导电材料嵌入到组织的期望区域中。

    PHRENIC NERVE PACING DEVICE
    8.
    发明申请
    PHRENIC NERVE PACING DEVICE 审中-公开

    公开(公告)号：WO2023014725A1

    公开(公告)日：2023-02-09

    申请号：PCT/US2022/039188

    申请日：2022-08-02

    Applicant: TEXAS MEDICAL CENTER ,  TEXAS HEART INSTITUTE

    Inventor： BLACK, Lance ,  BUCHAN, Skylar ,  JAWORSKI, Elizabeth ,  JOHN, Mathews ,  POST, Allison ,  RAZAVI, Mehdi

    IPC: A61N1/05 ,  A61B5/053

    Abstract: Disclosed herein, in some aspects, are endotracheal stimulation platforms, systems, and methods of their use for pacing the phrenic nerves, right and/or left phrenic nerves, of a subject. In some embodiments, one or more pairs of electrodes are provided through an ET tube to contact a portion of a tracheal wall, or trachea, so as to enable phrenic nerve pacing. In some cases, the one or more pairs of electrodes are configured to send electrical pulses that stimulate the phrenic nerve, thereby helping promote contraction and relaxation of the diaphragm muscle.

    METHOD AND DEVICE FOR DETECTION OF ARRHYTHMIAS AND MYOCARDIAL INJURY
    9.
    发明申请
    METHOD AND DEVICE FOR DETECTION OF ARRHYTHMIAS AND MYOCARDIAL INJURY 审中-公开
    用于检测脑膜炎和心肌损伤的方法和装置

    公开(公告)号：WO2017011540A1

    公开(公告)日：2017-01-19

    申请号：PCT/US2016/042068

    申请日：2016-07-13

    Applicant: TEXAS HEART INSTITUTE

    Inventor： RAZAVI, Mehdi ,  MADJID, Mohammad ,  WILLERSON, James T.

    IPC: A61B5/01 ,  A61B5/042

    CPC classification number: A61B18/1492 ,  A61B5/015 ,  A61B5/0422 ,  A61B5/4836 ,  A61B5/6858 ,  A61B34/20 ,  A61B2017/00221 ,  A61B2017/00734 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00821 ,  A61B2018/00827 ,  A61B2018/00875 ,  A61B2034/2074 ,  A61B2090/3966

    Abstract: Herein disclosed is a method of detecting and identifying the source of abnormal electrical currents in the heart to assist in ablating these currents, comprising the use of contact or non-contact temperature measurement devices. In an embodiment, source of abnormal electrical activity of the heart and its attached arteries and veins show different temperature patterns from normal segments. In an embodiment, the method further comprises analyzing the temperature of the chamber of interest, and determining regions of low or high temperature by extension metabolic activity. In an embodiment, the method comprises measuring myocardial temperature comprising placing an array of thermocouples imbedded on a basket in the cardiac chamber. In an embodiment, the thermocouples are placed in contact with the myocardial tissue.

    Abstract translation: 本文公开了一种检测和识别心脏中异常电流源以帮助消融这些电流的方法，包括使用接触或非接触式温度测量装置。 在一个实施例中，心脏及其连接的动脉和静脉的异常电活动源显示与正常段的不同的温度模式。 在一个实施方案中，该方法还包括分析感兴趣室的温度，以及通过延伸代谢活性确定低温或高温区域。 在一个实施例中，该方法包括测量心肌温度，包括将嵌入篮中的热电偶阵列放置在心室中。 在一个实施例中，热电偶被放置成与心肌组织接触。

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