公开(公告)号：WO2019074822A1

公开(公告)日：2019-04-18

申请号：PCT/US2018/054819

申请日：2018-10-08

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： BALOG, James Aaron ,  CHERNEY, Emily Charlotte ,  SHAN, Weifang ,  WILLIAMS, David K. ,  ZHANG, Liping

IPC: C07D215/18 ,  C07D401/04 ,  C07D401/06 ,  C07C275/00

CPC classification number: C07D401/04 ,  C07C275/26 ,  C07C2601/08 ,  C07C2601/14 ,  C07D215/18 ,  C07D401/06

Abstract: The present invention provides compounds of formula (I), formula (II) or formula (III), wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.

公开(公告)号：WO2014150646A1

公开(公告)日：2014-09-25

申请号：PCT/US2014/023877

申请日：2014-03-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： BALOG, James Aaron ,  HUANG, Audris ,  CHEN, Bin ,  CHEN, Libing ,  SHAN, Weifang

IPC: C07C275/42 ,  C07D305/06 ,  A61P35/00

CPC classification number: C07D305/06 ,  A61K31/196 ,  A61K31/337 ,  A61K31/41 ,  A61K31/42 ,  A61K31/498 ,  A61K31/505 ,  A61K45/06 ,  C07C275/42 ,  C07C2101/14 ,  C07C2601/14 ,  C07D239/42 ,  C07D241/42 ,  C07D255/02 ,  C07D261/14

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention. Formula (I).

Abstract translation: 公开了调节或抑制吲哚胺2,3-双加氧酶（IDO）的酶活性的化合物，含有所述化合物的药物组合物和治疗增殖性疾病如癌症，病毒感染和/或自身免疫疾病的方法，其利用 发明。 式（I）。

公开(公告)号：WO2016161279A1

公开(公告)日：2016-10-06

申请号：PCT/US2016/025544

申请日：2016-04-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： BALOG, James Aaron ,  CHERNEY, Emily Charlotte ,  MARKWALDER, Jay A. ,  SEITZ, Steven P. ,  SHAN, Weifang ,  WILLIAMS, David K. ,  NARA, Susheel Jethanand ,  ROY, Saumya ,  THANGAVEL, Soodamani ,  SISTLA, Ramesh Kumar ,  CHERUKU, Srinivas ,  THANGATHIRUPATHY, Srinivasan ,  KANYABOINA, Yadagiri ,  PULICHARLA, Nagalakshmi ,  AUDRIS, Huang

IPC: C07D309/14 ,  C07D405/12 ,  C07D487/04 ,  A61P35/00 ,  C07D413/12 ,  C07D487/08 ,  C07D265/30 ,  C07D211/08 ,  C07D295/155 ,  C07D407/12 ,  C07D207/08 ,  C07D307/22 ,  C07D335/02 ,  A61K31/35

CPC classification number: C07C275/40 ,  A61K31/17 ,  A61K31/196 ,  A61K31/277 ,  A61K31/351 ,  A61K31/382 ,  A61K31/397 ,  A61K31/428 ,  A61K31/437 ,  A61K31/445 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/538 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  C07C229/42 ,  C07C233/81 ,  C07C235/38 ,  C07C235/56 ,  C07C255/57 ,  C07C255/58 ,  C07C275/30 ,  C07C275/42 ,  C07D205/04 ,  C07D207/08 ,  C07D207/12 ,  C07D211/08 ,  C07D211/14 ,  C07D239/34 ,  C07D239/47 ,  C07D265/30 ,  C07D265/36 ,  C07D277/64 ,  C07D295/155 ,  C07D307/22 ,  C07D309/04 ,  C07D309/14 ,  C07D317/46 ,  C07D335/02 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08

Abstract: There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

Abstract translation: 公开了调节或抑制吲哚胺-2,3-双加氧酶（IDO）的酶活性的式（I）化合物，含有所述化合物的药物组合物和治疗增殖性疾病的方法，例如 癌症，病毒感染和/或利用本发明化合物的炎性病症。

公开(公告)号：WO2014047392A1

公开(公告)日：2014-03-27

申请号：PCT/US2013/060833

申请日：2013-09-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： GAVAI, Ashvinikumar V. ,  SHAN, Weifang ,  BALOG, James Aaron ,  QUESNELLE, Claude A. ,  HAN, Wen-Ching ,  DELUCCA, George V. ,  O'MALLEY, Daniel ,  FINK, Brian E.

IPC: C07D413/14 ,  C07D401/04 ,  C07D401/12 ,  C07D413/12 ,  C07D243/24 ,  C07D491/04 ,  A61K31/5513 ,  A61P35/00

CPC classification number: C07D243/24 ,  A61K31/5513 ,  A61K45/06 ,  C07D401/04 ,  C07D401/12 ,  C07D413/12 ,  C07D413/14 ,  C07D491/04 ,  C07D491/056

Abstract: Disclosed are compounds of Formula (I): wherein: R 2 is phenyl, fluorophenyl, chlorophenyl, trifluorophenyl, methylisoxazolyl, or pyridinyl; R 3 is H, CH 3 , CH 2 (cyclopropyl), pyridinyl, chloropyridinyl, or methoxypyridinyl: and R a , R b , y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.

Abstract translation: 公开了式（I）的化合物：其中：R 2是苯基，氟苯基，氯苯基，三氟苯基，甲基异恶唑基或吡啶基; R 3是H，CH 3，CH 2（环丙基），吡啶基，氯吡啶基或甲氧基吡啶基：和R a，R b，y和z在本文中定义。 还公开了使用这些化合物抑制Notch受体的方法，以及包含这些化合物的药物组合物。 这些化合物可用于治疗，预防或减缓各种治疗领域（例如癌症）中疾病或病症的发展。

公开(公告)号：WO2008030902A1

公开(公告)日：2008-03-13

申请号：PCT/US2007/077678

申请日：2007-09-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  SHAN, Weifang ,  BALOG, James Aaron ,  NATION, Andrew James ,  GAVAI, Ashvinikumar, V. ,  HAN, Wen-ching ,  SALVATI, Mark, E.

Inventor： SHAN, Weifang ,  BALOG, James Aaron ,  NATION, Andrew James ,  GAVAI, Ashvinikumar, V. ,  HAN, Wen-ching ,  SALVATI, Mark, E.

IPC: C07D417/14 ,  C07D275/06 ,  A61K31/425

CPC classification number: C07D275/06

Abstract: Disclosed are sultam compounds of Formula (I) or a pharmaceutically-acceptable salt thereof. Also disclosed are methods of using such compounds in the treatment of at least one nuclear hormone receptor-associated condition, such as, for example, cancer and immune disorders, and at least one pharmaceutical composition comprising such compounds.

Abstract translation: 公开了式（I）的磺胺化合物或其药学上可接受的盐。 还公开了使用这些化合物治疗至少一种核激素受体相关病症例如癌症和免疫病症的方法，以及至少一种包含这些化合物的药物组合物。

公开(公告)号：WO2020023356A1

公开(公告)日：2020-01-30

申请号：PCT/US2019/042773

申请日：2019-07-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： BALOG, James Aaron ,  SEITZ, Steven P. ,  MARKWALDER, Jay A. ,  WILLIAMS, David K. ,  SHAN, Weifang ,  NARA, Susheel Jethanand ,  ROY, Saumya ,  CHERUKU, Srinivas ,  PULICHARLA, Nagalakshmi

IPC: C07D307/79 ,  C07D313/08 ,  C07D405/10 ,  C07D405/14 ,  C07D413/10 ,  C07D417/14 ,  C07D487/04 ,  A61P35/00 ,  A61K31/55

Abstract: The present invention provides compounds of formula (I) wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.

公开(公告)号：WO2018209049A1

公开(公告)日：2018-11-15

申请号：PCT/US2018/032013

申请日：2018-05-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： BALOG, James Aaron ,  CHERNEY, Emily Charlotte ,  ZHANG, Liping ,  HUANG, Audris ,  SHAN, Weifang ,  WILLIAMS, David K. ,  ZHU, Xiao ,  GUO, Weiwei

IPC: C07D403/12 ,  C07D213/85 ,  C07D401/12 ,  C07D471/04 ,  A61K31/47 ,  A61P35/00 ,  A61K31/4745 ,  A61K31/444

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

公开(公告)号：WO2017192811A1

公开(公告)日：2017-11-09

申请号：PCT/US2017/030992

申请日：2017-05-04

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： WILLIAMS, David, K. ,  SHAN, Weifang ,  BALOG, James, Aaron

IPC: C07D213/84 ,  C07D241/42

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

Abstract translation: 公开了调节或抑制吲哚胺2,3-双加氧酶（IDO）的酶活性的化合物，含有所述化合物的药物组合物以及治疗增殖性疾病如癌症，病毒感染和/ 或利用本发明化合物的炎症。

公开(公告)号：WO2016161286A1

公开(公告)日：2016-10-06

申请号：PCT/US2016/025554

申请日：2016-04-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： BALOG, James, Aaron ,  GUO, Weiwei ,  HUANG, Audris ,  MARKWALDER, Jay, A. ,  SHAN, Weifang ,  WILLIAMS, David, K. ,  NARA, Susheel, Jethanand ,  ROY, Saumya

IPC: C07D309/14 ,  C07C275/42 ,  C07D317/66 ,  C07D401/12 ,  C07D405/12 ,  C07D239/42 ,  C07D261/14 ,  C07D487/04 ,  A61K31/17 ,  A61P35/00

CPC classification number: C07C275/40 ,  A61K31/17 ,  A61K31/196 ,  A61K31/277 ,  A61K31/351 ,  A61K31/382 ,  A61K31/397 ,  A61K31/428 ,  A61K31/437 ,  A61K31/445 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/538 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  C07C229/42 ,  C07C233/81 ,  C07C235/38 ,  C07C235/56 ,  C07C255/57 ,  C07C255/58 ,  C07C275/30 ,  C07C275/42 ,  C07D205/04 ,  C07D207/08 ,  C07D207/12 ,  C07D211/08 ,  C07D211/14 ,  C07D239/34 ,  C07D239/47 ,  C07D265/30 ,  C07D265/36 ,  C07D277/64 ,  C07D295/155 ,  C07D307/22 ,  C07D309/04 ,  C07D309/14 ,  C07D317/46 ,  C07D335/02 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08

Abstract: There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

Abstract translation: 公开了调节或抑制吲哚胺-2,3-双加氧酶（IDO）的酶活性的式（I）化合物，含有所述化合物的药物组合物和治疗增殖性疾病如癌症，病毒感染和/或炎症的方法 利用本发明化合物的病症。

公开(公告)号：WO2016161269A1

公开(公告)日：2016-10-06

申请号：PCT/US2016/025531

申请日：2016-04-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： BALOG, James Aaron ,  CHERNEY, Emily Charlotte ,  GUO, Weiwei ,  HUANG, Audris ,  MARKWALDER, Jay A. ,  SEITZ, Steven P. ,  SHAN, Weifang ,  WILLIAMS, David K. ,  MURUGESAN, Natesan ,  NARA, Susheel Jethanand ,  ROY, Saumya ,  THANGAVEL, Soodamani ,  SISTLA, Ramesh Kumar ,  CHERUKU, Srinivas ,  THANGATHIRUPATHY, Srinivasan ,  KANYABOINA, Yadagiri ,  PULICHARLA, Nagalakshmi

IPC: C07D309/14 ,  C07D317/66 ,  C07D401/12 ,  C07D405/12 ,  C07D239/42 ,  C07D261/14 ,  C07D487/04 ,  A61K31/17 ,  A61P35/00 ,  C07D335/02 ,  C07C229/00 ,  A61K31/136 ,  C07D409/12

CPC classification number: C07C275/40 ,  A61K31/17 ,  A61K31/196 ,  A61K31/277 ,  A61K31/351 ,  A61K31/382 ,  A61K31/397 ,  A61K31/428 ,  A61K31/437 ,  A61K31/445 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/538 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  C07C229/42 ,  C07C233/81 ,  C07C235/38 ,  C07C235/56 ,  C07C255/57 ,  C07C255/58 ,  C07C275/30 ,  C07C275/42 ,  C07D205/04 ,  C07D207/08 ,  C07D207/12 ,  C07D211/08 ,  C07D211/14 ,  C07D239/34 ,  C07D239/47 ,  C07D265/30 ,  C07D265/36 ,  C07D277/64 ,  C07D295/155 ,  C07D307/22 ,  C07D309/04 ,  C07D309/14 ,  C07D317/46 ,  C07D335/02 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

Abstract translation: 公开了调节或抑制吲哚胺2,3-双加氧酶（IDO）的酶活性的化合物，含有所述化合物的药物组合物和治疗增殖性疾病例如癌症，病毒感染和/或炎症性疾病的方法，其利用 发明。