公开(公告)号：WO2016210414A1

公开(公告)日：2016-12-29

申请号：PCT/US2016/039564

申请日：2016-06-27

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： BALOG, James Aaron ,  CHERNEY, Emily Charlotte ,  MARKWALDER, Jay A. ,  SHAN, Weifang ,  WILLIAMS, David K.

IPC: C07D239/42 ,  C07C275/42 ,  C07D261/14 ,  C07D285/12 ,  A61K31/17 ,  A61K31/136 ,  A61P35/00

CPC classification number: C07D239/42 ,  C07C233/44 ,  C07C275/40 ,  C07C275/42 ,  C07C311/49 ,  C07C311/51 ,  C07C2601/02 ,  C07C2601/14 ,  C07D261/14 ,  C07D285/12

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

Abstract translation: 公开了调节或抑制吲哚胺2,3-双加氧酶（IDO）的酶活性的化合物，含有所述化合物的药物组合物和使用所述化合物治疗增殖性疾病如癌症，病毒感染和/或炎症性疾病的方法 发明。

公开(公告)号：WO2015031295A1

公开(公告)日：2015-03-05

申请号：PCT/US2014/052600

申请日：2014-08-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： MARKWALDER, Jay A. ,  SEITZ, Steven P. ,  BALOG, James Aaron ,  HUANG, Audris ,  WILLIAMS, David K. ,  CHEN, Libing ,  MANDAL, Sunil Kumar ,  SRIVASTAVA, Shefali

IPC: C07D403/12 ,  C07D309/14 ,  C07D215/06 ,  C07D231/12 ,  C07D333/10 ,  C07D401/12 ,  C07D409/12 ,  C07D411/12 ,  C07D413/12 ,  C07D257/04 ,  C07D277/22 ,  C07C13/00 ,  A61K31/416 ,  A61P37/02

CPC classification number: C07D257/04 ,  A61K31/17 ,  A61K31/18 ,  A61K31/381 ,  A61K31/41 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/451 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/50 ,  A61K31/506 ,  A61K31/5375 ,  A61K45/06 ,  C07B59/002 ,  C07C275/42 ,  C07C311/05 ,  C07C311/09 ,  C07C317/44 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07D211/14 ,  C07D215/06 ,  C07D231/12 ,  C07D237/20 ,  C07D277/22 ,  C07D309/14 ,  C07D333/10 ,  C07D333/38 ,  C07D401/10 ,  C07D401/12 ,  C07D403/12 ,  C07D407/12 ,  C07D409/12 ,  C07D411/12 ,  C07D413/12 ,  C07D417/12

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention.

Abstract translation: 公开了调节或抑制吲哚胺2,3-双加氧酶（IDO）的酶活性的化合物，含有所述化合物的药物组合物和治疗增殖性疾病如癌症，病毒感染和/或自身免疫疾病的方法，其利用 发明。

公开(公告)号：WO2016161279A1

公开(公告)日：2016-10-06

申请号：PCT/US2016/025544

申请日：2016-04-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： BALOG, James Aaron ,  CHERNEY, Emily Charlotte ,  MARKWALDER, Jay A. ,  SEITZ, Steven P. ,  SHAN, Weifang ,  WILLIAMS, David K. ,  NARA, Susheel Jethanand ,  ROY, Saumya ,  THANGAVEL, Soodamani ,  SISTLA, Ramesh Kumar ,  CHERUKU, Srinivas ,  THANGATHIRUPATHY, Srinivasan ,  KANYABOINA, Yadagiri ,  PULICHARLA, Nagalakshmi ,  AUDRIS, Huang

IPC: C07D309/14 ,  C07D405/12 ,  C07D487/04 ,  A61P35/00 ,  C07D413/12 ,  C07D487/08 ,  C07D265/30 ,  C07D211/08 ,  C07D295/155 ,  C07D407/12 ,  C07D207/08 ,  C07D307/22 ,  C07D335/02 ,  A61K31/35

CPC classification number: C07C275/40 ,  A61K31/17 ,  A61K31/196 ,  A61K31/277 ,  A61K31/351 ,  A61K31/382 ,  A61K31/397 ,  A61K31/428 ,  A61K31/437 ,  A61K31/445 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/538 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  C07C229/42 ,  C07C233/81 ,  C07C235/38 ,  C07C235/56 ,  C07C255/57 ,  C07C255/58 ,  C07C275/30 ,  C07C275/42 ,  C07D205/04 ,  C07D207/08 ,  C07D207/12 ,  C07D211/08 ,  C07D211/14 ,  C07D239/34 ,  C07D239/47 ,  C07D265/30 ,  C07D265/36 ,  C07D277/64 ,  C07D295/155 ,  C07D307/22 ,  C07D309/04 ,  C07D309/14 ,  C07D317/46 ,  C07D335/02 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08

Abstract: There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

Abstract translation: 公开了调节或抑制吲哚胺-2,3-双加氧酶（IDO）的酶活性的式（I）化合物，含有所述化合物的药物组合物和治疗增殖性疾病的方法，例如 癌症，病毒感染和/或利用本发明化合物的炎性病症。

公开(公告)号：WO2020023355A1

公开(公告)日：2020-01-30

申请号：PCT/US2019/042771

申请日：2019-07-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： BALOG, James Aaron ,  MARKWALDER, Jay A. ,  SHAN, Weifang ,  WILLIAMS, David K. ,  NARA, Susheel Jethanand ,  ROY, Saumya ,  THANGAVEL, Soodamani ,  CHERUKU, Srinivas ,  SISTLA, Ramesh Kumar

IPC: A61P35/00 ,  C07D213/75 ,  C07D401/10 ,  C07D401/14 ,  C07D403/10 ,  C07D405/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/04 ,  A61K31/4439

Abstract: The present invention provides compounds of formula (I): wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.

公开(公告)号：WO2015002918A1

公开(公告)日：2015-01-08

申请号：PCT/US2014/044992

申请日：2014-07-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： MARKWALDER, Jay A. ,  SEITZ, Steven P. ,  BALOG, James Aaron ,  HUANG, Audris ,  MANDAL, Sunil Kumar ,  WILLIAMS, David K. ,  HART, Amy C. ,  INGHRIM, Jennifer

IPC: C07C275/42 ,  C07D213/75 ,  C07C311/51 ,  C07D257/04 ,  A61K31/17 ,  A61K31/18 ,  A61K31/41 ,  A61K31/44 ,  A61P35/00

CPC classification number: C07C275/42 ,  A61K31/18 ,  A61K31/196 ,  A61K31/277 ,  A61K31/343 ,  A61K31/41 ,  A61K31/4418 ,  A61K31/444 ,  A61K45/06 ,  C07C311/09 ,  C07C311/51 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/10 ,  C07D213/75 ,  C07D213/79 ,  C07D257/04 ,  C07D307/79 ,  C07D307/86 ,  C07D401/04

Abstract: There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

Abstract translation: 公开了调节或抑制吲哚胺2,3-双加氧酶（IDO）的酶活性的式（I）化合物，含有所述化合物的药物组合物和治疗增殖性疾病如癌症，病毒感染和/或炎症性疾病的方法 利用本发明的化合物。

公开(公告)号：WO2020023356A1

公开(公告)日：2020-01-30

申请号：PCT/US2019/042773

申请日：2019-07-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： BALOG, James Aaron ,  SEITZ, Steven P. ,  MARKWALDER, Jay A. ,  WILLIAMS, David K. ,  SHAN, Weifang ,  NARA, Susheel Jethanand ,  ROY, Saumya ,  CHERUKU, Srinivas ,  PULICHARLA, Nagalakshmi

IPC: C07D307/79 ,  C07D313/08 ,  C07D405/10 ,  C07D405/14 ,  C07D413/10 ,  C07D417/14 ,  C07D487/04 ,  A61P35/00 ,  A61K31/55

Abstract: The present invention provides compounds of formula (I) wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.

公开(公告)号：WO2018209049A1

公开(公告)日：2018-11-15

申请号：PCT/US2018/032013

申请日：2018-05-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： BALOG, James Aaron ,  CHERNEY, Emily Charlotte ,  ZHANG, Liping ,  HUANG, Audris ,  SHAN, Weifang ,  WILLIAMS, David K. ,  ZHU, Xiao ,  GUO, Weiwei

IPC: C07D403/12 ,  C07D213/85 ,  C07D401/12 ,  C07D471/04 ,  A61K31/47 ,  A61P35/00 ,  A61K31/4745 ,  A61K31/444

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

公开(公告)号：WO2016161269A1

公开(公告)日：2016-10-06

申请号：PCT/US2016/025531

申请日：2016-04-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： BALOG, James Aaron ,  CHERNEY, Emily Charlotte ,  GUO, Weiwei ,  HUANG, Audris ,  MARKWALDER, Jay A. ,  SEITZ, Steven P. ,  SHAN, Weifang ,  WILLIAMS, David K. ,  MURUGESAN, Natesan ,  NARA, Susheel Jethanand ,  ROY, Saumya ,  THANGAVEL, Soodamani ,  SISTLA, Ramesh Kumar ,  CHERUKU, Srinivas ,  THANGATHIRUPATHY, Srinivasan ,  KANYABOINA, Yadagiri ,  PULICHARLA, Nagalakshmi

IPC: C07D309/14 ,  C07D317/66 ,  C07D401/12 ,  C07D405/12 ,  C07D239/42 ,  C07D261/14 ,  C07D487/04 ,  A61K31/17 ,  A61P35/00 ,  C07D335/02 ,  C07C229/00 ,  A61K31/136 ,  C07D409/12

CPC classification number: C07C275/40 ,  A61K31/17 ,  A61K31/196 ,  A61K31/277 ,  A61K31/351 ,  A61K31/382 ,  A61K31/397 ,  A61K31/428 ,  A61K31/437 ,  A61K31/445 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/538 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  C07C229/42 ,  C07C233/81 ,  C07C235/38 ,  C07C235/56 ,  C07C255/57 ,  C07C255/58 ,  C07C275/30 ,  C07C275/42 ,  C07D205/04 ,  C07D207/08 ,  C07D207/12 ,  C07D211/08 ,  C07D211/14 ,  C07D239/34 ,  C07D239/47 ,  C07D265/30 ,  C07D265/36 ,  C07D277/64 ,  C07D295/155 ,  C07D307/22 ,  C07D309/04 ,  C07D309/14 ,  C07D317/46 ,  C07D335/02 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

Abstract translation: 公开了调节或抑制吲哚胺2,3-双加氧酶（IDO）的酶活性的化合物，含有所述化合物的药物组合物和治疗增殖性疾病例如癌症，病毒感染和/或炎症性疾病的方法，其利用 发明。

公开(公告)号：WO2019136112A1

公开(公告)日：2019-07-11

申请号：PCT/US2019/012118

申请日：2019-01-03

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： BALOG, James Aaron ,  SEITZ, Steven P. ,  WILLIAMS, David K. ,  ANDAPPAN MURUGAIAH SUBBAIAH, Murugaiah

IPC: C07D213/75 ,  C07D295/155 ,  A61P35/00 ,  A61K31/5375 ,  A61K31/44 ,  A61K31/685 ,  A61K31/661 ,  C07F9/09

CPC classification number: C07C275/42 ,  A61P35/00 ,  C07C2601/16 ,  C07D213/75 ,  C07D295/155 ,  C07F9/091 ,  C07F9/094 ,  C07F9/117 ,  C07F9/12 ,  C07F9/572 ,  C07F9/58 ,  C07F9/65515

Abstract: The present invention provides a compound of formula (II): an inhibitor of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases. Its prodrugs are disclosed.

公开(公告)号：WO2019074822A1

公开(公告)日：2019-04-18

申请号：PCT/US2018/054819

申请日：2018-10-08

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： BALOG, James Aaron ,  CHERNEY, Emily Charlotte ,  SHAN, Weifang ,  WILLIAMS, David K. ,  ZHANG, Liping

IPC: C07D215/18 ,  C07D401/04 ,  C07D401/06 ,  C07C275/00

CPC classification number: C07D401/04 ,  C07C275/26 ,  C07C2601/08 ,  C07C2601/14 ,  C07D215/18 ,  C07D401/06

Abstract: The present invention provides compounds of formula (I), formula (II) or formula (III), wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.