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公开(公告)号：WO2019209377A3
公开(公告)日：2019-10-31
申请号：PCT/US2018/063486
申请日：2018-11-30
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： ADALIAN, Dvin , CHEN, Samson , JILANI, Muhammad M. , SCHERER, Axel , MADERO, Xiomara Linnette , SMITH, Richard
IPC: G01N27/327 , G01N27/416
Abstract: Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.
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2.发明申请DEVICES AND METHODS FOR CELL LYSIS AND SAMPLE PREPARATION THROUGH CENTRIFUGATION 审中-公开通过离心进行细胞分析和样品制备的装置和方法
公开(公告)号：WO2014058868A1
公开(公告)日：2014-04-17
申请号：PCT/US2013/063865
申请日：2013-10-08
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： RAJAGOPAL, Aditya , KARTALOV, Emil, P. , ALLENDORPH, Carl, J. , SCHERER, Axel , CHEN, Samson
IPC: G01N1/28 , G01N33/483 , B04B5/00
CPC classification number: C12M47/06
Abstract: Methods and devices for molecular analysis are disclosed, based on centrifugation. A centrifuge device comprises strips of centrifuge tubes and elements to create a magnetic field. The magnetic shear forces applied to beads inside a solution with biological molecules permit the performance of different analytic techniques, such as lysis and sample preparation for PCR.
Abstract translation: 公开了基于离心的分子分析方法和装置。 离心机装置包括离心管和元件条，以产生磁场。 施加到具有生物分子的溶液中的珠的磁剪切力允许执行不同的分析技术，例如用于PCR的裂解和样品制备。
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公开(公告)号：WO2019050633A3
公开(公告)日：2019-03-14
申请号：PCT/US2018/043558
申请日：2018-07-24
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： CHEN, Samson , SCHERER, Axel , SMITH JR., Richard Daniel
Abstract: An implantable device contains a drug or biosensing compound, protected from the external environment within a human body by several barriers which are broken upon activation of the device through electrothermal, chemical, and mechanical processes. The device allows accurate and repeated dosing within a human body, thus reducing the number of implantation procedures required. This device extends the lifetime of a biosensor, reducing the number of implantation procedures required.
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公开(公告)号：WO2012145301A2
公开(公告)日：2012-10-26
申请号：PCT/US2012/033914
申请日：2012-04-17
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , CHEN, Samson , RAJAGOPAL, Aditya , SCHERER, Axel
Inventor： CHEN, Samson , RAJAGOPAL, Aditya , SCHERER, Axel
CPC classification number: H05K3/10 , B01L3/502707 , B01L3/502715 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , H01L23/473 , H01L2924/0002 , H05K1/0272 , H05K3/284 , H05K2201/10189 , H05K2203/1327 , Y10T29/49 , Y10T29/49002 , Y10T29/49155 , Y10T29/49165 , Y10T137/85938 , Y10T436/11 , Y10T436/25 , Y10T436/2575 , H01L2924/00
Abstract: A printed circuit board structure is coated with an encapsulant within which microfluidic channels have been formed. The microfluidic channels are formed by soldering fluidic connections to metal traces on a surface of the printed circuit board structure prior to encapsulation. The metal traces are removed by etching after encapsulation to form microchannels within the encapsulant.
Abstract translation: 印刷电路板结构涂覆有已经形成微流体通道的密封剂。 在封装之前，通过将流体连接焊接到印刷电路板结构的表面上的金属迹线来形成微流体通道。 在封装后通过蚀刻去除金属迹线，以在密封剂内形成微通道。
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Patent Agency Ranking
公开(公告)号：WO2023064908A1
公开(公告)日：2023-04-20
申请号：PCT/US2022/078126
申请日：2022-10-14
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , GOTTFRIED WILHELM LEIBNIZ UNIVERSITÄT HANNOVER , HELMHOLTZ ZENTRUM MÜNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH)
Inventor： PLETTENBURG, Oliver , AHLBRECHT, Christin , ADALIAN, Dvin , SCHERER, Axel , MADERO, Xiomara Linnette , CHEN, Samson , JILANI, Muhammad Musab
IPC: G01N27/327
Abstract: Methods and systems are described for fabricating thin hydrogel layers on biosensors by a drop-spin method, which includes placing a drop of the hydrogel on the electrode, spinning the wafer at high speed in a vacuum, and heating the wafer to cure. One and multilayer sensors can be fabricated in this way, by adding layers of hydrogel or metal.
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公开(公告)号：WO2019209377A2
公开(公告)日：2019-10-31
申请号：PCT/US2018/063486
申请日：2018-11-30
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： ADALIAN, Dvin , CHEN, Samson , JILANI, Muhammad M. , SCHERER, Axel , MADERO, Xiomara Linnette , SMITH, Richard
IPC: G01N27/327
Abstract: Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.
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公开(公告)号：WO2019067681A1
公开(公告)日：2019-04-04
申请号：PCT/US2018/053061
申请日：2018-09-27
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： CHEN, Samson , SCHERER, Axel
IPC: G01N27/327 , A61B5/145 , C12Q1/00
CPC classification number: A61B5/14865 , A61B5/14532 , A61B5/1459 , C12N9/0004 , C12N11/02 , C12N11/14 , C12Y101/01001 , C12Y101/03003 , C12Y101/03005 , C12Y101/03007 , C12Y101/03008 , C12Y101/0301 , C12Y101/03011 , C12Y101/03012 , C12Y101/03015 , C12Y101/03016 , C12Y101/03018 , C12Y101/03019 , C12Y101/0302 , C12Y101/03023 , C12Y101/03027 , C12Y101/03029 , C12Y101/0303 , C12Y101/03037 , C12Y101/03038 , C12Y101/0304 , C12Y101/03041 , G01N27/3272
Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
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公开(公告)号：WO2019050633A2
公开(公告)日：2019-03-14
申请号：PCT/US2018/043558
申请日：2018-07-24
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： CHEN, Samson , SCHERER, Axel , SMITH JR., Richard Daniel
Abstract: An implantable device contains a drug or biosensing compound, protected from the external environment within a human body by several barriers which are broken upon activation of the device through electrothermal, chemical, and mechanical processes. The device allows accurate and repeated dosing within a human body, thus reducing the number of implantation procedures required. This device extends the lifetime of a biosensor, reducing the number of implantation procedures required.
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公开(公告)号：WO2018217952A1
公开(公告)日：2018-11-29
申请号：PCT/US2018/034228
申请日：2018-05-23
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： SCHERER, Axel , PETILLO, Peter A. , CHEN, Samson , EMAMI, Azita
IPC: A01K1/03 , H04B1/16 , A01K5/01 , A01K5/02 , G01N27/30 , G01N27/327 , G01N27/333
Abstract: A smart cage includes radiofrequency transceivers and tags attached to laboratory animals. The tags include sensors to detect monitorable conditions of the laboratory animals. The sensors include working electrodes, counter electrodes, reference electrodes, and potentiostats. The top surface of the electrodes is coated with ionophores or enzymes which detect the monitorable conditions of the laboratory animals.
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