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公开(公告)号：WO2021087344A1
公开(公告)日：2021-05-06
申请号：PCT/US2020/058335
申请日：2020-10-30
Applicant: CEDARS-SINAI MEDICAL CENTER , BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
Inventor： DHARMAKUMAR, Rohan , FRANCIS, Joseph
IPC: C07K14/705 , C12Q1/6883 , G01N33/68
Abstract: The invention relates to methods of cardiovascular imaging and/or measurement of blood markers for detecting, diagnosing and/or prognosing cardiac or myocardial microbleeds, especially in subject with hypertension and cardiovascular diseases. Treatment methods are also provided for subjects identified, diagnosed, prognosed, or detected with cardiac or myocardial microbleeds. In some embodiments, the subject has hypertension-induced microbleeds, but has not had a myocardial infarction or reperfusion therapy.
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公开(公告)号：WO2012151583A1
公开(公告)日：2012-11-08
申请号：PCT/US2012/036813
申请日：2012-05-07
Applicant: CEDARS-SINAI MEDICAL CENTER , DHARMAKUMAR, Rohan , LI, Debiao
Inventor： DHARMAKUMAR, Rohan , LI, Debiao
IPC: A01N59/04
CPC classification number: A61B5/02007 , A61B5/0035 , A61B5/02028 , A61B5/026 , A61B5/0402 , A61B5/055 , A61B5/145 , A61B5/7257 , A61B6/032 , A61B6/037 , A61B6/4417 , A61B6/507 , A61B6/508 , A61B7/02 , A61B8/0883 , A61B8/4416 , A61B8/488 , A61D7/00 , A61M16/12 , G01R33/4806 , G01R33/481 , G01R33/4812 , G01R33/4814 , G01R33/60
Abstract: The invention provides methods for diagnosing coronary heart disease in a subject in need thereof comprising administering an admixture comprising CO2 to a subject to reach a predetermined PaCO2 in the subject to induce hyperemia, monitoring vascular reactivity in the subject and diagnosing the presence or absence of coronary heart disease in the subject, wherein decreased vascular reactivity in the subject compared to a control subject is indicative of coronary heart disease. The invention also provides methods for increasing sensitivity and specificity of BOLD MRI.
Abstract translation: 本发明提供了在有需要的受试者中诊断冠状动脉心脏病的方法，其包括向受试者施用包含CO 2的混合物以达到受试者中的预定PaCO 2以诱发充血，监测受试者的血管反应性并诊断冠状动脉的存在或不存在 心脏病在受试者中，其中与对照受试者相比，受试者血管反应性降低指示冠心病。 本发明还提供了增加BOLD MRI的灵敏度和特异性的方法。
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公开(公告)号：WO2015034951A1
公开(公告)日：2015-03-12
申请号：PCT/US2014/053938
申请日：2014-09-03
Applicant: CEDARS-SINAI MEDICAL CENTER
Inventor： DHARMAKUMAR, Rohan , AVINASH, Kali
CPC classification number: G01R33/50 , A61B5/0044 , A61B5/0452 , A61B5/055 , A61B2505/03 , G01R33/56308
Abstract: The invention provides methods for characterizing a myocardial infarction using magnetic resonance imaging, without the use of contrast agents, using, for example, a field strength of 3.0 Tesla or greater. Also provided is a method for detecting a chronic myocardial infarction in a subject suspected of having a myocardial infarction.
Abstract translation: 本发明提供使用磁共振成像来表征心肌梗塞的方法，不使用造影剂，例如使用3.0特斯拉或更高的场强。 还提供了用于检测疑似患有心肌梗死的受试者的慢性心肌梗死的方法。
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公开(公告)号：WO2015021078A1
公开(公告)日：2015-02-12
申请号：PCT/US2014/049832
申请日：2014-08-05
Applicant: CEDARS-SINAI MEDICAL CENTER
Inventor： DHARMAKUMAR, Rohan
IPC: A01N59/04
CPC classification number: A61K33/00 , A61F7/12 , A61F2007/126
Abstract: Provided herein are methods for reducing ischemia-reperfusion injury and/or microvascular obstructions by administering to the subject effective amounts of carbon dioxide and oxygen before, during and/or after re-establishing perfusion. In some embodiments, the methods further include using therapeutic hypothermia.
Abstract translation: 本文提供了通过在重建灌注之前，期间和/或之后向受试者施用有效量的二氧化碳和氧气来减少缺血再灌注损伤和/或微血管障碍的方法。 在一些实施方案中，所述方法还包括使用治疗性低温。
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公开(公告)号：WO2021188984A1
公开(公告)日：2021-09-23
申请号：PCT/US2021/023292
申请日：2021-03-19
Applicant: CEDARS-SINAI MEDICAL CENTER
Inventor： DHARMAKUMAR, Rohan
Abstract: Methods of treating a subject with myocardial infarction are provided, which include selective targeting time-dependent iron products at different phases of the infarction. It is discovered that during acute phase of myocardial infarction, ferrous iron in the form of heme accumulate, often followed by infarct expansion, and during the chronic phase, ferric iron in the form of crystals are dominant. Chelator agents specific for ferrous iron, heme or ferric iron are demonstrated in the protection of cardiomyocytes, reduction of infarct expansion, or improving cardiac remodeling following myocardial infarction. Also provided are methods for determining the presence of intramyocardial hemorrhage by measuring plasma level of cardiac troponin before and after re-vascularization or a reperfusion therapy, which can be used to guide therapeutic treatment or intervention procedures to control the hemorrhage and mitigate infarct expansion.
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Patent Agency Ranking6.发明申请ROBUST MYOCARDIAL BLOOD OXYGEN LEVEL DEPENDENT MAGNETIC RESONANCE IMAGING WITH LONG-ACTING CORONARY VASODILATORS 审中-公开强大的心肌血氧饱和度水平依赖磁共振成像与长期作用的冠状血管扩张剂
公开(公告)号：WO2017059302A1
公开(公告)日：2017-04-06
申请号：PCT/US2016/054890
申请日：2016-09-30
Applicant: CEDARS-SINAI MEDICAL CENTER
Inventor： DHARMAKUMAR, Rohan , YANG, Hsin-Jung
CPC classification number: A61B5/14542 , A61B5/0044 , A61B5/02007 , A61B5/055 , A61B5/7207 , A61B6/03 , A61B6/037 , A61B6/503 , G01R33/481 , G01R33/50 , G01R33/5601
Abstract: The invention provides various methods for imaging a subject's cardiovascular system. The imaging method may be used to provide a diagnosis or prognosis of various cardiovascular diseases in the subject, without contrast agents or radioactive tracers, and further generating a Gaussian Mixture Model to obtain a reference value of a normal myocardium.
Abstract translation: 本发明提供用于对受试者心血管系统进行成像的各种方法。 成像方法可用于提供受试者中各种心血管疾病的诊断或预后，无造影剂或放射性示踪剂，并进一步产生高斯混合模型以获得正常心肌的参考值。
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7.发明申请MRI BASED CHARACTERIZATION OF MICROVASCULAR OBSTRUCTION IN RESPONSE TO THERAPEUTIC HYPOTHERMIA FOLLOWING ACUTE MYOCARDIAL INFARCTION 审中-公开基于MRI的基于微创手术治疗急性心肌梗死患者治疗效果的研究
公开(公告)号：WO2012149226A2
公开(公告)日：2012-11-01
申请号：PCT/US2012/035307
申请日：2012-04-26
Applicant: CEDARS-SINAI MEDICAL CENTER , DHARMAKUMAR, Rohan
Inventor： DHARMAKUMAR, Rohan
IPC: A61B18/02
CPC classification number: A61F7/10 , A61B5/0044 , A61B5/055 , A61B2576/023 , A61F7/12 , A61F2007/126 , G01R33/5602 , G01R33/56366
Abstract: The invention provides methods for reducing microvascular obstructions, reducing hemorrhagic microvascular obstructions and/or reducing ischemia-reperfusion injury in a subject in need thereof by using therapeutic hypothermia and monitoring the outcome of the intervention with a non-invasive imaging standard.
Abstract translation: 本发明提供了通过使用治疗性低温并用非侵入性成像标准监测干预结果来减少微血管障碍，减少出血性微血管障碍和/或减少有需要的受试者的缺血再灌注损伤的方法。
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公开(公告)号：WO2020163783A1
公开(公告)日：2020-08-13
申请号：PCT/US2020/017320
申请日：2020-02-07
Applicant: CEDARS-SINAI MEDICAL CENTER
Inventor： DHARMAKUMAR, Rohan , YANG, Hsin-Jung
Abstract: Described herein are methods for cardiovascular imaging for diagnosing and/or detecting various cardiovascular diseases. Various embodiments of the invention provide using magnetic resonance imaging of the cardiovascular system of a subject at rest or a normocapnic condition, as well as at a stressed or hypercapnic condition, in a repeated manner enhancing the statistical power, such that fast, motion-corrected, free-breathing, whole-heart imaging of the cardiovascular system is utilized to identify impaired cardiovascular function in a manner with improved specificity and accuracy.
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9.发明申请
公开(公告)号：WO2019210145A1
公开(公告)日：2019-10-31
申请号：PCT/US2019/029316
申请日：2019-04-26
Applicant: CEDARS-SINAI MEDICAL CENTER
Inventor： DHARMAKUMAR, Rohan , YANG, Hsin-Jung
IPC: A61B5/00
Abstract: The invention provides various methods for imaging a subject's cardiovascular system. The imaging methods may be used to diagnose or prognose various cardiovascular diseases in the subject, without contrast agents or radioactive tracers.
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10.发明申请ASSESSMENT OF IRON DEPOSITION POST MYOCARDIAL INFARCTION AS A MARKER OF MYOCARDIAL HEMORRHAGE 审中-公开心肌梗塞后骨髓沉积评估作为心肌梗死的标志物
公开(公告)号：WO2012174157A1
公开(公告)日：2012-12-20
申请号：PCT/US2012/042310
申请日：2012-06-13
Applicant: CEDARS-SINAI MEDICAL CENTER , DHARMAKUMAR, Rohan , COKIC, Ivan
Inventor： DHARMAKUMAR, Rohan , COKIC, Ivan
IPC: A61B5/05
CPC classification number: A61B5/0263 , A61B5/0044 , A61B5/02042 , A61B5/02405 , A61B5/0472 , A61B5/055 , A61B5/14542 , A61B2576/023 , A61K45/06 , A61N1/362 , A61N1/3956
Abstract: The invention is directed to methods for diagnosing reperfusion/non-reperfusion hemorrhage and predicting cardiac arrhythmias and sudden cardiac death in subjects comprising using imaging techniques to detect regional iron oxide deposition. The invention also provides treatment methods for subject at increased risk of sudden cardiac death.
Abstract translation: 本发明涉及用于诊断再灌注/非再灌注出血和预测受试者心脏心律失常和心源性猝死的方法，包括使用成像技术检测局部氧化铁沉积。 本发明还提供了在心脏猝死风险增加的受试者的治疗方法。
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