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    MEDICAL IMAGING AND EFFICIENT SHARING OF MEDICAL IMAGING INFORMATION
    2.
    发明申请
    MEDICAL IMAGING AND EFFICIENT SHARING OF MEDICAL IMAGING INFORMATION 审中-公开
    医学影像学与医学影像信息的有效共享

    公开(公告)号：WO2017091835A3

    公开(公告)日：2017-07-27

    申请号：PCT/US2016064031

    申请日：2016-11-29

    Applicant: ARTERYS INC

    Inventor： BECKERS FABIEN ,  AXERIO-CILIES JOHN ,  TAERUM TORIN ARNI ,  HSIAO ALBERT ,  DE FRANCESCO GIOVANNI ,  BIDULOCK DARRYL ,  JUGDEV TRISTAN ,  NEWTON ROBERT

    IPC: A61B5/055

    CPC classification number: A61B5/055 ,  A61B5/0022 ,  A61B5/0044 ,  A61B5/02 ,  A61B5/02007 ,  A61B5/02014 ,  A61B5/021 ,  A61B5/026 ,  A61B5/0263 ,  A61B5/7207 ,  A61B5/725 ,  A61B5/7257 ,  A61B2576/023

    Abstract: An MRI image processing and analysis system may identify instances of structure in MRI flow data, e.g., coherency, derive contours and/or clinical markers based on the identified structures. The system may be remotely located from one or more MRI acquisition systems, and perform: perform error detection and/or correction on MRI data sets (e.g., phase error correction, phase aliasing, signal unwrapping, and/or on other artifacts); segmentation; visualization of flow (e.g., velocity, arterial versus venous flow, shunts) superimposed on anatomical structure, quantification; verification; and/or generation of patient specific 4-D flow protocols. An asynchronous command and imaging pipeline allows remote image processing and analysis in a timely and secure manner even with complicated or large medical imaging data sets and metadata.

    Abstract translation: MRI图像处理和分析系统可以识别MRI流量数据中的结构的实例，例如一致性，基于所识别的结构导出轮廓和/或临床标记。 该系统可以远离一个或多个MRI采集系统定位，并且执行：对MRI数据集（例如，相位误差校正，相位混叠，信号解缠和/或其他伪像）执行错误检测和/或校正; 分割; 叠加在解剖结构上的流动的可视化（例如，速度，动脉对静脉流动，分流），量化; 验证; 和/或生成患者特异性4-D流程方案。 异步命令和成像管线即使对于复杂或大型的医学成像数据集和元数据，也能够以及时和安全的方式进行远程图像处理和分析。

    ALIGNING A CARDIAC MODEL
    4.
    发明申请
    ALIGNING A CARDIAC MODEL 审中-公开
    遵循心脏模型

    公开(公告)号：WO2016196047A1

    公开(公告)日：2016-12-08

    申请号：PCT/US2016/033696

    申请日：2016-05-23

    Applicant: ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.

    Inventor： EVERLING, Bruce R.

    IPC: A61B5/06 ,  A61B5/11

    CPC classification number: A61B34/10 ,  A61B5/0044 ,  A61B5/0402 ,  A61B5/042 ,  A61B5/044 ,  A61B5/061 ,  A61B5/062 ,  A61B5/065 ,  A61B5/068 ,  A61B5/107 ,  A61B5/6852 ,  A61B2034/105 ,  G16H30/40 ,  G16H50/50

    Abstract: A method (94) for aligning a cardiac model can include receiving (95) an initial position signal from three position sensors (17, 39, 40) disposed along a distal end of a coronary sinus catheter (13) positioned in a coronary sinus (41) of a heart (10). The method (94) can include receiving (96) a subsequent position signal from the three position sensors (17, 39, 40). The method (94) can include determining (97) a positional change vector based on a change in position between an initial position associated with the initial position signal and a subsequent position associated with the subsequent position signal. The method (94) can include shifting (98) a point of interest associated with a cardiac model, using the positional change vector. The method (94) can include dynamically aligning (100) the cardiac model based on an updated position of the three position sensors (17, 39, 40).

    Abstract translation: 用于对准心脏模型的方法（94）可以包括从位于冠状窦内的冠状窦导管（13）的远端设置的三个位置传感器（17,39,40）接收（95）初始位置信号 41）心脏（10）。 方法（94）可以包括从三个位置传感器（17,39,40）接收（96）后续的位置信号。 方法（94）可以包括基于与初始位置信号相关联的初始位置与与后续位置信号相关联的后续位置之间的位置变化确定（97）位置变化向量。 方法（94）可以包括使用位置变化向量移位（98）与心脏模型相关联的兴趣点。 方法（94）可以包括基于三个位置传感器（17,39,40）的更新位置动态地对准（100）心脏模型。

    SYSTEM AND METHOD FOR ENHANCED MAGNETIC RESONANCE IMAGING OF TISSUE
    5.
    发明申请
    SYSTEM AND METHOD FOR ENHANCED MAGNETIC RESONANCE IMAGING OF TISSUE 审中-公开
    用于增强组织磁共振成像的系统和方法

    公开(公告)号：WO2016149586A1

    公开(公告)日：2016-09-22

    申请号：PCT/US2016/023071

    申请日：2016-03-18

    Applicant: IMRICOR MEDICAL SYSTEMS, INC.

    Inventor： WEDAN, Steven R.

    IPC: A61B5/05

    CPC classification number: A61B5/0044 ,  A61B5/0037 ,  A61B5/02007 ,  A61B5/0402 ,  A61B5/055 ,  A61B5/062 ,  A61B5/08 ,  A61B5/7257 ,  A61B5/7285 ,  A61B5/7292 ,  A61B2560/0266 ,  A61B2576/023

    Abstract: A method for producing a magnetic resonance image of a subject tissue to identify a lesion or scar tissue thereon in provided. The method includes acquiring an initial three-dimensional image of the subject tissue by a computer-implemented MRI system; identifying the surface of the subject tissue by the computer-implemented MRI system; selecting one or more points on the surface of the subject tissue by the computer-implemented MRI system; and acquiring by the computer-implemented MRI system, a first two-dimensional image for at least one of the selected points that is substantially tangential to the surface of the selected point.

    Abstract translation: 一种用于产生被检体组织的磁共振图像以在其中识别病变或瘢痕组织的方法。 该方法包括通过计算机实现的MRI系统获取主题组织的初始三维图像; 通过计算机实现的MRI系统识别主体组织的表面; 通过计算机实现的MRI系统选择主体组织表面上的一个或多个点; 以及通过所述计算机实施的MRI系统获取与所选择的点的表面基本相切的所选择的点中的至少一个的第一二维图像。

    SYSTEMS AND METHODS FOR MEASURING CARDIAC STRAIN
    8.
    发明申请
    SYSTEMS AND METHODS FOR MEASURING CARDIAC STRAIN 审中-公开
    用于测量心脏菌株的系统和方法

    公开(公告)号：WO2016065159A1

    公开(公告)日：2016-04-28

    申请号：PCT/US2015/056938

    申请日：2015-10-22

    Applicant: WASHINGTON UNIVERSITY

    Inventor： KAR, Julia ,  PASQUE, Michael K. ,  CUPPS, Brian P.

    IPC: A61B5/055 ,  G06T7/20 ,  G06F19/00

    CPC classification number: A61B5/0044 ,  A61B5/055 ,  A61B2576/023 ,  G01R33/5608 ,  G01R33/5611 ,  G01R33/56316 ,  G01R33/56333 ,  G06F19/321 ,  G06T7/0012 ,  G06T7/11 ,  G06T7/60 ,  G06T2200/04 ,  G06T2207/10088 ,  G06T2207/30048 ,  G16H30/40

    Abstract: A method for rapid computation of three-dimensional displacement and Lagrange strain in a high resolution filed of phase data obtained with Displacement Encoding with Stimulated Echoes (DENSE) in magnetic resonance images of the myocardium. The method includes semi-automated segmentation of a region of a heart, phase unwrapping the images in three dimensions, and a custom radial point interpolation method (RPIM). The RPIM is a meshfree numerical analysis method that uses radial basis functions and polynomial functions to calculate the Lagrange strain of DENSE displacement data acquired from the myocardium.

    Abstract translation: 一种快速计算三维位移和拉格朗日应变的方法，用于在心肌的磁共振图像中用激发回波（DENSE）进行位移编码获得的相位数据的高分辨率场。 该方法包括心脏区域的半自动分割，三维展开图像以及自定义径向点插值方法（RPIM）。 RPIM是一种无网格数值分析方法，其使用径向基函数和多项式函数来计算从心肌获取的DENSE位移数据的拉格朗日应变。

    SYSTEM AND METHOD FOR CONTROLLING DEPTH OF IMAGING IN TISSUES USING FLUORESCENCE MICROSCOPY UNDER ULTRAVIOLET EXCITATION FOLLOWING STAINING WITH FLUORESCING AGENTS
    9.
    发明申请
    SYSTEM AND METHOD FOR CONTROLLING DEPTH OF IMAGING IN TISSUES USING FLUORESCENCE MICROSCOPY UNDER ULTRAVIOLET EXCITATION FOLLOWING STAINING WITH FLUORESCING AGENTS 审中-公开
    使用荧光显微镜在荧光显微镜下控制成像深度的系统和方法

    公开(公告)号：WO2016043991A1

    公开(公告)日：2016-03-24

    申请号：PCT/US2015/048519

    申请日：2015-09-04

    Applicant: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： DEMOS, Stavros G. ,  LEVENSON, Richard

    IPC: G01N21/64 ,  C12Q1/68 ,  C12M1/34

    CPC classification number: G01N21/6458 ,  A61B5/0044 ,  A61B5/0071 ,  G01N21/6428 ,  G01N21/6445 ,  G01N21/6486 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2201/062

    Abstract: The present disclosure relates to a method for analyzing tissue specimens. In one implementation the method involves obtaining a tissue sample and exposing the sample to one or more fluorophores as contrast agents to enhance contrast of subcellular compartments of the tissue sample. The tissue sample is illuminated by an ultraviolet (UV) light having a wavelength between about 200 nm to about 400 nm, with the wavelength being selected to result in penetration to only a specified depth below a surface of the tissue sample. Inter-image operations between images acquired under different imaging parameters allow for improvement of the image quality via removal of unwanted image components. A microscope may be used to image the tissue sample and provide the image to an image acquisition system that makes use of a camera. The image acquisition system may create a corresponding image that is transmitted to a display system for processing and display.

    Abstract translation: 本公开涉及一种用于分析组织标本的方法。 在一个实施方案中，该方法包括获得组织样品并将样品暴露于作为造影剂的一种或多种荧光团，以增强组织样品的亚细胞区室的对比度。 组织样品被波长在约200nm至约400nm之间的紫外线（UV）光照射，其中选择的波长导致仅渗透到组织样品表面下方的指定深度。 在不同成像参数下获取的图像之间的图像间操作允许通过去除不需要的图像分量来改善图像质量。 可以使用显微镜来对组织样本进行成像，并将图像提供给使用照相机的图像采集系统。 图像采集系统可以创建被发送到显示系统以进行处理和显示的相应图像。

    METHOD AND SYSTEM FOR QUANTIFYING LIMITATIONS IN CORONARY ARTERY BLOOD FLOW DURING PHYSICAL ACTIVITY IN PATIENTS WITH CORONARY ARTERY DISEASE
    10.
    发明申请
    METHOD AND SYSTEM FOR QUANTIFYING LIMITATIONS IN CORONARY ARTERY BLOOD FLOW DURING PHYSICAL ACTIVITY IN PATIENTS WITH CORONARY ARTERY DISEASE 审中-公开
    冠状动脉疾病患者身体活动期间冠状动脉血流量限制的方法和系统

    公开(公告)号：WO2016040410A1

    公开(公告)日：2016-03-17

    申请号：PCT/US2015/049071

    申请日：2015-09-09

    Applicant: HEARTFLOW, INC.

    Inventor： TAYLOR, Charles, A.

    IPC: G06F19/00

    CPC classification number: A61B5/7275 ,  A61B5/0044 ,  A61B5/021 ,  A61B5/029 ,  A61B2576/023 ,  G06F19/00 ,  G16H50/30 ,  G16H50/50 ,  Y02A90/26

    Abstract: Embodiments include a system for determining cardiovascular information for a patient with coronary artery disease. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart and create a model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create, for a given level of physical activity, a physics-based model of blood flow through the patient's heart simulated during a selected level of physical activity; determine and normalize one or more values of at least one blood flow characteristic within the patient's heart during the simulated level of physical activity; and compare the one or more normalized values of the at least one blood flow characteristic to a threshold to determine whether the level of physical activity exceeds an acceptable level of risk.

    Abstract translation: 实施例包括用于确定患有冠状动脉疾病的患者的心血管信息的系统。 该系统可以包括至少一个计算机系统，其被配置为接收关于患者心脏的几何形状的患者特定数据，并且基于患者特定数据创建表示患者心脏的至少一部分的模型。 所述至少一个计算机系统可以进一步配置为针对给定水平的身体活动，在所选择的身体活动水平期间模拟通过患者心脏的基于物理学的基于物理的模型; 在模拟的身体活动水平期间确定和归一化患者心脏内的至少一个血流特性的一个或多个值; 并且将所述至少一个血流特征的一个或多个归一化值与阈值进行比较，以确定身体活动的水平是否超过可接受的风险水平。

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