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    FLEXIBLE MEMBRANE VALVE FOR CELL CULTURE VESSEL
    1.
    发明申请
    FLEXIBLE MEMBRANE VALVE FOR CELL CULTURE VESSEL 审中-公开
    用于细胞培养血管的柔性膜片

    公开(公告)号：WO2009128892A2

    公开(公告)日：2009-10-22

    申请号：PCT/US2009002302

    申请日：2009-04-14

    Applicant: CORNING INC ,  CATTADORIS HENRY J ,  MARTIN GREGORY R ,  TANNER ALLISON J

    Inventor： CATTADORIS HENRY J ,  MARTIN GREGORY R ,  TANNER ALLISON J

    IPC: C12M1/24

    CPC classification number: C12M37/04 ,  C12M23/08 ,  C12M23/10 ,  C12M23/24 ,  C12M23/26 ,  C12M23/38 ,  C12M37/02

    Abstract: An assembly for culturing cells includes a housing defining a reservoir for containing cell culture media and an opening in fluid communication with the reservoir. The cell culture assembly further includes a filter valve assembly configured to sealingly engage the opening. The filter valve assembly includes a flexible membrane, a contiguous side wall, an end wall, and a microbial filter. The end wall has an opening and extends across one end of the side wall to form a major cavity within the side wall and the end wall. The flexible membrane has a slit spanning the membrane and is disposable within the major cavity such that the membrane sealingly divides the major cavity into (i) a chamber formed between the end wall and the membrane and (ii) a minor cavity formed by the membrane and a portion of the side wall. The minor cavity is in fluid communication with the reservoir. The slit is biased in a closed position to prevent fluid from passing from the minor cavity into the chamber and is configured to open to allow gas to pass from the minor cavity into the chamber when the pressure differential across the membrane is above a threshold. The filter is disposed between the membrane and the opening such that air flowing through the opening in the end wall into the chamber passes through the filter.

    Abstract translation: 用于培养细胞的组件包括限定用于容纳细胞培养基的储存器和与储存器流体连通的开口的壳体。 细胞培养组件还包括被配置为密封地接合开口的过滤阀组件。 过滤阀组件包括柔性膜，邻接侧壁，端壁和微生物过滤器。 端壁具有开口并且延伸穿过侧壁的一端以在侧壁和端壁内形成主腔。 柔性膜具有横跨膜的狭缝，并且在主空腔内是一次性的，使得膜将主腔密封地划分为（i）形成在端壁和膜之间的腔室和（ii）由膜形成的小腔 和侧壁的一部分。 小空腔与储存器流体连通。 狭缝被偏压在关闭位置，以防止流体从小空腔进入腔室，并被构造成打开，以允许气体在薄膜上的压差高于阈值时从小腔进入腔室。 过滤器设置在膜和开口之间，使得流过端壁中的开口进入室的空气通过过滤器。

    HIGH DENSITY PERMEABLE SUPPORTS FOR HIGH THROUGHPUT SCREENING
    2.
    发明申请
    HIGH DENSITY PERMEABLE SUPPORTS FOR HIGH THROUGHPUT SCREENING 审中-公开
    高密度渗透性支持用于高通量筛选

    公开(公告)号：WO2008005244A3

    公开(公告)日：2008-04-03

    申请号：PCT/US2007014852

    申请日：2007-06-27

    Applicant: CORNING INC ,  MARTIN GREGORY R ,  TANNER ALLISON J

    Inventor： MARTIN GREGORY R ,  TANNER ALLISON J

    IPC: B01L3/00 ,  C12M3/06

    CPC classification number: C12M25/04 ,  B01L3/50255 ,  B01L3/50857 ,  B01L2300/0681 ,  B01L2300/0829 ,  C12M23/24 ,  C12M23/38

    Abstract: A class of designs is provided for a permeable support where the design principle includes a permeable support layer (250), such as a membrane, bonded midway between two arrays of wells (110, 130) or multiwell plates, attached at their bottom portions, forming a double-sided multiwell plate. Thus, opposite facing wells on either side of the permeable support layer are accessible by inversion of the double-sided multiwell plate. Well fluid is held in place in the novel multiwell plate by capillary forces in the case of aligned upper and lower well arrays or by surface tension on patterned well regions on a permeable membrane layer. No additional components are necessary to form compartments for fluid retention. These new plate designs allow the surface area of the permeable support layer to be maximized, eliminate potential wicking and. cross contamination issues that may arise from multiple component sidewalls, and take advantage of the small well diameters to retain fluid by utilizing the effects of surface tension or capillary forces.

    Abstract translation: 提供了一类用于可渗透支撑件的设计，其中设计原理包括在其底部附接的两个井组（110,130）或多孔板之间的中间的粘合剂（例如膜）的可渗透支撑层（250） 形成双面多孔板。 因此，可渗透支撑层的任一侧上的相对面对的孔可通过双面多孔板的倒置进入。 在新颖的多孔板中，在对准的上下阵列的情况下通过毛细作用力将液体保持在适当的位置，或者通过可渗透膜层上的图案化阱区域上的表面张力来保持良好的流体。 不需要额外的部件来形成用于流体保持的隔室。 这些新的板设计允许可渗透支撑层的表面积最大化，消除潜在的芯吸。 可能由多个部件侧壁产生的交叉污染问题，并且通过利用表面张力或毛细管力的作用，利用小孔直径来保留流体。

    LIMITED ACCESS MULTI-LAYER CELL CULTURE SYSTEM
    3.
    发明申请
    LIMITED ACCESS MULTI-LAYER CELL CULTURE SYSTEM 审中-公开
    有限访问多层细胞培养系统

    公开(公告)号：WO2009094125A3

    公开(公告)日：2010-08-26

    申请号：PCT/US2009000303

    申请日：2009-01-16

    Applicant: CORNING INC ,  MARTIN GREGORY R ,  TANNER ALLISON J

    Inventor： MARTIN GREGORY R ,  TANNER ALLISON J

    IPC: C12M1/14

    CPC classification number: C12M23/34 ,  C12M23/04 ,  C12M23/08 ,  C12M23/38 ,  C12M23/40

    Abstract: The present invention provides a multi-layer cell culture device having a rectangular footprint and having multiple cell culture chambers separated by tracheal air spaces, each cell culture chamber having a port and a port cover or an external manifold structured and arranged to allow for transfer of fluid into and out of the cell culture device with reduced risk of contamination, and methods of using the device.

    Abstract translation: 本发明提供了一种具有矩形足迹并具有由气管空气间隔开的多个细胞培养室的多层细胞培养装置，每个细胞培养室具有端口和端口盖或外部歧管，其构造和布置成允许 流入和流出细胞培养装置的污染风险降低，以及使用该装置的方法。

    FLOAT VALVE FOR CELL CULTURE VESSEL
    5.
    发明申请
    FLOAT VALVE FOR CELL CULTURE VESSEL 审中-公开
    细胞培养皿用浮球

    公开(公告)号：WO2009128894A2

    公开(公告)日：2009-10-22

    申请号：PCT/US2009002304

    申请日：2009-04-14

    Applicant: CORNING INC ,  CATTADORIS HENRY J ,  MARTIN GREGORY R ,  TANNER ALLISON J

    Inventor： CATTADORIS HENRY J ,  MARTIN GREGORY R ,  TANNER ALLISON J

    IPC: C12M1/24

    CPC classification number: C12M23/08 ,  C12M23/56 ,  C12M29/20 ,  C12M37/02

    Abstract: A cell culture vessel includes a housing defining a reservoir, an inlet and an outlet in fluid communication with the reservoir, a valve assembly, and an antimicrobial filter. The valve assembly includes (i) a side wall defining a passageway for fluid flow between the reservoir and the outlet, (ii) a floating element disposed in the passageway and configured to float on the culture medium, (iii) a stop feature configured to sealingly engage the floating element to prevent the culture medium from flowing from the reservoir through the outlet, and (iv) a capture feature configured to retain the floating element within the passageway and to allow fluid to flow from the reservoir through the passageway. The microbial filter is positioned such that air flowing in the outlet to the passageway passes through the filter.

    Abstract translation: 细胞培养容器包括限定储存器的壳体，与储存器流体连通的入口和出口，阀组件和抗微生物过滤器。 阀组件包括（i）限定通道的侧壁，用于在储存器和出口之间流体流动，（ii）浮置元件，其设置在通道中并且构造成浮在培养基上，（iii）停止特征， 密封地接合浮动元件以防止培养基从储存器通过出口流动，以及（iv）捕获特征构造成将浮动元件保持在通道内并允许流体从储存器流过通道。 微生物过滤器被定位成使得在出口处流到通道的空气通过过滤器。

    LARGE SCALE CELL CULTURE VESSEL
    6.
    发明申请
    LARGE SCALE CELL CULTURE VESSEL 审中-公开
    大规模细胞培养船

    公开(公告)号：WO2008069902A3

    公开(公告)日：2008-08-07

    申请号：PCT/US2007023923

    申请日：2007-11-14

    Applicant: CORNING INC ,  MARTIN GREGORY R ,  TANNER ALLISON J ,  UPTON TODD M

    Inventor： MARTIN GREGORY R ,  TANNER ALLISON J ,  UPTON TODD M

    IPC: C12M1/00

    CPC classification number: C12M23/34 ,  C12M23/14 ,  C12M23/24 ,  C12M29/04

    Abstract: A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of flexible cell culture compartments in combination with a spacer material maintaining air space(s). The expandable compartments of the cell culture apparatus have imparted therein gas permeable membranes in combination with air spaces that will allow the free flow of gases between the cell culture compartments and the external environment. Furthermore an interconnecting passageway is provided between each compartment and between the cell culturing vessel and the external environment. The expandable vessel promotes the growth of large numbers of adherent or suspension cells by providing the volumes of nutrient medium and gaseous exchange.

    Abstract translation: 公开了一种培养细胞的多层细胞培养装置。 细胞培养装置被定义为具有多个柔性细胞培养室与保持空气间隔的间隔物组合的整体结构。 细胞培养装置的可扩张隔室在其中赋予气体可渗透的膜与空气空间的组合，这将允许细胞培养室和外部环境之间的气体自由流动。 此外，在每个隔室之间和细胞培养容器与外部环境之间提供互连通道。 可膨胀的血管通过提供体积的营养培养基和气体交换来促进大量粘附或悬浮细胞的生长。

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