公开(公告)号：WO2018183896A1

公开(公告)日：2018-10-04

申请号：PCT/US2018/025472

申请日：2018-03-30

Applicant: FORWARD BIOTECH, INC.

Inventor： GLASGOW, Ian, K.

IPC: B01L3/00 ,  G01F25/00

CPC classification number: B01L3/50857 ,  B01L2200/0605 ,  B01L2200/143 ,  B01L2200/148 ,  B01L2300/028 ,  B01L2300/0809 ,  B01L2300/161 ,  B01L2400/0406 ,  G01F25/0092

Abstract: A liquid evaluation system can include a cartridge including a channel configured to pull a liquid into the channel by capillary action. The cartridge can include a first plate and a second plate located in close proximity to the first plate. An internal facing surface of each plate can include a corresponding region forming the channel. Each of the regions can have an affinity for the liquid. The close proximity of the plates and the regions having an affinity for the liquid cause the liquid to be pulled into the channel by capillary action. The cartridge can include one or more additional attributes and/or the system can include one or more additional components for performing the evaluation.

公开(公告)号：WO2016190817A1

公开(公告)日：2016-12-01

申请号：PCT/SG2016/050248

申请日：2016-05-26

Applicant: JN MEDSYS PTE LTD

Inventor： NG, Kian Kok Johnson ,  TEU, Koon Kiat ,  LING, Mei Tze Belinda ,  SIM, Jia Wen

IPC: G01N1/28 ,  G01N1/40 ,  B01L3/00

CPC classification number: G01N1/40 ,  B01L3/5082 ,  B01L3/50857 ,  B01L2200/06 ,  B01L2200/141 ,  B01L2200/16 ,  B01L2300/043 ,  B01L2300/0832 ,  B01L2300/0838 ,  B01L2400/0406 ,  B01L2400/049 ,  C12Q1/6848 ,  C12Q1/686

Abstract: There is provided a method of charging an array of micro-capillaries, the micro-capillaries having at least one end that is open for fluid communication, the method comprising the steps of: (a) filling the array of micro-capillaries with an assay liquid; (b) controllably evaporating at least some of the assay liquid to remove it from the microcapillary and creating a void space in each of the capillaries between the assay liquid and the open end; and (c) filling the void space with a liquid that is immiscible with said assay liquid. There is also provided a use of the disclosed method for conducting a polymerase chain reaction and a device for charging an array of micro-capillaries.

Abstract translation: 提供了一种对微毛细管阵列进行充电的方法，所述微毛细管具有至少一个开放的用于流体连通的端部，所述方法包括以下步骤：（a）用测定法填充微毛细管阵列 液体; （b）可控地蒸发至少一些分析液体以将其从微毛细管中除去并在测定液体和开放端之间的每个毛细管中产生空隙空间; 和（c）用与所述测定液体不混溶的液体填充空隙空间。 还提供了用于进行聚合酶链反应的所公开的方法的使用和用于对微毛细管阵列进行充电的装置。

公开(公告)号：WO2015200803A1

公开(公告)日：2015-12-30

申请号：PCT/US2015/037997

申请日：2015-06-26

Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

Inventor： FANG-YEN, Christopher

IPC: B01L3/14 ,  C40B30/06 ,  C40B60/12

CPC classification number: C12M23/12 ,  B01L3/5085 ,  B01L3/50857 ,  B01L2300/0829 ,  B01L2300/0858 ,  B01L2300/10 ,  C12M23/22 ,  C12N5/0068 ,  C12N2533/00 ,  C12N2535/10

Abstract: A composition, including a substrate having a planar array of depressions each defined by concave walls and a moat disposed around each depression of said array of depressions.

Abstract translation: 一种组合物，包括具有由凹壁限定的凹陷的平面阵列的衬底和设置在所述凹陷阵列的每个凹陷周围的护城河。

公开(公告)号：WO2015127334A1

公开(公告)日：2015-08-27

申请号：PCT/US2015/016995

申请日：2015-02-22

Applicant: INDERMUHLE, Pierre ,  STUCK, Alexander ,  HEGGLIN, Alicia

Inventor： INDERMUHLE, Pierre ,  STUCK, Alexander ,  HEGGLIN, Alicia

IPC: B01L3/00

CPC classification number: G01N33/5304 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/50857 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0642 ,  B01L2200/16 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2300/0874 ,  B01L2400/0406 ,  B01L2400/0688

Abstract: An assay assembly that includes an assay bar having a plurality flow cells is disclosed. Each of the flow cells includes an inlet, an outlet, and an inside surface defining an inner volume. The outlet includes a valve that is configured to retain liquid within the inner volume of the flow cell. Each assay bar is configured to be reversibly stacked upon another assay bar, such that the flow cells of the stacked assay bars are in fluid communication with each other. This way, the outlet of a first flow cell of a first assay bar is in fluid communication with the inlet of a second flow cell of a second assay bar. The assay assembly may include a multitude of assay bars to form a composite assay assembly, with the flow cells of the stacked assay bars being in fluid communication with each other.

Abstract translation: 公开了一种包含具有多个流动池的分析条的测定组件。 每个流动池包括入口，出口和限定内部容积的内表面。 出口包括被配置成将液体保持在流动池的内部容积内的阀。 每个测定条被配置为可逆地堆叠在另一个测定条上，使得堆叠的测定条的流动池彼此流体连通。 这样，第一测定条的第一流动池的出口与第二测定条的第二流动池的入口流体连通。 测定组件可以包括多个测定条以形成复合测定组件，其中堆叠的测定条的流动池彼此流体连通。

公开(公告)号：WO2013049702A2

公开(公告)日：2013-04-04

申请号：PCT/US2012058096

申请日：2012-09-28

Applicant: LIFE TECHNOLOGIES CORP

Inventor： FREUDENTHAL JACOB K ,  DAHLHOFF GEOFFREY ,  MAHER KEVIN ,  CHEN MINGSONG ,  LIM GARY ,  DANEHY RONALD ,  FORTESCUE DAVID ,  SHEN MING ,  SOH WOON LIANG TERENCE ,  CHENG FRANCIS ,  WU RUOYUN ,  LEE THIAM CHYE ,  CHAPPELL GARY ,  LIM CHEE KIONG ,  DERE JEFF ,  STRAUB TED ,  FONSECA JORGE ,  BOO KUAN MOON ,  LAU SOO YONG

IPC: B01L7/00 ,  B01L3/00 ,  C12Q1/68

CPC classification number: C12Q1/686 ,  B01L3/50855 ,  B01L3/50857 ,  B01L7/52 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/143 ,  B01L2300/021 ,  B01L2300/046 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1827 ,  B01L2300/1844

Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.

Abstract translation: 提供生物分析系统。 该系统包括被配置为容纳多个样品保持器中的任何一个的可互换组件，每个样品保持器被配置为接收多个样品。 该系统还包括被配置为使多个样品循环通过一系列温度的控制系统。 该系统还包括被配置为检测从多个样本发射的荧光信号的光学系统。 特别地，光学系统可以包括单个场透镜，激发源，光学传感器和多个滤光器组件。 激发源可以是一个或多个发光二极管。 场透镜可以是双凸透镜。

公开(公告)号：WO2012007537A1

公开(公告)日：2012-01-19

申请号：PCT/EP2011/062015

申请日：2011-07-13

Applicant: DUBLIN CITY UNIVERSITY ,  LEONARD, Paul ,  DIMOV, Ivan ,  O'KENNEDY, Richard ,  FITZGERALD, Valerie

Inventor： LEONARD, Paul ,  DIMOV, Ivan ,  O'KENNEDY, Richard ,  FITZGERALD, Valerie

IPC: B01L3/00

CPC classification number: G01N33/54306 ,  B01L3/5085 ,  B01L3/50857 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/12 ,  B01L2300/16 ,  C12Q1/6818 ,  C12Q1/6837 ,  G01N33/53 ,  G01N33/5302 ,  G01N33/545 ,  G01N33/569 ,  G01N33/68

Abstract: The present invention describes a spatial addressing technique that uses a very high-density micro-pore array for high-throughput screening of biological interactions. The therapeutic, diagnostic and drug-discovery implications of being able to identify, select and characterize specific protein-protein, protein-DNA and/or protein-carbohydrate interactions from heterogeneous populations of millions (to billions) of cells is discussed. Importantly, this technique possesses the screening and selection capacity of current display-based screening systems (i.e. millions-billions) but with greater efficiency and shorter time.

Abstract translation: 本发明描述了使用非常高密度微孔阵列进行生物相互作用的高通量筛选的空间寻址技术。 讨论了能够识别，选择和表征特定蛋白质蛋白质，蛋白质DNA和/或蛋白质 - 碳水化合物相互作用的治疗，诊断和药物发现影响，从数百万（至数十亿）细胞的异质群体。 重要的是，这种技术具有当前基于显示屏的筛选系统（即数百万亿）的筛选和选择能力，但具有更高的效率和更短的时间。

公开(公告)号：WO2011094572A2

公开(公告)日：2011-08-04

申请号：PCT/US2011022966

申请日：2011-01-28

Applicant: TAKAYAMA SHUICHI ,  TUNG YI-CHUNG ,  HSIAO AMY YU-CHING ,  JAN EDWARD

Inventor： TAKAYAMA SHUICHI ,  TUNG YI-CHUNG ,  HSIAO AMY YU-CHING ,  JAN EDWARD

IPC: G01N35/10 ,  B01L3/00 ,  C12M3/02 ,  C12Q1/02 ,  G01N33/48

CPC classification number: C12N5/0062 ,  B01L3/50853 ,  B01L3/50857 ,  B01L3/5088 ,  B01L2200/025 ,  B01L2200/141 ,  B01L2200/142 ,  B01L2300/0829 ,  B01L2300/161 ,  B33Y80/00 ,  C12M23/12 ,  C12M25/01 ,  G01N35/028 ,  G01N2035/1046

Abstract: The present disclosure relates general to devices, systems, and methods of using such devices in creating and handling hanging drops of fluid. The present disclosure also relates to cell culture devices, methods and/or systems of using such devices as well as the use of cell culture devices, for example, for research and high throughput screening.

Abstract translation: 本公开总体上涉及使用这样的设备来创建和处理悬滴液体的设备，系统和方法。 本公开还涉及细胞培养装置，使用这种装置的方法和/或系统以及细胞培养装置的用途，例如用于研究和高通量筛选。

公开(公告)号：WO2009148507A1

公开(公告)日：2009-12-10

申请号：PCT/US2009/003112

申请日：2009-05-20

Applicant: CORNING INCORPORATED ,  FANG, Ye ,  WANG, Jianguo ,  ZHANG, Ying

Inventor： FANG, Ye ,  WANG, Jianguo ,  ZHANG, Ying

IPC: C12M1/18 ,  B01L3/00

CPC classification number: C12M23/16 ,  B01L3/50857 ,  B01L2200/12 ,  B01L2300/0829 ,  B01L2300/0838 ,  B01L2300/0893 ,  C12M23/12

Abstract: A cell culture apparatus includes a substrate having formed therein a micro-pillared well array. The micro-pillared well array includes a plurality of micro-pillared wells. Each micro-pillared structure includes a plurality of spaced-apart micro-pillars having distal ends shaped to form a well. The well is suitable for cell culture.

Abstract translation: 细胞培养装置包括其中形成有微柱状阵列的基板。 微支柱阵列包括多个微柱孔。 每个微支柱结构包括多个间隔开的微柱，其具有成形为形成井的远端。 该井适合细胞培养。

公开(公告)号：WO2009111696A1

公开(公告)日：2009-09-11

申请号：PCT/US2009/036324

申请日：2009-03-06

Applicant: BIOTROVE, INC. ,  BRENAN, Colin, J. H. ,  MORRISON, Tom ,  KANIGAN, Tanya, S.

Inventor： BRENAN, Colin, J. H. ,  MORRISON, Tom ,  KANIGAN, Tanya, S.

IPC: C12P19/34

CPC classification number: C12Q1/686 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50851 ,  B01L3/50857 ,  B01L7/52 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2300/0819 ,  B01L2300/0848 ,  B01L2300/0877 ,  B01L2300/12 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1833 ,  B01L2300/1844 ,  B01L2300/185 ,  B01L2300/1894

Abstract: One aspect of the invention provides container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a conductive member for heating the interior volume. Another aspect of the invention provides container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a plurality of conductive members for heating an interior volume. Another aspect of the invention provides a container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a first conductive member located in the interior volume and adapted to contact a first end of the microfluidic array.

Abstract translation: 本发明的一个方面提供用于热循环多个微流体阵列中的样品的容器。 容器包括限定内部容积的多个壁和用于加热内部空间的导电构件。 本发明的另一方面提供了用于在微流体阵列中热循环多个样品的容器。 容器包括限定内部容积的多个壁和用于加热内部容积的多个导电构件。 本发明的另一方面提供了一种用于在微流体阵列中热循环多个样品的容器。 容器包括限定内部容积的多个壁和位于内部容积中并适于接触微流体阵列的第一端的第一导电构件。

公开(公告)号：WO2008082713A2

公开(公告)日：2008-07-10

申请号：PCT/US2007076807

申请日：2007-08-24

Applicant: CALIFORNIA INST OF TECHN ,  HASSIBI ARJANG

Inventor： HASSIBI ARJANG

IPC: C40B30/04 ,  C40B60/12 ,  G06G7/48

CPC classification number: C40B60/12 ,  B01L3/50857 ,  B01L2300/0819 ,  B01L2300/1822 ,  C40B30/04 ,  C40B30/10 ,  C40B40/08 ,  C40B40/10 ,  G01N33/54386 ,  G01N33/557

Abstract: A biosensor array, system and method for affinity based assays that are able to simultaneously obtain high quality measurements of the binding characteristics of multiple analytes, and that are able to determine the amounts of those analytes in solution. The invention also provides a fully integrated bioarray for detecting real-time characteristics of affinity based assays.

Abstract translation: 用于基于亲和力的测定的生物传感器阵列，系统和方法，其能够同时获得多个分析物的结合特征的高质量测量，并且能够确定溶液中的那些分析物的量。 本发明还提供用于检测基于亲和力的测定的实时特征的完全一体化的生物阵列。