公开(公告)号：WO2015174913A1

公开(公告)日：2015-11-19

申请号：PCT/SE2015/050537

申请日：2015-05-12

Applicant: DOXA AKTIEBOLAG

Inventor： HERMANSSON, Leif ,  LÖÖF, Jesper ,  ABRAHAMSSON, Emil

IPC: A61L27/10 ,  A61L27/12 ,  A61K6/00 ,  A61K6/02 ,  A61K6/06 ,  C04B28/06 ,  C04B40/02 ,  C04B40/06

CPC classification number: A61L27/105 ,  A61K6/0073 ,  A61K6/0082 ,  A61K6/0088 ,  A61K6/0205 ,  A61K6/0631 ,  A61K6/0643 ,  A61K6/0662 ,  A61K6/0675 ,  A61L27/12 ,  A61L2400/18 ,  A61L2430/02 ,  A61L2430/12 ,  C01F7/164 ,  C01P2004/51 ,  C01P2004/61 ,  C03C3/091 ,  C04B7/32 ,  C04B28/06 ,  C04B28/18 ,  C04B35/111 ,  C04B35/14 ,  C04B35/195 ,  C04B35/48 ,  C04B35/488 ,  C04B35/624 ,  C04B35/62665 ,  C04B2111/00836 ,  C04B2235/3222 ,  C04B40/0071 ,  C04B40/0268

Abstract: The present invention generally relates to the use of pre-formed bodies of Chemically Bonded Ceramics (CBCs) biomaterial for implantation purposes wherein the bodies are prepared ex vivoallowing process parameters to be optimized for desired long term properties of theresulting CBC biomaterial. More particularly, the pre-formed CBC material bodies of the present inven- tion are sintered. The pre-formed body of CBC material is machined to the desired geometry and then implanted using a CBC cementation pastefor fix- ation of the body to tissue. The invention also relates to a method of prepar- ing pre-formed bodies of CBC biomaterial for implantation purposes, meth- ods of preparing an implant thereof having desired geometry, and a method of implantation of the implant, as well as a kit for use in the method of im- plantation.

Abstract translation: 本发明一般涉及用于植入目的的化学结合陶瓷（CBC）生物材料的预成型体的用途，其中制备的体外离体过程参数被优化用于所需的CBC生物材料的期望的长期性质。 更具体地，本发明的预成形CBC材料体是烧结的。 将CBC材料的预成型体加工成所需的几何形状，然后使用CBC胶结膏将其固定在身体到组织上。 本发明还涉及一种制备用于植入目的的CBC生物材料的预成形体的方法，其制备具有所需几何形状的植入物的方法以及植入物的植入方法以及用于使用的试剂盒 在种植方法中。

公开(公告)号：WO2004000240A1

公开(公告)日：2003-12-31

申请号：PCT/SE2003/000955

申请日：2003-06-11

Applicant: DOXA AKTIEBOLAG ,  HERMANSSON, Leif ,  AHNFELT, Nils-Otto ,  LÖÖF, Jesper ,  ENGQVIST, Håkan

Inventor： HERMANSSON, Leif ,  AHNFELT, Nils-Otto ,  LÖÖF, Jesper ,  ENGQVIST, Håkan

IPC: A61K6/06

CPC classification number: A61K6/033 ,  A61K6/0005 ,  A61K6/0008 ,  A61K6/0205 ,  A61K6/0276 ,  A61K6/0612 ,  A61K6/0643 ,  C04B28/06 ,  C04B28/34 ,  C04B2103/0067 ,  C04B2111/00836 ,  C04B14/22 ,  C04B22/124 ,  C04B24/2641 ,  C04B40/0263 ,  C04B40/065 ,  A61K6/083 ,  C08L33/08 ,  A61K6/087 ,  C08L89/00 ,  A61K6/097 ,  C08L1/02 ,  C08L83/04 ,  C08L29/14

Abstract: A system for a chemically bonded ceramic material, comprising an aqueous hydration liquid and a powdered material, the binder phase of which essentially consisting of a cement system, which powdered material has the capacity following saturation with the hydration liquid reacting with the binder phase to hydrate to a chemically bonded ceramic material. According to the invention, the powdered material comprises a first part component for the formationof an organic phase in the ceramic material and the hydration liquid comprises a second part component for the formation of said organic phase. The invention also relates to the powdered material and the hydration liquid, respectively, the formed ceramic material, a method for the production of the material and a device for storing the powdered material and mixing it with the hydration liquid.

Abstract translation: 一种用于化学结合的陶瓷材料的系统，包括水性水合液体和粉末材料，其粘结相基本上由水泥系统组成，该粉末材料具有饱和的能力，其中水合液体与粘结相反应以水合 到化学键合的陶瓷材料。 根据本发明，粉末材料包括用于在陶瓷材料中形成有机相的第一部分成分，并且水合液体包含用于形成所述有机相的第二部分成分。 本发明还涉及粉末材料和水合液体，分别形成的陶瓷材料，用于生产材料的方法和用于储存粉末材料并将其与水合液体混合的装置。

公开(公告)号：WO2015147741A1

公开(公告)日：2015-10-01

申请号：PCT/SE2015/050378

申请日：2015-03-30

Applicant: DOXA AKTIEBOLAG (PUBL)

Inventor： HERMANSSON, Leif ,  LÖÖF, Jesper ,  ABRAHAMSSON, Emil

IPC: A61L27/10 ,  A61L27/12 ,  A61K6/00 ,  A61K6/02 ,  A61K6/06 ,  C04B28/06 ,  C04B40/02 ,  C04B40/06

CPC classification number: A61L27/105 ,  A61K6/0017 ,  A61K6/0082 ,  A61K6/0088 ,  A61K6/0205 ,  A61K6/0631 ,  A61K6/0643 ,  A61K6/0662 ,  A61K6/0675 ,  A61L27/12 ,  A61L2430/02 ,  A61L2430/12 ,  C04B28/02 ,  C04B28/06 ,  C04B28/065 ,  C04B28/28 ,  C04B28/34 ,  C04B2111/00836 ,  C04B7/32 ,  C04B22/124 ,  C04B40/0616

Abstract: The present invention generally relates to the use of pre-formed bodies of Chemically Bonded Ceramics (CBCs) biomaterial for implantation purposes wherein the bodies are prepared ex vivo allowing process parameters to be optimized for desired long term properties of the resulting CBC biomaterial. The pre-formed body of CBC material is machined to the desired geometry and the hardened CBC material implant is then implanted using a CBC cementation paste. The invention also relates to a method of preparing pre-formed hardened bodies of CBC biomaterial for implantation purposes, methods of preparing an implant thereof having desired geometry, and a method of implantation of the implant, as well as a kit for use in the method of implantation.

Abstract translation: 本发明一般涉及用于植入目的的化学结合陶瓷（CBC）生物材料的预成型体的用途，其中所述体是离体制备的，允许对所得CBC生物材料的期望长期性质优化工艺参数。 将CBC材料的预成型体加工成所需的几何形状，然后使用CBC胶结膏将硬化的CBC材料植入物植入。 本发明还涉及一种制备用于植入目的的CBC生物材料的预成形硬化体的方法，其具有所需几何形状的植入物的制备方法以及植入物的植入方法以及用于该方法的试剂盒 的植入。

公开(公告)号：WO2004000239A1

公开(公告)日：2003-12-31

申请号：PCT/SE2003/000954

申请日：2003-06-11

Applicant: DOXA AKTIEBOLAG ,  HERMANSSON, Leif ,  KRAFT, Lars ,  ENGQVIST, Håkan ,  AHNFELT, Nils-Otto ,  LÖÖF, Jesper ,  SCHULZ-WALZ, Jan-Erik

Inventor： HERMANSSON, Leif ,  KRAFT, Lars ,  ENGQVIST, Håkan ,  AHNFELT, Nils-Otto ,  LÖÖF, Jesper ,  SCHULZ-WALZ, Jan-Erik

IPC: A61K6/06

CPC classification number: A61K6/033 ,  A61K6/0612 ,  A61K6/0643 ,  C04B28/34 ,  C04B2111/00836 ,  C04B7/32 ,  C04B14/06 ,  C04B14/366 ,  C04B20/008 ,  C04B22/064 ,  C04B22/10 ,  C04B24/14 ,  C04B40/06 ,  C04B14/303 ,  C04B22/062 ,  C04B22/0093 ,  C04B2103/0094

Abstract: A system for a dental filling material or an implant material, alternatively a system for bonding between a tooth or a bone and a dental filling material and a implant material, respectively, which system comprises a water based hydration liquid and a powdered material, the binder phase of which powdered material essentially consisting of a calcium based cement system, which powdered material has the capacity following saturation with the liquid reacting with the binder phase to hydrate to a chemically bonded ceramic material. According to the invention, said powdered material and/or said hydration liquid comprises water soluble phosphate or a phase that has the capacity to form water soluble phosphate, whereby the system exhibits the capacity during hydration to form apatite. The invention also relates to the powdered material and the hydration liquid as such, an implant material and a method of achieving bonding.

Abstract translation: 用于牙科填充材料或植入物材料的系统，或者分别用于在牙齿或骨骼和牙齿填充材料和植入物材料之间结合的系统，所述系统包括水基水化液体和粉末材料，所述粘合剂 其粉末材料基本上由钙基水泥系统组成，该粉末材料具有随着与粘合剂相反应的液体饱和的能力以水合化为化学键合的陶瓷材料。 根据本发明，所述粉末材料和/或所述水合液体包括水溶性磷酸盐或具有形成水溶性磷酸盐的能力的相，由此该体系在水合期间显示形成磷灰石的能力。 本发明还涉及粉末材料和水合液体，植入材料和实现结合的方法。