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    BIOIMPEDANCE CIRCUMFERENCE MEASUREMENT
    1.
    发明申请
    BIOIMPEDANCE CIRCUMFERENCE MEASUREMENT 审中-公开
    生物循环测量

    公开(公告)号：WO2014137363A1

    公开(公告)日：2014-09-12

    申请号：PCT/US2013/036921

    申请日：2013-04-17

    Applicant: FRESENIUS MEDICAL CARE HOLDINGS, INC.

    Inventor： ZHU, Fansan ,  LEVIN, Nathan, W.

    IPC: A61B5/103

    CPC classification number: A61B5/0537 ,  A61B5/6828 ,  A61B2560/0412

    Abstract: Apparatus is disclosed for measuring the circumference of a limb of an individual, e.g., the individual's arm and/or calf. The apparatus uses one or more magnetic strips which surround the limb and contain magnetic coding of length information. Tension is applied to the magnetic strip by a tensioning assembly, which can be a pressure cuff or a stepping motor, and a magnetic read head reads the magnetic coding of length information from the strip. When used in a bioimpedance analysis procedure, the length information can be used to convert measured voltage differences into normalized bioimpedance values, e.g., resistivity values.

    Abstract translation: 公开了用于测量个体的肢体的周长的装置，例如个体的手臂和/或小腿。 该装置使用围绕肢体的一个或多个磁条并且包含长度信息的磁编码。 通过张紧组件将张力施加到磁条上，张紧组件可以是压力袖带或步进电机，并且磁读头读取来自条带的长度信息的磁编码。 当用于生物阻抗分析程序时，长度信息可用于将测量的电压差转换成归一化的生物阻抗值，例如电阻率值。

    DRY WEIGHT PREDICTOR
    2.
    发明申请
    DRY WEIGHT PREDICTOR 审中-公开
    干重预测

    公开(公告)号：WO2012051261A2

    公开(公告)日：2012-04-19

    申请号：PCT/US2011/055916

    申请日：2011-10-12

    Applicant: FRESENIUS MEDICAL CARE HOLDINGS, INC. ,  LEVIN, Nathan, W. ,  ZHU, Fansan

    Inventor： LEVIN, Nathan, W. ,  ZHU, Fansan

    IPC: G06F19/10

    CPC classification number: A61B5/0537 ,  A61B5/6828 ,  G06F19/3481

    Abstract: Methods and apparatus for predicting/estimating the dry weight of an individual, e.g., a patient undergoing dialysis treatment, are provided. The techniques employ a bioimpedance measurement (303) on the individual's calf (101) to obtain information regarding the extracellular fluid volume of the calf. Using a measurement of the calf's circumference (309), a resistivity value is calculated, normalized by the individual's body mass index (BMI), and then offset by a reference value to obtain a new variable, ΔnRho, which is shown, by comparison with a "gold standard" (FIGS. 5-9), to be highly effective in predicting/estimating dry weight (FIGS. 10-13 and 15-16). The techniques are easy to use and provide accurate dry weight predictions/estimations without substantially adding to the complexity or cost of dialysis procedures. The techniques can also be used for individuals who are not renal patients, e.g., patients suffering from other diseases in which fluid overload can occur, athletes, fitness enthusiasts, and the like.

    Abstract translation: 提供了用于预测/估计个体（例如正在进行透析治疗的患者）的干重的方法和设备。 该技术在个体的小腿（101）上采用生物阻抗测量（303）来获得关于小腿的细胞外液体积的信息。 使用小腿周长的测量（309），计算电阻率值，通过个体的身体质量指数（BMI）归一化，然后偏移参考值以获得新变量ΔnRho，通过与 “金标准” （图5-9）在预测/估计干重时非常有效（图10-13和15-16）。 这些技术易于使用，并提供准确的干重预测/估算，而不会增加透析程序的复杂性或成本。 该技术还可以用于不是肾病人的个体，例如患有可能发生体液过量的其他疾病的患者，运动员，健身爱好者等等。

    TECHNIQUES FOR DETERMINING CHARACTERISTICS OF DIALYSIS ACCESS SITES USING IMAGE INFORMATION
    5.
    发明申请
    TECHNIQUES FOR DETERMINING CHARACTERISTICS OF DIALYSIS ACCESS SITES USING IMAGE INFORMATION 审中-公开

    公开(公告)号：WO2022076776A1

    公开(公告)日：2022-04-14

    申请号：PCT/US2021/054106

    申请日：2021-10-08

    Applicant: FRESENIUS MEDICAL CARE HOLDINGS, INC.

    Inventor： ZHU, Fansan ,  KOTANKO, Peter

    IPC: G06T7/00 ,  G16H30/40 ,  A61B5/00 ,  A61B5/026 ,  A61B5/02

    Abstract: A dialysis access site monitoring system may generate a treatment recommendation for treating a condition of an access site based on a video of the access site. The dialysis access site monitoring system may operate to generate video information based on a video of a dialysis access site of a patient, determine change in the number of pixels (CNP) information of the video information, the CNP information associated with movement of a skin surface of the patient due to blood flow through the dialysis access site, determine frequency domain information of the CNP information, determine a maximum-to-median power (M2) value of the frequency domain information, and determine at least one access site characteristic based on the M2 value. The at least one access site characteristic may include access blood flow (ABF) and/or a prediction or estimation of stenosis. Other embodiments are described.

    SKIN SODIUM MEASUREMENT USING BIOIMPEDANCE
    7.
    发明申请
    SKIN SODIUM MEASUREMENT USING BIOIMPEDANCE 审中-公开

    公开(公告)号：WO2020131562A1

    公开(公告)日：2020-06-25

    申请号：PCT/US2019/065949

    申请日：2019-12-12

    Applicant: FRESENIUS MEDICAL CARE HOLDINGS, INC.

    Inventor： ZHU, Fansan ,  KOTANKO, Peter

    IPC: A61B5/053 ,  A61B5/145

    Abstract: A technique for determining skin sodium content using bioimpedance spectroscopy includes applying a current at a predetermined frequency to skin of a subject, measuring a voltage across the skin of the subject produced by the current, determining a resistance across the skin of the subject at the predetermined frequency using the measured voltage, and determining skin sodium content using the measured voltage.

    SYSTEMS AND METHODS FOR MONITORING FLUID VOLUMES DURING PERITONEAL DIALYSIS
    8.
    发明申请
    SYSTEMS AND METHODS FOR MONITORING FLUID VOLUMES DURING PERITONEAL DIALYSIS 审中-公开

    公开(公告)号：WO2021072149A1

    公开(公告)日：2021-04-15

    申请号：PCT/US2020/054910

    申请日：2020-10-09

    Applicant: FRESENIUS MEDICAL CARE HOLDINGS, INC.

    Inventor： KOTANKO, Peter ,  ZHU, Fansan

    IPC: A61M1/00

    Abstract: Techniques for monitoring fluid volumes during peritoneal analysis include: computing lower abdominal fluid volumes, continuously during a dwell time of a peritoneal dialysis treatment, based at least on bioimpedance data from electrodes positioned on a patient's upper thighs; and computing intraperitoneal volumes, continuously during the dwell time of the peritoneal dialysis treatment, based at least on bioimpedance data from the electrodes positioned on the patient's upper thighs and electrodes positioned on the patient's torso.

    TECHNIQUES FOR DETERMINING FLUID VOLUMES USING BIOIMPEDANCE INFORMATION
    9.
    发明申请
    TECHNIQUES FOR DETERMINING FLUID VOLUMES USING BIOIMPEDANCE INFORMATION 审中-公开

    公开(公告)号：WO2019014241A1

    公开(公告)日：2019-01-17

    申请号：PCT/US2018/041474

    申请日：2018-07-10

    Applicant: FRESENIUS MEDICAL CARE HOLDINGS, INC.

    Inventor： ZHU, Fansan ,  KOTANKO, Peter ,  LEVIN, Nathan W.

    IPC: A61B5/145 ,  A61B5/00 ,  A61B5/053

    Abstract: Techniques and apparatuses for determining fluid volumes of a patient are described. In one embodiment, for example, an apparatus may include at least one memory, and logic coupled to the at least one memory. The logic may be configured to receive baseline bioimpedance information for at least a portion of a human body at a baseline pressure, receive pressurized bioimpedance information of the portion of the human body at a pressurized pressure, the pressurized pressure greater than the baseline pressure and configured to substantially remove blood volume from the portion at the pressurized pressure, and determine at least one of interstitial fluid volume (V IT ) or peripheral blood volume (BV P ) based on the baseline bioimpedance information and the pressurized bioimpedance information. Other embodiments are described.

    DETECTING INDICATIONS OF INTRADIALYTIC MORBID EVENTS BY MEASUREMENT OF RELATIVE BLOOD VOLUME, BLOOD PRESSURE AND HEART RATE
    10.
    发明申请
    DETECTING INDICATIONS OF INTRADIALYTIC MORBID EVENTS BY MEASUREMENT OF RELATIVE BLOOD VOLUME, BLOOD PRESSURE AND HEART RATE 审中-公开
    通过测量相对血液体积，血压和心率来检测干细胞因子活动的适应症

    公开(公告)号：WO2014035947A1

    公开(公告)日：2014-03-06

    申请号：PCT/US2013/056769

    申请日：2013-08-27

    Applicant: FRESENIUS MEDICAL CARE HOLDINGS, INC.

    Inventor： ZHU, Fansan ,  KOTANKO, Peter ,  THIJSSEN, Stephan ,  LEVIN, Nathan, W.

    IPC: A61B5/02

    CPC classification number: A61B5/746 ,  A61B5/021 ,  A61M1/16 ,  A61M1/1603 ,  A61M1/1615 ,  A61M1/341 ,  A61M1/3413 ,  A61M1/3609 ,  A61M2230/06 ,  A61M2230/30

    Abstract: A method of detecting an indication of a potential intradialytic morbid event (IME) by monitoring a patient's condition during excess fluid removal by ultrafiltration during a hemodialysis treatment includes determining the patient's relative blood volume (RBV), and removing a portion of the volume of excess fluid from blood of the patient at an initial ultrafiltration rate while periodically monitoring a second derivative over time of the relative blood volume (SDRBV). The method then includes continuing to remove excess fluid from blood of the patient at the same ultrafiltration rate, or, optionally, incrementally increasing the ultrafiltration rate. The method further includes triggering an alarm for an IME for the patient if the SDRBV is in a range of between a low SDRBV alarm level and a high SDRBV alarm level, and, alternatively or additionally monitoring the patient's normalized blood pressure ratio, and taking a remedial action if the alarm is triggered.

    Abstract translation: 通过在血液透析治疗期间通过超滤过量流体去除过程中监测患者的状况来检测潜在的体内病态事件（IME）的指示的方法包括确定患者的相对血容量（RBV），以及去除部分过量体积 以最初的超滤速率从患者的血液中流出液体，同时周期性地监测相对血液体积（SDRBV）随时间变化的二次导数。 然后该方法包括以相同的超滤速率继续从患者血液中除去多余的液体，或者任选地递增地提高超滤速率。 该方法还包括如果SDRBV在低SDRBV警报水平和高SDRBV警报水平之间的范围内，触发针对患者的IME的警报，或者或另外监视患者的标准化血压比，并且 如果报警被触发则补救措施。

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