公开(公告)号：WO2018217233A2

公开(公告)日：2018-11-29

申请号：PCT/US2017/065845

申请日：2017-12-12

Applicant: GENERAL ELECTRIC COMPANY ,  BRIGHAM YOUNG UNIVERSITY

Inventor： ASHE, Jeffrey, M. ,  NAGARKAR, Kaustubh, Ravindra ,  PULEO, Christopher, Michael ,  KEIMEL, Chistropher Fred ,  GALLIGAN, Craig, Patrick ,  LIN, Yizhen ,  STOFFEL, Nancy, Cecelia ,  VANFLEET, Richard ,  DAVIS, Robert ,  CHEN, Guohai

IPC: A61B5/0478 ,  A61B5/1473 ,  A61B5/145 ,  A61B7/02 ,  A61N1/05 ,  A61B5/11 ,  A61B17/00

Abstract: The present approach relates to the fabrication and use of a probe array having multiple individual probes. In one embodiment, the probes of the probe array may be functionalized such that certain of the probes are suitable for electrical sensing (e.g., recording) or stimulation, non-electrical sensing or stimulation (e.g., chemical sensing and/or release of biomolecules when activated), or a combination of electrical and non-electrical sensing or stimulation.

公开(公告)号：WO2018217233A3

公开(公告)日：2018-11-29

申请号：PCT/US2017/065845

申请日：2017-12-12

Applicant: GENERAL ELECTRIC COMPANY ,  BRIGHAM YOUNG UNIVERSITY

Inventor： ASHE, Jeffrey, M. ,  NAGARKAR, Kaustubh, Ravindra ,  PULEO, Christopher, Michael ,  KEIMEL, Chistropher Fred ,  GALLIGAN, Craig, Patrick ,  LIN, Yizhen ,  STOFFEL, Nancy, Cecelia ,  VANFLEET, Richard ,  DAVIS, Robert ,  CHEN, Guohai

IPC: A61B5/0478 ,  A61B5/1473 ,  A61B5/145 ,  A61B7/02 ,  A61N1/05 ,  A61B5/11 ,  A61B17/00

Abstract: The present approach relates to the fabrication and use of a probe array having multiple individual probes. In one embodiment, the probes of the probe array may be functionalized such that certain of the probes are suitable for electrical sensing (e.g., recording) or stimulation, non-electrical sensing or stimulation (e.g., chemical sensing and/or release of biomolecules when activated), or a combination of electrical and non-electrical sensing or stimulation.

公开(公告)号：WO2018151915A1

公开(公告)日：2018-08-23

申请号：PCT/US2018/015148

申请日：2018-01-25

Applicant: GENERAL ELECTRIC COMPANY

Inventor： NAGARKAR, Kaustubh, Ravindra ,  ASHE, Jeffrey, Michael ,  DAVIS, Eric, Patrick ,  STOFFEL, Nancy, Cecelia

IPC: A61B5/00

CPC classification number: A61B5/6861 ,  A61B5/076 ,  A61B2560/0468 ,  A61B2562/04 ,  A61B2562/125 ,  B33Y80/00 ,  C23C14/34 ,  H05K1/0313 ,  H05K1/113 ,  H05K1/181 ,  H05K3/303 ,  H05K3/4038 ,  H05K5/0026 ,  H05K5/0095 ,  H05K5/0247 ,  H05K5/064 ,  H05K2201/0141 ,  H05K2201/10098 ,  H05K2201/10151 ,  H05K2201/10522

Abstract: A system includes an implantable sensor assembly. The implantable sensor assembly includes a housing. The housing includes a substrate layer comprising an interior surface and an exterior surface, and a cap layer, wherein the substrate layer and the cap layer are coupled to form an enclosed cavity that at least partially encloses the interior surface of the substrate layer within the cavity and wherein both the substrate layer and the cap layer are formed from an insulating material. The implantable sensor assembly also includes one or more electronic components disposed within the cavity of the housing and one or more probes disposed on the exterior surface of the substrate layer and electrically coupled to the one or more electronic components by one or more electrical connections extending through the housing.