公开(公告)号：WO2015041719A1

公开(公告)日：2015-03-26

申请号：PCT/US2014/024492

申请日：2014-03-12

Applicant: GOOGLE INC.

Inventor： LIU, Zenghe ,  ETZKORN, James

IPC: G02C7/04 ,  G01N33/50 ,  G01N1/10

CPC classification number: A61B5/14507 ,  A61B5/14532 ,  A61B5/6821

Abstract: Apparatus, systems and methods employing contact lenses having one or more sensor that sense an analyte in tear fluid and one or more recesses that collect the tear fluid. In some aspects, a contact lens includes a substrate that forms at least part of a body of the contact lens and a recess formed within the substrate configured to collect tear fluid when the contact lens is worn. The contact lens further includes at least one sensor disposed within the substrate configured to sense presence of an analyte in the collected tear fluid.

Abstract translation: 使用具有感测泪液中的分析物的一个或多个传感器和收集泪液的一个或多个凹部的隐形眼镜的装置，系统和方法。 在一些方面，隐形眼镜包括形成隐形眼镜的主体的至少一部分的基底和形成在基底内的凹陷，构造成当佩戴隐形眼镜时收集泪液。 隐形眼镜还包括布置在基底内的至少一个传感器，其配置成感测所收集的泪液中分析物的存在。

公开(公告)号：WO2014158415A1

公开(公告)日：2014-10-02

申请号：PCT/US2014/016328

申请日：2014-02-13

Applicant: GOOGLE INC.

Inventor： ETZKORN, James

IPC: G02C7/04 ,  G01N33/48 ,  A61B5/00

CPC classification number: A61B5/14546 ,  A61B3/10 ,  A61B3/101 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/1477 ,  A61B5/6813 ,  A61B5/6821 ,  A61B2560/0214 ,  A61B2562/12 ,  G02C7/04 ,  H05K1/186 ,  H05K3/048 ,  H05K3/4682 ,  Y10T29/49002 ,  Y10T29/49018 ,  Y10T29/49117 ,  Y10T29/49124 ,  Y10T29/4913 ,  Y10T29/49146 ,  Y10T29/49147

Abstract: A mountable device includes a bio-compatible structure embedded in a polymer that defines at least one mounting surface. The bio-compatible structure has a first side defined by a first layer of bio-compatible material, a second side defined by a second layer of bio-compatible material, an electronic component, and a conductive pattern that defines sensor electrodes. A portion of the second layer of bio-compatible material is removed by etching to create at least one opening in the second side in which the sensor electrodes are exposed. The etching further removes a portion of the first layer of bio¬ compatible material so as to create at least one opening in the first side that is connected to the at least opening in the second side. With this arrangement of openings, analytes can reach the sensor electrodes from either the first side or the second side of the bio -compatible stmcture.

Abstract translation: 可安装的装置包括嵌入在聚合物中的生物相容结构，其限定至少一个安装表面。 生物相容结构具有由第一生物相容材料层限定的第一侧，由第二生物相容材料层限定的第二侧，电子部件和限定传感器电极的导电图案。 第二层生物相容性材料的一部分通过蚀刻去除，以在传感器电极暴露的第二侧产生至少一个开口。 蚀刻进一步除去生物相容性材料的第一层的一部分，以便在第一侧中形成至少一个连接到第二侧的至少开口的开口。 通过这种开口排列，分析物可以从生物相容性结构的第一侧或第二侧到达传感器电极。

公开(公告)号：WO2014113174A1

公开(公告)日：2014-07-24

申请号：PCT/US2013/076019

申请日：2013-12-18

Applicant: GOOGLE INC.

Inventor： ETZKORN, James ,  AMIRPARVIZ, Babak

IPC: G02B27/02

CPC classification number: A61B5/6821 ,  A61B5/0002 ,  A61B5/0004 ,  A61B5/14507 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/6867 ,  G01N27/3271 ,  G02C7/04 ,  H01L21/568 ,  H01L23/3107 ,  H01L2224/81001 ,  Y10T29/49826

Abstract: An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode and a reference electrode that reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. An example assembly process includes: forming a sacrificial layer on a working substrate; forming a first layer of a bio-compatible material on the sacrificial layer; providing an electronics module on the first layer of the bio-compatible material, forming a second layer of the bio-compatible material to cover the electronics module; and annealing the first and second layers of the bio-compatible material together to form an encapsulated structure having the electronics module fully encapsulated by the bio-compatible material.

Abstract translation: 一种可眼睛安装的装置包括嵌入聚合物材料中的电化学传感器，其被配置用于安装到眼睛的表面。 电化学传感器包括工作电极和与分析物反应的参比电极，以产生与可眼睛安装的装置暴露的流体中的分析物的浓度相关的传感器测量。 示例性组装过程包括：在工作衬底上形成牺牲层; 在所述牺牲层上形成生物相容性材料的第一层; 在所述生物相容材料的第一层上提供电子模块，形成所述生物相容材料的第二层以覆盖所述电子模块; 以及将所述生物相容性材料的所述第一和第二层退火在一起以形成具有由所述生物相容性材料完全包封的所述电子模块的封装结构。

公开(公告)号：WO2016003537A1

公开(公告)日：2016-01-07

申请号：PCT/US2015/029220

申请日：2015-05-05

Applicant: GOOGLE INC.

Inventor： ETZKORN, James

IPC: G06K19/07 ,  G06K19/10

CPC classification number: H01Q1/2225 ,  H01Q1/273 ,  H01Q1/44 ,  H01Q7/00

Abstract: A manufacturing method for a wireless device may involve placing a plurality of antennas on a plastic layer, wherein each of the antennas comprises one or more conductive loops positioned within an inner diameter and an outer diameter; placing a plurality of sensor chips on the plastic layer such that each sensor chip is interconnected to a respective antenna on the plastic layer and is positioned within the inner diameter and outer diameter of the respective antenna, wherein each sensor chip has a respective sensor facing away from the plastic layer and has respective electrical contacts interconnected with the respective antenna; and providing an encapsulation layer over the plurality of antennas and the plurality of sensor chips on the plastic layer.

Abstract translation: 无线设备的制造方法可以包括将多个天线放置在塑料层上，其中每个天线包括位于内径和外径内的一个或多个导电回路; 将多个传感器芯片放置在塑料层上，使得每个传感器芯片互连到塑料层上的相应天线并且位于相应天线的内径和外径内，其中每个传感器芯片具有面向对方的相应传感器 并且具有与相应天线互连的相应电触点; 以及在塑料层上的多个天线和多个传感器芯片上提供封装层。

公开(公告)号：WO2015100265A1

公开(公告)日：2015-07-02

申请号：PCT/US2014/071985

申请日：2014-12-22

Applicant: GOOGLE INC.

Inventor： ETZKORN, James ,  HO, Harvey ,  LIU, Zenghe

IPC: G06K9/00

CPC classification number: A61B5/6821 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/1486 ,  Y10T29/49155

Abstract: A method may involve providing a conductive pattern on a bio-compatible layer. The conductive pattern may include a first conductive layer that comprises a first metal and a second conductive layer that comprises a second metal. The second conductive layer may be over the first conductive layer, and the first metal may be more malleable than the second metal. The method may also include mounting an electrical component to the conductive pattern to provide an electrochemical sensor. The electrochemical sensor may be configured for use in a body-mountable device.

Abstract translation: 一种方法可以涉及在生物相容层上提供导电图案。 导电图案可以包括第一导电层，其包括第一金属和包括第二金属的第二导电层。 第二导电层可以在第一导电层之上，并且第一金属可以比第二金属更具有延展性。 该方法还可以包括将电气部件安装到导电图案以提供电化学传感器。 电化学传感器可被配置为用于体内安装的装置。

公开(公告)号：WO2014204575A1

公开(公告)日：2014-12-24

申请号：PCT/US2014/034839

申请日：2014-04-21

Applicant: GOOGLE INC.

Inventor： ETZKORN, James ,  LIU, Zenghe

IPC: G01N27/26 ,  G01N27/416 ,  G02C7/04 ,  A61F2/14 ,  G08C17/00

CPC classification number: A61B5/1486 ,  A61B3/101 ,  A61B5/0002 ,  A61B5/0004 ,  A61B5/002 ,  A61B5/14507 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1477 ,  A61B5/6821 ,  A61B5/7264 ,  A61B2560/0214 ,  G01N27/30 ,  G01N27/3271 ,  G01N27/4166 ,  G02C7/04

Abstract: An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. The working electrode can have a first side edge and a second side edge. The reference electrode can be situated such that at least a portion of the first and second side edges of the working electrode are adjacent respective sections of the reference electrode.

Abstract translation: 一种可眼睛安装的装置包括嵌入聚合物材料中的电化学传感器，其被配置用于安装到眼睛的表面。 电化学传感器包括工作电极，参比电极和选择性地与分析物反应以产生与可眼睛安装的装置暴露于的流体中的分析物的浓度相关的传感器测量的试剂。 工作电极可以具有第一侧边缘和第二侧边缘。 参考电极可以被定位成使得工作电极的第一和第二侧边缘的至少一部分与参考电极的相应部分相邻。

公开(公告)号：WO2014052125A1

公开(公告)日：2014-04-03

申请号：PCT/US2013/060421

申请日：2013-09-18

Applicant: GOOGLE INC.

Inventor： ETZKORN, James ,  LIU, Zenghe

IPC: A61B3/00 ,  G01N33/48 ,  G02C7/04 ,  A61B3/125

CPC classification number: A61B3/101 ,  A61B5/14507 ,  A61B5/1455 ,  G02C7/049

Abstract: Apparatus, systems and methods are provided that employ contact lenses that facilitate testing for an analyte present within tear fluid. In an aspect, a contact lens includes a substrate that forms at least part of a body of the contact lens and one or more cavities disposed within the substrate configured to collect and store tear fluid over time when the contact lens is worn over an eye. In another aspect, a contact lens includes a substrate that forms at least part of a body of the contact lens and one or more receptors disposed on or within the substrate, the one or more receptors are configured to bind to a known ligand.

Abstract translation: 提供了使用容易测试在泪液内存在的分析物的隐形眼镜的装置，系统和方法。 在一方面，隐形眼镜包括形成隐形眼镜的主体的至少一部分的基底和设置在基底内的一个或多个空腔，其构造成当隐形眼镜佩戴在眼睛上时随时间收集和存储泪液。 在另一方面，隐形眼镜包括形成隐形眼镜的主体的至少一部分的基底和设置在底物上或内的一个或多个受体，所述一种或多种受体被配置为结合已知的配体。

公开(公告)号：WO2016036908A1

公开(公告)日：2016-03-10

申请号：PCT/US2015/048236

申请日：2015-09-03

Applicant: GOOGLE INC.

Inventor： BARROWS, Daniel, Patrick ,  ETZKORN, James

IPC: A61B3/00 ,  C08L71/02

CPC classification number: A61B5/1477 ,  A61B5/14507 ,  A61B5/14532 ,  A61B5/6821 ,  A61B2562/12 ,  B29C63/0013 ,  B29K2029/00 ,  G02B1/043 ,  G02C7/00 ,  G02C7/04 ,  G02C11/10

Abstract: A body-mountable device may be formed of a polymeric material. A molding form can define a cavity and polymeric material can be formed using the mold to create a device shaped in accordance with the cavity. Electronics disposed on a substrate can be encapsulated within the polymeric material by forming a first layer of polymeric material, positioning the substrate on the first layer, and then forming a second layer of polymeric material over the substrate. A channel can expose a sensor disposed on the substrate. The channel may be formed while molding the second layer of polymeric material over the substrate. The molding form can include a protrusion that extends toward the sensor. A sacrificial sealant material can be applied to the sensor or the protrusion to create a seal between the protrusion and the sensor. The polymeric material forms around the sealed protrusion to create the channel.

Abstract translation: 身体安装装置可以由聚合物材料形成。 模制形式可以限定空腔，并且可以使用模具形成聚合材料以形成根据空腔成形的装置。 设置在基底上的电子可以通过形成聚合物材料的第一层，将基底定位在第一层上，然后在基底上形成第二层聚合材料，将其包封在聚合物材料内。 通道可以暴露设置在基板上的传感器。 可以在衬底上模制第二层聚合物材料的同时形成通道。 模制形式可以包括向传感器延伸的突起。 可以将牺牲密封剂材料施加到传感器或突起以在突起和传感器之间形成密封。 聚合物材料围绕密封突起形成以形成通道。

公开(公告)号：WO2014201268A1

公开(公告)日：2014-12-18

申请号：PCT/US2014/042152

申请日：2014-06-12

Applicant: GOOGLE INC.

Inventor： ETZKORN, James ,  O'DRISCOLL, Stephen

IPC: A61B5/05

CPC classification number: A61B5/14532 ,  A61B5/002 ,  A61B5/1486 ,  A61B5/682 ,  A61B5/6821 ,  A61B2562/12 ,  G02C7/04 ,  Y10T156/1028

Abstract: Body-mountable devices and methods for embedding a structure in a body-mountable device are described. A body-mountable device includes a transparent polymer and a structure embedded in the transparent polymer. The transparent polymer defines a posterior side and an anterior side of the body-mountable device. The structure has an outer diameter and an inner diameter and includes a sensor configured to detect an analyte and an antenna. The antenna includes a plurality of conductive loops spaced apart from each other between the outer diameter and the inner diameter.

Abstract translation: 描述了用于将结构嵌入体内安装的装置中的车身安装装置和方法。 体内安装装置包括透明聚合物和嵌入透明聚合物中的结构。 透明聚合物限定身体安装装置的后侧和前侧。 该结构具有外径和内径，并且包括被配置为检测分析物和天线的传感器。 天线包括在外径和内径之间彼此间隔开的多个导电环。

公开(公告)号：WO2014052128A1

公开(公告)日：2014-04-03

申请号：PCT/US2013/060432

申请日：2013-09-18

Applicant: GOOGLE INC.

Inventor： LIU, Zenghe ,  ETZKORN, James

IPC: G01N33/48 ,  G01N33/50 ,  G01N33/53

CPC classification number: G01N33/528 ,  B01J2219/00612 ,  B01J2219/00621 ,  G01N21/6486 ,  G01N21/75 ,  G01N33/5304 ,  G01N33/54366 ,  G01N33/54386 ,  G01N33/62 ,  G01N33/66 ,  G01N33/92 ,  G01N33/98 ,  G01N2333/46 ,  Y10T436/144444

Abstract: Contact lens testing apparatuses and method for testing contact lenses for analytes are presented. In an aspect, a device is provided that includes a housing configured to hold one or more contact lenses, and a testing compartment provided within the housing and comprising a reagent, the reagent configured to facilitate a chemical reaction in response to the existence of a predetermined biomarker disposed on or within a contact lens placed in the testing compartment, wherein the chemical reaction produces a known result related to state information of an individual from which the biomarker was generated.

Abstract translation: 介绍了用于测试分析物的隐形眼镜的隐形眼镜测试仪器和方法。 一方面，提供了一种装置，其包括构造成保持一个或多个隐形眼镜的壳体，以及设置在壳体内并包括试剂的测试室，所述试剂被配置为响应于存在预定的 放置在测试室中的隐形眼镜上或其内的生物标志物，其中化学反应产生与生成生物标志物的个体的状态信息相关的已知结果。