公开(公告)号：WO2016059498A1

公开(公告)日：2016-04-21

申请号：PCT/IB2015/057466

申请日：2015-09-30

Applicant: KONINKLIJKE PHILIPS N.V. ,  SUNNYBROOK HEALTH SCIENCES CENTRE

Inventor： BHARAT, Shyam ,  DEHGHAN MARVAST, Ehsan ,  KRUECKER, Jochen ,  RAVI, Ananth ,  UHLEMANN, Falk ,  KUNG, Cynthia Ming-fu ,  AMTHOR, Thomas Erik

IPC: A61B19/00

CPC classification number: G06T7/0012 ,  A61B5/4381 ,  A61B34/20 ,  A61B90/37 ,  A61B2034/2051 ,  A61B2090/364 ,  A61B2090/378 ,  G06T7/10 ,  G06T2207/10132

Abstract: An interventional therapy system (100, 200, 300, 900) may include at least one controller (102, 202, 910) which may obtain a reference image dataset (540) of an object of interest (OOI); segment the reference image dataset to determine peripheral outlines (545) of the OOI in the plurality image slices; acquire a current image of the OOI (548) using an ultrasound probe (114, 224); select a peripheral outline (CBS, 545) of a selected image slice of the plurality of slices of the reference image dataset which is determined to correspond to the current image; and/or modify the selected peripheral outline of the image slice of the plurality of slices of the reference image dataset in accordance with at least one deformation vector (549).

Abstract translation: 介入治疗系统（100,200,300,900）可以包括至少一个控制器（102,202,910），其可以获得感兴趣对象（50I）的参考图像数据集（540）; 分割参考图像数据集以确定多个图像切片中的OOI的外围轮廓（545）; 使用超声探头（114,224）获取所述OOI（548）的当前图像; 选择被确定为对应于当前图像的参考图像数据集的多个切片的选定图像切片的外围轮廓（CBS，545）; 和/或根据至少一个变形向量（549）修改参考图像数据集的多个切片的所选择的外围轮廓。

公开(公告)号：WO2015044239A1

公开(公告)日：2015-04-02

申请号：PCT/EP2014/070428

申请日：2014-09-25

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： UHLEMANN, Falk ,  OVERWEG, Johannes Adrianus

IPC: A61N5/10 ,  A61B19/00

CPC classification number: A61N5/1039 ,  A61B2090/374 ,  A61B2090/3954 ,  A61N5/1001 ,  A61N5/1071

Abstract: The invention provides for a medical instrument (400, 500, 600, 700) comprising a magnetic resonance imaging system (404) and an external beam radiotherapy system (402) for irradiating a target zone (438) of a subject with a beam (442) of ionizing radiation within the imaging zone. The medical instrument further comprises a processor (448) for controlling the medical instrument. Execution of instructions cause the processor to: acquire (100, 200) first magnetic resonance data (458); reconstruct (102, 202) a first magnetic resonance image (460) from the first magnetic resonance data; receive (104, 204) planning data (462), wherein the planning data specifies a spatially dependent radiation dose for the target zone; register (106, 206) the planning data to the first magnetic resonance image; and calculate (108, 208) an external beam dosage plan (468) and a brachytherapy dosage plan (468) using the spatially dependent radiation dose and the first magnetic resonance image.

Abstract translation: 本发明提供一种包括磁共振成像系统（404）和外部束放射治疗系统（402）的医疗器械（400,500,600,700），用于用束（442）照射被检体的目标区域（438） ）成像区域内的电离辐射。 医疗仪器还包括用于控制医疗器械的处理器（448）。 执行指令使处理器：获取（100,200）第一磁共振数据（458）; 从第一磁共振数据重建（102,202）第一磁共振图像（460）; 接收（104,204）规划数据（462），其中所述规划数据指定所述目标区域的空间依赖的辐射剂量; 将所述规划数据寄存器（106,206）注册到所述第一磁共振图像; 并且使用空间依赖的辐射剂量和第一磁共振图像计算（108,208）外部束剂量计划（468）和近距离放射治疗剂量计划（468）。

公开(公告)号：WO2019086399A1

公开(公告)日：2019-05-09

申请号：PCT/EP2018/079617

申请日：2018-10-30

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： UHLEMANN, Falk

IPC: G16H40/20

Abstract: Presented are concepts for matching a subject to one or more resources or workflow steps. Once such concept comprises obtaining data associated with a subject, the data comprising, for each of a plurality of parameters, a parameter value relating to the subject. A plurality of data groups for characterising the subject is then generated and a classification process is applied to each data group so as to generate a classification result for each data group. The subject is then matched to one or more resources or workflow steps based on the classification results.

公开(公告)号：WO2015169498A1

公开(公告)日：2015-11-12

申请号：PCT/EP2015/056108

申请日：2015-03-23

Applicant: KONINKLIJKE PHILIPS N.V. ,  SUNNYBROOK HEALTH SCIENCES CENTRE

Inventor： AMTHOR, Thomas Erik ,  UHLEMANN, Falk ,  BHARAT, Shyam ,  DEHGHAN MARVAST, Ehsan ,  KUNG, Cynthia Ming-fu ,  RAVI, Ananth ,  KRUECKER, Jochen

IPC: A61N5/10

CPC classification number: A61N5/103 ,  A61N5/1027 ,  A61N2005/1041

Abstract: The generation of the pattern and for the adaptation to the specific geometry requires a lot of manual work. It is an object of the invention to simplify the workflow for the clinician during treatment planning. This object is achieved by a treatment planning system configured for determining a set of catheter or needle insertion positions to be used during treatment comprising. The treatment planning system comprises an image providing module for providing a medical image from which at least one treatment target structure can be derived. Further the treatment planning system comprises a pattern providing module for providing one or a set of standard patterns for catheter or needle insertion comprising a plurality of catheter or needle insertion positions, wherein the catheter or needle positions relate to treatment positions in the at least one treatment target structure.

Abstract translation: 模式的生成和适应特定几何需要大量的人工工作。 本发明的一个目的是简化治疗计划期间临床医生的工作流程。 该目的通过一种治疗计划系统来实现，所述治疗计划系统被配置用于确定在治疗期间使用的一组导管或针插入位置，包括。 治疗计划系统包括用于提供医学图像的图像提供模块，从该图像可以导出至少一个治疗目标结构。 此外，治疗计划系统包括模式提供模块，用于提供包括多个导管或针插入位置的导管或针插入的一个或一组标准图案，其中导管或针位置涉及至少一个治疗中的治疗位置 目标结构。

公开(公告)号：WO2015086480A1

公开(公告)日：2015-06-18

申请号：PCT/EP2014/076807

申请日：2014-12-08

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： UHLEMANN, Falk ,  KRUEGER, Sascha ,  WIRTZ, Daniel ,  WEISS, Steffen

IPC: G01R33/34 ,  G01R33/341 ,  G01R33/58

CPC classification number: A61B90/39 ,  A61B5/055 ,  A61B2090/3958 ,  G01R33/285 ,  G01R33/34007 ,  G01R33/34069 ,  G01R33/341 ,  G01R33/58

Abstract: The invention provides for a medical apparatus (100) with a magnetic resonance coil assembly (102, 102') comprising a magnetic resonance antenna with a first antenna portion (108, 108') and a second antenna portion (110, 110') for receiving magnetic resonance location data (1246) from a fiducial marker (118, 300, 400, 500). The magnetic resonance coil assembly further comprises a clamp with a first clamping portion (104, 104') and a second clamping portion (106, 106') operable for being moved between an open and a closed configuration. The first clamping portion comprises the first antenna portion. The second clamping portion comprises the second antenna portion. The first and second clamping portions are operable for securing the fiducial marker within a signal reception volume (111) in the closed configuration. When in the open position, the first and second clamping portions enable the fiducial marker being moved into or out of the signal reception volume.

Abstract translation: 本发明提供具有磁共振线圈组件（102,102'）的医疗设备（100），该磁共振线圈组件包括具有第一天线部分（108,108'）和第二天线部分（110,110'）的磁共振天线，用于 从基准标记（118,300,400,500）接收磁共振位置数据（1246）。 磁共振线圈组件还包括具有第一夹持部分（104,104'）的夹具和可操作以在打开和闭合构型之间移动的第二夹持部分（106,106'）。 第一夹持部分包括第一天线部分。 第二夹持部分包括第二天线部分。 第一和第二夹持部分可操作以将基准标记固定在关闭构造中的信号接收体积（111）内。 当处于打开位置时，第一和第二夹紧部分使得基准标记物被移入或移出信号接收体积。

公开(公告)号：WO2015044065A1

公开(公告)日：2015-04-02

申请号：PCT/EP2014/070079

申请日：2014-09-22

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： UHLEMANN, Falk ,  OVERWEG, Johannes Adrianus

IPC: A61N5/10 ,  A61B5/055

CPC classification number: A61N5/1049 ,  A61B5/0035 ,  A61B5/0555 ,  A61B2576/00 ,  A61N5/1039 ,  A61N5/1067 ,  A61N5/1071 ,  A61N5/1077 ,  A61N2005/1054 ,  A61N2005/1055 ,  A61N2005/1074 ,  A61N2005/1087 ,  A61N2005/1089

Abstract: The invention provides for a medical instrument (200, 300, 400, 500, 600, 700) comprising a magnetic resonance imaging system (204) operable for acquiring magnetic resonance data (266) from a subject (236) within an imaging zone (232) and an external beam radiotherapy system (202) operable for irradiating a target zone (238) within the imaging zone. The medical instrument further has a radiation beam generation system (208, 302, 302', 302") operable for generating a radiation beam (242, 304, 304', 304") and a radiation beam detection system (243, 502, 502') operable for acquiring radiation beam detection data (270) descriptive of the radiation beam. Instructions cause a processor (248) controlling the instrument to receive (100) planning data (260) descriptive of a spatially dependent radiation dose and generate (102) external beam radiotherapy control commands (264) using the radiation dose. The instructions causes the processor to repeatedly: control (106) the external beam radiotherapy system to irradiate the target zone using the external beam radiotherapy system control commands; generate (108) the radiation beams using the radiation beam generation system; measure (110) the radiation beam detection data using the radiation beam detection system; acquire (112) the magnetic resonance imaging data using the magnetic resonance imaging system, generate (114) a magnetic resonance image (268) using the magnetic resonance image data, determine (116) a registration (274) of the magnetic resonance image to the radiation beam detection data; calculate (118) a mapping (276) using the registration; and modify the external beam radiotherapy system control commands using the mapping.

Abstract translation: 本发明提供一种包括磁共振成像系统（204）的医疗器械（200,300,400,500,600,700），所述磁共振成像系统可操作用于从成像区域内的对象（236）获取磁共振数据（266） ）和外部束放射治疗系统（202），其可操作用于照射成像区域内的目标区域（238）。 医疗器械还具有可操作以产生辐射束（242,304,304'，304“）和辐射束检测系统（243,502,502）的辐射束产生系统（208,302,302'，302”） '）可用于获取描述辐射束的辐射束检测数据（270）。 指令使处理器（248）控制仪器接收（100）描述空间依赖的辐射剂量的规划数据（260），并使用辐射剂量产生（102）外部束放射治疗控制命令（264）。 指令使处理器重复：使用外部束放射治疗系统控制命令控制（106）外束放射治疗系统照射目标区域; 使用辐射束产生系统产生（108）辐射束; 使用辐射束检测系统测量（110）辐射束检测数据; 使用磁共振成像系统获取（112）磁共振成像数据，使用磁共振图像数据生成（114）磁共振图像（268），确定（116）磁共振图像的配准（274）到 辐射束检测数据; 使用注册计算（118）映射（276）; 并使用映射修改外部束放射治疗系统控制命令。

公开(公告)号：WO2018134445A1

公开(公告)日：2018-07-26

申请号：PCT/EP2018/051610

申请日：2018-01-23

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： UHLEMANN, Falk ,  NIELSEN, Tim ,  WUELBERN, Jan, Hendrik

IPC: G01R33/563 ,  G01R33/567

CPC classification number: G01R33/56325 ,  G01R33/5676

Abstract: The invention provides for a magnetic resonance imaging system (100, 200) comprising a memory (148) for storing machine executable instructions (150) and pulse sequence commands (152). The pulse sequence commands are configured for acquiring a four dimensional magnetic resonance data set (162) from an imaging region of interest (109). The four dimensional magnetic resonance data set is at least divided into three dimensional data magnetic resonance data sets (400, 402, 404, 406, 408) indexed by a repetitive motion phase of the subject. The three dimensional data magnetic resonance data sets are further at least divided into and indexed by k-space portions (410, 412, 414, 416, 418, 420, 422, 424, 426, 428, 430, 432, 434, 436). The magnetic resonance imaging system further comprises a processor (144) for controlling the magnetic resonance imaging system. Execution of the machine executable instructions causes the processor during a first operational portion (310) to iteratively: receive (300) a motion signal (156) descriptive of the repetitive motion phase; acquire (302) an initial k-space portion using the pulse sequence commands, wherein the initial k-space portion is selected from the k-space portions; store (304) the motion signal and the initial k-space portion in a buffer (158) for each iteration of the first operational portion; at least partially construct (306) a motion phase mapping (160) between the motion signal and the repetitive motion phase; and continue (308) the first operational portion until the motion phase mapping is complete. Execution of the machine executable instructions causes the processor to assign (312) the initial k-space portion for each iteration of the first operational portion in the temporary buffer to the four dimensional magnetic resonance data set using the motion phase mapping. Execution of the machine executable instructions causes the processor during a second operational portion (332) to iteratively: receive (314) the motion signal; determine (316) a predicted next motion phase using the motion signal and the motion phase mapping; select (318) a subsequent k-space portion (154) from the k-space portions of the four dimensional magnetic resonance data set using the predicted next motion phase; acquire (320) the subsequent k-space portion using the pulse sequence commands; rereceive (322) the motion signal; determine (324) a current motion phase using the re-received motion signal and the motion phase mapping; assign (326) the subsequent k-space portion to the four dimensional magnetic resonance data set using the current motion phase; and repeat (328) the second operational portion until the k-space portions for each repetitive motion phase has been assigned.

公开(公告)号：WO2015197335A1

公开(公告)日：2015-12-30

申请号：PCT/EP2015/062423

申请日：2015-06-03

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： LIPS, Oliver ,  OVERWEG, Johannes Adrianus ,  UHLEMANN, Falk

IPC: G01R33/48 ,  G01R33/385

CPC classification number: A61B5/0035 ,  A61B5/055 ,  A61B6/037 ,  A61B6/4417 ,  G01R33/385 ,  G01R33/3856 ,  G01R33/481 ,  G01T1/1603

Abstract: The invention provides for a magnetic resonance imaging gradient coil assembly (110) comprising a cylindrical coil carrier tube (129). The cylindrical coil carrier tube has an inner surface (125) and an outer surface (129). The cylindrical coil carrier tube has a cylindrical axis of symmetry (200). The cylindrical coil carrier tube has a center (203). The cylindrical coil carrier tube has a photon detector ring receptacle (122) recessed into the inner surface of the cylindrical coil carrier tube. The detector ring receptacle is centered about the center. The photon detector ring receptacle comprises side walls(126) formed from the cylindrical carrier tube and a solid back wall (128) formed from the cylindrical carrier tube. The magnetic resonance imaging gradient coil assembly further comprises a set of magnetic resonance imaging gradient coils (208, 210) attached to the cylindrical coil carrier tube.

Abstract translation: 本发明提供一种包括圆柱形线圈载体管（129）的磁共振成像梯度线圈组件（110）。 圆柱形线圈架管具有内表面（125）和外表面（129）。 圆柱形线圈载体管具有圆柱形对称轴（200）。 圆柱形线圈架管具有中心（203）。 圆柱形线圈载体管具有凹入圆柱形线圈载体管的内表面中的光子检测器环插座（122）。 检测器环插座以中心为中心。 光子检测器环插座包括由圆柱形载体管形成的侧壁（126）和由圆柱形载体管形成的固体后壁（128）。 磁共振成像梯度线圈组件还包括附接到圆柱形线圈载体管的一组磁共振成像梯度线圈（208,210）。

公开(公告)号：WO2014033583A1

公开(公告)日：2014-03-06

申请号：PCT/IB2013/056656

申请日：2013-08-15

Applicant: KONINKLIJKE PHILIPS N.V. ,  PHILIPS DEUTSCHLAND GMBH

Inventor： KRUECKER, Jochen ,  BHARAT, Shyam ,  KUNG, Cynthia Ming-fu ,  HALL, Christopher Stephen ,  UHLEMANN, Falk

IPC: A61B17/34 ,  A61B19/00 ,  A61N5/10

CPC classification number: A61B19/5244 ,  A61B17/3403 ,  A61B34/20 ,  A61B2017/00274 ,  A61B2017/3411 ,  A61B2034/2051 ,  A61B2034/2072 ,  A61N5/1001 ,  A61N5/1007 ,  A61N5/1049 ,  A61N2005/1012 ,  A61N2005/1051 ,  A61N2005/1058

Abstract: A system with integrated tracking includes a procedure-specific hardware component (112 or 116) disposed at or near a region of interest. A field generator (114) is configured to generate a field with a field of view covering the region of interest. A mounting device (115) is connected to the field generator and is coupled to the procedure-specific hardware. The field generator is fixedly positioned by the mounting device to permit workflow access to the region of interest without interfering with the field generator and to provide a known position of the field generator relative to the region of interest. A tracking device (110) is configured to be inserted in or near the region of interest to be tracked within the field of view of the field generator to generate tracking data.

Abstract translation: 具有集成跟踪的系统包括设置在感兴趣区域处或附近的特定于程序的硬件组件（112或116）。 场发生器（114）被配置为产生具有覆盖感兴趣区域的视场的场。 安装装置（115）连接到场发生器并且耦合到程序特定的硬件。 场发生器通过安装装置固定地定位，以允许工作流程进入感兴趣区域而不干扰场发生器，并提供现场发电机相对于感兴趣区域的已知位置。 跟踪装置（110）被配置为插入到场发生器的视野内要跟踪的感兴趣区域中或附近，以产生跟踪数据。

公开(公告)号：WO2014016762A1

公开(公告)日：2014-01-30

申请号：PCT/IB2013/056019

申请日：2013-07-23

Applicant: KONINKLIJKE PHILIPS N.V. ,  PHILIPS DEUTSCHLAND GMBH

Inventor： AMTHOR, Thomas Erik ,  KRUEGER, Sascha ,  WEISS, Steffen ,  UHLEMANN, Falk

IPC: A61N5/10 ,  A61N1/32 ,  A61N1/05 ,  A61B18/14 ,  A61N1/20 ,  A61B18/00

CPC classification number: A61N5/1007 ,  A61B18/1492 ,  A61B34/10 ,  A61B34/25 ,  A61B90/37 ,  A61B2018/00107 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00994 ,  A61B2018/143 ,  A61B2018/1472 ,  A61B2090/374 ,  A61B2090/376 ,  A61B2090/3762 ,  A61B2090/378 ,  A61M39/22 ,  A61N1/0502 ,  A61N1/205 ,  A61N1/327 ,  A61N5/1002 ,  A61N5/1027 ,  A61N2005/1008 ,  A61N2005/1021 ,  A61N2005/1024

Abstract: A medical device for multiple treatment therapies includes a hollow tube (102) having a first end portion with an electrode (104) disposed at the first end portion and an insulator (108) configured over a length of the tube such that conductive materials of the tube, except for the electrode, are electrically isolated from an exterior surface the tube. A conductive connection (127) is configured to electrically couple to the electrode to provide a voltage thereto. A selectively closeable valve (106) is configured to dispense a medical fluid from the tube.

Abstract translation: 用于多重治疗疗法的医疗装置包括具有第一端部的中空管（102），第一端部具有设置在第一端部处的电极（104）和在管的长度上配置的绝缘体（108），使得导电材料 除了电极之外，管与管的外表面电隔离。 导电连接（127）被配置为电耦合到电极以向其提供电压。 选择性关闭阀（106）构造成从管分配医用流体。